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The map label for this gene is pyrH

Identifier: 108762561

GI number: 108762561

Start: 6650433

End: 6651185

Strand: Reverse

Name: pyrH

Synonym: MXAN_5342

Alternate gene names: 108762561

Gene position: 6651185-6650433 (Counterclockwise)

Preceding gene: 108757293

Following gene: 108761597

Centisome position: 72.77

GC content: 65.07

Gene sequence:

>753_bases
ATGTCCTCCGACACGAAGAAGCCGCTCCCGTATCAGCGCATTCTCCTCAAGCTCTCGGGCGAGGCCCTGATGGGGGAGGG
GAAGTACGGCATCCATCCGCCCACGCTGATGGGCATCGCCGAGGAAGTCATCGAGTTGGCGCAGGCCGGCGTGGAGGTCG
CGCTGGTGATTGGCGGCGGCAACATCTTCCGGGGGGTCGCGGGCGCCACGGAGGGCATGGACCGCGCCAGCGCCGACTAC
ATGGGCATGCTGGCCACCTGCATCAACTCCATGGCCATGCAGGACGCGCTGGAGAAGAAGGGTCTGCACACGCGCGTGCT
GTCCGCCATCAAGATGGAGCAGATTGCCGAGCCGTACATCCGCCGGCGCGCCGTGCGCCACCTGGAGAAGGGCCGCGTGG
TGATTTTCGCGGCGGGCACCGGCAACCCGTACTTCACCACCGACACCGCCGCCTCCCTGCGCGCCATGGAAATCAACGCG
CAGGTCATCCTGAAGGCAACCAAGGTGGACGGGGTGTACAGCGCGGACCCGAAGAAGGACCCCACCGCACGGCGCTATCG
GTCGCTGACTTACATGGACGTGTTGAAGCAGAATCTCAACGTCATGGACTCCACGGCCATCTCGCTGTGCATGGACAACA
AGCTGCCCATCATCGTGTTCGACCTGACGCAGCGGGGCAACATCCGCCGCGCGGTGCTGGGTGAAGGGGACATTGGTACG
TTGGTGGGTGGCAGCGAGACGGTCTGGGCCTGA

Upstream 100 bases:

>100_bases
GATTGGCCCCTCCCCGTGCGACCGCCAGCGGACGATGTGGGGCCGGCCCACCGACTCCAGCGTTGATCCCTCGCGGAGCG
GGGGATAGAAGCGGTGGCGC

Downstream 100 bases:

>100_bases
GTCCCGACCCACCGGCAAGCACTCAAGGAGAGAACGCAATGAGTGGAGACGTCGTCGCCGAACTGAAGGGCCGTATCGAC
AAATCGCTCGAGGGCCTGCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MSSDTKKPLPYQRILLKLSGEALMGEGKYGIHPPTLMGIAEEVIELAQAGVEVALVIGGGNIFRGVAGATEGMDRASADY
MGMLATCINSMAMQDALEKKGLHTRVLSAIKMEQIAEPYIRRRAVRHLEKGRVVIFAAGTGNPYFTTDTAASLRAMEINA
QVILKATKVDGVYSADPKKDPTARRYRSLTYMDVLKQNLNVMDSTAISLCMDNKLPIIVFDLTQRGNIRRAVLGEGDIGT
LVGGSETVWA

Sequences:

>Translated_250_residues
MSSDTKKPLPYQRILLKLSGEALMGEGKYGIHPPTLMGIAEEVIELAQAGVEVALVIGGGNIFRGVAGATEGMDRASADY
MGMLATCINSMAMQDALEKKGLHTRVLSAIKMEQIAEPYIRRRAVRHLEKGRVVIFAAGTGNPYFTTDTAASLRAMEINA
QVILKATKVDGVYSADPKKDPTARRYRSLTYMDVLKQNLNVMDSTAISLCMDNKLPIIVFDLTQRGNIRRAVLGEGDIGT
LVGGSETVWA
>Mature_249_residues
SSDTKKPLPYQRILLKLSGEALMGEGKYGIHPPTLMGIAEEVIELAQAGVEVALVIGGGNIFRGVAGATEGMDRASADYM
GMLATCINSMAMQDALEKKGLHTRVLSAIKMEQIAEPYIRRRAVRHLEKGRVVIFAAGTGNPYFTTDTAASLRAMEINAQ
VILKATKVDGVYSADPKKDPTARRYRSLTYMDVLKQNLNVMDSTAISLCMDNKLPIIVFDLTQRGNIRRAVLGEGDIGTL
VGGSETVWA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=52.5423728813559, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_MYXXD (Q1D1I1)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633492.1
- ProteinModelPortal:   Q1D1I1
- SMR:   Q1D1I1
- STRING:   Q1D1I1
- GeneID:   4106312
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_5342
- TIGR:   MXAN_5342
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q1D1I1
- ProtClustDB:   PRK00358
- BioCyc:   MXAN246197:MXAN_5342-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27078; Mature: 26947

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: NA

Important sites: BINDING 59-59 BINDING 60-60 BINDING 64-64 BINDING 79-79 BINDING 167-167 BINDING 173-173 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDTKKPLPYQRILLKLSGEALMGEGKYGIHPPTLMGIAEEVIELAQAGVEVALVIGGG
CCCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECC
NIFRGVAGATEGMDRASADYMGMLATCINSMAMQDALEKKGLHTRVLSAIKMEQIAEPYI
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RRRAVRHLEKGRVVIFAAGTGNPYFTTDTAASLRAMEINAQVILKATKVDGVYSADPKKD
HHHHHHHHHCCCEEEEEECCCCCEEECCHHHHEEEEEECEEEEEEEECCCCEECCCCCCC
PTARRYRSLTYMDVLKQNLNVMDSTAISLCMDNKLPIIVFDLTQRGNIRRAVLGEGDIGT
CHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCEEEEEECCCCCEEEEEECCCCCEE
LVGGSETVWA
EECCCCCCCC
>Mature Secondary Structure 
SSDTKKPLPYQRILLKLSGEALMGEGKYGIHPPTLMGIAEEVIELAQAGVEVALVIGGG
CCCCCCCCCHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECC
NIFRGVAGATEGMDRASADYMGMLATCINSMAMQDALEKKGLHTRVLSAIKMEQIAEPYI
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RRRAVRHLEKGRVVIFAAGTGNPYFTTDTAASLRAMEINAQVILKATKVDGVYSADPKKD
HHHHHHHHHCCCEEEEEECCCCCEEECCHHHHEEEEEECEEEEEEEECCCCEECCCCCCC
PTARRYRSLTYMDVLKQNLNVMDSTAISLCMDNKLPIIVFDLTQRGNIRRAVLGEGDIGT
CHHHHHHHHHHHHHHHHHCCHHHHHHHHEEECCCCCEEEEEECCCCCEEEEEECCCCCEE
LVGGSETVWA
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA