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The map label for this gene is lpdA [H]

Identifier: 108798220

GI number: 108798220

Start: 1352050

End: 1353462

Strand: Direct

Name: lpdA [H]

Synonym: Mmcs_1249

Alternate gene names: 108798220

Gene position: 1352050-1353462 (Clockwise)

Preceding gene: 108798217

Following gene: 108798221

Centisome position: 23.7

GC content: 69.92

Gene sequence:

>1413_bases
GTGCTCGTGGCAACCCGCATCGTGATCATCGGCGGCGGGCCCGCCGGTTATGAGGCGGCACTGGTTGCCGCAGGACCCGA
AACCCACGTCACCGTCATCGACTCCGACGGGGTGGGCGGTGCGTGCGTGCTCTACGACTGCGTGCCGTCGAAGACCTTCA
TCGCCTCGACAGGGGTGCGCACCGAACTGCGCCGCGCGACCGGCCTCGGGTTCGACATCAGCATCTCCGACGCCAAGGTC
TCGCTGCCGCAGATCCACAACCGCGTCAAGACGCTGGCCCGCTCACAGTCCGCCGACATCGGCAGCCAACTGCTGCGGGA
GGGCGTCACGGTCATCGGCGGCCGCGGGGAACTGGTCGACGACGTGCCGGGGCTGGCGCAGCACCGGGTCCGGGTCCGAA
CGCACGACGGCAAGACCGGTGTCCTCAAGGCCGACGTGGTGCTCATCGCCACCGGCGCCAGCCCCCGCGTGCTGCCCAAC
GCGGAGCCCGACGGCGAGCGCATCCTCACCTGGCGTCAGCTCTACGACCTGACCGAACTGCCCGAACATCTGGTGATCGT
GGGCTCCGGTGTCACGGGCGCCGAGTTCTGCAACGCCTACACCGAACTCGGCGTAACGGTGACCGTGGTCGCCAGCCGCG
ACCAGATCCTGCCGCACGAGGACAGCGACGCCGCCGCCGTCCTGGAAGAGGTGTTCGCCGAACGCGGCGTGACCCTGGTC
AAGAACGCCCGTGCCGAATCGGTGACCCGCACCGAGAACGGGGTCAAGGTGCAGATGGCCGACGGCCGCTGTGTGGAGGG
CAGCCACGCGCTGATGACCGTCGGCTCGGTGCCCAACACCGAGGGGCTCGGCCTCGAGCGGGTCGGCATCGAACTCGCCC
GCGGCGGTTACATCCCCGTCGACCGGGTGTCACGCACACCGGCGGCGGGCATCTACGCCGCCGGTGACTGCACCGGCCTG
CTGCCGCTGGCGTCGGTGGCGGCCATGCAGGGCCGGATCGCGATGTACCACGCTCTCGGCGAGGGGGTGGCCCCGATCCG
GTTGCGCACCGTCGCCTCGGCCACGTTCACCCGTCCCGAGATCGCCGCCGTGGGGATCCCGCAGACCGCGATCGACGACG
GCAGTGTGCCCGCCCGCACCCTGATGCTGCCGTTGAACACCAACGCCCGCGCGAAGATGTCCCTGCTGCGGCACGGCTTC
GTCAAGATCTTCTGCCGTCCGGCGACGGGCGTGGTCATCGGCGGTGTGGTGGTGGCCCCGATCGCGTCGGAGCTGATCCT
GCCGATCGCGCTGGCGGTGCAGAACCGCATCTCGGTGACCGACCTCGCGCAGACTCTGTCGGTGTACCCGTCGTTGTCGG
GTTCGATCGTGGAGGCCGCGCGTCGGCTCATGGCGCACGACGATCTGGACTGA

Upstream 100 bases:

>100_bases
GTTCGACCCGTAGGCGGCGTAGAGCGGCACGGTAGGAGAGCTTAACCGGCGACCGGCCGGCCGCGACCGGAAGCGCCCGC
CGACAGCAAGCGGCTAGATT

Downstream 100 bases:

>100_bases
ACCCCGCGGACGCGAGGAGCAAAGGAAAAGCACGTAGCCTGGGAACGGTGAGTGACCCGATCGCAGGTAACGGGCAGACT
TTGCTCGGGCCCGACCAGCG

Product: flavoprotein disulfide reductase

Products: NA

Alternate protein names: NAD(P)H quinone reductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MLVATRIVIIGGGPAGYEAALVAAGPETHVTVIDSDGVGGACVLYDCVPSKTFIASTGVRTELRRATGLGFDISISDAKV
SLPQIHNRVKTLARSQSADIGSQLLREGVTVIGGRGELVDDVPGLAQHRVRVRTHDGKTGVLKADVVLIATGASPRVLPN
AEPDGERILTWRQLYDLTELPEHLVIVGSGVTGAEFCNAYTELGVTVTVVASRDQILPHEDSDAAAVLEEVFAERGVTLV
KNARAESVTRTENGVKVQMADGRCVEGSHALMTVGSVPNTEGLGLERVGIELARGGYIPVDRVSRTPAAGIYAAGDCTGL
LPLASVAAMQGRIAMYHALGEGVAPIRLRTVASATFTRPEIAAVGIPQTAIDDGSVPARTLMLPLNTNARAKMSLLRHGF
VKIFCRPATGVVIGGVVVAPIASELILPIALAVQNRISVTDLAQTLSVYPSLSGSIVEAARRLMAHDDLD

Sequences:

>Translated_470_residues
MLVATRIVIIGGGPAGYEAALVAAGPETHVTVIDSDGVGGACVLYDCVPSKTFIASTGVRTELRRATGLGFDISISDAKV
SLPQIHNRVKTLARSQSADIGSQLLREGVTVIGGRGELVDDVPGLAQHRVRVRTHDGKTGVLKADVVLIATGASPRVLPN
AEPDGERILTWRQLYDLTELPEHLVIVGSGVTGAEFCNAYTELGVTVTVVASRDQILPHEDSDAAAVLEEVFAERGVTLV
KNARAESVTRTENGVKVQMADGRCVEGSHALMTVGSVPNTEGLGLERVGIELARGGYIPVDRVSRTPAAGIYAAGDCTGL
LPLASVAAMQGRIAMYHALGEGVAPIRLRTVASATFTRPEIAAVGIPQTAIDDGSVPARTLMLPLNTNARAKMSLLRHGF
VKIFCRPATGVVIGGVVVAPIASELILPIALAVQNRISVTDLAQTLSVYPSLSGSIVEAARRLMAHDDLD
>Mature_470_residues
MLVATRIVIIGGGPAGYEAALVAAGPETHVTVIDSDGVGGACVLYDCVPSKTFIASTGVRTELRRATGLGFDISISDAKV
SLPQIHNRVKTLARSQSADIGSQLLREGVTVIGGRGELVDDVPGLAQHRVRVRTHDGKTGVLKADVVLIATGASPRVLPN
AEPDGERILTWRQLYDLTELPEHLVIVGSGVTGAEFCNAYTELGVTVTVVASRDQILPHEDSDAAAVLEEVFAERGVTLV
KNARAESVTRTENGVKVQMADGRCVEGSHALMTVGSVPNTEGLGLERVGIELARGGYIPVDRVSRTPAAGIYAAGDCTGL
LPLASVAAMQGRIAMYHALGEGVAPIRLRTVASATFTRPEIAAVGIPQTAIDDGSVPARTLMLPLNTNARAKMSLLRHGF
VKIFCRPATGVVIGGVVVAPIASELILPIALAVQNRISVTDLAQTLSVYPSLSGSIVEAARRLMAHDDLD

Specific function: May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4- benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NAD(P)H is the physiological reductant rather than NADH [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=27.9317697228145, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI50301238, Length=442, Percent_Identity=25.7918552036199, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=24.2630385487528, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI22035672, Length=439, Percent_Identity=24.373576309795, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI33519430, Length=436, Percent_Identity=23.394495412844, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI33519428, Length=436, Percent_Identity=23.394495412844, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI33519426, Length=436, Percent_Identity=23.394495412844, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI148277065, Length=436, Percent_Identity=23.394495412844, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI148277071, Length=436, Percent_Identity=23.394495412844, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI291045268, Length=436, Percent_Identity=23.1651376146789, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1786307, Length=471, Percent_Identity=28.0254777070064, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI87082354, Length=425, Percent_Identity=26.3529411764706, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=26.4192139737991, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=24.3619489559165, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32565766, Length=470, Percent_Identity=27.6595744680851, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=24.6346555323591, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=447, Percent_Identity=26.8456375838926, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=447, Percent_Identity=26.8456375838926, Blast_Score=95, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321091, Length=476, Percent_Identity=27.7310924369748, Blast_Score=166, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=441, Percent_Identity=22.4489795918367, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325240, Length=483, Percent_Identity=21.9461697722567, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358499, Length=461, Percent_Identity=29.7180043383948, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=25.3138075313808, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640549, Length=478, Percent_Identity=25.3138075313808, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24640551, Length=478, Percent_Identity=25.3138075313808, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=23.2365145228216, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.5.2 [H]

Molecular weight: Translated: 49137; Mature: 49137

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVATRIVIIGGGPAGYEAALVAAGPETHVTVIDSDGVGGACVLYDCVPSKTFIASTGVR
CEEEEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCEEEECCCCH
TELRRATGLGFDISISDAKVSLPQIHNRVKTLARSQSADIGSQLLREGVTVIGGRGELVD
HHHHHHHCCCEEEEECCCEECHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCCC
DVPGLAQHRVRVRTHDGKTGVLKADVVLIATGASPRVLPNAEPDGERILTWRQLYDLTEL
CCCCHHHCEEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHCC
PEHLVIVGSGVTGAEFCNAYTELGVTVTVVASRDQILPHEDSDAAAVLEEVFAERGVTLV
CCEEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEE
KNARAESVTRTENGVKVQMADGRCVEGSHALMTVGSVPNTEGLGLERVGIELARGGYIPV
ECCCHHHHEECCCCEEEEECCCEEECCCCEEEEECCCCCCCCCCHHHHCEEEECCCCCCH
DRVSRTPAAGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVAPIRLRTVASATFTRPE
HHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCEEEEEHHCCCCCCEEEEEEHHHHCCCCC
IAAVGIPQTAIDDGSVPARTLMLPLNTNARAKMSLLRHGFVKIFCRPATGVVIGGVVVAP
EEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCEEEEEEECCCCEEECHHHHHH
IASELILPIALAVQNRISVTDLAQTLSVYPSLSGSIVEAARRLMAHDDLD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLVATRIVIIGGGPAGYEAALVAAGPETHVTVIDSDGVGGACVLYDCVPSKTFIASTGVR
CEEEEEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCCEEEEEECCCCCEEEECCCCH
TELRRATGLGFDISISDAKVSLPQIHNRVKTLARSQSADIGSQLLREGVTVIGGRGELVD
HHHHHHHCCCEEEEECCCEECHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCCCCC
DVPGLAQHRVRVRTHDGKTGVLKADVVLIATGASPRVLPNAEPDGERILTWRQLYDLTEL
CCCCHHHCEEEEEECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHCC
PEHLVIVGSGVTGAEFCNAYTELGVTVTVVASRDQILPHEDSDAAAVLEEVFAERGVTLV
CCEEEEEECCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEE
KNARAESVTRTENGVKVQMADGRCVEGSHALMTVGSVPNTEGLGLERVGIELARGGYIPV
ECCCHHHHEECCCCEEEEECCCEEECCCCEEEEECCCCCCCCCCHHHHCEEEECCCCCCH
DRVSRTPAAGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVAPIRLRTVASATFTRPE
HHCCCCCCCCEEECCCCCCHHHHHHHHHHCCCEEEEEHHCCCCCCEEEEEEHHHHCCCCC
IAAVGIPQTAIDDGSVPARTLMLPLNTNARAKMSLLRHGFVKIFCRPATGVVIGGVVVAP
EEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCEEEEEEECCCCEEECHHHHHH
IASELILPIALAVQNRISVTDLAQTLSVYPSLSGSIVEAARRLMAHDDLD
HHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]