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The map label for this gene is hisB

Identifier: 108800027

GI number: 108800027

Start: 3236738

End: 3237364

Strand: Reverse

Name: hisB

Synonym: Mmcs_3061

Alternate gene names: 108800027

Gene position: 3237364-3236738 (Counterclockwise)

Preceding gene: 108800028

Following gene: 108800026

Centisome position: 56.74

GC content: 65.55

Gene sequence:

>627_bases
ATGACCGACATGCTGACCGGCACCCGCCGCGCCCGCGTCGAACGCAAGACCAAGGAATCGGACATCGTCGTCGATCTCGA
CCTCGACGGCACCGGCATCGTCGACATCCGCACCGGCGTGCCGTTCTTCGATCACATGCTGACCTCGTTGGGCAGCCACG
CCAGCTTCGACCTCACCGTGCACGCCACGGGCGATATCGAGATCGAAGGGCACCACACGGTCGAGGACACCGCGATCGTG
CTCGGGCAGGCGCTCGGTCAGGCGCTCGGCGACAAGAAGGGCATCCGCCGTTTCGGTGACGCGTTCATCCCGATGGACGA
GACACTCGCCCACGCCGCGGTCGACGTGTCCGGTCGCCCGTACTTCGTGCACACCGGTGAACCCGACTACATGGTCGAGT
TCACCATCGCCGGATCGAGTGCGCCCTACCACACGGTGATCAACCGTCACGTCTTCGAATCGTTGGCGTTCAACGCCCGC
ATCGCGCTGCATGTGCGCACGATCTACGGCCGCGATCCGCACCACATCACCGAGGCGCAGTACAAGGCCGTCGCGCGCGC
GTTGCGCCAGGCCGTCGAACTCGATCCGCGGGTGACGGGTGTGCCGTCCACGAAAGGCTCACTGTGA

Upstream 100 bases:

>100_bases
ACCTGCGGACCACAATCGGGTTGGCCGAAGAGAACGATGCGCTGCTGACCGCCTCAGCCCGCCTCGTCGAGACCGAACTC
GCGGCAACATTAGGAGCCTT

Downstream 100 bases:

>100_bases
GCAGGAAAGTCGTCATCCTCGACTACGGCTCGGGCAATCTGCGCTCGGCGCAGCGCGCGGTCGAGCGCACCGGTGCCGAC
GTCGAGGTCACCGCCGACGC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTDMLTGTRRARVERKTKESDIVVDLDLDGTGIVDIRTGVPFFDHMLTSLGSHASFDLTVHATGDIEIEGHHTVEDTAIV
LGQALGQALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRPYFVHTGEPDYMVEFTIAGSSAPYHTVINRHVFESLAFNAR
IALHVRTIYGRDPHHITEAQYKAVARALRQAVELDPRVTGVPSTKGSL

Sequences:

>Translated_208_residues
MTDMLTGTRRARVERKTKESDIVVDLDLDGTGIVDIRTGVPFFDHMLTSLGSHASFDLTVHATGDIEIEGHHTVEDTAIV
LGQALGQALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRPYFVHTGEPDYMVEFTIAGSSAPYHTVINRHVFESLAFNAR
IALHVRTIYGRDPHHITEAQYKAVARALRQAVELDPRVTGVPSTKGSL
>Mature_207_residues
TDMLTGTRRARVERKTKESDIVVDLDLDGTGIVDIRTGVPFFDHMLTSLGSHASFDLTVHATGDIEIEGHHTVEDTAIVL
GQALGQALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRPYFVHTGEPDYMVEFTIAGSSAPYHTVINRHVFESLAFNARI
ALHVRTIYGRDPHHITEAQYKAVARALRQAVELDPRVTGVPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=202, Percent_Identity=45.049504950495, Blast_Score=154, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6324776, Length=226, Percent_Identity=35.8407079646018, Blast_Score=135, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_MYCSJ (A3Q129)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071347.1
- ProteinModelPortal:   A3Q129
- SMR:   A3Q129
- STRING:   A3Q129
- EnsemblBacteria:   EBMYCT00000050170
- GeneID:   4878790
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3077
- eggNOG:   COG0131
- GeneTree:   EBGT00050000017533
- HOGENOM:   HBG289010
- OMA:   RQAVEYD
- ProtClustDB:   PRK00951
- BioCyc:   MSP164757:MJLS_3077-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22759; Mature: 22628

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMLTGTRRARVERKTKESDIVVDLDLDGTGIVDIRTGVPFFDHMLTSLGSHASFDLTV
CCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEE
HATGDIEIEGHHTVEDTAIVLGQALGQALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRP
EECCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHEEECCCCE
YFVHTGEPDYMVEFTIAGSSAPYHTVINRHVFESLAFNARIALHVRTIYGRDPHHITEAQ
EEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCHHHHHH
YKAVARALRQAVELDPRVTGVPSTKGSL
HHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDMLTGTRRARVERKTKESDIVVDLDLDGTGIVDIRTGVPFFDHMLTSLGSHASFDLTV
CCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEE
HATGDIEIEGHHTVEDTAIVLGQALGQALGDKKGIRRFGDAFIPMDETLAHAAVDVSGRP
EECCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHEEECCCCE
YFVHTGEPDYMVEFTIAGSSAPYHTVINRHVFESLAFNARIALHVRTIYGRDPHHITEAQ
EEEECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCHHHHHH
YKAVARALRQAVELDPRVTGVPSTKGSL
HHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA