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The map label for this gene is yhdT [H]

Identifier: 108563848

GI number: 108563848

Start: 1480267

End: 1481604

Strand: Direct

Name: yhdT [H]

Synonym: HPAG1_1423

Alternate gene names: 108563848

Gene position: 1480267-1481604 (Clockwise)

Preceding gene: 108563847

Following gene: 108563849

Centisome position: 92.73

GC content: 42.53

Gene sequence:

>1338_bases
ATGGGGAGGAATCAAGGAGCTTATTTGGATCCGTCTGAGTCGATTTTGATGTTGATGGTTGCTTTTTTATTGGTGCTGTT
GAACGCTTTTTTTGTGCTTTCAGAGTTTGCCCTTGTGAAAGTGCGTAAAACCCGCTTAGAAGAGCTGGTTAAAATCGGTA
ATTCCAACGCTAAACTCGCTTTAAAGATGAGTCAAAGACTAGACACTTATTTGAGCGCAACGCAGTTAGGCATCACCCTT
TCTTCATTAGCTTTAGGCTGGGTGGGTGAGCCCGCTATCGCAAAATTGTTAGCCGCGCTGTTTGAGTCTATGGATTTGAG
AGAAAATCCTATTTTTATCCATTCAATGAGCGTGGTTATAGCGTTTTTAAGCATCACTTTTTTGCATGTCGTGTTGGGCG
AGATTGTGCCTAAATCTTTAGCGATCGCTAAATCTGAAAAAGCCGCTCTTTTTGCCGCGCGCCCTTTGCATGTGTTTTGG
GTGGTGTTTTACCCGGTGGTGCGCCTGTTTGATGTGATCGCTCATTTCTTTTTAAAAAAAGTGGGCATCAATCCTAAAGA
ACATGACGGCACGCATTCTGAAGAAGAGTTAAAAATCATTGTGGGCGAGAGTTTGAGAGAGGGCATTATTGATTCAGTGG
AGGGCGAAATCATTAAAAACGCGGTGGATTTTTCTGACACGAGTGCTAAAGAAATCATGACCCCACGAAAAGACATGGTG
TGTTTGGACGAAGAAAACAGCTATGAAGAAAATATAGACATTGTTTTAAAAGGCCATTTCACGCGCTACCCTTATTGTAA
AGGCTCTAAAGATAACATTATCGGCATGGTGCATATTAGGGATTTGCTTTCTCGCTCTATTTTTACCCCTAAAATGCATG
ATTTCAAGCAAATCGTTAGGAAAATGATCATCGTCCCCGAGAGCGCTTCCATTTCTCAAATCCTTATTAAAATGAAAAAA
GAGCAAATCCATACCGCTTTGGTGATTGATGAATACGGCGGCACAGCCGGGCTGCTCACTATGGAAGACATTATTGAAGA
GATCATGGGCGAGATTAGCGACGAATACGACTTGAAACAAGAGGGCATAAACAAGCTTGAAGAGGGCGTGTTTGAATTAG
AGGGCATGCTGGATTTAGAGAGCGTAGAAGAAGCGCTTCACATTGAATTTGACAAAGAATGCGAGCAGGTAACGCTTGGG
GGCTATGTTTTTAGCTTGTTAGAACGCATGCCTATGGAGGGGGATATAATCGTTTCGCATGGGTATGCCTTTGAAGTCTT
AAGCGTGGATGGGGCTAGGATAAAACGCTTAAAAGCGAGTAAAGAAAATAAGGATTAG

Upstream 100 bases:

>100_bases
AAAGGCTTGATTTTTAAAGTTAGGCTTAATCTTTTATGTTAAAATTCTGAGATTTTATATTTATATTTTATCTTTATCGT
TAGGTTTTAGGTTTAAAGTC

Downstream 100 bases:

>100_bases
GATAAAGGAATGAGCATGAAAAAAACAACCCTCTTTGTATTGGGCTTATTATTCAATAGCTCTTTAAGCGCTGTTGATGG
AGTTTCTAAAACCGAGCCTT

Product: hemolysin domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MGRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLALKMSQRLDTYLSATQLGITL
SSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVIAFLSITFLHVVLGEIVPKSLAIAKSEKAALFAARPLHVFW
VVFYPVVRLFDVIAHFFLKKVGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAVDFSDTSAKEIMTPRKDMV
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFKQIVRKMIIVPESASISQILIKMKK
EQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQEGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLG
GYVFSLLERMPMEGDIIVSHGYAFEVLSVDGARIKRLKASKENKD

Sequences:

>Translated_445_residues
MGRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLALKMSQRLDTYLSATQLGITL
SSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVIAFLSITFLHVVLGEIVPKSLAIAKSEKAALFAARPLHVFW
VVFYPVVRLFDVIAHFFLKKVGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAVDFSDTSAKEIMTPRKDMV
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFKQIVRKMIIVPESASISQILIKMKK
EQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQEGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLG
GYVFSLLERMPMEGDIIVSHGYAFEVLSVDGARIKRLKASKENKD
>Mature_444_residues
GRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLALKMSQRLDTYLSATQLGITLS
SLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVIAFLSITFLHVVLGEIVPKSLAIAKSEKAALFAARPLHVFWV
VFYPVVRLFDVIAHFFLKKVGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAVDFSDTSAKEIMTPRKDMVC
LDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFKQIVRKMIIVPESASISQILIKMKKE
QIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQEGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLGG
YVFSLLERMPMEGDIIVSHGYAFEVLSVDGARIKRLKASKENKD

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=387, Percent_Identity=41.343669250646, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1790664, Length=429, Percent_Identity=25.4079254079254, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI145693175, Length=415, Percent_Identity=24.8192771084337, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786879, Length=248, Percent_Identity=27.8225806451613, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082033, Length=242, Percent_Identity=23.9669421487603, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788119, Length=241, Percent_Identity=25.7261410788382, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324512, Length=250, Percent_Identity=26.8, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 49974; Mature: 49843

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LKMSQRLDTYLSATQLGITLSSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVI
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
AFLSITFLHVVLGEIVPKSLAIAKSEKAALFAARPLHVFWVVFYPVVRLFDVIAHFFLKK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAVDFSDTSAKEIMTPRKDMV
HCCCCCCCCCCCCHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEE
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFKQIVR
EECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHH
KMIIVPESASISQILIKMKKEQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQ
HHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEHHHHHHHHHHHCCCCCHHHH
EGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLGGYVFSLLERMPMEGDIIVSH
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHCCCCCCEEEEC
GYAFEVLSVDGARIKRLKASKENKD
CCEEEEEECCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
GRNQGAYLDPSESILMLMVAFLLVLLNAFFVLSEFALVKVRKTRLEELVKIGNSNAKLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LKMSQRLDTYLSATQLGITLSSLALGWVGEPAIAKLLAALFESMDLRENPIFIHSMSVVI
EEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
AFLSITFLHVVLGEIVPKSLAIAKSEKAALFAARPLHVFWVVFYPVVRLFDVIAHFFLKK
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGINPKEHDGTHSEEELKIIVGESLREGIIDSVEGEIIKNAVDFSDTSAKEIMTPRKDMV
HCCCCCCCCCCCCHHHEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCEE
CLDEENSYEENIDIVLKGHFTRYPYCKGSKDNIIGMVHIRDLLSRSIFTPKMHDFKQIVR
EECCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCHHHHHHHHH
KMIIVPESASISQILIKMKKEQIHTALVIDEYGGTAGLLTMEDIIEEIMGEISDEYDLKQ
HHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEHHHHHHHHHHHCCCCCHHHH
EGINKLEEGVFELEGMLDLESVEEALHIEFDKECEQVTLGGYVFSLLERMPMEGDIIVSH
HHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHEEHHHHHHHHHHHCCCCCCEEEEC
GYAFEVLSVDGARIKRLKASKENKD
CCEEEEEECCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]