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The map label for this gene is menB [H]

Identifier: 108763330

GI number: 108763330

Start: 3695375

End: 3696268

Strand: Direct

Name: menB [H]

Synonym: MXAN_3154

Alternate gene names: 108763330

Gene position: 3695375-3696268 (Clockwise)

Preceding gene: 108762727

Following gene: 108758756

Centisome position: 40.43

GC content: 67.11

Gene sequence:

>894_bases
ATGGTCTCGGACATCTTCAATCCGGCGCGCTGGAAGGCCGTCGAGGGCTTCAAGTTCAAGGACATCACCTTCCACCGCGC
GGTGGACCAGGGCACGGTCCGCATCGCGTTCAACCGCCCGGAGGTCCGCAACGCCTTCCGGCCCCGCACCGTGGATGAGC
TGTCCCGCGCGCTGGAGGCCACGCGCTTCATGACGGACGTGGGGTGCGTGCTCATCACGGGCAACGGGCCGTCGCCCAAG
GATGGCGGCTGGGCCTTCTGCTCCGGTGGTGACCAGCGCATCCGCGGCAAGGACGGCTACAAGTACGAGGGCGAGGAGGG
TGAGTCCGACCCCGCGCGCCTGGGCCGGCTCCACATCCTGGAGGTTCAGCGGCAGATTCGTTTCCTGCCCAAGGCCGTCA
TCGCCGTGGTGCCCGGCTGGGCCGTGGGCGGTGGGCACAGCCTTCACGTCGTCTGTGACATGACCATCGCAAGCAAGGAG
CACGCGGTGTTCAAGCAGACGGACGCGGACGTGGCGTCGTTCGACGCGGGCTACGGTTCTGCGCTGCTGGCGCGGCAGAT
TGGTCAGAAGCGGGCGCGGGAGATCTTCTTCGTGGGCGCCAACTACTCGGCGGAGGAGGCCTTCCAGATGGGCATGGTCA
ACGCCGTGGTGCCCCATGCGCAGTTGGAGGAGTTCGCGCTGGAGTGGGCGGCGGAGATCAACACGAAGAGCCCTACGGCC
ATCAAGATGTTGAAGTACGCGTTCAACCTGCCCGACGACGGACTGGTGGGCCAGCAGCTCTTCGCGGGCGAGGCCACCCG
CCTGGCCTACGGCACCGACGAGGCGCAGGAAGGCCGCGACGCCTTCGTCCAGAAGCGCAAGCGCGACTTCAAGCGCTTCC
CCTGGTCGTACTGA

Upstream 100 bases:

>100_bases
GATGGCGCCCGTGCGGGCTGCGCGCGCATCCCTGGACGGGCGCTGCCGCTGCGCCTAGGGTCCGCGCGCATCCACTTCTC
TCCCCCCGAGTGAGAACACC

Downstream 100 bases:

>100_bases
AACCGCGGACGCCGAGGCGGCGCGGACGCCCTGGGAATACCCATCCAGGGTGATGGTCGGTGGAAGGGGCCTCGTGTTCT
AGGCCTCTTCCATGCCGAAG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MVSDIFNPARWKAVEGFKFKDITFHRAVDQGTVRIAFNRPEVRNAFRPRTVDELSRALEATRFMTDVGCVLITGNGPSPK
DGGWAFCSGGDQRIRGKDGYKYEGEEGESDPARLGRLHILEVQRQIRFLPKAVIAVVPGWAVGGGHSLHVVCDMTIASKE
HAVFKQTDADVASFDAGYGSALLARQIGQKRAREIFFVGANYSAEEAFQMGMVNAVVPHAQLEEFALEWAAEINTKSPTA
IKMLKYAFNLPDDGLVGQQLFAGEATRLAYGTDEAQEGRDAFVQKRKRDFKRFPWSY

Sequences:

>Translated_297_residues
MVSDIFNPARWKAVEGFKFKDITFHRAVDQGTVRIAFNRPEVRNAFRPRTVDELSRALEATRFMTDVGCVLITGNGPSPK
DGGWAFCSGGDQRIRGKDGYKYEGEEGESDPARLGRLHILEVQRQIRFLPKAVIAVVPGWAVGGGHSLHVVCDMTIASKE
HAVFKQTDADVASFDAGYGSALLARQIGQKRAREIFFVGANYSAEEAFQMGMVNAVVPHAQLEEFALEWAAEINTKSPTA
IKMLKYAFNLPDDGLVGQQLFAGEATRLAYGTDEAQEGRDAFVQKRKRDFKRFPWSY
>Mature_297_residues
MVSDIFNPARWKAVEGFKFKDITFHRAVDQGTVRIAFNRPEVRNAFRPRTVDELSRALEATRFMTDVGCVLITGNGPSPK
DGGWAFCSGGDQRIRGKDGYKYEGEEGESDPARLGRLHILEVQRQIRFLPKAVIAVVPGWAVGGGHSLHVVCDMTIASKE
HAVFKQTDADVASFDAGYGSALLARQIGQKRAREIFFVGANYSAEEAFQMGMVNAVVPHAQLEEFALEWAAEINTKSPTA
IKMLKYAFNLPDDGLVGQQLFAGEATRLAYGTDEAQEGRDAFVQKRKRDFKRFPWSY

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=295, Percent_Identity=29.4915254237288, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI31542718, Length=273, Percent_Identity=29.6703296703297, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788597, Length=290, Percent_Identity=45.8620689655172, Blast_Score=254, Evalue=5e-69,
Organism=Escherichia coli, GI1787659, Length=269, Percent_Identity=28.996282527881, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082183, Length=265, Percent_Identity=26.7924528301887, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1787660, Length=264, Percent_Identity=29.1666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI221142681, Length=269, Percent_Identity=25.6505576208178, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=259, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=222, Percent_Identity=27.4774774774775, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25145438, Length=272, Percent_Identity=27.5735294117647, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20129971, Length=257, Percent_Identity=27.2373540856031, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653477, Length=257, Percent_Identity=27.2373540856031, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24653139, Length=270, Percent_Identity=27.4074074074074, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 33014; Mature: 33014

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDIFNPARWKAVEGFKFKDITFHRAVDQGTVRIAFNRPEVRNAFRPRTVDELSRALEA
CCCCCCCCHHHHEECCCEEECEEEEHCCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHH
TRFMTDVGCVLITGNGPSPKDGGWAFCSGGDQRIRGKDGYKYEGEEGESDPARLGRLHIL
HHHHHHCCEEEEECCCCCCCCCCEEEECCCCCEECCCCCCEECCCCCCCCHHHHCCHHHH
EVQRQIRFLPKAVIAVVPGWAVGGGHSLHVVCDMTIASKEHAVFKQTDADVASFDAGYGS
HHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEEEEECCCCCHHHCCCCCCHHHCCCCCCH
ALLARQIGQKRAREIFFVGANYSAEEAFQMGMVNAVVPHAQLEEFALEWAAEINTKSPTA
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHH
IKMLKYAFNLPDDGLVGQQLFAGEATRLAYGTDEAQEGRDAFVQKRKRDFKRFPWSY
HHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVSDIFNPARWKAVEGFKFKDITFHRAVDQGTVRIAFNRPEVRNAFRPRTVDELSRALEA
CCCCCCCCHHHHEECCCEEECEEEEHCCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHH
TRFMTDVGCVLITGNGPSPKDGGWAFCSGGDQRIRGKDGYKYEGEEGESDPARLGRLHIL
HHHHHHCCEEEEECCCCCCCCCCEEEECCCCCEECCCCCCEECCCCCCCCHHHHCCHHHH
EVQRQIRFLPKAVIAVVPGWAVGGGHSLHVVCDMTIASKEHAVFKQTDADVASFDAGYGS
HHHHHHHHHHHHHHHHCCCCEECCCCEEEEEEEEEECCCCCHHHCCCCCCHHHCCCCCCH
ALLARQIGQKRAREIFFVGANYSAEEAFQMGMVNAVVPHAQLEEFALEWAAEINTKSPTA
HHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHH
IKMLKYAFNLPDDGLVGQQLFAGEATRLAYGTDEAQEGRDAFVQKRKRDFKRFPWSY
HHHHHHHHCCCCCCCCCHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]