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The map label for this gene is surA [H]

Identifier: 108758581

GI number: 108758581

Start: 531505

End: 532482

Strand: Reverse

Name: surA [H]

Synonym: MXAN_0468

Alternate gene names: 108758581

Gene position: 532482-531505 (Counterclockwise)

Preceding gene: 108760198

Following gene: 108762691

Centisome position: 5.83

GC content: 68.61

Gene sequence:

>978_bases
ATGGCGGGAATGAAGAAGCTGGTGGCGGCAATCGCGGCGGTGGCGCTCCTGGGGAGCGGCGGCGCGGCGCACGCGGAGCT
GGTGGACAAAGTGGCCGCGGTGGTGAATCGCGACATCATCGCGCTGTCCGAGGTGCAGCAGCGCGCGGCGCCAGAGATGG
CCCGCGTCAACGACCCGGACCCGCGCAAGCGCGGCGAGCAGCGGCTGCAGCTGATGAAGACGGCCCTGGACACCCTCATC
GGCGAGAAGCTGATGGAGTCCGAAATCGCGCAGCTGGGCATCACCGCCAGCGAGGCGGAGGTGGATGAGCTGGTGGCGGA
CGTGCGCCAGCAGAACAACATCACCGACCCCGCGCAGTTCGAGCAGCTCCTGCTGGGTGAAGGCCTCACCATGGCCACCT
ACCGGGACATGATGCGCAAGCGCATCCTGCGTGACCGCCTGCTGCGCATGAAGGTGGGCCCCCAGGTGAAGATTACCGAG
GAGGACCTCAAGGCCGCGTACACGCAGTACACGCGCATGGAGAGCGGTGACTCGGAGGTCCACGCGCGCCACATCCTGGT
GCAGGTGGACGCCAAGGCCACGGCGGAGCAGGTGGAAGCCGCCAAGAAGCGGGCGGAGGCCATCGCCACGGAAGCGCGCC
GGCCGGGCATGGACTTCGCCTCGCTGGCCCGCGCCCGCAGCGAAGGCCCCAGCGCCGCGGACGGCGGTGACCTGGGCTGG
TTCAAGCGGGGCGTCATGGTTCCAGCCTTCGAGAAGGCCGCGTTCGGCCTCCCCGAGGGCGGCGTCAGTGAGCCGGTACG
CACCAACTTCGGCTGGCACGTGCTGAAGGTGGAGGAGCGCCGCACGGTGGCCGCCGCGTCCTACGAGGAGATGCGCCCCA
AGCTGGAGGGCAAGCTGCTCCAGGAGAAGACGGAGAAGTTCCTCGACCAGTACGTGCAGGAACTGCGGCAGAAGGCCAAC
GTCGACGTGAAGCTGTAG

Upstream 100 bases:

>100_bases
GCCATCCGCGGGCGTCCGACGCCTCAGCAGGCGACGGCGGAGTGACGACGAAATCGAAGACCGGGGCGGCGGTTGGACGC
GCCCGGGGCGGTACGGAAGG

Downstream 100 bases:

>100_bases
CCGCCGTGGGCCTTCCGCACGTCGGAATCTCCCTGGGGGACGTGTCGGGCATCGGGCCGGAGGTGACGGCCGCGGCCCTG
ACGAAGCCCTCCGTGCGCAA

Product: peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAGMKKLVAAIAAVALLGSGGAAHAELVDKVAAVVNRDIIALSEVQQRAAPEMARVNDPDPRKRGEQRLQLMKTALDTLI
GEKLMESEIAQLGITASEAEVDELVADVRQQNNITDPAQFEQLLLGEGLTMATYRDMMRKRILRDRLLRMKVGPQVKITE
EDLKAAYTQYTRMESGDSEVHARHILVQVDAKATAEQVEAAKKRAEAIATEARRPGMDFASLARARSEGPSAADGGDLGW
FKRGVMVPAFEKAAFGLPEGGVSEPVRTNFGWHVLKVEERRTVAAASYEEMRPKLEGKLLQEKTEKFLDQYVQELRQKAN
VDVKL

Sequences:

>Translated_325_residues
MAGMKKLVAAIAAVALLGSGGAAHAELVDKVAAVVNRDIIALSEVQQRAAPEMARVNDPDPRKRGEQRLQLMKTALDTLI
GEKLMESEIAQLGITASEAEVDELVADVRQQNNITDPAQFEQLLLGEGLTMATYRDMMRKRILRDRLLRMKVGPQVKITE
EDLKAAYTQYTRMESGDSEVHARHILVQVDAKATAEQVEAAKKRAEAIATEARRPGMDFASLARARSEGPSAADGGDLGW
FKRGVMVPAFEKAAFGLPEGGVSEPVRTNFGWHVLKVEERRTVAAASYEEMRPKLEGKLLQEKTEKFLDQYVQELRQKAN
VDVKL
>Mature_324_residues
AGMKKLVAAIAAVALLGSGGAAHAELVDKVAAVVNRDIIALSEVQQRAAPEMARVNDPDPRKRGEQRLQLMKTALDTLIG
EKLMESEIAQLGITASEAEVDELVADVRQQNNITDPAQFEQLLLGEGLTMATYRDMMRKRILRDRLLRMKVGPQVKITEE
DLKAAYTQYTRMESGDSEVHARHILVQVDAKATAEQVEAAKKRAEAIATEARRPGMDFASLARARSEGPSAADGGDLGWF
KRGVMVPAFEKAAFGLPEGGVSEPVRTNFGWHVLKVEERRTVAAASYEEMRPKLEGKLLQEKTEKFLDQYVQELRQKANV
DVKL

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=114, Percent_Identity=36.8421052631579, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786238, Length=278, Percent_Identity=27.3381294964029, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790211, Length=70, Percent_Identity=45.7142857142857, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 35834; Mature: 35702

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGMKKLVAAIAAVALLGSGGAAHAELVDKVAAVVNRDIIALSEVQQRAAPEMARVNDPD
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCC
PRKRGEQRLQLMKTALDTLIGEKLMESEIAQLGITASEAEVDELVADVRQQNNITDPAQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHH
EQLLLGEGLTMATYRDMMRKRILRDRLLRMKVGPQVKITEEDLKAAYTQYTRMESGDSEV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCHHH
HARHILVQVDAKATAEQVEAAKKRAEAIATEARRPGMDFASLARARSEGPSAADGGDLGW
HHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHH
FKRGVMVPAFEKAAFGLPEGGVSEPVRTNFGWHVLKVEERRTVAAASYEEMRPKLEGKLL
HHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
QEKTEKFLDQYVQELRQKANVDVKL
HHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AGMKKLVAAIAAVALLGSGGAAHAELVDKVAAVVNRDIIALSEVQQRAAPEMARVNDPD
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCC
PRKRGEQRLQLMKTALDTLIGEKLMESEIAQLGITASEAEVDELVADVRQQNNITDPAQF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHH
EQLLLGEGLTMATYRDMMRKRILRDRLLRMKVGPQVKITEEDLKAAYTQYTRMESGDSEV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCHHH
HARHILVQVDAKATAEQVEAAKKRAEAIATEARRPGMDFASLARARSEGPSAADGGDLGW
HHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHH
FKRGVMVPAFEKAAFGLPEGGVSEPVRTNFGWHVLKVEERRTVAAASYEEMRPKLEGKLL
HHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
QEKTEKFLDQYVQELRQKANVDVKL
HHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]