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The map label for this gene is clpP

Identifier: 108762291

GI number: 108762291

Start: 2341818

End: 2342438

Strand: Direct

Name: clpP

Synonym: MXAN_2014

Alternate gene names: 108762291

Gene position: 2341818-2342438 (Clockwise)

Preceding gene: 108763895

Following gene: 108761752

Centisome position: 25.62

GC content: 61.19

Gene sequence:

>621_bases
ATGCCCTTCATGCCCGTTCCCTACGTCATCGAGCAGACCCACCGGGGTGAGCGCTCGTACGACATCTACAGCCGGCTCCT
GAAGGACCGCATCGTGATGCTGGGCACGGAGATCGACGATGACGTGGCCAACGTCATCGTCGCCCAGTTGCTGTTCCTGG
AGTCGGAAGACCCGGACAAGGACATCAACCTCTACATCAACTCGCCGGGTGGCTCGGTGACGGCGGGCCTCGCCATCTAC
GACACCATGCAGTACGTGAAGTGTCCGGTGTCCACCATCTGCGTCGGGCAGGCGGCCTCCATGGGGGCCGTCCTCCTGCT
CGCCGGTGCCAAGGGCAAGCGTTACGCCCTGCCGTCCAGTCGCATCATGATTCACCAGCCTCTGGGTGGTGTGCGCGGTC
AGGCAACGGACATTGAAATCCAGGCGAAGGAAATCCTCCGGATGAAGGCGAAGCTCAACGAGCTCATCGTCAAGCACACC
GGACAGTCCATCGAGCGTGTCGAGAAGGACACGGACCGCGACTACTTCATGGGCGCGTCCGAGGCAAAGGCCTACGGCAT
CATCGATGAGATCCAGAATCCCCGGAAGGTCGTGGGACTGGGTAAGGAAGAGAAGAAGTAG

Upstream 100 bases:

>100_bases
CGAGCGGCTCGGGTTGTCTCTCCGACTCCGGGAGGAAAAGACGATTGAATTCCTGAGGAGCCGGGCGAAGTATTCGTAAG
GTTCCCTCACCGAGGTCGAC

Downstream 100 bases:

>100_bases
GCGGATTGCCGAGGCTTCGGGGCCTCGGCCGGCAGCCGGAGCCGCGGGAATGCGCCCCCGCGACTCCGGCTTTCTGCTTT
CTGCGTCACGGCACAGGTCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MPFMPVPYVIEQTHRGERSYDIYSRLLKDRIVMLGTEIDDDVANVIVAQLLFLESEDPDKDINLYINSPGGSVTAGLAIY
DTMQYVKCPVSTICVGQAASMGAVLLLAGAKGKRYALPSSRIMIHQPLGGVRGQATDIEIQAKEILRMKAKLNELIVKHT
GQSIERVEKDTDRDYFMGASEAKAYGIIDEIQNPRKVVGLGKEEKK

Sequences:

>Translated_206_residues
MPFMPVPYVIEQTHRGERSYDIYSRLLKDRIVMLGTEIDDDVANVIVAQLLFLESEDPDKDINLYINSPGGSVTAGLAIY
DTMQYVKCPVSTICVGQAASMGAVLLLAGAKGKRYALPSSRIMIHQPLGGVRGQATDIEIQAKEILRMKAKLNELIVKHT
GQSIERVEKDTDRDYFMGASEAKAYGIIDEIQNPRKVVGLGKEEKK
>Mature_205_residues
PFMPVPYVIEQTHRGERSYDIYSRLLKDRIVMLGTEIDDDVANVIVAQLLFLESEDPDKDINLYINSPGGSVTAGLAIYD
TMQYVKCPVSTICVGQAASMGAVLLLAGAKGKRYALPSSRIMIHQPLGGVRGQATDIEIQAKEILRMKAKLNELIVKHTG
QSIERVEKDTDRDYFMGASEAKAYGIIDEIQNPRKVVGLGKEEKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=186, Percent_Identity=60.2150537634409, Blast_Score=241, Evalue=4e-64,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=65.9685863874346, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=188, Percent_Identity=59.0425531914894, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=59.2783505154639, Blast_Score=240, Evalue=4e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_MYXXD (Q1DAT0)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630243.1
- ProteinModelPortal:   Q1DAT0
- SMR:   Q1DAT0
- STRING:   Q1DAT0
- GeneID:   4106037
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2014
- TIGR:   MXAN_2014
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   CQRMERD
- PhylomeDB:   Q1DAT0
- ProtClustDB:   PRK00277
- BioCyc:   MXAN246197:MXAN_2014-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22787; Mature: 22656

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 100-100 ACT_SITE 125-125

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFMPVPYVIEQTHRGERSYDIYSRLLKDRIVMLGTEIDDDVANVIVAQLLFLESEDPDK
CCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCC
DINLYINSPGGSVTAGLAIYDTMQYVKCPVSTICVGQAASMGAVLLLAGAKGKRYALPSS
CEEEEEECCCCCEEEHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCEEECCCC
RIMIHQPLGGVRGQATDIEIQAKEILRMKAKLNELIVKHTGQSIERVEKDTDRDYFMGAS
CEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCCCC
EAKAYGIIDEIQNPRKVVGLGKEEKK
CCHHHCCHHHHCCCHHEECCCCCCCC
>Mature Secondary Structure 
PFMPVPYVIEQTHRGERSYDIYSRLLKDRIVMLGTEIDDDVANVIVAQLLFLESEDPDK
CCCCCCHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCCC
DINLYINSPGGSVTAGLAIYDTMQYVKCPVSTICVGQAASMGAVLLLAGAKGKRYALPSS
CEEEEEECCCCCEEEHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCEEECCCC
RIMIHQPLGGVRGQATDIEIQAKEILRMKAKLNELIVKHTGQSIERVEKDTDRDYFMGAS
CEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHCCCCC
EAKAYGIIDEIQNPRKVVGLGKEEKK
CCHHHCCHHHHCCCHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA