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The map label for this gene is hslU

Identifier: 108761314

GI number: 108761314

Start: 3539056

End: 3540435

Strand: Direct

Name: hslU

Synonym: MXAN_3013

Alternate gene names: 108761314

Gene position: 3539056-3540435 (Clockwise)

Preceding gene: 108762078

Following gene: 108757298

Centisome position: 38.72

GC content: 68.04

Gene sequence:

>1380_bases
TTGTCCGCCTTCACGCCTCGCGAGGTCGTCAGCGAGCTGGACCGCTACATCGTCGGGCAGAACGCCGCCAAGCGCGCCGT
CGCCATTGCCCTGCGCAACCGGTGGCGCCGCCAGCAGGTCGATGACGATCTGCGCGACGAAATCCACCCGAAGAACATCA
TCATGATTGGCCCCACCGGCGTGGGGAAGACGGAGATTGCCCGCCGCCTGGCGAAGCTCGCCCAGGCGCCCTTCGTCAAG
GTGGAGGCCTCCAAGTTCACCGAGGTCGGCTACGTCGGCCGTGACGTCGAGTCGATGATTCGCGACCTCGTCGAGGCCGC
CATCGCGCTGGTCCGCGAGGAGGAGACCGAGAAGGTCGGCCCCCGCGCCGAGGAACTGGCCGAGGACCGCTTGATCGAGC
TGATGCAGGGCGGCGGCGTGAAGTCGTCGTCCGCGACGCCGCCGTTCGGCTTCGCCCCACCGCCACCCCCACCGGTCCAG
CGTGTCAGCGACAGCGCGCGCGAGAAGTTCCGCGCCCAGCTCCGCGCCGGCACCCTGGATGACGTGGAGGTGGAGGTGGA
GACCGCGGAGTCGTCGCCCACCTTCATGCGGGGCTTCTCCGGCCAGGGCATGGAGGAGATTGGCGTCAACCTCCAGGACC
TCTTCAAGAACGTGCCGGGCATGAACAAGACGCGCCGCCGTCGCGTGCGCGTGCCCGAGGCGCTTCAGCTCCTGCGCAAG
GAAGAGGCCGCCAAGCTGGTGGACCCCGACCGCGTCCAGCGCGAGGCCGTGGCCCGCGCCGAGATGAACGGCATCATCTT
CATCGACGAAATCGACAAGATTGCCAGCCGTGAGGGCGGCAAGGGCGGGGGCGGCCCGGACGTGTCCCGGGAGGGCGTCC
AGCGGGACATCCTCCCCATCGTCGAGGGCTCCACCATCAACACCAAGTATGGCGTGGTGAAGACGGACCACATGCTCTTC
ATCGCCGCTGGCGCCTTCCACGTCTCCAAGCCCAGCGACCTCATCCCGGAATTGCAGGGCCGCTTCCCCATCCGCGTGGA
GCTGGAGCCCCTGACGGGCGAGGACCTGGTCCGAATCCTCCGGGAGCCGAAGAATTCGCTCTTGCGACAGTACACGGCCC
TGCTCAGCACCGAAGGTGTGCGTCTGTCCTTCACCGACGACGCGGTGACGGAGCTGGCGCGCATCGCCCAGCAGGCCAAC
GAGAGCACGGCGAACATCGGCGCCCGGCGGCTGCACACCATCCTGGAGCGACTGCTGGACGAGGTGTCTTTCTCCGCCAG
TGAGATGGGCCCCCGGGATTTCCAGGTGGACGCCGCCTACGTGCGCGAGCGCCTGGCCGCCATCGTCCAGGACGAGGACC
TGTCGCGCTACATCCTGTAG

Upstream 100 bases:

>100_bases
CCAGTCGCTCACCATCGCGGGTGAAATCGACATCTACACCAACGCCAACATCTCCATCGAAGAGCTCTAGGAGACACACC
CCGTGGCCGAATCGCGCAAG

Downstream 100 bases:

>100_bases
CGCGCTATATGCGGAGGGGTACCGTACCGCACGAAGGATGACTGCCTTGTCGCAATCCGAGCCGTCCCTCTCCGCATCGT
CCGACTCCTCCACCGACGCC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTGVGKTEIARRLAKLAQAPFVK
VEASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVGPRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQ
RVSDSAREKFRAQLRAGTLDDVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRK
EEAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPIVEGSTINTKYGVVKTDHMLF
IAAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRILREPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQAN
ESTANIGARRLHTILERLLDEVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL

Sequences:

>Translated_459_residues
MSAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTGVGKTEIARRLAKLAQAPFVK
VEASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVGPRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQ
RVSDSAREKFRAQLRAGTLDDVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRK
EEAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPIVEGSTINTKYGVVKTDHMLF
IAAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRILREPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQAN
ESTANIGARRLHTILERLLDEVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL
>Mature_458_residues
SAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTGVGKTEIARRLAKLAQAPFVKV
EASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVGPRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQR
VSDSAREKFRAQLRAGTLDDVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRKE
EAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPIVEGSTINTKYGVVKTDHMLFI
AAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRILREPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQANE
STANIGARRLHTILERLLDEVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=91, Percent_Identity=41.7582417582418, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1790366, Length=463, Percent_Identity=55.2915766738661, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1786642, Length=180, Percent_Identity=32.7777777777778, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319704, Length=107, Percent_Identity=43.9252336448598, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648291, Length=251, Percent_Identity=30.2788844621514, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648289, Length=251, Percent_Identity=30.2788844621514, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_MYXXD (Q1D801)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_631222.1
- ProteinModelPortal:   Q1D801
- SMR:   Q1D801
- STRING:   Q1D801
- GeneID:   4102853
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_3013
- TIGR:   MXAN_3013
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q1D801
- ProtClustDB:   PRK05201
- BioCyc:   MXAN246197:MXAN_3013-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 50897; Mature: 50765

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 269-269 BINDING 337-337 BINDING 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTG
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLAQAPFVKVEASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVG
CCHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQRVSDSAREKFRAQLRAGTLD
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRK
CCEEEEEECCCCCHHHHCCCCCCHHHHCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHH
EEAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPI
HHHHHCCCHHHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VEGSTINTKYGVVKTDHMLFIAAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRIL
CCCCCCCCCCCEEEECCEEEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHH
REPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQANESTANIGARRLHTILERLLD
HHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL
HHCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
SAFTPREVVSELDRYIVGQNAAKRAVAIALRNRWRRQQVDDDLRDEIHPKNIIMIGPTG
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLAQAPFVKVEASKFTEVGYVGRDVESMIRDLVEAAIALVREEETEKVG
CCHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PRAEELAEDRLIELMQGGGVKSSSATPPFGFAPPPPPPVQRVSDSAREKFRAQLRAGTLD
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
DVEVEVETAESSPTFMRGFSGQGMEEIGVNLQDLFKNVPGMNKTRRRRVRVPEALQLLRK
CCEEEEEECCCCCHHHHCCCCCCHHHHCCCHHHHHHHCCCCCHHHHHHCCCHHHHHHHHH
EEAAKLVDPDRVQREAVARAEMNGIIFIDEIDKIASREGGKGGGGPDVSREGVQRDILPI
HHHHHCCCHHHHHHHHHHHHHCCCEEEEECHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VEGSTINTKYGVVKTDHMLFIAAGAFHVSKPSDLIPELQGRFPIRVELEPLTGEDLVRIL
CCCCCCCCCCCEEEECCEEEEEECCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHH
REPKNSLLRQYTALLSTEGVRLSFTDDAVTELARIAQQANESTANIGARRLHTILERLLD
HHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
EVSFSASEMGPRDFQVDAAYVRERLAAIVQDEDLSRYIL
HHCCCHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA