Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 108761725

GI number: 108761725

Start: 6227943

End: 6228404

Strand: Reverse

Name: mutM [H]

Synonym: MXAN_4980

Alternate gene names: 108761725

Gene position: 6228404-6227943 (Counterclockwise)

Preceding gene: 108762499

Following gene: 108761490

Centisome position: 68.15

GC content: 69.05

Gene sequence:

>462_bases
GTGGGCATCTCCGTGGCGCGCGGTCAGGCGCCGGCACCATGCATGTGCGGAGGAGACGTCCGCGTGGCAGAGGTACCTGA
AGTCGAAATCATCACCCGGGATTTGCGGCAGGCCGTCGTGGTCGGCAACCGGGACGCGGACGAGAGCCTATGGCAGGCGG
GGATTGCCCCACGCAGGCTGGCGTCGTCTCTCACGGCCGATGAGGTGGTGCGGCTGGACCGCGCCATCCAGGCGGTGCTC
GATGAAGGGCTCCGCATGCGGGGAACCCAGCGAGACCTCTTCGGCGTTCAGGGCCAGGCGAAGCACCGGCGCAACGTGTT
TGGCCGCGCCGGGGCGCCGTGCCCGCGCTGTGCCACACCGGTCTCCCATCAACGCATCGGTGGACGGAACACGTACTGGT
GTTCCTCGTGCCAGCCCCTGGCGAGCGCACCCGAAGTCCCCGCGCAATCCTCGCTGCTCTGA

Upstream 100 bases:

>100_bases
GGAGGTCCGCGCCTGAGCCCCAGGGGCGCGTCCGCTTGCGGGCGGCCCTGGGGCTGAGCATCGCGCGCTCCGCTCGGAGG
GCAGTCAGGCCCCATGGCGG

Downstream 100 bases:

>100_bases
ATCGCGGCGCGTCGCGTGGACCCGTTGATGCCAGGATCCCCGCGAGGCTTCCTCGCGCCCGTGCGTTCGTTCCGGTCAGG
CCCGCATGTTAGATCACGTC

Product: formamidopyrimidine DNA-glyxosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MGISVARGQAPAPCMCGGDVRVAEVPEVEIITRDLRQAVVVGNRDADESLWQAGIAPRRLASSLTADEVVRLDRAIQAVL
DEGLRMRGTQRDLFGVQGQAKHRRNVFGRAGAPCPRCATPVSHQRIGGRNTYWCSSCQPLASAPEVPAQSSLL

Sequences:

>Translated_153_residues
MGISVARGQAPAPCMCGGDVRVAEVPEVEIITRDLRQAVVVGNRDADESLWQAGIAPRRLASSLTADEVVRLDRAIQAVL
DEGLRMRGTQRDLFGVQGQAKHRRNVFGRAGAPCPRCATPVSHQRIGGRNTYWCSSCQPLASAPEVPAQSSLL
>Mature_152_residues
GISVARGQAPAPCMCGGDVRVAEVPEVEIITRDLRQAVVVGNRDADESLWQAGIAPRRLASSLTADEVVRLDRAIQAVLD
EGLRMRGTQRDLFGVQGQAKHRRNVFGRAGAPCPRCATPVSHQRIGGRNTYWCSSCQPLASAPEVPAQSSLL

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=109, Percent_Identity=41.2844036697248, Blast_Score=72, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 16430; Mature: 16299

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGISVARGQAPAPCMCGGDVRVAEVPEVEIITRDLRQAVVVGNRDADESLWQAGIAPRRL
CCCCCCCCCCCCCCEECCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHH
ASSLTADEVVRLDRAIQAVLDEGLRMRGTQRDLFGVQGQAKHRRNVFGRAGAPCPRCATP
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHCCCCCCCCCCCCCC
VSHQRIGGRNTYWCSSCQPLASAPEVPAQSSLL
CCHHHCCCCCCEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GISVARGQAPAPCMCGGDVRVAEVPEVEIITRDLRQAVVVGNRDADESLWQAGIAPRRL
CCCCCCCCCCCCCEECCCEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHH
ASSLTADEVVRLDRAIQAVLDEGLRMRGTQRDLFGVQGQAKHRRNVFGRAGAPCPRCATP
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHCCCCCCCCCCCCCC
VSHQRIGGRNTYWCSSCQPLASAPEVPAQSSLL
CCHHHCCCCCCEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA