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The map label for this gene is hisC [C]

Identifier: 108800311

GI number: 108800311

Start: 3544985

End: 3546007

Strand: Reverse

Name: hisC [C]

Synonym: Mmcs_3345

Alternate gene names: 108800311

Gene position: 3546007-3544985 (Counterclockwise)

Preceding gene: 108800315

Following gene: 108800310

Centisome position: 62.15

GC content: 74.88

Gene sequence:

>1023_bases
GTGCCACGTCCCGCGCCGCAGGCGATCAGGTACCACGGCGACCAGGCCGTGCTGCCCGGCATGCTCGACTTCGCCGTCAA
CGTGCGCGCCGCCGCGCCGCCGTCGTGGCTGGCCGAGCGCCTCGCGGACCGCCTGGCCGACCTCGGCCGCTATCCGTCGC
CCGCCGACGAACGCCGCGCCGTGGCCGCGGTGGCGGCCCGGCACGGGCGCGCCGAGGACGAGGTCGCGCTGCTGGCCGGC
GGGGCGGAGGGCTTCGCGCTGCTCGCCCGCCTGCAGCCCCGGTTGGCCGCGCTCGTCGCGCCGTCGTTCACCGAACCCGA
TGCGGTGTTCGCCGCCGCGGGGGTGCCCCTCGCACACGTGGTGCTCGATCCACCGTTCGCGCTGACCGGCGCCCGGGTAC
CGGATGCGGCCGATCTCGTGGTGGTGGGCAACCCCACCAACCCCACCGGGGTGCTGCACCCCAGGGCCGACATCCTCGCG
CTGCGCCGACCCGGCCGGATCGTGGTGGTCGACGAGGCGTTCGCCGACGCGGTGCCCGGGGAGCCGGAGTCGCTGGCCGA
CGATGCCCCGCCGGACGTGCTGGTGCTGCGCAGCCTCACCAAGACCTGGGCGCTGGCCGGGCTACGGGTCGGGTATGCGC
TCGGTGCCCCCGACGTGCTGCGGCGGTTGACCGCGCAGCGCGCACACTGGGCGCTGGGGACGCTGCAGTTGGAGGCGCTC
GCCGCATGCAATGCGCCGTCCGCGCTACGCGAGGCCAAAGCCGGTGCGGAACGGCTCGCGGCGCTGCGGGCGGAGATGGT
GACCGGCCTGCGCCGGATCGGCGCCGAGTGTGTCGCCGGCTCCGCACCGTTCGTGCTGTTCGCGGTGCCGGATGCCGAGT
TGGTGCGAAAACGATTGGAAGTCAGGGGGATCGCAGTGCGGCGGTGCGACACATTCGTCGGCCTGGATGGTCAGTTCCTG
AGGGCGGCGGTCCGCGAGGAGTGGCCGGTGCTCGCCGAGGCGCTGGCGGAGGCGATGCGATGA

Upstream 100 bases:

>100_bases
GGCCAGCGTGTCGGTCACGCCCCCATTCTCCCCGAAGTCCGCACCGGCGTTCGCGGGGTCGTCCGGCTTCGCGTCGCGTC
GCGCGCATTACTGTCGTGCT

Downstream 100 bases:

>100_bases
GCGTACGGCTGGCCGACGTCATCGGCGTGCTCGACGAGGCGTATCCGCCGCGATTGGCCGAGGACTGGGATTCGGTCGGG
CTGGTGTGCGGTGACCCCGA

Product: hypothetical protein

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MPRPAPQAIRYHGDQAVLPGMLDFAVNVRAAAPPSWLAERLADRLADLGRYPSPADERRAVAAVAARHGRAEDEVALLAG
GAEGFALLARLQPRLAALVAPSFTEPDAVFAAAGVPLAHVVLDPPFALTGARVPDAADLVVVGNPTNPTGVLHPRADILA
LRRPGRIVVVDEAFADAVPGEPESLADDAPPDVLVLRSLTKTWALAGLRVGYALGAPDVLRRLTAQRAHWALGTLQLEAL
AACNAPSALREAKAGAERLAALRAEMVTGLRRIGAECVAGSAPFVLFAVPDAELVRKRLEVRGIAVRRCDTFVGLDGQFL
RAAVREEWPVLAEALAEAMR

Sequences:

>Translated_340_residues
MPRPAPQAIRYHGDQAVLPGMLDFAVNVRAAAPPSWLAERLADRLADLGRYPSPADERRAVAAVAARHGRAEDEVALLAG
GAEGFALLARLQPRLAALVAPSFTEPDAVFAAAGVPLAHVVLDPPFALTGARVPDAADLVVVGNPTNPTGVLHPRADILA
LRRPGRIVVVDEAFADAVPGEPESLADDAPPDVLVLRSLTKTWALAGLRVGYALGAPDVLRRLTAQRAHWALGTLQLEAL
AACNAPSALREAKAGAERLAALRAEMVTGLRRIGAECVAGSAPFVLFAVPDAELVRKRLEVRGIAVRRCDTFVGLDGQFL
RAAVREEWPVLAEALAEAMR
>Mature_339_residues
PRPAPQAIRYHGDQAVLPGMLDFAVNVRAAAPPSWLAERLADRLADLGRYPSPADERRAVAAVAARHGRAEDEVALLAGG
AEGFALLARLQPRLAALVAPSFTEPDAVFAAAGVPLAHVVLDPPFALTGARVPDAADLVVVGNPTNPTGVLHPRADILAL
RRPGRIVVVDEAFADAVPGEPESLADDAPPDVLVLRSLTKTWALAGLRVGYALGAPDVLRRLTAQRAHWALGTLQLEALA
ACNAPSALREAKAGAERLAALRAEMVTGLRRIGAECVAGSAPFVLFAVPDAELVRKRLEVRGIAVRRCDTFVGLDGQFLR
AAVREEWPVLAEALAEAMR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=302, Percent_Identity=27.1523178807947, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 35876; Mature: 35745

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00092 N6_MTASE ; PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPAPQAIRYHGDQAVLPGMLDFAVNVRAAAPPSWLAERLADRLADLGRYPSPADERRA
CCCCCCCHHHCCCCCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
VAAVAARHGRAEDEVALLAGGAEGFALLARLQPRLAALVAPSFTEPDAVFAAAGVPLAHV
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEE
VLDPPFALTGARVPDAADLVVVGNPTNPTGVLHPRADILALRRPGRIVVVDEAFADAVPG
EECCCCCCCCCCCCCCCCEEEECCCCCCCCEECCCHHHHEECCCCEEEEEEHHHHCCCCC
EPESLADDAPPDVLVLRSLTKTWALAGLRVGYALGAPDVLRRLTAQRAHWALGTLQLEAL
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AACNAPSALREAKAGAERLAALRAEMVTGLRRIGAECVAGSAPFVLFAVPDAELVRKRLE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
VRGIAVRRCDTFVGLDGQFLRAAVREEWPVLAEALAEAMR
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
PRPAPQAIRYHGDQAVLPGMLDFAVNVRAAAPPSWLAERLADRLADLGRYPSPADERRA
CCCCCCHHHCCCCCCCCCHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
VAAVAARHGRAEDEVALLAGGAEGFALLARLQPRLAALVAPSFTEPDAVFAAAGVPLAHV
HHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEE
VLDPPFALTGARVPDAADLVVVGNPTNPTGVLHPRADILALRRPGRIVVVDEAFADAVPG
EECCCCCCCCCCCCCCCCEEEECCCCCCCCEECCCHHHHEECCCCEEEEEEHHHHCCCCC
EPESLADDAPPDVLVLRSLTKTWALAGLRVGYALGAPDVLRRLTAQRAHWALGTLQLEAL
CCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AACNAPSALREAKAGAERLAALRAEMVTGLRRIGAECVAGSAPFVLFAVPDAELVRKRLE
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHH
VRGIAVRRCDTFVGLDGQFLRAAVREEWPVLAEALAEAMR
HHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]