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The map label for this gene is fadI [H]

Identifier: 108760875

GI number: 108760875

Start: 6687591

End: 6688892

Strand: Reverse

Name: fadI [H]

Synonym: MXAN_5372

Alternate gene names: 108760875

Gene position: 6688892-6687591 (Counterclockwise)

Preceding gene: 108760710

Following gene: 108760112

Centisome position: 73.18

GC content: 68.74

Gene sequence:

>1302_bases
ATGGCAAGCGAGAAGCGCAACGGCCCCCGAAGGGTGGCCATCGTCCGCGGCCTGCGGACCCCGTTCGTCAAGGCGGGCTC
CGTCTTCTCAGGGCTGACGGCGCTGGATTTGGGCCGCCTGGTGGTCCAGGAGTTGGTCCAGAAGACGGACCTGGACCCGA
ACGTCATCGACCAGGTGGTGTTCGGCCAGGTCATCCCCACGTTGACGGCCCCGTCCATTGCCCGCGAGGTCGTCATCGCG
GCGGGGCTGCCGAAGAAGATTGATGCCTTCACGGTGTCGCGCGCGTGCGCCACGTCCATCCAGGCGCTGACGACGGCGGC
CAACGCGATTGCCACGGGCGAGGCGGACGTCATCATCGCCGGTGGCACCGAGTCCATGTCGGACGCGCCCATCTTCACCA
GCCGGCCGCTGGCCCACGCGCTGGTGGCGGCGTCCAAGGGGCGCTCGCTGCCGGACAAGCTCAAGCCCTTCCAGCGCCTC
AAGGCCAAGGATTTGCTGCCGGTGCCCCCGGCCATCGCCGAGTACTCCACCGGCATGACGATGGGGGAGAGCGCGGAGAA
GATGGCCAAGGAGAACGGCATCTCCCGCGAGGAGCAGGACCGCATCGCCTTCAACTCGCACCGCAACGCGGCCAAGGCGT
GGAAGGACGGTCTGTTCGACAACGAGGTCATGCACGTCGTCGTGCCGCCGAAGTTCGACAAGACGGCGGAGCGCGACAAC
ATCGTCCGTGAAGACTCCAGCATGGAGGCGCTGGGGCAGCTCAAGCCGGCGTTCGACCGCAAGTACGGCACGATTACGGC
GGGCAACGCGTCGCCGCTGACGGACGGCGCCGCGGCGCTGCTGCTGATGAGCGAGGAGAAGGCGCGCGCGCTGGGCTACG
AGCCGTTGGGCTTCCTCCGCAGCCACGCCTACGCGGCCACGGACCCGGGCGACCAGTTGCTCCAGGGCCCAGCCTACGCG
GTGCCCACGGCGCTCAAGCGCGCGGGCATGACGCTGGCGGACATCGACCTGGTGGAGATGCACGAGGCCTTCGCCGCACA
GGTGGCCAGCAACATCCAGGCGCTGGCGTCCCAGGCCTTCGCGAAGAAGGCGGGCTGGAGCGCGCCGGTGGGCGAAATCG
ACCGGGAGCGGCTGAACGTGACGGGTGGCTCCATCGCCATCGGTCATCCCTTTGGGGCCACGGGGGCGCGCATCGTCACC
CAGGCCATCAATGAGCTGAAGCGTCGGAACAAGAACACGGCGATGTGCACCGTCTGCGCGGCGGGCGGCCTGGGCGCAGT
CGTCATCCTGGAGCGTGCGTGA

Upstream 100 bases:

>100_bases
GAGTGTCCACCGATTGATTTTTGAATCAACGGACGATTGACGCGGCGCATCGCCGCTCGTTAGATGCCCACCTCCCGACT
TCGCTGGAGGTGTGGCACAC

Downstream 100 bases:

>100_bases
TGGCCACCAAGGCGGAAGAGCTCGAGGTGAAGCAGGGCTTCTCGTACCAGGTGGAGGGCGGCGTCGCCGTCATCACCTTC
GACCTGCCGGACTCGCCGGT

Product: 3-ketoacyl-CoA thiolase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MASEKRNGPRRVAIVRGLRTPFVKAGSVFSGLTALDLGRLVVQELVQKTDLDPNVIDQVVFGQVIPTLTAPSIAREVVIA
AGLPKKIDAFTVSRACATSIQALTTAANAIATGEADVIIAGGTESMSDAPIFTSRPLAHALVAASKGRSLPDKLKPFQRL
KAKDLLPVPPAIAEYSTGMTMGESAEKMAKENGISREEQDRIAFNSHRNAAKAWKDGLFDNEVMHVVVPPKFDKTAERDN
IVREDSSMEALGQLKPAFDRKYGTITAGNASPLTDGAAALLLMSEEKARALGYEPLGFLRSHAYAATDPGDQLLQGPAYA
VPTALKRAGMTLADIDLVEMHEAFAAQVASNIQALASQAFAKKAGWSAPVGEIDRERLNVTGGSIAIGHPFGATGARIVT
QAINELKRRNKNTAMCTVCAAGGLGAVVILERA

Sequences:

>Translated_433_residues
MASEKRNGPRRVAIVRGLRTPFVKAGSVFSGLTALDLGRLVVQELVQKTDLDPNVIDQVVFGQVIPTLTAPSIAREVVIA
AGLPKKIDAFTVSRACATSIQALTTAANAIATGEADVIIAGGTESMSDAPIFTSRPLAHALVAASKGRSLPDKLKPFQRL
KAKDLLPVPPAIAEYSTGMTMGESAEKMAKENGISREEQDRIAFNSHRNAAKAWKDGLFDNEVMHVVVPPKFDKTAERDN
IVREDSSMEALGQLKPAFDRKYGTITAGNASPLTDGAAALLLMSEEKARALGYEPLGFLRSHAYAATDPGDQLLQGPAYA
VPTALKRAGMTLADIDLVEMHEAFAAQVASNIQALASQAFAKKAGWSAPVGEIDRERLNVTGGSIAIGHPFGATGARIVT
QAINELKRRNKNTAMCTVCAAGGLGAVVILERA
>Mature_432_residues
ASEKRNGPRRVAIVRGLRTPFVKAGSVFSGLTALDLGRLVVQELVQKTDLDPNVIDQVVFGQVIPTLTAPSIAREVVIAA
GLPKKIDAFTVSRACATSIQALTTAANAIATGEADVIIAGGTESMSDAPIFTSRPLAHALVAASKGRSLPDKLKPFQRLK
AKDLLPVPPAIAEYSTGMTMGESAEKMAKENGISREEQDRIAFNSHRNAAKAWKDGLFDNEVMHVVVPPKFDKTAERDNI
VREDSSMEALGQLKPAFDRKYGTITAGNASPLTDGAAALLLMSEEKARALGYEPLGFLRSHAYAATDPGDQLLQGPAYAV
PTALKRAGMTLADIDLVEMHEAFAAQVASNIQALASQAFAKKAGWSAPVGEIDRERLNVTGGSIAIGHPFGATGARIVTQ
AINELKRRNKNTAMCTVCAAGGLGAVVILERA

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=43.0260047281324, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI4501853, Length=428, Percent_Identity=34.1121495327103, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI167614485, Length=424, Percent_Identity=32.7830188679245, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4557237, Length=428, Percent_Identity=31.7757009345794, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI148539872, Length=428, Percent_Identity=29.9065420560748, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI194353979, Length=264, Percent_Identity=26.1363636363636, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1788683, Length=422, Percent_Identity=51.1848341232227, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI87082165, Length=426, Percent_Identity=37.3239436619718, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788554, Length=424, Percent_Identity=36.3207547169811, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787663, Length=427, Percent_Identity=36.0655737704918, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI48994986, Length=431, Percent_Identity=35.0348027842227, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17551802, Length=431, Percent_Identity=44.5475638051044, Blast_Score=351, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI133906874, Length=423, Percent_Identity=34.2789598108747, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=429, Percent_Identity=32.1678321678322, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI25147385, Length=428, Percent_Identity=30.3738317757009, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=428, Percent_Identity=25.4672897196262, Blast_Score=104, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6325229, Length=432, Percent_Identity=32.6388888888889, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322031, Length=379, Percent_Identity=31.6622691292876, Blast_Score=169, Evalue=9e-43,
Organism=Drosophila melanogaster, GI17137578, Length=432, Percent_Identity=43.287037037037, Blast_Score=346, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24640423, Length=438, Percent_Identity=31.2785388127854, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24655093, Length=423, Percent_Identity=31.2056737588652, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI17648125, Length=429, Percent_Identity=29.8368298368298, Blast_Score=178, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 45774; Mature: 45643

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEKRNGPRRVAIVRGLRTPFVKAGSVFSGLTALDLGRLVVQELVQKTDLDPNVIDQVV
CCCCCCCCCCEEEHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FGQVIPTLTAPSIAREVVIAAGLPKKIDAFTVSRACATSIQALTTAANAIATGEADVIIA
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GGTESMSDAPIFTSRPLAHALVAASKGRSLPDKLKPFQRLKAKDLLPVPPAIAEYSTGMT
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
MGESAEKMAKENGISREEQDRIAFNSHRNAAKAWKDGLFDNEVMHVVVPPKFDKTAERDN
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
IVREDSSMEALGQLKPAFDRKYGTITAGNASPLTDGAAALLLMSEEKARALGYEPLGFLR
HHCCCCHHHHHHHCCHHHCCCCCEEECCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHH
SHAYAATDPGDQLLQGPAYAVPTALKRAGMTLADIDLVEMHEAFAAQVASNIQALASQAF
HCCCCCCCCHHHHHCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKAGWSAPVGEIDRERLNVTGGSIAIGHPFGATGARIVTQAINELKRRNKNTAMCTVCA
HHHCCCCCCCCHHHHHHEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
AGGLGAVVILERA
CCCCCEEEEEECC
>Mature Secondary Structure 
ASEKRNGPRRVAIVRGLRTPFVKAGSVFSGLTALDLGRLVVQELVQKTDLDPNVIDQVV
CCCCCCCCCEEEHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FGQVIPTLTAPSIAREVVIAAGLPKKIDAFTVSRACATSIQALTTAANAIATGEADVIIA
HHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
GGTESMSDAPIFTSRPLAHALVAASKGRSLPDKLKPFQRLKAKDLLPVPPAIAEYSTGMT
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHCCCC
MGESAEKMAKENGISREEQDRIAFNSHRNAAKAWKDGLFDNEVMHVVVPPKFDKTAERDN
CCHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
IVREDSSMEALGQLKPAFDRKYGTITAGNASPLTDGAAALLLMSEEKARALGYEPLGFLR
HHCCCCHHHHHHHCCHHHCCCCCEEECCCCCCCCCCCEEEEEECCHHHHHCCCCHHHHHH
SHAYAATDPGDQLLQGPAYAVPTALKRAGMTLADIDLVEMHEAFAAQVASNIQALASQAF
HCCCCCCCCHHHHHCCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKKAGWSAPVGEIDRERLNVTGGSIAIGHPFGATGARIVTQAINELKRRNKNTAMCTVCA
HHHCCCCCCCCHHHHHHEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
AGGLGAVVILERA
CCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA