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The map label for this gene is rnc

Identifier: 108762302

GI number: 108762302

Start: 4480008

End: 4480790

Strand: Direct

Name: rnc

Synonym: MXAN_3762

Alternate gene names: 108762302

Gene position: 4480008-4480790 (Clockwise)

Preceding gene: 108757250

Following gene: 108761539

Centisome position: 49.02

GC content: 69.48

Gene sequence:

>783_bases
GTGATGCGTTTGAGTGGTGCGGACAAGATGAGCCCGTCCGAGCGGGTGCAGTTGTTGGAGTCGCGGTTGGGGTTGAGCTT
CTCCCGGATGGAGACGGCGCTGGAGGCCCTGACGCACAAGACGTACGTCAATGAGACGCGGGACAAGGAGCTGAAGGACA
ACCAGCGCCTGGAGTTCCTGGGCGACTCGGTGGTCAACCTGGCCGTCAGCCACCGGTTGATGGCGCGCTGCCCGGGGCTG
CCCGAAGGCGACCTGACGAAGATGCGCGCCCGCGTCGTCAACGAGGACGGCCTGGCCCGCGTGGCCCGGACCATCCCGCT
GGGCGACCTGCTGCTGCTGGGGCGGGGCGAGCTCATGTCCGGCGGCCGGGAGAAGAACTCCGTCCTGGCGGACGCGCTGG
AGGCCGTCTTCGGCGCGGTGTTCCTCACCAGCGGCCTGGACGCCGCGGTGACGCTGGTGGACCGGTATTTCGCGGACCTG
CTGGACGAGGTCTCCAGCGGCCAGGGGCGGCTCGACTACAAGACGCTGCTCCAGGAGATGGCCCACGAGCGGCTCAAGCT
CCAGCCCCGCTACCGCGTCGTCTCGGAGTCCGGTCCGGAACACTCCAAGGTGTTCGAGGTGGAGCTGATGCTGGGGGAGA
CGGCCTTCGCCCGGGCCACCGGCCGGAGCAAGAAGGAGGCGGAGCAGTCCGCCGCGCAAGCGACGCTGGAGAAGCTGCGG
GAAGACGCTGCGTGTCCCACCTCCCCCCCGCCCGGAACGCCGCGACACGACACCCCGGCGTGA

Upstream 100 bases:

>100_bases
TCGAGCTGGATGAGTTCCCAGGCATCGTGCGGATGGTGGCGGACCTGTTGAAGGTCCCTCCCGCGGCCGTGAGGCTGGTG
GGCCCGGACGCACCTCAGGA

Downstream 100 bases:

>100_bases
AACCCCTTGGATGGGGCAGGGGGCGGCGCGTAAGGTGCCGCGCCGACATGCCCCCCGCCTCCCTCCGAAAGACGCTCGCG
CTGGTGACCTGCCTGCTGGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MMRLSGADKMSPSERVQLLESRLGLSFSRMETALEALTHKTYVNETRDKELKDNQRLEFLGDSVVNLAVSHRLMARCPGL
PEGDLTKMRARVVNEDGLARVARTIPLGDLLLLGRGELMSGGREKNSVLADALEAVFGAVFLTSGLDAAVTLVDRYFADL
LDEVSSGQGRLDYKTLLQEMAHERLKLQPRYRVVSESGPEHSKVFEVELMLGETAFARATGRSKKEAEQSAAQATLEKLR
EDAACPTSPPPGTPRHDTPA

Sequences:

>Translated_260_residues
MMRLSGADKMSPSERVQLLESRLGLSFSRMETALEALTHKTYVNETRDKELKDNQRLEFLGDSVVNLAVSHRLMARCPGL
PEGDLTKMRARVVNEDGLARVARTIPLGDLLLLGRGELMSGGREKNSVLADALEAVFGAVFLTSGLDAAVTLVDRYFADL
LDEVSSGQGRLDYKTLLQEMAHERLKLQPRYRVVSESGPEHSKVFEVELMLGETAFARATGRSKKEAEQSAAQATLEKLR
EDAACPTSPPPGTPRHDTPA
>Mature_260_residues
MMRLSGADKMSPSERVQLLESRLGLSFSRMETALEALTHKTYVNETRDKELKDNQRLEFLGDSVVNLAVSHRLMARCPGL
PEGDLTKMRARVVNEDGLARVARTIPLGDLLLLGRGELMSGGREKNSVLADALEAVFGAVFLTSGLDAAVTLVDRYFADL
LDEVSSGQGRLDYKTLLQEMAHERLKLQPRYRVVSESGPEHSKVFEVELMLGETAFARATGRSKKEAEQSAAQATLEKLR
EDAACPTSPPPGTPRHDTPA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=230, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=26.6094420600858, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1788920, Length=225, Percent_Identity=39.1111111111111, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=27.5862068965517, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137682, Length=236, Percent_Identity=28.3898305084746, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_MYXXD (Q1D5X9)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631944.1
- ProteinModelPortal:   Q1D5X9
- SMR:   Q1D5X9
- STRING:   Q1D5X9
- GeneID:   4106048
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3762
- TIGR:   MXAN_3762
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- PhylomeDB:   Q1D5X9
- BioCyc:   MXAN246197:MXAN_3762-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 28550; Mature: 28550

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRLSGADKMSPSERVQLLESRLGLSFSRMETALEALTHKTYVNETRDKELKDNQRLEFL
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GDSVVNLAVSHRLMARCPGLPEGDLTKMRARVVNEDGLARVARTIPLGDLLLLGRGELMS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHEECCCHHHC
GGREKNSVLADALEAVFGAVFLTSGLDAAVTLVDRYFADLLDEVSSGQGRLDYKTLLQEM
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AHERLKLQPRYRVVSESGPEHSKVFEVELMLGETAFARATGRSKKEAEQSAAQATLEKLR
HHHHHCCCCHHHHHCCCCCCCHHEEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
EDAACPTSPPPGTPRHDTPA
HHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMRLSGADKMSPSERVQLLESRLGLSFSRMETALEALTHKTYVNETRDKELKDNQRLEFL
CCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
GDSVVNLAVSHRLMARCPGLPEGDLTKMRARVVNEDGLARVARTIPLGDLLLLGRGELMS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHEECCCHHHC
GGREKNSVLADALEAVFGAVFLTSGLDAAVTLVDRYFADLLDEVSSGQGRLDYKTLLQEM
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AHERLKLQPRYRVVSESGPEHSKVFEVELMLGETAFARATGRSKKEAEQSAAQATLEKLR
HHHHHCCCCHHHHHCCCCCCCHHEEEEEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
EDAACPTSPPPGTPRHDTPA
HHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA