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The map label for this gene is yqeC [H]

Identifier: 108796984

GI number: 108796984

Start: 3295

End: 4188

Strand: Direct

Name: yqeC [H]

Synonym: Mmcs_0003

Alternate gene names: 108796984

Gene position: 3295-4188 (Clockwise)

Preceding gene: 108796983

Following gene: 108796985

Centisome position: 0.06

GC content: 68.68

Gene sequence:

>894_bases
ATGCAACTGGGTCTGGTGGGGCTCGGCAAGATGGGCTTCAACATGCGGGAACGCCTTCGCGAAGGCGGACACGAAGTCGT
CGGCTTCGATCCCCGGCCCGAGGTGACCGACGTCCCGTCGCTCGCCGCGCTGGCCGACGCGCTGGCCCCGCCCAGGGTGG
TGTGGGTGATGGTGCCGTCCGGTCCGGTCACGCACGACACGATCGTGTCGCTCGCCGAGGTGCTGGGTGAGGGCGACCTG
GTGATCGACGGCGGCAACTCCCGCTTCACCGAGGACGCTCCGCACGCAGAGCTGTTGAAAGCCAAGGGAATCGGCTTCAT
CGACGCGGGTGTGTCCGGCGGTGTCTGGGGGCTGGCGGAGGGGTATGGCCTGATGGTCGGCGGCGACGACGCCGACATCG
AGCGGGTCATGCCGATCTTCGACACCCTGCGCCCCCCGGGTGACCGGGCGGACGGGTTCGTCCACGCGGGACCCGTCGGC
GCGGGTCATTTCGCCAAGATGGTGCACAACGGCGTCGAGTACGCGTTGATGACCGCCTACGGCGAGGGTTATGAGTTGTT
GGCCGCCGAGGAGTTGATCCGCGATCCGCAGGCGGTGTACCAGGCCTGGACGAACGGCACGGTGGTCCGGTCATGGCTGC
AGCAGCTGCTCGCCAAGGCCCTCCGGGAGGATCCCGGCCTGGCCGAGATCTCCGGCTACACCGAGGATTCCGGCGAAGGC
CGGTGGACGGTCGAGGAGGCGATCCGCCTCCGCGTGCCGGTGCCGTCCATCGCGGCATCGCTGTTCGCGCGGTTCGAATC
GCGCCAGGAGGACTCCCCCACCATGAAGGCAGTCTCGGCGTTGCGGAACCAGTTCGGCGGGCACGCCGTCCAGAGGATCA
GCAAGTCGGGGTAG

Upstream 100 bases:

>100_bases
GCGCCGGACCGTTCCCGGCCCTGCAGACCGATTACGTTTACCTGTTGATGCCGGTACGGCTTCCCGGCTGACCGGACCGA
CGCAACCAAGAGGGGCGGAC

Downstream 100 bases:

>100_bases
ATGCCGCGGTTGCGAGGTGCAATGAGATGCCGCGGACGCGAGGAGCAATGAGTTGTTCGTCCGGCATCTGACGCTGACCG
ACTTCCGGTCCTGGGCGCGC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQLGLVGLGKMGFNMRERLREGGHEVVGFDPRPEVTDVPSLAALADALAPPRVVWVMVPSGPVTHDTIVSLAEVLGEGDL
VIDGGNSRFTEDAPHAELLKAKGIGFIDAGVSGGVWGLAEGYGLMVGGDDADIERVMPIFDTLRPPGDRADGFVHAGPVG
AGHFAKMVHNGVEYALMTAYGEGYELLAAEELIRDPQAVYQAWTNGTVVRSWLQQLLAKALREDPGLAEISGYTEDSGEG
RWTVEEAIRLRVPVPSIAASLFARFESRQEDSPTMKAVSALRNQFGGHAVQRISKSG

Sequences:

>Translated_297_residues
MQLGLVGLGKMGFNMRERLREGGHEVVGFDPRPEVTDVPSLAALADALAPPRVVWVMVPSGPVTHDTIVSLAEVLGEGDL
VIDGGNSRFTEDAPHAELLKAKGIGFIDAGVSGGVWGLAEGYGLMVGGDDADIERVMPIFDTLRPPGDRADGFVHAGPVG
AGHFAKMVHNGVEYALMTAYGEGYELLAAEELIRDPQAVYQAWTNGTVVRSWLQQLLAKALREDPGLAEISGYTEDSGEG
RWTVEEAIRLRVPVPSIAASLFARFESRQEDSPTMKAVSALRNQFGGHAVQRISKSG
>Mature_297_residues
MQLGLVGLGKMGFNMRERLREGGHEVVGFDPRPEVTDVPSLAALADALAPPRVVWVMVPSGPVTHDTIVSLAEVLGEGDL
VIDGGNSRFTEDAPHAELLKAKGIGFIDAGVSGGVWGLAEGYGLMVGGDDADIERVMPIFDTLRPPGDRADGFVHAGPVG
AGHFAKMVHNGVEYALMTAYGEGYELLAAEELIRDPQAVYQAWTNGTVVRSWLQQLLAKALREDPGLAEISGYTEDSGEG
RWTVEEAIRLRVPVPSIAASLFARFESRQEDSPTMKAVSALRNQFGGHAVQRISKSG

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=293, Percent_Identity=32.4232081911263, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1788341, Length=321, Percent_Identity=31.4641744548287, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI145693186, Length=218, Percent_Identity=32.5688073394495, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786719, Length=299, Percent_Identity=25.752508361204, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=31.7241379310345, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321695, Length=290, Percent_Identity=31.0344827586207, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321977, Length=303, Percent_Identity=31.023102310231, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639279, Length=298, Percent_Identity=30.8724832214765, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 31729; Mature: 31729

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLGLVGLGKMGFNMRERLREGGHEVVGFDPRPEVTDVPSLAALADALAPPRVVWVMVPS
CCCCCEECCCCCCCHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECC
GPVTHDTIVSLAEVLGEGDLVIDGGNSRFTEDAPHAELLKAKGIGFIDAGVSGGVWGLAE
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCC
GYGLMVGGDDADIERVMPIFDTLRPPGDRADGFVHAGPVGAGHFAKMVHNGVEYALMTAY
CCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHCCHHEEEEEEC
GEGYELLAAEELIRDPQAVYQAWTNGTVVRSWLQQLLAKALREDPGLAEISGYTEDSGEG
CCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
RWTVEEAIRLRVPVPSIAASLFARFESRQEDSPTMKAVSALRNQFGGHAVQRISKSG
CEEHHHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MQLGLVGLGKMGFNMRERLREGGHEVVGFDPRPEVTDVPSLAALADALAPPRVVWVMVPS
CCCCCEECCCCCCCHHHHHHCCCCEEECCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECC
GPVTHDTIVSLAEVLGEGDLVIDGGNSRFTEDAPHAELLKAKGIGFIDAGVSGGVWGLAE
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCC
GYGLMVGGDDADIERVMPIFDTLRPPGDRADGFVHAGPVGAGHFAKMVHNGVEYALMTAY
CCEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHHCCHHEEEEEEC
GEGYELLAAEELIRDPQAVYQAWTNGTVVRSWLQQLLAKALREDPGLAEISGYTEDSGEG
CCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
RWTVEEAIRLRVPVPSIAASLFARFESRQEDSPTMKAVSALRNQFGGHAVQRISKSG
CEEHHHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]