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The map label for this gene is thrA [H]

Identifier: 108759004

GI number: 108759004

Start: 2644911

End: 2647370

Strand: Reverse

Name: thrA [H]

Synonym: MXAN_2278

Alternate gene names: 108759004

Gene position: 2647370-2644911 (Counterclockwise)

Preceding gene: 108757768

Following gene: 108757335

Centisome position: 28.97

GC content: 71.71

Gene sequence:

>2460_bases
ATGAGGGTGATGAAATTCGGGGGGACGAGCGTGGGCAACGCCGAGCGGATGCGCGGCGTGGCGGACCTGGCCGCGGCGGC
GCGCAAGCAGACGCGGGTGATGATGGTCGCCTCGGCCGTGTCCGGCATCACCAACCTCCTGTTGGAAGCGGCCCGCGCGG
CCCAGGAAGGTCAGCCGGTGGAGTCGCTCCACGGCCGCTTCGAGGACGTCCACCGCGGCATCATCCGCGAGCTGGCGCCG
GAGCTGGGGGAGGCGCGGCAGCGCTCGCTGGAAGAGGGACTTTCCACGCTGGCCTCGGAGCTGCGCGGGCTGCTGCAGGG
CGTGGGGCTGCTGCGGGAATGTTCGCCCTCCGTGCTCGCGCACCTGTCCGGACTGGGCGAGCGCGCCGCGTGCCTGATTC
TGGGCGCGCTGATGCACGCACGCGGACTGGAGCCGCACGCAGTGGAGCCACGGGACGTCATCCTCTGCGCGGGGGACCCG
CTCCAGGCCACGCCGCTCCAGGAGGAGACCCGGGCGCGCTTCACGCCGCTGCGCGAGGCCGGCGGTCCCGGGTTGATGCT
GATGCCGGGCTTCTTCGGCGGTGACACCCGGGGCAAGACGATGTGCCTGGGCCGGGGTGGCTCGGATTATTCGGCGGCGC
TGGCGGCGGCGGCGCTGGACGCGGAGCTGCTGGAGATCTGGACGGACGTGGACGGCATCTTCAGCGCCGACCCGCGGCTG
GTGCCAGAAGCCTTCCCGCTGCCCGAGGTGAGCTTCGAGGAAGCCATGGAGCTGGCCTACTTCGGCGCCAAGGTGCTCCA
CCCCAAGACGATTGCGCCCGCGCGCGAGCGCGGCATCCCCGTGCGCGTCTGCAACAGCTTCCGCCCCGACCACCCGGGCA
CCCGCGTCACCGACGACGCCGCGCCGCCCGAGCACCCGGTGCGCGGCCTCTCCTTCCTTCCCGGCATCGCCCTGGTGAAC
CTGGGCGGCGCGGGGCTCAAGGGCGTTCCGGGCACCGCCGCCCGCGTCTTCGAGTCCATGGCCCTCGCCAACATCTCCGT
GGTGCTCATCACCCAGGGCTCCAGCGAATGCTCCATCAGCTTCTGCGTCCAGCAGGCGGACGCGGAGCGCGCCGTGCAGG
CCCTGGAAGTCGCGTTCGAGATGGAGCGCGCGGCGGGCAAGGTGGACACCATCGAGCAGCAGCGCGGGCTCGCCGTGCTC
AGCATCGTCGGTGATGGCATGCGCCACCGCGTGGGCGTGGCGGGCACCTTCTTCAGCGCGCTGGCGGACGTGGGTTGCAG
CATCGCCGCCATCGCGCAGGGCTCCAGCGAGCGCAGCATCTCCGCGGTCATCGCGGAGACGGACGGTCCCCGCGCCCTGG
CCCATGTCCACGGTCGGTGCTTCGGCACCACGGAAGTCGTGGAGCTGCTGCTGGCCGGCGTGGGCAGCGTGGGCGGCGAG
CTGCTCAAGCAGGTCCACCAGCAGGCGCCCAAGCTGCGCGCCCACGGCGTGGACCTGCGCGTCTGCGTCATCGCCAACAG
CAAGCGCGTCGCGACGGCGAGCGAGGGAATTCCCCTGGAGGACTGGAAGCAGCGGCTGGCGGCCAGCAGCGACGGCGCGC
CCCTGGACGCCTTCCGCGACTGGGCCCGCGCGAAGCGGCCGGGCCGGCCCGTCTTCGTGGACTGCACCAGCAGCGAGGAC
ATCGCGCTCGCCTACCCGTCGCTGATGGAGGCGGGGCTCCACGTCGTCACCGCCAACAAGAAGGCCAACGCCGGCCAGTG
GAGCCACTACCGCAAGCTGCGCGAGACGGCCTCCCGTCACCAACGCCGCTTCCTCTACGAGACGAACGTGGGCGCGGCGC
TGCCCGTCATCGACACGCTGAAGAACATGCTTCGCACGGGAGACCGGGTGCTGCGCGTGGAAGGCATTCTCTCCGGCTCG
CTGTCATTCATCCTGGGCCTGACGGAGGAAGGCGTCCCCTTGTCGCAGGCGGTGGGCACCGCCATGGAGAAGCGCTTCAC
CGAACCCGACCCGCGCGACGACCTCCACGGCACCGACGTGGCGCGCAAGGTGCTCATCCTCGCCCGCGAGCTGGGCCGCC
AGGTGGAGTTGGAGCAGGTGACGCTGGACTCCCTGCTGCCGTCGGACTTCGACGCCACCGGGCCGCTGGATGACTTCCTC
GCCCGGCTCCCCCAGGTGGACGCCGCCTTCCAGCGCCGCGTGGAGACACTCCGCGCGGAGGGCAAGGTGCTACGCTACGT
GGGCAGCGTCACGGAGGACGGTTGCTTTGTCGGGCTCGTGCCGGTGCCCCTGACGCACCCGCTGGCGGCGGTGAAGGGCG
GAGAGAACGCGCTCAGCTTCACCTCGGAGCGCTACAGCCCCACACCGCTGGTGATTCGCGGCTATGGCGCGGGCGCCGCG
GTGACAGCGGCTGGCGTGCTGGCGGACGTGCTCCGCCTGGTCGACGGGCCACTCCCCTGA

Upstream 100 bases:

>100_bases
TTTTCACATGCCGCAGGAGCCCCGACATGCAGCCCTCCTCGCAGTCGACACCGACAAACCCGCCGTCCCGCCTCGCCGCC
TTCCACGCGGAGGTGCGCTC

Downstream 100 bases:

>100_bases
GTTGACGCCCGGTCCGACAGGTCCGCGGCCGATGTACGTTTGAAGTTGGCTGCGGACTTGTCGACAATGCCCCGCCTGCC
CTCGAATGCGCGAGAGGCAA

Product: aspartate kinase/homoserine dehydrogenase

Products: NA

Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 819; Mature: 819

Protein sequence:

>819_residues
MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPVESLHGRFEDVHRGIIRELAP
ELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLAHLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDP
LQATPLQEETRARFTPLREAGGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL
VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDAAPPEHPVRGLSFLPGIALVN
LGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSISFCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVL
SIVGDGMRHRVGVAGTFFSALADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE
LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRDWARAKRPGRPVFVDCTSSED
IALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRHQRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGS
LSFILGLTEEGVPLSQAVGTAMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL
ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSFTSERYSPTPLVIRGYGAGAA
VTAAGVLADVLRLVDGPLP

Sequences:

>Translated_819_residues
MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPVESLHGRFEDVHRGIIRELAP
ELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLAHLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDP
LQATPLQEETRARFTPLREAGGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL
VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDAAPPEHPVRGLSFLPGIALVN
LGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSISFCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVL
SIVGDGMRHRVGVAGTFFSALADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE
LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRDWARAKRPGRPVFVDCTSSED
IALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRHQRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGS
LSFILGLTEEGVPLSQAVGTAMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL
ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSFTSERYSPTPLVIRGYGAGAA
VTAAGVLADVLRLVDGPLP
>Mature_819_residues
MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPVESLHGRFEDVHRGIIRELAP
ELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLAHLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDP
LQATPLQEETRARFTPLREAGGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL
VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDAAPPEHPVRGLSFLPGIALVN
LGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSISFCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVL
SIVGDGMRHRVGVAGTFFSALADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE
LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRDWARAKRPGRPVFVDCTSSED
IALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRHQRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGS
LSFILGLTEEGVPLSQAVGTAMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL
ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSFTSERYSPTPLVIRGYGAGAA
VTAAGVLADVLRLVDGPLP

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=826, Percent_Identity=45.0363196125908, Blast_Score=654, Evalue=0.0,
Organism=Escherichia coli, GI1790376, Length=822, Percent_Identity=28.4671532846715, Blast_Score=288, Evalue=1e-78,
Organism=Escherichia coli, GI1790455, Length=470, Percent_Identity=31.7021276595745, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320893, Length=499, Percent_Identity=31.2625250501002, Blast_Score=186, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322599, Length=364, Percent_Identity=36.8131868131868, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 86964; Mature: 86964

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPV
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ESLHGRFEDVHRGIIRELAPELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDPLQATPLQEETRARFTPLREA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCHHHC
GGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL
CCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCCC
APPEHPVRGLSFLPGIALVNLGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSIS
CCCCCCCCCHHHCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCCHH
FCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVLSIVGDGMRHRVGVAGTFFSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHH
LADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE
HHHCCCCEEEHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHCHHHHH
LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRD
HHHHHHHHCCCHHHCCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHH
WARAKRPGRPVFVDCTSSEDIALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRH
HHHHCCCCCCEEEECCCCCCEEEECHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
QRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGSLSFILGLTEEGVPLSQAVGT
HHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCEEEECCCCCCCHHHHHHH
AMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSF
HHCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCHHHC
TSERYSPTPLVIRGYGAGAAVTAAGVLADVLRLVDGPLP
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRVMKFGGTSVGNAERMRGVADLAAAARKQTRVMMVASAVSGITNLLLEAARAAQEGQPV
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
ESLHGRFEDVHRGIIRELAPELGEARQRSLEEGLSTLASELRGLLQGVGLLRECSPSVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLSGLGERAACLILGALMHARGLEPHAVEPRDVILCAGDPLQATPLQEETRARFTPLREA
HHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHCCCHHHC
GGPGLMLMPGFFGGDTRGKTMCLGRGGSDYSAALAAAALDAELLEIWTDVDGIFSADPRL
CCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
VPEAFPLPEVSFEEAMELAYFGAKVLHPKTIAPARERGIPVRVCNSFRPDHPGTRVTDDA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCCC
APPEHPVRGLSFLPGIALVNLGGAGLKGVPGTAARVFESMALANISVVLITQGSSECSIS
CCCCCCCCCHHHCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHCEEEEEEECCCCCCCHH
FCVQQADAERAVQALEVAFEMERAAGKVDTIEQQRGLAVLSIVGDGMRHRVGVAGTFFSA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHH
LADVGCSIAAIAQGSSERSISAVIAETDGPRALAHVHGRCFGTTEVVELLLAGVGSVGGE
HHHCCCCEEEHHCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHCHHHHH
LLKQVHQQAPKLRAHGVDLRVCVIANSKRVATASEGIPLEDWKQRLAASSDGAPLDAFRD
HHHHHHHHCCCHHHCCCCEEEEEEECCCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHH
WARAKRPGRPVFVDCTSSEDIALAYPSLMEAGLHVVTANKKANAGQWSHYRKLRETASRH
HHHHCCCCCCEEEECCCCCCEEEECHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
QRRFLYETNVGAALPVIDTLKNMLRTGDRVLRVEGILSGSLSFILGLTEEGVPLSQAVGT
HHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEEHHHHHCCCCEEEECCCCCCCHHHHHHH
AMEKRFTEPDPRDDLHGTDVARKVLILARELGRQVELEQVTLDSLLPSDFDATGPLDDFL
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHH
ARLPQVDAAFQRRVETLRAEGKVLRYVGSVTEDGCFVGLVPVPLTHPLAAVKGGENALSF
HHCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCHHHC
TSERYSPTPLVIRGYGAGAAVTAAGVLADVLRLVDGPLP
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]