Click here to switch to the map view.

The map label for this gene is clpP2 [H]

Identifier: 108800543

GI number: 108800543

Start: 3809538

End: 3810185

Strand: Reverse

Name: clpP2 [H]

Synonym: Mmcs_3577

Alternate gene names: 108800543

Gene position: 3810185-3809538 (Counterclockwise)

Preceding gene: 108800544

Following gene: 108800542

Centisome position: 66.78

GC content: 64.97

Gene sequence:

>648_bases
ATGAGCAACCAGACCGATCCCCGCCTCCAGCCGCAGGCGCGCTACATCCTGCCGTCGTTCATCGAGCACTCGAGCTTCGG
CGTCAAGGAATCCAACCCGTACAACAAGCTCTTCGAGGAACGCATCATCTTCCTCGGCGTGCAGGTGGACGACGCGTCGG
CGAACGACATCATGGCCCAGCTGCTGGTCCTCGAGTCGCTCGATCCCGACCGCGACATCACCATGTACATCAACTCGCCC
GGTGGCTCCTTCACGAGCCTGATGGCGATCTACGACACCATGCAGTACGTGCGCGCGGACATCCAGACGGTGTGCCTGGG
CCAGGCCGCCTCGGCCGCCGCGGTGCTGCTGGCCGCCGGCACACCCGGTAAGCGGCTCGCGCTGCCGAACGCCCGGATCC
TCATCCACCAGCCCGCGCTGTCCGGCGTGATCCAGGGTCAGTTCTCCGATCTGGAGATCCAGGCCAAGGAGATCGAGCGG
ATGCGCACGCTGATGGAGGTCACCCTGGCGCGGCACACCGGCAAGGACCCCGAGACGATCCGCAAGGACACCGATCGCGA
CAAGATCCTGACCGCCGAAGAGGCCAAGGACTACGGGATCATCGACACCGTCCTCGAGTACCGGAAGCTGTCGGCTCAGA
CGTCCTGA

Upstream 100 bases:

>100_bases
CGGACCGCGACCGCTGGTTCACCGCGCAGGAAGCGCTCGAATACGGATTCGTCGACCACATCATCACCAGCGCCAGCATC
AACGACGGAGTGGCCCCCTA

Downstream 100 bases:

>100_bases
CCACCGGCGGGGACGCCCATTCGGTCACGAGGCCAACAATGCCGTGCGCGGTATTGTTGGCCTCAGCCGTTCGCTCCGGT
CACGGTGACGACACGCCAGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MSNQTDPRLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSP
GGSFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRLALPNARILIHQPALSGVIQGQFSDLEIQAKEIER
MRTLMEVTLARHTGKDPETIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTS

Sequences:

>Translated_215_residues
MSNQTDPRLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSP
GGSFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRLALPNARILIHQPALSGVIQGQFSDLEIQAKEIER
MRTLMEVTLARHTGKDPETIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTS
>Mature_214_residues
SNQTDPRLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPG
GSFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRLALPNARILIHQPALSGVIQGQFSDLEIQAKEIERM
RTLMEVTLARHTGKDPETIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=44.2105263157895, Blast_Score=168, Evalue=3e-42,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=48.9690721649485, Blast_Score=205, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=42.4870466321244, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=44.2708333333333, Blast_Score=165, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23862; Mature: 23730

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQTDPRLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQ
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHH
LLVLESLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAG
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
TPGKRLALPNARILIHQPALSGVIQGQFSDLEIQAKEIERMRTLMEVTLARHTGKDPETI
CCCCEEECCCCEEEEECCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
RKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTS
HCCCCCHHEEEHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNQTDPRLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQ
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHHH
LLVLESLDPDRDITMYINSPGGSFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAG
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
TPGKRLALPNARILIHQPALSGVIQGQFSDLEIQAKEIERMRTLMEVTLARHTGKDPETI
CCCCEEECCCCEEEEECCHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHH
RKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTS
HCCCCCHHEEEHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]