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The map label for this gene is mrcA [H]

Identifier: 108762542

GI number: 108762542

Start: 6471724

End: 6474222

Strand: Direct

Name: mrcA [H]

Synonym: MXAN_5181

Alternate gene names: 108762542

Gene position: 6471724-6474222 (Clockwise)

Preceding gene: 108758068

Following gene: 108757380

Centisome position: 70.81

GC content: 69.87

Gene sequence:

>2499_bases
GTGTGCCTGGTGCTCGGCGCCATCACCCTGGCGAGCGGCTACGCGTACTACAGCCAGGACCTGCCCTCCGTGGACGCGCT
GCGCAACTACCAGCCGCCGCAGGTGACGAAGGTGACGTGCGGTGACGGCACGCTCTGCGCCGAGTTCGCGCACGAGCGGC
GCACGTTGATTCGCGTGGAGGACCTGCCGCCCCACGTCCGCAACGCCTTCCTGGCCGCCGAGGACGCGGACTTCTACAAG
CACGAGGGCCTGGACTTCTTCGGCATCACCCGCGCGGCCATCAAGAACCTCATCCCCAACAGCCGCAAGTCCGGCGCGTC
CACCATCACCCAGCAGGTGGTGAAGAACCTGCTGCTGTCCCCTGAGCGCAGCTTCTCCCGCAAGGCGCGCGAGTGGATTC
TCACGCCACGCGTGGAGGAAGCGCTCACCAAGGACCAGATTCTCTCGCTCTACATCAACCAGTCCTACTACGGGCAGCGC
CGCTACGGCATGGAGGAGGCGGCGCTCTTCTACTTCGGCAAGCACGCCAAGGACTTGAACGTGGGCGAGGCCGCCGTGCT
CGCGGGCACGGTGCAGCTCCCGCACCGCATCAACCCGGTGACGAACATCACGCGGGCGAAGTCGCGTCAGCGCTACGTGC
TGGACCAGATGGCGCGCAACGGCTTCGTGTCCGCGGACGTGGCGGAGGCGGAGAAGGAGAAGCCCATCGTCCTGGCTCCC
CGGCGGGGCAAGGTGGTGGGGCCGTATTACACGGAGGAGATTCGCCGCACGCTCATCGCGCGCTACGGCGAGCAGGCGGT
GATGGAGGGCGGGCTGCGCGTGGACATCGCCATGGTGCCCAAGCTCCAGCTCGCGGCGGAGCAGTCGGTGCGTGACGGCC
TGGAGGCGGTGGACCGGCGCCAGGGCTACCGCGGTCCCCGTGGCGCGCTGGAGAAGGGCCAGTGGGAGCGATACCGGGCC
CTCATCGCCACGCGCATCGAGGAGGCGGGCCGCCGGCAGAAGGACCAGGGCTACGTCGCGGACCTGTCCTCGCTGGCGAA
GGTGGAGAAGGAAGAGCCGAAGACGCCCGAGATCGCGGGTGCGCCCCTGGACCCGCTGGAAGAGGAAGGCACCGAGGAGC
AGCGGCCGGACCTGTCGCCCGAAGACGAGGCGCCCCTCTCCGCGGACCAACTCCTGGCGCAGTCCGTGCGCCTCAAGCCC
ATGGAGGAAGGCCTGCGCCTCACGGGCTACGTCATGCAGGTGGACGACAAGCGCAACGTGGCCCGCGTGGACCTGGTGGG
CCGCACCGCCGAGGTGGCCTTCGCCGCCGCCTCCTGGGCGCGGCAGAAGGGCAAGAGCGCGCCGAAGAAGATTTCCGACG
TCTTCACGGAGGGGGAGCTCGTCTTCGTGCGCGTGCTCAAGGCACCGCCCGCGCCAGCCTTCGTGGAAGCGGCGCTGGAC
CAGGTTCCCGAGGTGCAGGGCGGGCTGGTGGTCATCCGTCCGGAGAACCGGCACGTGGTGGCGCTGGTGGGCGGCTACGA
CGCGGAGCGCTCGTCCTTCAACCGCGCCACGCAGGCGAAGCGGCAGCCTGGCTCGTCCTTCAAGCCATTCCTCTACGCCG
CCGCCATGGGCAGTGGCCGCTACACGCCGCTGTCCAAGGTCAATGACGCCCCTGAAGCCGTCCGCGACCCGTACACGGGC
AAGACGTGGAAGCCGCAGAACTACGACCGTCGGTTCCACGGGCCGATGACGCTGCGCGAGGCGCTCACCAAGTCGAAGAA
CACGGTGTCCGTGCGCCTCATCGAGGCGCTCACCCCGGCCACCACCATCGACGTCGCGCGCCGGGCTGGCATCCACTCCC
CGCTGCCGGAGAACCTCACGCTGGCCCTGGGCACCGGTGAAGTCACGATGCTGGAGGCCGCCAACGCCTACGCCACGCTC
CAGGCCAATGGCCGCTATGCGGAGCCCTTGCTGCTGCTGCGCGTGCGCGATGCGCGCGGCAAGGTGCTGGAGGAGCATCA
GCCGGCCTTCGAGGAGACGCTGCCGCCCGCGGTGGCCTACCTCACCACGTCGCTGATGCGCAGCGTGGTGGAGGACGGCT
CGGGCCGGGCCGTGCTCGCGCTGGAGCGCCCCGCCGCTGGCAAGACGGGCACCACGCAGCAGTCCCGCGACACGTGGTTC
TCCGGCTACACGGCGGACTGGGTGGCCAGCGCATGGGTGGGCTTCGACAACAACTCGCCGCTGGGCGGCAGTGAGACGGG
TGGCCGCGCCGCGCTGCCCATCTGGCTCCAGTTCATGCGCGTGGCCCACGAAGGGCTGCCCACGCGGGAGTTCGAGGTGC
CCCCCGGCGTCGTGCAAGTGCGCATCGACCCCATCAGCGGACTGCTGGCGGGCAACTCCGTCCCGGGCCGGCTGGAGCCC
TTCCTCGAAGGCACGCAGCCCACCGCGGAGGCACCGCCGCCGGGACAGGTGACCACCGACCAGTTCTTCCTCGACGAAGG
CAACAGGCGGGGACTGTGA

Upstream 100 bases:

>100_bases
GCCCGATTCCTCCACACCCACTCCCCCCGCGCCGCCTTCGCGACCGGGGTTCGGTGCCCGGCTGTGGCGCTGGACGAAGC
GGCTGCTCATCACCGGCCTC

Downstream 100 bases:

>100_bases
GCCCTGCCCGAGCCCTGCTGCTCGCCCCTGTGCTGGCCACGCTCGTGGCGCGGGCGGCGCCTGCGGCCGACACCACCGCC
GCCATTCCCCGACTCGCCCG

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 832; Mature: 832

Protein sequence:

>832_residues
MCLVLGAITLASGYAYYSQDLPSVDALRNYQPPQVTKVTCGDGTLCAEFAHERRTLIRVEDLPPHVRNAFLAAEDADFYK
HEGLDFFGITRAAIKNLIPNSRKSGASTITQQVVKNLLLSPERSFSRKAREWILTPRVEEALTKDQILSLYINQSYYGQR
RYGMEEAALFYFGKHAKDLNVGEAAVLAGTVQLPHRINPVTNITRAKSRQRYVLDQMARNGFVSADVAEAEKEKPIVLAP
RRGKVVGPYYTEEIRRTLIARYGEQAVMEGGLRVDIAMVPKLQLAAEQSVRDGLEAVDRRQGYRGPRGALEKGQWERYRA
LIATRIEEAGRRQKDQGYVADLSSLAKVEKEEPKTPEIAGAPLDPLEEEGTEEQRPDLSPEDEAPLSADQLLAQSVRLKP
MEEGLRLTGYVMQVDDKRNVARVDLVGRTAEVAFAAASWARQKGKSAPKKISDVFTEGELVFVRVLKAPPAPAFVEAALD
QVPEVQGGLVVIRPENRHVVALVGGYDAERSSFNRATQAKRQPGSSFKPFLYAAAMGSGRYTPLSKVNDAPEAVRDPYTG
KTWKPQNYDRRFHGPMTLREALTKSKNTVSVRLIEALTPATTIDVARRAGIHSPLPENLTLALGTGEVTMLEAANAYATL
QANGRYAEPLLLLRVRDARGKVLEEHQPAFEETLPPAVAYLTTSLMRSVVEDGSGRAVLALERPAAGKTGTTQQSRDTWF
SGYTADWVASAWVGFDNNSPLGGSETGGRAALPIWLQFMRVAHEGLPTREFEVPPGVVQVRIDPISGLLAGNSVPGRLEP
FLEGTQPTAEAPPPGQVTTDQFFLDEGNRRGL

Sequences:

>Translated_832_residues
MCLVLGAITLASGYAYYSQDLPSVDALRNYQPPQVTKVTCGDGTLCAEFAHERRTLIRVEDLPPHVRNAFLAAEDADFYK
HEGLDFFGITRAAIKNLIPNSRKSGASTITQQVVKNLLLSPERSFSRKAREWILTPRVEEALTKDQILSLYINQSYYGQR
RYGMEEAALFYFGKHAKDLNVGEAAVLAGTVQLPHRINPVTNITRAKSRQRYVLDQMARNGFVSADVAEAEKEKPIVLAP
RRGKVVGPYYTEEIRRTLIARYGEQAVMEGGLRVDIAMVPKLQLAAEQSVRDGLEAVDRRQGYRGPRGALEKGQWERYRA
LIATRIEEAGRRQKDQGYVADLSSLAKVEKEEPKTPEIAGAPLDPLEEEGTEEQRPDLSPEDEAPLSADQLLAQSVRLKP
MEEGLRLTGYVMQVDDKRNVARVDLVGRTAEVAFAAASWARQKGKSAPKKISDVFTEGELVFVRVLKAPPAPAFVEAALD
QVPEVQGGLVVIRPENRHVVALVGGYDAERSSFNRATQAKRQPGSSFKPFLYAAAMGSGRYTPLSKVNDAPEAVRDPYTG
KTWKPQNYDRRFHGPMTLREALTKSKNTVSVRLIEALTPATTIDVARRAGIHSPLPENLTLALGTGEVTMLEAANAYATL
QANGRYAEPLLLLRVRDARGKVLEEHQPAFEETLPPAVAYLTTSLMRSVVEDGSGRAVLALERPAAGKTGTTQQSRDTWF
SGYTADWVASAWVGFDNNSPLGGSETGGRAALPIWLQFMRVAHEGLPTREFEVPPGVVQVRIDPISGLLAGNSVPGRLEP
FLEGTQPTAEAPPPGQVTTDQFFLDEGNRRGL
>Mature_832_residues
MCLVLGAITLASGYAYYSQDLPSVDALRNYQPPQVTKVTCGDGTLCAEFAHERRTLIRVEDLPPHVRNAFLAAEDADFYK
HEGLDFFGITRAAIKNLIPNSRKSGASTITQQVVKNLLLSPERSFSRKAREWILTPRVEEALTKDQILSLYINQSYYGQR
RYGMEEAALFYFGKHAKDLNVGEAAVLAGTVQLPHRINPVTNITRAKSRQRYVLDQMARNGFVSADVAEAEKEKPIVLAP
RRGKVVGPYYTEEIRRTLIARYGEQAVMEGGLRVDIAMVPKLQLAAEQSVRDGLEAVDRRQGYRGPRGALEKGQWERYRA
LIATRIEEAGRRQKDQGYVADLSSLAKVEKEEPKTPEIAGAPLDPLEEEGTEEQRPDLSPEDEAPLSADQLLAQSVRLKP
MEEGLRLTGYVMQVDDKRNVARVDLVGRTAEVAFAAASWARQKGKSAPKKISDVFTEGELVFVRVLKAPPAPAFVEAALD
QVPEVQGGLVVIRPENRHVVALVGGYDAERSSFNRATQAKRQPGSSFKPFLYAAAMGSGRYTPLSKVNDAPEAVRDPYTG
KTWKPQNYDRRFHGPMTLREALTKSKNTVSVRLIEALTPATTIDVARRAGIHSPLPENLTLALGTGEVTMLEAANAYATL
QANGRYAEPLLLLRVRDARGKVLEEHQPAFEETLPPAVAYLTTSLMRSVVEDGSGRAVLALERPAAGKTGTTQQSRDTWF
SGYTADWVASAWVGFDNNSPLGGSETGGRAALPIWLQFMRVAHEGLPTREFEVPPGVVQVRIDPISGLLAGNSVPGRLEP
FLEGTQPTAEAPPPGQVTTDQFFLDEGNRRGL

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG5009

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=313, Percent_Identity=38.0191693290735, Blast_Score=219, Evalue=6e-58,
Organism=Escherichia coli, GI1786343, Length=306, Percent_Identity=36.2745098039216, Blast_Score=139, Evalue=1e-33,
Organism=Escherichia coli, GI1788867, Length=221, Percent_Identity=33.9366515837104, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI1789601, Length=165, Percent_Identity=37.5757575757576, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.-

Molecular weight: Translated: 91490; Mature: 91490

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLVLGAITLASGYAYYSQDLPSVDALRNYQPPQVTKVTCGDGTLCAEFAHERRTLIRVE
CEEEEEEHHHHCCCHHHHCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCEEEEEC
DLPPHVRNAFLAAEDADFYKHEGLDFFGITRAAIKNLIPNSRKSGASTITQQVVKNLLLS
CCCHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PERSFSRKAREWILTPRVEEALTKDQILSLYINQSYYGQRRYGMEEAALFYFGKHAKDLN
CCHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCHHHCCHHHHHHHHHCCCCCCCC
VGEAAVLAGTVQLPHRINPVTNITRAKSRQRYVLDQMARNGFVSADVAEAEKEKPIVLAP
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEC
RRGKVVGPYYTEEIRRTLIARYGEQAVMEGGLRVDIAMVPKLQLAAEQSVRDGLEAVDRR
CCCCEECCHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
QGYRGPRGALEKGQWERYRALIATRIEEAGRRQKDQGYVADLSSLAKVEKEEPKTPEIAG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
APLDPLEEEGTEEQRPDLSPEDEAPLSADQLLAQSVRLKPMEEGLRLTGYVMQVDDKRNV
CCCCCHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHCCCEEEEEEEEECCCCCE
ARVDLVGRTAEVAFAAASWARQKGKSAPKKISDVFTEGELVFVRVLKAPPAPAFVEAALD
EEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
QVPEVQGGLVVIRPENRHVVALVGGYDAERSSFNRATQAKRQPGSSFKPFLYAAAMGSGR
HCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
YTPLSKVNDAPEAVRDPYTGKTWKPQNYDRRFHGPMTLREALTKSKNTVSVRLIEALTPA
CCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEHHHCCH
TTIDVARRAGIHSPLPENLTLALGTGEVTMLEAANAYATLQANGRYAEPLLLLRVRDARG
HHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEECCCCCCCCEEEEEEECCCC
KVLEEHQPAFEETLPPAVAYLTTSLMRSVVEDGSGRAVLALERPAAGKTGTTQQSRDTWF
CHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCC
SGYTADWVASAWVGFDNNSPLGGSETGGRAALPIWLQFMRVAHEGLPTREFEVPPGVVQV
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
RIDPISGLLAGNSVPGRLEPFLEGTQPTAEAPPPGQVTTDQFFLDEGNRRGL
EECCCCCEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MCLVLGAITLASGYAYYSQDLPSVDALRNYQPPQVTKVTCGDGTLCAEFAHERRTLIRVE
CEEEEEEHHHHCCCHHHHCCCCCHHHHHCCCCCCEEEEECCCCHHHHHHHHCCCEEEEEC
DLPPHVRNAFLAAEDADFYKHEGLDFFGITRAAIKNLIPNSRKSGASTITQQVVKNLLLS
CCCHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
PERSFSRKAREWILTPRVEEALTKDQILSLYINQSYYGQRRYGMEEAALFYFGKHAKDLN
CCHHHHHHHHHHCCCCCHHHHHHHHHHEEEEECCCCCCHHHCCHHHHHHHHHCCCCCCCC
VGEAAVLAGTVQLPHRINPVTNITRAKSRQRYVLDQMARNGFVSADVAEAEKEKPIVLAP
CCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEC
RRGKVVGPYYTEEIRRTLIARYGEQAVMEGGLRVDIAMVPKLQLAAEQSVRDGLEAVDRR
CCCCEECCHHHHHHHHHHHHHHCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
QGYRGPRGALEKGQWERYRALIATRIEEAGRRQKDQGYVADLSSLAKVEKEEPKTPEIAG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
APLDPLEEEGTEEQRPDLSPEDEAPLSADQLLAQSVRLKPMEEGLRLTGYVMQVDDKRNV
CCCCCHHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCHHCCCEEEEEEEEECCCCCE
ARVDLVGRTAEVAFAAASWARQKGKSAPKKISDVFTEGELVFVRVLKAPPAPAFVEAALD
EEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHH
QVPEVQGGLVVIRPENRHVVALVGGYDAERSSFNRATQAKRQPGSSFKPFLYAAAMGSGR
HCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
YTPLSKVNDAPEAVRDPYTGKTWKPQNYDRRFHGPMTLREALTKSKNTVSVRLIEALTPA
CCCHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEHHHCCH
TTIDVARRAGIHSPLPENLTLALGTGEVTMLEAANAYATLQANGRYAEPLLLLRVRDARG
HHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCCCEEEEECCCCCCCCEEEEEEECCCC
KVLEEHQPAFEETLPPAVAYLTTSLMRSVVEDGSGRAVLALERPAAGKTGTTQQSRDTWF
CHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCC
SGYTADWVASAWVGFDNNSPLGGSETGGRAALPIWLQFMRVAHEGLPTREFEVPPGVVQV
CCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEE
RIDPISGLLAGNSVPGRLEPFLEGTQPTAEAPPPGQVTTDQFFLDEGNRRGL
EECCCCCEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]