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The map label for this gene is tmk

Identifier: 108563864

GI number: 108563864

Start: 1496772

End: 1497347

Strand: Direct

Name: tmk

Synonym: HPAG1_1439

Alternate gene names: 108563864

Gene position: 1496772-1497347 (Clockwise)

Preceding gene: 108563863

Following gene: 108563865

Centisome position: 93.76

GC content: 41.67

Gene sequence:

>576_bases
ATGTATGTGGTGTTAGAAGGCGTTGATGGCGTGGGCAAAAGCACTCAAGTAGGATTGTTAAAAGACCGGTTTAAAAACGC
CCTTTTTACCAAAGAGCCAGGGGGGACAAAAATGGGCGAGAGTTTAAGGCATATCGCTTTAAATGAAAACATCAGCGAAT
TGGCTAGAGCGTTTTTATTTTTAAGCGATAGGGCTGAGCATACAGAAAGCGTGATCAAACCGGCATTGAAAGAAAAAAGA
CTCATCATTAGCGACAGGAGCTTGATTTCTGGCATGGCTTATAGCGAGTTTTCAAGCTTGGAATTAAACCTGCTCGCCAC
TCAAAGCGTCTTGCCTGCAAAAATCATTCTTTTAGTGATAGACAAAGAGGGCTTAAAACAGCGCTTAAGCCTTAAAAGTT
TAGACAAAATAGAAAACCAAGGCACAGAAAAATTACTCACCATCCAGCAAAAGCTCAAAACTCACGCTCATGCGTTACAA
GAAAAATTCGGGTGCGAAGTTTTGGAATTAGACGCTCAAAAAAGCGTTGGGGATTTGCACCGCCAGATTGCAGCCTTTAT
TGAATGCGTTGTTTAA

Upstream 100 bases:

>100_bases
TTCATCAGCTCTTCTATCGTGCGATCCATTATCGCGCATAAGGGTGATGCGAGCCATTTAGTGCCTAAAGAAATTTATCC
TTTGATTTCAAAGGCTTAAA

Downstream 100 bases:

>100_bases
CTTGTTTGAAGCTTTCTTTTAAGCCTCTTTGCCCAAATTGCTTAAACGATCTGCCCTTAAATTTAAAAGTAAGGGTTTTA
GATGGCGTGAGCGTGTATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MYVVLEGVDGVGKSTQVGLLKDRFKNALFTKEPGGTKMGESLRHIALNENISELARAFLFLSDRAEHTESVIKPALKEKR
LIISDRSLISGMAYSEFSSLELNLLATQSVLPAKIILLVIDKEGLKQRLSLKSLDKIENQGTEKLLTIQQKLKTHAHALQ
EKFGCEVLELDAQKSVGDLHRQIAAFIECVV

Sequences:

>Translated_191_residues
MYVVLEGVDGVGKSTQVGLLKDRFKNALFTKEPGGTKMGESLRHIALNENISELARAFLFLSDRAEHTESVIKPALKEKR
LIISDRSLISGMAYSEFSSLELNLLATQSVLPAKIILLVIDKEGLKQRLSLKSLDKIENQGTEKLLTIQQKLKTHAHALQ
EKFGCEVLELDAQKSVGDLHRQIAAFIECVV
>Mature_191_residues
MYVVLEGVDGVGKSTQVGLLKDRFKNALFTKEPGGTKMGESLRHIALNENISELARAFLFLSDRAEHTESVIKPALKEKR
LIISDRSLISGMAYSEFSSLELNLLATQSVLPAKIILLVIDKEGLKQRLSLKSLDKIENQGTEKLLTIQQKLKTHAHALQ
EKFGCEVLELDAQKSVGDLHRQIAAFIECVV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=158, Percent_Identity=32.9113924050633, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_HELPH (Q1CRB6)

Other databases:

- EMBL:   CP000241
- RefSeq:   YP_628180.1
- ProteinModelPortal:   Q1CRB6
- SMR:   Q1CRB6
- STRING:   Q1CRB6
- GeneID:   4099134
- GenomeReviews:   CP000241_GR
- KEGG:   hpa:HPAG1_1439
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   EKLLTIQ
- ProtClustDB:   PRK00698
- BioCyc:   HPYL357544:HPAG1_1439-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21198; Mature: 21198

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVLEGVDGVGKSTQVGLLKDRFKNALFTKEPGGTKMGESLRHIALNENISELARAFLF
CEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LSDRAEHTESVIKPALKEKRLIISDRSLISGMAYSEFSSLELNLLATQSVLPAKIILLVI
HHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEHHCCCCCEEEEEEEE
DKEGLKQRLSLKSLDKIENQGTEKLLTIQQKLKTHAHALQEKFGCEVLELDAQKSVGDLH
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
RQIAAFIECVV
HHHHHHHHHCC
>Mature Secondary Structure
MYVVLEGVDGVGKSTQVGLLKDRFKNALFTKEPGGTKMGESLRHIALNENISELARAFLF
CEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LSDRAEHTESVIKPALKEKRLIISDRSLISGMAYSEFSSLELNLLATQSVLPAKIILLVI
HHCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEHHCCCCCEEEEEEEE
DKEGLKQRLSLKSLDKIENQGTEKLLTIQQKLKTHAHALQEKFGCEVLELDAQKSVGDLH
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHH
RQIAAFIECVV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA