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The map label for this gene is hisA

Identifier: 108758023

GI number: 108758023

Start: 5185332

End: 5186048

Strand: Reverse

Name: hisA

Synonym: MXAN_4226

Alternate gene names: 108758023

Gene position: 5186048-5185332 (Counterclockwise)

Preceding gene: 108762544

Following gene: 108758246

Centisome position: 56.74

GC content: 69.87

Gene sequence:

>717_bases
GTGATTGCGATTCCAGCCATCGATCTGCGCGAGGGCGCGTGTGTCCAACTCGTGGGCGGCTCGTACGCGGCGGAGAAGGT
CCGGGTGGAGGAACCGCTGGAGGCATTGAAGCAGTGGCGCCGTCACGGCTTCCGCGCGTTCCATGTCGTGGACCTGGACG
CGGCGCTGGGCAAGGGCTCCAACGCGGACGCCATCTTCCAACTGACCGCCTACGAGCGAGGGCTCACCTTCTCCGTGGGC
GGCGGCGTGCGCGATTCCGACCGGGTGGAGACCGTCCTGTCAGGCGGAGCCGAGTTCGTGGTGGTGGGAACTCGCGCCAT
CGAAGACGCCGGCTGGCTGGCGGACATCGCCAACCGCTTCCCCGGCCGGGTGGTGGTGGCCGCGGACGTGAAGGGGCGAG
AGGTGGTGACGCGAGGCTGGACGGCGGGAAGCCATCGGGACATCCGGGAGGTGCTGGCGGCCTTCGAGCCCTTGCCGCTG
GGGGGCCTGCTCGTGACGGCGGTCCACAAGGAGGGCCAGTTGTCGGGAGTGGACCTGCCGTTGATGCGGGAGGTGGCGAG
CACCAGCCGGCACCGTCTGTACGCGTCGGGTGGCGTGACGACGATGGAGGACCTGCGGGCCCTCGCGGCGGCGGGCGCAT
ACGGGGCCGTCATTGGCATGGCGCTGTACACCGGAAGGCTGGATGCGAGCGCAGTCGCTCGGGAGTTCGCGGGATGA

Upstream 100 bases:

>100_bases
CGGTGCGCAGGGGAAGGGTGGTGGGTGTGCAGTTCCACCCGGAGAAGTCCTCCACGGCGGGCGTGCGCTTCGTGCAGGCC
TTCCTGCGGGAGGTGGCGCC

Downstream 100 bases:

>100_bases
CCACTGTCATTCGGGAGACGAAGGAGACGCAGGTCCGGGTGGAGCTGGCGCCGGGCAAGGGCGTCACGAACGTGGACACG
GGGTTGAAGTTCTTCGACCA

Product: putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MIAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSNADAIFQLTAYERGLTFSVG
GGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPGRVVVAADVKGREVVTRGWTAGSHRDIREVLAAFEPLPL
GGLLVTAVHKEGQLSGVDLPLMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLDASAVAREFAG

Sequences:

>Translated_238_residues
MIAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSNADAIFQLTAYERGLTFSVG
GGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPGRVVVAADVKGREVVTRGWTAGSHRDIREVLAAFEPLPL
GGLLVTAVHKEGQLSGVDLPLMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLDASAVAREFAG
>Mature_238_residues
MIAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGSNADAIFQLTAYERGLTFSVG
GGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRFPGRVVVAADVKGREVVTRGWTAGSHRDIREVLAAFEPLPL
GGLLVTAVHKEGQLSGVDLPLMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLDASAVAREFAG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=233, Percent_Identity=28.3261802575107, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_MYXXD (Q1D4M2)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_632401.1
- ProteinModelPortal:   Q1D4M2
- SMR:   Q1D4M2
- STRING:   Q1D4M2
- GeneID:   4105180
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_4226
- TIGR:   MXAN_4226
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- ProtClustDB:   CLSK2468161
- BioCyc:   MXAN246197:MXAN_4226-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25158; Mature: 25158

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGS
CEECCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHCCCC
NADAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRF
CCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHC
PGRVVVAADVKGREVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKEGQLSGVDLP
CCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHH
LMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLDASAVAREFAG
HHHHHHHHHHCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MIAIPAIDLREGACVQLVGGSYAAEKVRVEEPLEALKQWRRHGFRAFHVVDLDAALGKGS
CEECCCEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEHHHHCCCC
NADAIFQLTAYERGLTFSVGGGVRDSDRVETVLSGGAEFVVVGTRAIEDAGWLADIANRF
CCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHC
PGRVVVAADVKGREVVTRGWTAGSHRDIREVLAAFEPLPLGGLLVTAVHKEGQLSGVDLP
CCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHH
LMREVASTSRHRLYASGGVTTMEDLRALAAAGAYGAVIGMALYTGRLDASAVAREFAG
HHHHHHHHHHCEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA