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The map label for this gene is mug [H]

Identifier: 108763489

GI number: 108763489

Start: 2758541

End: 2759041

Strand: Reverse

Name: mug [H]

Synonym: MXAN_2371

Alternate gene names: 108763489

Gene position: 2759041-2758541 (Counterclockwise)

Preceding gene: 108763152

Following gene: 108762478

Centisome position: 30.19

GC content: 71.06

Gene sequence:

>501_bases
ATGCCGGACGTCATCGCGCCCCGGCTGCGCGTGCTCTTCTGCGGCATCAACCCCAGCCTCTACTCCGCGGTGGTGGGCTA
TCACTTCGCGCGGCCCGGCAATCGCTTCTGGCCCACGCTGCATGCCGCGGGCATCACTCCGCACACTTTCCAACCCACGG
AGCAGGAGGCCTTGCTCGCGCTGGGCTACGGCATCACCAACGTGGTGGACCGCGCCACCGCCACCGCGGACCTGCTGAAC
CCCGCCGAGCTGGCCCGGGGCGCGAAGGCGCTGGAAGCCAAGGTGGCGCGCTACCAGCCCCGCTTCCTCGCGGTGCTGGG
CGTGAGCGCCTACCGCATCGCCTTTGGCCGTCCCAAGGCCGCGCTGGGCACGCAACCGGAGCGCCTGGGCGACACGCGCT
TGTGGGTGCTGCCCAATCCCAGCGGGCTCAACGCGCACTACCAACTCGACGCGCTGGGCCGCCTTTTCGCCGAGCTGCGA
CGCGCCGTGGAGCAGGGCTGA

Upstream 100 bases:

>100_bases
TGGGGGGTTGCCTTCCCAGGTAGGCTCGCGAAGATGCGCCCCCATGACACCGCTCCGTCGCCCCTCGCGAGATGAGCTGG
ACGCAGCCGCCGGTCGCACC

Downstream 100 bases:

>100_bases
CGACTCCCGGTACGAGTTCGCGGTGCCTCGCGCACCGTGCCTTGACCCATGGGTGCGCCCGCATGCAACGCTGCCCGCCA
GGTTCCCCCGGACCTGCATC

Product: G/U mismatch-specific DNA glycosylase

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MPDVIAPRLRVLFCGINPSLYSAVVGYHFARPGNRFWPTLHAAGITPHTFQPTEQEALLALGYGITNVVDRATATADLLN
PAELARGAKALEAKVARYQPRFLAVLGVSAYRIAFGRPKAALGTQPERLGDTRLWVLPNPSGLNAHYQLDALGRLFAELR
RAVEQG

Sequences:

>Translated_166_residues
MPDVIAPRLRVLFCGINPSLYSAVVGYHFARPGNRFWPTLHAAGITPHTFQPTEQEALLALGYGITNVVDRATATADLLN
PAELARGAKALEAKVARYQPRFLAVLGVSAYRIAFGRPKAALGTQPERLGDTRLWVLPNPSGLNAHYQLDALGRLFAELR
RAVEQG
>Mature_165_residues
PDVIAPRLRVLFCGINPSLYSAVVGYHFARPGNRFWPTLHAAGITPHTFQPTEQEALLALGYGITNVVDRATATADLLNP
AELARGAKALEAKVARYQPRFLAVLGVSAYRIAFGRPKAALGTQPERLGDTRLWVLPNPSGLNAHYQLDALGRLFAELRR
AVEQG

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=156, Percent_Identity=32.0512820512821, Blast_Score=84, Evalue=7e-17,
Organism=Escherichia coli, GI1789449, Length=163, Percent_Identity=43.558282208589, Blast_Score=139, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21356805, Length=144, Percent_Identity=34.7222222222222, Blast_Score=100, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 18085; Mature: 17954

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDVIAPRLRVLFCGINPSLYSAVVGYHFARPGNRFWPTLHAAGITPHTFQPTEQEALLA
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHH
LGYGITNVVDRATATADLLNPAELARGAKALEAKVARYQPRFLAVLGVSAYRIAFGRPKA
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHEEECCCCCC
ALGTQPERLGDTRLWVLPNPSGLNAHYQLDALGRLFAELRRAVEQG
CCCCCHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PDVIAPRLRVLFCGINPSLYSAVVGYHFARPGNRFWPTLHAAGITPHTFQPTEQEALLA
CCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCHHHHHHH
LGYGITNVVDRATATADLLNPAELARGAKALEAKVARYQPRFLAVLGVSAYRIAFGRPKA
HHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHEEECCCCCC
ALGTQPERLGDTRLWVLPNPSGLNAHYQLDALGRLFAELRRAVEQG
CCCCCHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA