| Definition | Myxococcus xanthus DK 1622 chromosome, complete genome. |
|---|---|
| Accession | NC_008095 |
| Length | 9,139,763 |
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The map label for this gene is cypB [H]
Identifier: 108761539
GI number: 108761539
Start: 4480739
End: 4481545
Strand: Direct
Name: cypB [H]
Synonym: MXAN_3763
Alternate gene names: 108761539
Gene position: 4480739-4481545 (Clockwise)
Preceding gene: 108762302
Following gene: 108760484
Centisome position: 49.02
GC content: 69.76
Gene sequence:
>807_bases GTGTCCCACCTCCCCCCCGCCCGGAACGCCGCGACACGACACCCCGGCGTGAAACCCCTTGGATGGGGCAGGGGGCGGCG CGTAAGGTGCCGCGCCGACATGCCCCCCGCCTCCCTCCGAAAGACGCTCGCGCTGGTGACCTGCCTGCTGGCGGGCTCCG TCCTCGCCGCTGATTCCGGCAAATGGACCCGGAAGGCCGCGGCCGGCAAGGACCTCTACGCCACGCTCCAGACGAGCGAG GGCACCATCGTCGTCCGGCTCTTCGCCAAGGACGCGCCCAAGACGGTGGCCAACTTCGTGGGCCTGGCCGCCGGTGAGAA GGCATGGCGGGACCCGAAGACGGGGAAGATGTCGAAGGAGCCGCTGTATGACGGCACGGTGTTCCACCGCGTGATTCCGG GCTTCATGATTCAGGGCGGGGACCCCACGGGCACCGGCTTCGGCGATCCGGGCTACCGCTTCGCGGACGAGTTCCAGAGC GGCCGCACGTTCGACAAGGTGGGCCTGCTGGCCATGGCCAACGCGGGGCCCAACACCAACGGCAGCCAGTTCTTCATCAC CACCTCCACGCCCGGACACCTCGCCGGCAAGCACACCATCTTCGGTGAGGTGCTCAGCGGCTATGACGTGGTGGAGAAGA TCAGCAATCGTCCTCGGGACAACCGGGACCGCCCGCGCACCGCGGTGGTGCTCACCCGCGTGGTGCTGGGCGACAAGGCT CCCGCGGGCGTGACGGCCCCCGCGGCGAGCAAGGGAGCGGCGCCCAAGAAGGACGCGGGCGCGAAGACGGTTTCACCAAG GCCGTGA
Upstream 100 bases:
>100_bases TGGGGGAGACGGCCTTCGCCCGGGCCACCGGCCGGAGCAAGAAGGAGGCGGAGCAGTCCGCCGCGCAAGCGACGCTGGAG AAGCTGCGGGAAGACGCTGC
Downstream 100 bases:
>100_bases CACATGACCGGGTTCGTCCTCGGACGGGCCCCCACACGGGAGGGTAGCATGGGATTGTTGGACGAGGCCCGCGCGGGCAA TGACCTTTACGCCACCTTCG
Product: cyclophilin-type peptidylprolyl cis-trans isomerase
Products: NA
Alternate protein names: PPIase B; Cyclophilin ScCypB; Rotamase B; S-cyclophilin [H]
Number of amino acids: Translated: 268; Mature: 267
Protein sequence:
>268_residues MSHLPPARNAATRHPGVKPLGWGRGRRVRCRADMPPASLRKTLALVTCLLAGSVLAADSGKWTRKAAAGKDLYATLQTSE GTIVVRLFAKDAPKTVANFVGLAAGEKAWRDPKTGKMSKEPLYDGTVFHRVIPGFMIQGGDPTGTGFGDPGYRFADEFQS GRTFDKVGLLAMANAGPNTNGSQFFITTSTPGHLAGKHTIFGEVLSGYDVVEKISNRPRDNRDRPRTAVVLTRVVLGDKA PAGVTAPAASKGAAPKKDAGAKTVSPRP
Sequences:
>Translated_268_residues MSHLPPARNAATRHPGVKPLGWGRGRRVRCRADMPPASLRKTLALVTCLLAGSVLAADSGKWTRKAAAGKDLYATLQTSE GTIVVRLFAKDAPKTVANFVGLAAGEKAWRDPKTGKMSKEPLYDGTVFHRVIPGFMIQGGDPTGTGFGDPGYRFADEFQS GRTFDKVGLLAMANAGPNTNGSQFFITTSTPGHLAGKHTIFGEVLSGYDVVEKISNRPRDNRDRPRTAVVLTRVVLGDKA PAGVTAPAASKGAAPKKDAGAKTVSPRP >Mature_267_residues SHLPPARNAATRHPGVKPLGWGRGRRVRCRADMPPASLRKTLALVTCLLAGSVLAADSGKWTRKAAAGKDLYATLQTSEG TIVVRLFAKDAPKTVANFVGLAAGEKAWRDPKTGKMSKEPLYDGTVFHRVIPGFMIQGGDPTGTGFGDPGYRFADEFQSG RTFDKVGLLAMANAGPNTNGSQFFITTSTPGHLAGKHTIFGEVLSGYDVVEKISNRPRDNRDRPRTAVVLTRVVLGDKAP AGVTAPAASKGAAPKKDAGAKTVSPRP
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=45.3416149068323, Blast_Score=129, Evalue=4e-30, Organism=Homo sapiens, GI64276486, Length=157, Percent_Identity=43.312101910828, Blast_Score=122, Evalue=2e-28, Organism=Homo sapiens, GI24308049, Length=167, Percent_Identity=43.1137724550898, Blast_Score=121, Evalue=7e-28, Organism=Homo sapiens, GI4505991, Length=197, Percent_Identity=40.6091370558376, Blast_Score=120, Evalue=1e-27, Organism=Homo sapiens, GI4758950, Length=222, Percent_Identity=40.0900900900901, Blast_Score=119, Evalue=2e-27, Organism=Homo sapiens, GI42560244, Length=148, Percent_Identity=45.2702702702703, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI19557636, Length=167, Percent_Identity=37.7245508982036, Blast_Score=115, Evalue=5e-26, Organism=Homo sapiens, GI4826932, Length=142, Percent_Identity=48.5915492957746, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI256017253, Length=136, Percent_Identity=47.0588235294118, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI221139811, Length=136, Percent_Identity=47.0588235294118, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI256017251, Length=136, Percent_Identity=47.0588235294118, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI6631100, Length=154, Percent_Identity=45.4545454545455, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI178057341, Length=140, Percent_Identity=45.7142857142857, Blast_Score=105, Evalue=3e-23, Organism=Homo sapiens, GI209417936, Length=140, Percent_Identity=45, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI30102944, Length=140, Percent_Identity=45, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI219842199, Length=140, Percent_Identity=45, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI5454154, Length=162, Percent_Identity=42.5925925925926, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI22547212, Length=161, Percent_Identity=41.6149068322981, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI7657473, Length=161, Percent_Identity=41.6149068322981, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI5031987, Length=143, Percent_Identity=48.2517482517483, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI10863927, Length=141, Percent_Identity=46.8085106382979, Blast_Score=103, Evalue=2e-22, Organism=Homo sapiens, GI22547215, Length=161, Percent_Identity=41.6149068322981, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI169163387, Length=140, Percent_Identity=45.7142857142857, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI169164185, Length=141, Percent_Identity=45.3900709219858, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI169163623, Length=141, Percent_Identity=45.3900709219858, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI310129267, Length=139, Percent_Identity=41.0071942446043, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI310120620, Length=139, Percent_Identity=41.0071942446043, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=41.0071942446043, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI310127646, Length=141, Percent_Identity=43.9716312056738, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI310114371, Length=141, Percent_Identity=43.9716312056738, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI310119221, Length=141, Percent_Identity=43.9716312056738, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI303305009, Length=164, Percent_Identity=40.2439024390244, Blast_Score=92, Evalue=4e-19, Organism=Homo sapiens, GI5174637, Length=178, Percent_Identity=38.2022471910112, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI45439316, Length=165, Percent_Identity=39.3939393939394, Blast_Score=92, Evalue=5e-19, Organism=Homo sapiens, GI150418007, Length=144, Percent_Identity=42.3611111111111, Blast_Score=90, Evalue=3e-18, Organism=Homo sapiens, GI169214050, Length=156, Percent_Identity=40.3846153846154, Blast_Score=88, Evalue=9e-18, Organism=Homo sapiens, GI310132444, Length=140, Percent_Identity=41.4285714285714, Blast_Score=88, Evalue=9e-18, Organism=Homo sapiens, GI310113152, Length=140, Percent_Identity=41.4285714285714, Blast_Score=88, Evalue=9e-18, Organism=Homo sapiens, GI239751853, Length=156, Percent_Identity=40.3846153846154, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI113428306, Length=156, Percent_Identity=40.3846153846154, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI20911035, Length=172, Percent_Identity=31.3953488372093, Blast_Score=86, Evalue=5e-17, Organism=Homo sapiens, GI310127745, Length=133, Percent_Identity=45.1127819548872, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI310119290, Length=133, Percent_Identity=45.1127819548872, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI310114540, Length=171, Percent_Identity=38.5964912280702, Blast_Score=84, Evalue=2e-16, Organism=Homo sapiens, GI27735045, Length=157, Percent_Identity=33.1210191082803, Blast_Score=73, Evalue=3e-13, Organism=Homo sapiens, GI14277126, Length=168, Percent_Identity=30.952380952381, Blast_Score=72, Evalue=6e-13, Organism=Escherichia coli, GI1786736, Length=185, Percent_Identity=31.8918918918919, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI1789763, Length=192, Percent_Identity=32.8125, Blast_Score=68, Evalue=7e-13, Organism=Caenorhabditis elegans, GI17539496, Length=164, Percent_Identity=44.5121951219512, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17551282, Length=164, Percent_Identity=46.3414634146341, Blast_Score=124, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17551284, Length=164, Percent_Identity=46.3414634146341, Blast_Score=123, Evalue=8e-29, Organism=Caenorhabditis elegans, GI71980594, Length=166, Percent_Identity=39.1566265060241, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI71980590, Length=155, Percent_Identity=41.2903225806452, Blast_Score=121, Evalue=5e-28, Organism=Caenorhabditis elegans, GI17552784, Length=176, Percent_Identity=39.7727272727273, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17532641, Length=231, Percent_Identity=35.4978354978355, Blast_Score=118, Evalue=3e-27, Organism=Caenorhabditis elegans, GI17506311, Length=168, Percent_Identity=42.2619047619048, Blast_Score=113, Evalue=1e-25, Organism=Caenorhabditis elegans, GI17552780, Length=155, Percent_Identity=46.4516129032258, Blast_Score=110, Evalue=7e-25, Organism=Caenorhabditis elegans, GI17506307, Length=155, Percent_Identity=45.8064516129032, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17566266, Length=140, Percent_Identity=47.8571428571429, Blast_Score=108, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17559074, Length=144, Percent_Identity=45.8333333333333, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71997782, Length=136, Percent_Identity=41.9117647058824, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17565860, Length=179, Percent_Identity=41.8994413407821, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17532643, Length=158, Percent_Identity=40.5063291139241, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17539498, Length=142, Percent_Identity=41.5492957746479, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17552782, Length=146, Percent_Identity=43.1506849315069, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI32563659, Length=175, Percent_Identity=29.1428571428571, Blast_Score=88, Evalue=4e-18, Organism=Saccharomyces cerevisiae, GI6323562, Length=160, Percent_Identity=46.25, Blast_Score=117, Evalue=2e-27, Organism=Saccharomyces cerevisiae, GI6320510, Length=202, Percent_Identity=40.5940594059406, Blast_Score=117, Evalue=3e-27, Organism=Saccharomyces cerevisiae, GI6320359, Length=140, Percent_Identity=48.5714285714286, Blast_Score=112, Evalue=5e-26, Organism=Saccharomyces cerevisiae, GI6321848, Length=195, Percent_Identity=38.974358974359, Blast_Score=108, Evalue=8e-25, Organism=Saccharomyces cerevisiae, GI6323246, Length=151, Percent_Identity=45.0331125827815, Blast_Score=104, Evalue=2e-23, Organism=Saccharomyces cerevisiae, GI6322492, Length=179, Percent_Identity=38.5474860335196, Blast_Score=90, Evalue=4e-19, Organism=Saccharomyces cerevisiae, GI6319914, Length=162, Percent_Identity=33.9506172839506, Blast_Score=66, Evalue=7e-12, Organism=Drosophila melanogaster, GI19922376, Length=198, Percent_Identity=36.8686868686869, Blast_Score=134, Evalue=6e-32, Organism=Drosophila melanogaster, GI17986117, Length=156, Percent_Identity=46.1538461538462, Blast_Score=129, Evalue=2e-30, Organism=Drosophila melanogaster, GI20130249, Length=155, Percent_Identity=45.8064516129032, Blast_Score=111, Evalue=5e-25, Organism=Drosophila melanogaster, GI24650807, Length=151, Percent_Identity=44.3708609271523, Blast_Score=109, Evalue=2e-24, Organism=Drosophila melanogaster, GI45549139, Length=140, Percent_Identity=48.5714285714286, Blast_Score=107, Evalue=1e-23, Organism=Drosophila melanogaster, GI19922912, Length=180, Percent_Identity=41.1111111111111, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI24652460, Length=181, Percent_Identity=34.8066298342541, Blast_Score=100, Evalue=7e-22, Organism=Drosophila melanogaster, GI21357249, Length=198, Percent_Identity=33.8383838383838, Blast_Score=100, Evalue=1e-21, Organism=Drosophila melanogaster, GI24664125, Length=155, Percent_Identity=40, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI21357783, Length=155, Percent_Identity=40, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI24586038, Length=161, Percent_Identity=39.7515527950311, Blast_Score=98, Evalue=6e-21, Organism=Drosophila melanogaster, GI17647301, Length=139, Percent_Identity=42.4460431654676, Blast_Score=95, Evalue=5e-20, Organism=Drosophila melanogaster, GI17136360, Length=161, Percent_Identity=39.1304347826087, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI21355677, Length=193, Percent_Identity=31.0880829015544, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24661775, Length=156, Percent_Identity=32.0512820512821, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI21355237, Length=156, Percent_Identity=32.0512820512821, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24661771, Length=156, Percent_Identity=32.0512820512821, Blast_Score=69, Evalue=2e-12,
Paralogues:
None
Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 28317; Mature: 28186
Theoretical pI: Translated: 11.01; Mature: 11.01
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSHLPPARNAATRHPGVKPLGWGRGRRVRCRADMPPASLRKTLALVTCLLAGSVLAADSG CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEECCCC KWTRKAAAGKDLYATLQTSEGTIVVRLFAKDAPKTVANFVGLAAGEKAWRDPKTGKMSKE CCHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC PLYDGTVFHRVIPGFMIQGGDPTGTGFGDPGYRFADEFQSGRTFDKVGLLAMANAGPNTN CCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHCEEEEECCCCCCC GSQFFITTSTPGHLAGKHTIFGEVLSGYDVVEKISNRPRDNRDRPRTAVVLTRVVLGDKA CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC PAGVTAPAASKGAAPKKDAGAKTVSPRP CCCCCCCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure SHLPPARNAATRHPGVKPLGWGRGRRVRCRADMPPASLRKTLALVTCLLAGSVLAADSG CCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEECCCC KWTRKAAAGKDLYATLQTSEGTIVVRLFAKDAPKTVANFVGLAAGEKAWRDPKTGKMSKE CCHHHHHCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCC PLYDGTVFHRVIPGFMIQGGDPTGTGFGDPGYRFADEFQSGRTFDKVGLLAMANAGPNTN CCCCCHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHCEEEEECCCCCCC GSQFFITTSTPGHLAGKHTIFGEVLSGYDVVEKISNRPRDNRDRPRTAVVLTRVVLGDKA CCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC PAGVTAPAASKGAAPKKDAGAKTVSPRP CCCCCCCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9025285 [H]