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The map label for this gene is clpP [H]

Identifier: 108800544

GI number: 108800544

Start: 3810185

End: 3810772

Strand: Reverse

Name: clpP [H]

Synonym: Mmcs_3578

Alternate gene names: 108800544

Gene position: 3810772-3810185 (Counterclockwise)

Preceding gene: 108800545

Following gene: 108800543

Centisome position: 66.79

GC content: 66.67

Gene sequence:

>588_bases
ATGCGTGGCGGGGCGCCGGGCCTCACGCTCCAGGACTCGGTCTACGAGCGTCTGCTCGCCGAGCGCATCATCTTCCTCGG
CTCGCAGGTGGACGACGACATCGCCAACCGCCTGTGCGCCCAGATCTTGCTGCTCTCGGCGGAGGACCCGACGAAGGACA
TCCACCTCTACATCAACTCGCCCGGCGGCTCGATCAGCGCCGGCATGGCGATCTACGACACGATGGTCCTGGCCCCGTGC
GACGTCGCGACCTACGCGATGGGCATGGCCGCGTCCATGGGTGAGTTCCTGCTCGCCGCGGGCACCAAGGGTAAGCGTTA
CGCCCTGCCCCACGCCCGCATCCTGATGCACCAGCCGCTCGGCGGTATCACCGGTGGCGCGGCCGACATCGCGATCCAGG
CCGAGCAGTTCGCGGCGATCAAGAAGGAGATGTTCCGCCTCAACGCCGAGTTCACCGGGCAGACCATCGAACGCATCGAG
GCCGACTCGGACCGCGACCGCTGGTTCACCGCGCAGGAAGCGCTCGAATACGGATTCGTCGACCACATCATCACCAGCGC
CAGCATCAACGACGGAGTGGCCCCCTAA

Upstream 100 bases:

>100_bases
GCTCACGCAGGTTGGTTAGTGTCGAGAAGACATCGACGAACACACCGCGAACTGGCGGACCCCAGACGTAAGAGAAAGCA
GGTATCCAGTCGTGACTGTT

Downstream 100 bases:

>100_bases
TGAGCAACCAGACCGATCCCCGCCTCCAGCCGCAGGCGCGCTACATCCTGCCGTCGTTCATCGAGCACTCGAGCTTCGGC
GTCAAGGAATCCAACCCGTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRGGAPGLTLQDSVYERLLAERIIFLGSQVDDDIANRLCAQILLLSAEDPTKDIHLYINSPGGSISAGMAIYDTMVLAPC
DVATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGITGGAADIAIQAEQFAAIKKEMFRLNAEFTGQTIERIE
ADSDRDRWFTAQEALEYGFVDHIITSASINDGVAP

Sequences:

>Translated_195_residues
MRGGAPGLTLQDSVYERLLAERIIFLGSQVDDDIANRLCAQILLLSAEDPTKDIHLYINSPGGSISAGMAIYDTMVLAPC
DVATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGITGGAADIAIQAEQFAAIKKEMFRLNAEFTGQTIERIE
ADSDRDRWFTAQEALEYGFVDHIITSASINDGVAP
>Mature_195_residues
MRGGAPGLTLQDSVYERLLAERIIFLGSQVDDDIANRLCAQILLLSAEDPTKDIHLYINSPGGSISAGMAIYDTMVLAPC
DVATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPLGGITGGAADIAIQAEQFAAIKKEMFRLNAEFTGQTIERIE
ADSDRDRWFTAQEALEYGFVDHIITSASINDGVAP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=172, Percent_Identity=47.093023255814, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1786641, Length=172, Percent_Identity=57.5581395348837, Blast_Score=208, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17538017, Length=172, Percent_Identity=48.8372093023256, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI20129427, Length=171, Percent_Identity=46.1988304093567, Blast_Score=167, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 20981; Mature: 20981

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGGAPGLTLQDSVYERLLAERIIFLGSQVDDDIANRLCAQILLLSAEDPTKDIHLYINS
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
PGGSISAGMAIYDTMVLAPCDVATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPL
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHEEECCC
GGITGGAADIAIQAEQFAAIKKEMFRLNAEFTGQTIERIEADSDRDRWFTAQEALEYGFV
CCCCCCCHHEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
DHIITSASINDGVAP
HHHHHHCCCCCCCCC
>Mature Secondary Structure
MRGGAPGLTLQDSVYERLLAERIIFLGSQVDDDIANRLCAQILLLSAEDPTKDIHLYINS
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
PGGSISAGMAIYDTMVLAPCDVATYAMGMAASMGEFLLAAGTKGKRYALPHARILMHQPL
CCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHEEECCC
GGITGGAADIAIQAEQFAAIKKEMFRLNAEFTGQTIERIEADSDRDRWFTAQEALEYGFV
CCCCCCCHHEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
DHIITSASINDGVAP
HHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]