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The map label for this gene is hemE

Identifier: 108760710

GI number: 108760710

Start: 6689029

End: 6690075

Strand: Reverse

Name: hemE

Synonym: MXAN_5373

Alternate gene names: 108760710

Gene position: 6690075-6689029 (Counterclockwise)

Preceding gene: 108758596

Following gene: 108760875

Centisome position: 73.2

GC content: 69.82

Gene sequence:

>1047_bases
GTGAACGACCGACTCCTCCGCGCGGCGCGCCGCCAGCCCACAGACACGACGCCGGTATGGCTGATGCGCCAGGCGGGCCG
CTACCTGCCCGAGTACCGGGCCATCCGCGGCAACATCGCCTTCCTGGACTTGTGCAAGCACCCGGACCTGGCGGCGGAAG
TCACCGTCCAGCCGGTGACGCGCCTGGGTGTGGACGCGGCCATCATCTTCTCGGACATCCTCATCCCCGTGGAGGCCATG
GGCATCACCCTGGAGCTGGGGGACAAGGGGCCGCACTTCCCCGACCCCGTGCGCTCCGCGGCGGACATCGACAAGCTGGG
CGTGCCGGACCCGGTGGAGGGCACCGGCTTCGTGGCCGAGGCCATCCGCCGCACGCGCAAGGCACTCAATGACTCCGTGC
CCGTCATCGGCTTCGCGGGCGCGCCCTTCACCCTGGCCGCGTACATGGTGGAGGGGGGCGGCTCCAAGAGCTACATCCTC
ATCAAGCGGCTGATGTTCGAGCAGCCCGAGTTGGCGCACCGCCTCTTCGGCAAGCTCACCGACACGCTCATCCCCTACCT
GAAGATGCAGGTGGAGGCGGGCGCGAGCATCGTCCAGATTTTCGACTCGTGGGGCGGCGCGCTGTCGCCATGGGACTACG
AGCGCTTCTGCATTCCCTACCTCAAGCGCATGGTGTCCGAGCTGAAGGCCACCGGCGTGCCCGTCATCGTGTTCGGCGTG
GGCATGTCCTCGCACCTGTCGCTGCTCAAGAGCACCGGCGCGGACGTGGTGGGCCTGGACTGGACGCTGCCCATGGACGA
GGGCCGGAAGGTGCTGGGGCCGGACGTGGCGGTGCAGGGCAACCTGGACCCGCTGCACCTGTTCCTCCCCCGCGAGGAGC
TGGACGGCCGCGTGAAGGACATCCTCCGCCGCGCGGGCCCCGAAGGGCACATCTTCAACCTGGGCCACGGCATCCTCCCG
CCCACGGACCCCGACGCCGCGAAGTTCCTGGTGGAGGCCGTCCACCGCCACGGCGTGGCCCTGCGCCAGGGCACGCTGGG
TGCCTAG

Upstream 100 bases:

>100_bases
AAGGCACCGGGCCGCTGCGCCAGACGCTGGCGTGGAGCCAGCGCTGACCGCACCTGTTTCATTCGCCCCGCCTGGCGCGG
GGCCCACTCCGAGGTTCGAA

Downstream 100 bases:

>100_bases
GGTCGCCTTCCCCCGGGGCGGACAGTCGCCCCGGGGGAGTGTCCACCGATTGATTTTTGAATCAACGGACGATTGACGCG
GCGCATCGCCGCTCGTTAGA

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MNDRLLRAARRQPTDTTPVWLMRQAGRYLPEYRAIRGNIAFLDLCKHPDLAAEVTVQPVTRLGVDAAIIFSDILIPVEAM
GITLELGDKGPHFPDPVRSAADIDKLGVPDPVEGTGFVAEAIRRTRKALNDSVPVIGFAGAPFTLAAYMVEGGGSKSYIL
IKRLMFEQPELAHRLFGKLTDTLIPYLKMQVEAGASIVQIFDSWGGALSPWDYERFCIPYLKRMVSELKATGVPVIVFGV
GMSSHLSLLKSTGADVVGLDWTLPMDEGRKVLGPDVAVQGNLDPLHLFLPREELDGRVKDILRRAGPEGHIFNLGHGILP
PTDPDAAKFLVEAVHRHGVALRQGTLGA

Sequences:

>Translated_348_residues
MNDRLLRAARRQPTDTTPVWLMRQAGRYLPEYRAIRGNIAFLDLCKHPDLAAEVTVQPVTRLGVDAAIIFSDILIPVEAM
GITLELGDKGPHFPDPVRSAADIDKLGVPDPVEGTGFVAEAIRRTRKALNDSVPVIGFAGAPFTLAAYMVEGGGSKSYIL
IKRLMFEQPELAHRLFGKLTDTLIPYLKMQVEAGASIVQIFDSWGGALSPWDYERFCIPYLKRMVSELKATGVPVIVFGV
GMSSHLSLLKSTGADVVGLDWTLPMDEGRKVLGPDVAVQGNLDPLHLFLPREELDGRVKDILRRAGPEGHIFNLGHGILP
PTDPDAAKFLVEAVHRHGVALRQGTLGA
>Mature_348_residues
MNDRLLRAARRQPTDTTPVWLMRQAGRYLPEYRAIRGNIAFLDLCKHPDLAAEVTVQPVTRLGVDAAIIFSDILIPVEAM
GITLELGDKGPHFPDPVRSAADIDKLGVPDPVEGTGFVAEAIRRTRKALNDSVPVIGFAGAPFTLAAYMVEGGGSKSYIL
IKRLMFEQPELAHRLFGKLTDTLIPYLKMQVEAGASIVQIFDSWGGALSPWDYERFCIPYLKRMVSELKATGVPVIVFGV
GMSSHLSLLKSTGADVVGLDWTLPMDEGRKVLGPDVAVQGNLDPLHLFLPREELDGRVKDILRRAGPEGHIFNLGHGILP
PTDPDAAKFLVEAVHRHGVALRQGTLGA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=44.6022727272727, Blast_Score=299, Evalue=3e-81,
Organism=Escherichia coli, GI2367337, Length=342, Percent_Identity=47.953216374269, Blast_Score=319, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6320252, Length=352, Percent_Identity=42.0454545454545, Blast_Score=273, Evalue=2e-74,
Organism=Drosophila melanogaster, GI19921920, Length=343, Percent_Identity=42.2740524781341, Blast_Score=277, Evalue=6e-75,
Organism=Drosophila melanogaster, GI221330099, Length=343, Percent_Identity=42.2740524781341, Blast_Score=277, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_MYXXD (Q1D1F0)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633523.1
- ProteinModelPortal:   Q1D1F0
- SMR:   Q1D1F0
- STRING:   Q1D1F0
- GeneID:   4102359
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_5373
- TIGR:   MXAN_5373
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q1D1F0
- BioCyc:   MXAN246197:MXAN_5373-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 37950; Mature: 37950

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 72-72 BINDING 148-148 BINDING 203-203 BINDING 316-316

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDRLLRAARRQPTDTTPVWLMRQAGRYLPEYRAIRGNIAFLDLCKHPDLAAEVTVQPVT
CCCHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCEEEEEECCCCCCCCEEEECHHH
RLGVDAAIIFSDILIPVEAMGITLELGDKGPHFPDPVRSAADIDKLGVPDPVEGTGFVAE
HHCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
AIRRTRKALNDSVPVIGFAGAPFTLAAYMVEGGGSKSYILIKRLMFEQPELAHRLFGKLT
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
DTLIPYLKMQVEAGASIVQIFDSWGGALSPWDYERFCIPYLKRMVSELKATGVPVIVFGV
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
GMSSHLSLLKSTGADVVGLDWTLPMDEGRKVLGPDVAVQGNLDPLHLFLPREELDGRVKD
CHHHHHHHHHHCCCCEEECEEECCHHCCCEECCCCEEEECCCCCEEEEECHHHHCCHHHH
ILRRAGPEGHIFNLGHGILPPTDPDAAKFLVEAVHRHGVALRQGTLGA
HHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure
MNDRLLRAARRQPTDTTPVWLMRQAGRYLPEYRAIRGNIAFLDLCKHPDLAAEVTVQPVT
CCCHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCCEEEEEECCCCCCCCEEEECHHH
RLGVDAAIIFSDILIPVEAMGITLELGDKGPHFPDPVRSAADIDKLGVPDPVEGTGFVAE
HHCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHH
AIRRTRKALNDSVPVIGFAGAPFTLAAYMVEGGGSKSYILIKRLMFEQPELAHRLFGKLT
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
DTLIPYLKMQVEAGASIVQIFDSWGGALSPWDYERFCIPYLKRMVSELKATGVPVIVFGV
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEC
GMSSHLSLLKSTGADVVGLDWTLPMDEGRKVLGPDVAVQGNLDPLHLFLPREELDGRVKD
CHHHHHHHHHHCCCCEEECEEECCHHCCCEECCCCEEEECCCCCEEEEECHHHHCCHHHH
ILRRAGPEGHIFNLGHGILPPTDPDAAKFLVEAVHRHGVALRQGTLGA
HHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA