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The map label for this gene is nuoD

Identifier: 108758426

GI number: 108758426

Start: 3179453

End: 3180700

Strand: Reverse

Name: nuoD

Synonym: MXAN_2729

Alternate gene names: 108758426

Gene position: 3180700-3179453 (Counterclockwise)

Preceding gene: 108759239

Following gene: 108763204

Centisome position: 34.8

GC content: 66.83

Gene sequence:

>1248_bases
ATGGCTGACACCCTCAAGCCCGAAGCGCCGAACCCCGACACCGACGCGTACGCCCACGAGTCGGAGCTGGACGCCCACCT
CCAGACCAAGCGGATGGTCATCAACATGGGCCCCTCCCACCCGGCCACGCACGGCACCGTGCGGCTGAAGGTGGAGCTCG
AGGGTGAGACGATCGTCAAGATCGACCCTGAGATTGGCTTCCTGCACCGCGGCTTCCAGAAGAGCTGCGAGAACGTCACG
TGGACGCAGTGCCTGCCCTACACGGACCGGCTCAACTACCTGTCCGCGATGATGAACAACTTCGGGTTCCTCAACGCCGT
GGAGAAGCTCATCGGCCTGGAGATTCCCGAGCGCGCCCAGTACATCCGCGTCATCGGCTCCGAGCTCCACCGCCTGACGG
ACCACCTGACGTGCGTGGGCGCCACCGGCCTGGAGATGGGCGGCTTCGCGCCGTTCCTCCTCGCCATGGAGTTCCGCGAG
CTGCTCCATGACCGCACCGCCGAGCTGACCGGCGCGCGCCTCACCACCAGCTTCGGCCGCGTGGGTGGCAGCAACCGCGA
CCTGCCCGAGGGCTGGATTCCCCGCGTCCACAAGACGCTGGACCAGGGACTGGCGCTGCTCGACGAGATGGAAGGCCTGC
TGACGAACAACCGCATCTTCGTGGACCGCACGAAGGGCACGGGTGTCATCAGCGCCGAGGACGCCATCGAGTACGGCTAC
ACCGGCCCCGCGCTGCGCGCGTGCGGCGTGGACTACGACATCCGCAAGACGAAGCCCTACTGGGTCTACGACCGGTTCGA
CTTCGACATCCCGGTGGGCGAGCACGGCGACAACTACGACCGCTACCTGGTCCGGCTCGAGGAGATGCGTCAGTCCATCC
GCATCCTGCGCCAGGCCATGGACACCATCCCCGCGGGCCCCATCATCGTGGATGACTGGCGCATCGCGCTGCCGCCCAAG
CCCGAGGTCTACGGCACCATCGAAGGCGTGATGTCGCACTTCAAGCTGGTGATGGAGGGCATCCAGGTGCCCGCCGGCGA
GGTGTACGACGCCACCGAGGCCTCCAACGGCGAGCTGGGCTGGTACCTGGTGAGCGACGGCCGCGGCCGTCCCTACAAGG
TCCACGTTCGCGCCCCGGGCTTCCCGGTGCTCGCGGCCGTCCCCCACATCATCGAAGGCAAGATGCTGGCGGACCTCATC
CCTACGTTTGACACCATCAACATGATCGGCGGCGAGGTCGAGCAGTGA

Upstream 100 bases:

>100_bases
CTACGCGCTGCGTGACCGGCAGCCGCTCATCCCCGAGCGCCCCATCAAGGACATCTTCCGCGGTCCCGGCACCAGCGGGC
TCTCCTGAGCGAGGACATCC

Downstream 100 bases:

>100_bases
GCGACAACGACACGAAGAAGCCCACCGGTGATGCGCAGCCGCCTCCGAAGGGGGCGCCCACGGACACGCCCGCGGCCAAG
ATTGGCTCGGAGCCGTCCAA

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MADTLKPEAPNPDTDAYAHESELDAHLQTKRMVINMGPSHPATHGTVRLKVELEGETIVKIDPEIGFLHRGFQKSCENVT
WTQCLPYTDRLNYLSAMMNNFGFLNAVEKLIGLEIPERAQYIRVIGSELHRLTDHLTCVGATGLEMGGFAPFLLAMEFRE
LLHDRTAELTGARLTTSFGRVGGSNRDLPEGWIPRVHKTLDQGLALLDEMEGLLTNNRIFVDRTKGTGVISAEDAIEYGY
TGPALRACGVDYDIRKTKPYWVYDRFDFDIPVGEHGDNYDRYLVRLEEMRQSIRILRQAMDTIPAGPIIVDDWRIALPPK
PEVYGTIEGVMSHFKLVMEGIQVPAGEVYDATEASNGELGWYLVSDGRGRPYKVHVRAPGFPVLAAVPHIIEGKMLADLI
PTFDTINMIGGEVEQ

Sequences:

>Translated_415_residues
MADTLKPEAPNPDTDAYAHESELDAHLQTKRMVINMGPSHPATHGTVRLKVELEGETIVKIDPEIGFLHRGFQKSCENVT
WTQCLPYTDRLNYLSAMMNNFGFLNAVEKLIGLEIPERAQYIRVIGSELHRLTDHLTCVGATGLEMGGFAPFLLAMEFRE
LLHDRTAELTGARLTTSFGRVGGSNRDLPEGWIPRVHKTLDQGLALLDEMEGLLTNNRIFVDRTKGTGVISAEDAIEYGY
TGPALRACGVDYDIRKTKPYWVYDRFDFDIPVGEHGDNYDRYLVRLEEMRQSIRILRQAMDTIPAGPIIVDDWRIALPPK
PEVYGTIEGVMSHFKLVMEGIQVPAGEVYDATEASNGELGWYLVSDGRGRPYKVHVRAPGFPVLAAVPHIIEGKMLADLI
PTFDTINMIGGEVEQ
>Mature_414_residues
ADTLKPEAPNPDTDAYAHESELDAHLQTKRMVINMGPSHPATHGTVRLKVELEGETIVKIDPEIGFLHRGFQKSCENVTW
TQCLPYTDRLNYLSAMMNNFGFLNAVEKLIGLEIPERAQYIRVIGSELHRLTDHLTCVGATGLEMGGFAPFLLAMEFREL
LHDRTAELTGARLTTSFGRVGGSNRDLPEGWIPRVHKTLDQGLALLDEMEGLLTNNRIFVDRTKGTGVISAEDAIEYGYT
GPALRACGVDYDIRKTKPYWVYDRFDFDIPVGEHGDNYDRYLVRLEEMRQSIRILRQAMDTIPAGPIIVDDWRIALPPKP
EVYGTIEGVMSHFKLVMEGIQVPAGEVYDATEASNGELGWYLVSDGRGRPYKVHVRAPGFPVLAAVPHIIEGKMLADLIP
TFDTINMIGGEVEQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=387, Percent_Identity=45.7364341085271, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI260898743, Length=377, Percent_Identity=46.1538461538462, Blast_Score=342, Evalue=3e-94,
Organism=Escherichia coli, GI145693162, Length=385, Percent_Identity=37.9220779220779, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789076, Length=304, Percent_Identity=26.9736842105263, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788832, Length=395, Percent_Identity=22.7848101265823, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17555284, Length=386, Percent_Identity=42.4870466321244, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17568379, Length=386, Percent_Identity=43.0051813471503, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=43.298969072165, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221459469, Length=393, Percent_Identity=43.0025445292621, Blast_Score=352, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_MYXXD (Q1D8S7)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630946.1
- ProteinModelPortal:   Q1D8S7
- SMR:   Q1D8S7
- STRING:   Q1D8S7
- GeneID:   4104746
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2729
- TIGR:   MXAN_2729
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   THPATHG
- PhylomeDB:   Q1D8S7
- ProtClustDB:   CLSK946260
- BioCyc:   MXAN246197:MXAN_2729-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 46353; Mature: 46221

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTLKPEAPNPDTDAYAHESELDAHLQTKRMVINMGPSHPATHGTVRLKVELEGETIVK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCCCCCCEEEEEEEECCCEEEE
IDPEIGFLHRGFQKSCENVTWTQCLPYTDRLNYLSAMMNNFGFLNAVEKLIGLEIPERAQ
ECCCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHH
YIRVIGSELHRLTDHLTCVGATGLEMGGFAPFLLAMEFRELLHDRTAELTGARLTTSFGR
HHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGGSNRDLPEGWIPRVHKTLDQGLALLDEMEGLLTNNRIFVDRTKGTGVISAEDAIEYGY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHCCC
TGPALRACGVDYDIRKTKPYWVYDRFDFDIPVGEHGDNYDRYLVRLEEMRQSIRILRQAM
CCHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DTIPAGPIIVDDWRIALPPKPEVYGTIEGVMSHFKLVMEGIQVPAGEVYDATEASNGELG
HHCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
WYLVSDGRGRPYKVHVRAPGFPVLAAVPHIIEGKMLADLIPTFDTINMIGGEVEQ
EEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHCCHHHHHHCCCCCCC
>Mature Secondary Structure 
ADTLKPEAPNPDTDAYAHESELDAHLQTKRMVINMGPSHPATHGTVRLKVELEGETIVK
CCCCCCCCCCCCCCCCCCHHHHHHHHHEEEEEEECCCCCCCCCCEEEEEEEECCCEEEE
IDPEIGFLHRGFQKSCENVTWTQCLPYTDRLNYLSAMMNNFGFLNAVEKLIGLEIPERAQ
ECCCCCHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHH
YIRVIGSELHRLTDHLTCVGATGLEMGGFAPFLLAMEFRELLHDRTAELTGARLTTSFGR
HHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
VGGSNRDLPEGWIPRVHKTLDQGLALLDEMEGLLTNNRIFVDRTKGTGVISAEDAIEYGY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEHHHHHHCCC
TGPALRACGVDYDIRKTKPYWVYDRFDFDIPVGEHGDNYDRYLVRLEEMRQSIRILRQAM
CCHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DTIPAGPIIVDDWRIALPPKPEVYGTIEGVMSHFKLVMEGIQVPAGEVYDATEASNGELG
HHCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
WYLVSDGRGRPYKVHVRAPGFPVLAAVPHIIEGKMLADLIPTFDTINMIGGEVEQ
EEEEECCCCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA