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The map label for this gene is phhA [H]

Identifier: 108757987

GI number: 108757987

Start: 6404014

End: 6405591

Strand: Reverse

Name: phhA [H]

Synonym: MXAN_5127

Alternate gene names: 108757987

Gene position: 6405591-6404014 (Counterclockwise)

Preceding gene: 108757200

Following gene: 108761468

Centisome position: 70.08

GC content: 71.04

Gene sequence:

>1578_bases
ATGATGATGACTCCCACGGAACGGACGATTGCCCGCCTGCCTGCTCATCTGCGTCGCTACGTGGTGAGCCAGGACTACGC
GGCGTATACGTCGCGGGACCAGGCCGTCTGGCGGAATATCCTGGGCTCCTTGAGGGGCCACCTGGCGGACAAGGCGCACC
CCGTCTACCTGGAGGGCCTGGAGGCCACGGGCATCGGCTCGGAGTGCATCCCCAGCCTGGATGAGATGAACGAGAAGCTC
GCTCGACTGGGGTGGGCCTGTGTGGGGGTGCGTGGCTTCATTCCTCCCGCCGTCTTCACGGAGCTCCAGGCGATGGGCGT
CCTGGCGATTGCCGCGGACATCCGCACCCACGAGCACATCGAGTACACGCCGGCGCCGGACATCGTCCATGAGAGCGCCG
GGCACGCGCCCATCATCGCCAACCGCCGCTACGCGGAGTACCTCAAGGCCTGCGGGCTGGTGGGCTTCAAGGCCATTGCC
AGCGTGGAGGACCAGGCCGTCTTCGAGGCCATCCGGAACCTGTCGGTGGTGAAGGAGGACCCGGACGCCAGCGAGGAGGA
AGCGGCGCACGCGCAGGCCCGGCTGGAGGCCGCCAGCGCGAGCCGCCGCTACGTCAGCGAGAGCACGCGGGCGAGCCGCC
TCTACTGGTGGACGGCTGAGTACGGCCTCATCGGGAGCGTGGCGTCGCCGCGCATCTACGGCGCGGGGCTGCTGTCCAGT
ATCGGCGAGGCGCAGCACTGCCTGACGCCGGCGGTGAAGAAGCTGCCGCTGAGCGTGGCCTGCGCGGACATGGACTACGA
CATCACCCGCATGCAGCCGCAGCTCTTCGTGGCGCGGGACTTCGAGCACCTGTTCGAGGTGCTGGCGGAGTTCGAGTCCA
CGCTGTCGTGGAAGCGCGGCGGCGACTTCGGCCTGACGGAGGCGCTGCGCGCGCGGACCGTCAATCACCTGGTGCTGGCG
GACGGCCGCGAGGTGACGGGCCGGGTGCTGGAGATGCTCGCCGCGCCGCGCGAGGTGGCGCCGGGGCTGGGCACCGCGCT
TGTCTGCATGGAGGGGCCCATCATGGCCTCGCGAGGCGGGCGCGCCCTGGACGACAAGCCGTGGAGCGGGCCGGCGCTGG
TGGCGTTCGGCGCGGGGACCTTGCCGGAGCGCGGGCCCTTCAAGCTGTCGCTGGAGAGTGGGCTGGAGCTGGAGGGCTTC
GCCACGGACGGCGGCCAGGTGCTGGCGCTGCGCGGCCGGTTGGCGGGGCGCGAGCTGGCGCTGCCCGCGGTGGCGAAGCT
CTTCGTCAGCACGCACCTGCCCTCGGTGGCGGGTGGGCCTTCGGACCCGGCGACGTGGGACCGCTGGTACGGCGAGCTGA
GCGCCTTCGCGGAAGGGGATGGCGAGGAGAAGGCCCGCACACGCAAGGCCCTGGCGCTGCACCCGGCGCTGGCCGCGCTC
TACCGCGAGGTCCGGAAGATGCGGGAGACGCACTCCGTGAAGCCTGAGCGGCTGAGCCAGATTGCCGCGGCGGCCACGGA
CTTCCCGGATGACTGGCTGCTTCGCGCCGAAGTGGAAGAGCTGCGCCGCCGCGTCTGA

Upstream 100 bases:

>100_bases
AGTTCGACGTTAAAACGACGAAGACGTCGATTTCTGACGGATTTCCGTTCGCCTGGAGAAAGGATATCTTTCGAAAAGTA
GAAGATTCCGCCTGAGGTGA

Downstream 100 bases:

>100_bases
GTCAGCGCCCCCAGTCCTTCTCCTCCAGGCCCTCCCGGAGGACCCAGCGCAGGTGTTCGTCGAAGTCGAAGGTGCAGCCC
GAGACGTCGGGCGCTCCATC

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MMMTPTERTIARLPAHLRRYVVSQDYAAYTSRDQAVWRNILGSLRGHLADKAHPVYLEGLEATGIGSECIPSLDEMNEKL
ARLGWACVGVRGFIPPAVFTELQAMGVLAIAADIRTHEHIEYTPAPDIVHESAGHAPIIANRRYAEYLKACGLVGFKAIA
SVEDQAVFEAIRNLSVVKEDPDASEEEAAHAQARLEAASASRRYVSESTRASRLYWWTAEYGLIGSVASPRIYGAGLLSS
IGEAQHCLTPAVKKLPLSVACADMDYDITRMQPQLFVARDFEHLFEVLAEFESTLSWKRGGDFGLTEALRARTVNHLVLA
DGREVTGRVLEMLAAPREVAPGLGTALVCMEGPIMASRGGRALDDKPWSGPALVAFGAGTLPERGPFKLSLESGLELEGF
ATDGGQVLALRGRLAGRELALPAVAKLFVSTHLPSVAGGPSDPATWDRWYGELSAFAEGDGEEKARTRKALALHPALAAL
YREVRKMRETHSVKPERLSQIAAAATDFPDDWLLRAEVEELRRRV

Sequences:

>Translated_525_residues
MMMTPTERTIARLPAHLRRYVVSQDYAAYTSRDQAVWRNILGSLRGHLADKAHPVYLEGLEATGIGSECIPSLDEMNEKL
ARLGWACVGVRGFIPPAVFTELQAMGVLAIAADIRTHEHIEYTPAPDIVHESAGHAPIIANRRYAEYLKACGLVGFKAIA
SVEDQAVFEAIRNLSVVKEDPDASEEEAAHAQARLEAASASRRYVSESTRASRLYWWTAEYGLIGSVASPRIYGAGLLSS
IGEAQHCLTPAVKKLPLSVACADMDYDITRMQPQLFVARDFEHLFEVLAEFESTLSWKRGGDFGLTEALRARTVNHLVLA
DGREVTGRVLEMLAAPREVAPGLGTALVCMEGPIMASRGGRALDDKPWSGPALVAFGAGTLPERGPFKLSLESGLELEGF
ATDGGQVLALRGRLAGRELALPAVAKLFVSTHLPSVAGGPSDPATWDRWYGELSAFAEGDGEEKARTRKALALHPALAAL
YREVRKMRETHSVKPERLSQIAAAATDFPDDWLLRAEVEELRRRV
>Mature_525_residues
MMMTPTERTIARLPAHLRRYVVSQDYAAYTSRDQAVWRNILGSLRGHLADKAHPVYLEGLEATGIGSECIPSLDEMNEKL
ARLGWACVGVRGFIPPAVFTELQAMGVLAIAADIRTHEHIEYTPAPDIVHESAGHAPIIANRRYAEYLKACGLVGFKAIA
SVEDQAVFEAIRNLSVVKEDPDASEEEAAHAQARLEAASASRRYVSESTRASRLYWWTAEYGLIGSVASPRIYGAGLLSS
IGEAQHCLTPAVKKLPLSVACADMDYDITRMQPQLFVARDFEHLFEVLAEFESTLSWKRGGDFGLTEALRARTVNHLVLA
DGREVTGRVLEMLAAPREVAPGLGTALVCMEGPIMASRGGRALDDKPWSGPALVAFGAGTLPERGPFKLSLESGLELEGF
ATDGGQVLALRGRLAGRELALPAVAKLFVSTHLPSVAGGPSDPATWDRWYGELSAFAEGDGEEKARTRKALALHPALAAL
YREVRKMRETHSVKPERLSQIAAAATDFPDDWLLRAEVEELRRRV

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4557819, Length=277, Percent_Identity=26.3537906137184, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 57214; Mature: 57214

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMTPTERTIARLPAHLRRYVVSQDYAAYTSRDQAVWRNILGSLRGHLADKAHPVYLEGL
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECC
EATGIGSECIPSLDEMNEKLARLGWACVGVRGFIPPAVFTELQAMGVLAIAADIRTHEHI
CCCCCCHHHCCCHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCE
EYTPAPDIVHESAGHAPIIANRRYAEYLKACGLVGFKAIASVEDQAVFEAIRNLSVVKED
EECCCCHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCC
PDASEEEAAHAQARLEAASASRRYVSESTRASRLYWWTAEYGLIGSVASPRIYGAGLLSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
IGEAQHCLTPAVKKLPLSVACADMDYDITRMQPQLFVARDFEHLFEVLAEFESTLSWKRG
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDFGLTEALRARTVNHLVLADGREVTGRVLEMLAAPREVAPGLGTALVCMEGPIMASRGG
CCCCHHHHHHHHHHCEEEEECCCHHHHHHHHHHHCCHHHCCCCCEEEEEECCCEEECCCC
RALDDKPWSGPALVAFGAGTLPERGPFKLSLESGLELEGFATDGGQVLALRGRLAGRELA
CCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCCHHH
LPAVAKLFVSTHLPSVAGGPSDPATWDRWYGELSAFAEGDGEEKARTRKALALHPALAAL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YREVRKMRETHSVKPERLSQIAAAATDFPDDWLLRAEVEELRRRV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMMTPTERTIARLPAHLRRYVVSQDYAAYTSRDQAVWRNILGSLRGHLADKAHPVYLEGL
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEECC
EATGIGSECIPSLDEMNEKLARLGWACVGVRGFIPPAVFTELQAMGVLAIAADIRTHEHI
CCCCCCHHHCCCHHHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCE
EYTPAPDIVHESAGHAPIIANRRYAEYLKACGLVGFKAIASVEDQAVFEAIRNLSVVKED
EECCCCHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCC
PDASEEEAAHAQARLEAASASRRYVSESTRASRLYWWTAEYGLIGSVASPRIYGAGLLSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
IGEAQHCLTPAVKKLPLSVACADMDYDITRMQPQLFVARDFEHLFEVLAEFESTLSWKRG
HHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GDFGLTEALRARTVNHLVLADGREVTGRVLEMLAAPREVAPGLGTALVCMEGPIMASRGG
CCCCHHHHHHHHHHCEEEEECCCHHHHHHHHHHHCCHHHCCCCCEEEEEECCCEEECCCC
RALDDKPWSGPALVAFGAGTLPERGPFKLSLESGLELEGFATDGGQVLALRGRLAGRELA
CCCCCCCCCCCEEEEECCCCCCCCCCEEEECCCCCEEEEEECCCCEEEEEECCCCCCHHH
LPAVAKLFVSTHLPSVAGGPSDPATWDRWYGELSAFAEGDGEEKARTRKALALHPALAAL
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YREVRKMRETHSVKPERLSQIAAAATDFPDDWLLRAEVEELRRRV
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]