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The map label for this gene is hisB [H]

Identifier: 108758246

GI number: 108758246

Start: 5184799

End: 5185335

Strand: Reverse

Name: hisB [H]

Synonym: MXAN_4225

Alternate gene names: 108758246

Gene position: 5185335-5184799 (Counterclockwise)

Preceding gene: 108758023

Following gene: 108762116

Centisome position: 56.73

GC content: 66.11

Gene sequence:

>537_bases
ATGACCACTGTCATTCGGGAGACGAAGGAGACGCAGGTCCGGGTGGAGCTGGCGCCGGGCAAGGGCGTCACGAACGTGGA
CACGGGGTTGAAGTTCTTCGACCACATGCTGGCCACCTTCGCGCGCTACGCGGGGCTGGACCTCTCGCTGCATGCGCGGG
GGGACCTCACGCACCATGTGATGGAGGACGTGGCCATCACGCTGGGCACGGCGGTGCAGCAGGTGATTCCAGCCACGGCC
GCGCGTTTCGCCGAGCGCACCATTCCCATGGACGACGCGCTGGTGCAGGCCTGTCTGGATGCAGGGGGGCGCTTTTATTA
CCAGGGCCCGTTGAAGAACCGGCTCTACGAGCACTGGATGCGCTCGTTCAGCGAGCACGCCCGGGTGACGTTGCACCTGC
GGGTGCTGCGCGGAAAGGACAGCCACCACGCGACAGAGGCGTCCTTCAAGGCGCTGGGGCTGGCGCTGCGGGATGCCATG
GTGGACTCCGGCTCGGTGTTCAGCATGAAGGGCTCCGTGTCCCTGGAGGTGAAGTGA

Upstream 100 bases:

>100_bases
TGCGGGCCCTCGCGGCGGCGGGCGCATACGGGGCCGTCATTGGCATGGCGCTGTACACCGGAAGGCTGGATGCGAGCGCA
GTCGCTCGGGAGTTCGCGGG

Downstream 100 bases:

>100_bases
TGCTCACGCGGCGGCTCGTCGTCTGTCTGGACGTGAAGGGCGGACGCGTGGTGAAGGGCGTCCAGTTCGAGGGACTTCGC
GACGTGGGTGACCCGGTGGA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MTTVIRETKETQVRVELAPGKGVTNVDTGLKFFDHMLATFARYAGLDLSLHARGDLTHHVMEDVAITLGTAVQQVIPATA
ARFAERTIPMDDALVQACLDAGGRFYYQGPLKNRLYEHWMRSFSEHARVTLHLRVLRGKDSHHATEASFKALGLALRDAM
VDSGSVFSMKGSVSLEVK

Sequences:

>Translated_178_residues
MTTVIRETKETQVRVELAPGKGVTNVDTGLKFFDHMLATFARYAGLDLSLHARGDLTHHVMEDVAITLGTAVQQVIPATA
ARFAERTIPMDDALVQACLDAGGRFYYQGPLKNRLYEHWMRSFSEHARVTLHLRVLRGKDSHHATEASFKALGLALRDAM
VDSGSVFSMKGSVSLEVK
>Mature_177_residues
TTVIRETKETQVRVELAPGKGVTNVDTGLKFFDHMLATFARYAGLDLSLHARGDLTHHVMEDVAITLGTAVQQVIPATAA
RFAERTIPMDDALVQACLDAGGRFYYQGPLKNRLYEHWMRSFSEHARVTLHLRVLRGKDSHHATEASFKALGLALRDAMV
DSGSVFSMKGSVSLEVK

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=185, Percent_Identity=37.8378378378378, Blast_Score=107, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6324776, Length=180, Percent_Identity=37.2222222222222, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 19670; Mature: 19539

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVIRETKETQVRVELAPGKGVTNVDTGLKFFDHMLATFARYAGLDLSLHARGDLTHHV
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHH
MEDVAITLGTAVQQVIPATAARFAERTIPMDDALVQACLDAGGRFYYQGPLKNRLYEHWM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHH
RSFSEHARVTLHLRVLRGKDSHHATEASFKALGLALRDAMVDSGSVFSMKGSVSLEVK
HHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEC
>Mature Secondary Structure 
TTVIRETKETQVRVELAPGKGVTNVDTGLKFFDHMLATFARYAGLDLSLHARGDLTHHV
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHH
MEDVAITLGTAVQQVIPATAARFAERTIPMDDALVQACLDAGGRFYYQGPLKNRLYEHWM
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHH
RSFSEHARVTLHLRVLRGKDSHHATEASFKALGLALRDAMVDSGSVFSMKGSVSLEVK
HHHHHCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA