Click here to switch to the map view.

The map label for this gene is ksgA [H]

Identifier: 108563781

GI number: 108563781

Start: 1408241

End: 1409056

Strand: Reverse

Name: ksgA [H]

Synonym: HPAG1_1356

Alternate gene names: 108563781

Gene position: 1409056-1408241 (Counterclockwise)

Preceding gene: 108563784

Following gene: 108563780

Centisome position: 88.27

GC content: 39.34

Gene sequence:

>816_bases
ATGGTAGTAGCTAAAAAGTCTTTAGGACAGCATTTTTTAACGGACGAGTCGTTTTTAGACAGAATTGTCGATGCTTTGCC
CCCCTTAAACCCGTTGAAATTAGTTGAAATTGGCGTGGGGCTAGGGGATTTGACTCTTAAGTTGTTGGATCGCTATCCTT
TAAAGACTTATGAGATAGATAGTAGCTTGTGCGAGAAAATGCGATCAAAATTAAAGGTGCAAAAAAAGCCTTTTAAATTA
GAATTAGTGGAAAAAGACGCTCTTTTTTTGAAAGAAGAAGAGCCTTATTTTTTGATCTCTAATTTGCCTTATTATATCGC
TACTAGGCTTGTTTTAAACGCGCTCAAAGACCCTAAATGCAGGGGCTTATTGGTGATGACGCAAAAGGAAGTGGCGCTCA
AGTTTTGCGCTAAAGATTCACAGAACGCCTTAAGCGTTTTAGCACACGCCATAGGGAACGCTACCCTTTTGTTTGATGTG
CCGCCTAGCGCGTTTAGCCCGCCTCCAAAGGTGTTTTCTAGCGTGTTTGAAGTGATTAAAGAGTCGCTGAAAGAAAAGGC
GTTAGCTTCACTAGCCCAAGTGCCATTTTTTGAAGAAGCCCTACAAAAAGGGTTTGAAACATTAGAAGATTTTTTGAAAG
CTTGTTTCTCATCTCCCAGGAAGACGCTTTCAAACAATCTTAAAAAAAGCGTTTCTTATAAAGAAAAGCTTGATAAGGTG
TTAGATTTTCTAGCGTTAGAAAACCAACCAACAAGCGTGAGGGCGTCTGAGATAAAAGATTATCTCAAGCTCTTAAATTA
CCTTTTAAAAGGCTAA

Upstream 100 bases:

>100_bases
ATCTTTGAATGAAAAAAGCTATAATAAAGAAGTTGCATTAAAAAGGAAAGACAAATCCCCTTTTTAAGGTATAATATGAG
AAATTTTAGAAGCGCTTCTT

Downstream 100 bases:

>100_bases
TGCCTTTTTAAAAAATTACTATAAAGGAATAAAAGTTATGACGGATAACAATCATTACGAAAATCATGAAAACCATGAAA
ACAGCAGTGAAAATTCAAAA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MVVAKKSLGQHFLTDESFLDRIVDALPPLNPLKLVEIGVGLGDLTLKLLDRYPLKTYEIDSSLCEKMRSKLKVQKKPFKL
ELVEKDALFLKEEEPYFLISNLPYYIATRLVLNALKDPKCRGLLVMTQKEVALKFCAKDSQNALSVLAHAIGNATLLFDV
PPSAFSPPPKVFSSVFEVIKESLKEKALASLAQVPFFEEALQKGFETLEDFLKACFSSPRKTLSNNLKKSVSYKEKLDKV
LDFLALENQPTSVRASEIKDYLKLLNYLLKG

Sequences:

>Translated_271_residues
MVVAKKSLGQHFLTDESFLDRIVDALPPLNPLKLVEIGVGLGDLTLKLLDRYPLKTYEIDSSLCEKMRSKLKVQKKPFKL
ELVEKDALFLKEEEPYFLISNLPYYIATRLVLNALKDPKCRGLLVMTQKEVALKFCAKDSQNALSVLAHAIGNATLLFDV
PPSAFSPPPKVFSSVFEVIKESLKEKALASLAQVPFFEEALQKGFETLEDFLKACFSSPRKTLSNNLKKSVSYKEKLDKV
LDFLALENQPTSVRASEIKDYLKLLNYLLKG
>Mature_271_residues
MVVAKKSLGQHFLTDESFLDRIVDALPPLNPLKLVEIGVGLGDLTLKLLDRYPLKTYEIDSSLCEKMRSKLKVQKKPFKL
ELVEKDALFLKEEEPYFLISNLPYYIATRLVLNALKDPKCRGLLVMTQKEVALKFCAKDSQNALSVLAHAIGNATLLFDV
PPSAFSPPPKVFSSVFEVIKESLKEKALASLAQVPFFEEALQKGFETLEDFLKACFSSPRKTLSNNLKKSVSYKEKLDKV
LDFLALENQPTSVRASEIKDYLKLLNYLLKG

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657198, Length=277, Percent_Identity=24.9097472924188, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI156415992, Length=284, Percent_Identity=25, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1786236, Length=288, Percent_Identity=29.8611111111111, Blast_Score=95, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25146882, Length=286, Percent_Identity=26.5734265734266, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324989, Length=281, Percent_Identity=29.5373665480427, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21358017, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30519; Mature: 30519

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAKKSLGQHFLTDESFLDRIVDALPPLNPLKLVEIGVGLGDLTLKLLDRYPLKTYEID
CCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEECC
SSLCEKMRSKLKVQKKPFKLELVEKDALFLKEEEPYFLISNLPYYIATRLVLNALKDPKC
HHHHHHHHHHHHHHCCCCEEEEECCCHHEEECCCCEEEECCCHHHHHHHHHHHHHCCCCC
RGLLVMTQKEVALKFCAKDSQNALSVLAHAIGNATLLFDVPPSAFSPPPKVFSSVFEVIK
CEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHH
ESLKEKALASLAQVPFFEEALQKGFETLEDFLKACFSSPRKTLSNNLKKSVSYKEKLDKV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LDFLALENQPTSVRASEIKDYLKLLNYLLKG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVAKKSLGQHFLTDESFLDRIVDALPPLNPLKLVEIGVGLGDLTLKLLDRYPLKTYEID
CCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCEECC
SSLCEKMRSKLKVQKKPFKLELVEKDALFLKEEEPYFLISNLPYYIATRLVLNALKDPKC
HHHHHHHHHHHHHHCCCCEEEEECCCHHEEECCCCEEEECCCHHHHHHHHHHHHHCCCCC
RGLLVMTQKEVALKFCAKDSQNALSVLAHAIGNATLLFDVPPSAFSPPPKVFSSVFEVIK
CEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHH
ESLKEKALASLAQVPFFEEALQKGFETLEDFLKACFSSPRKTLSNNLKKSVSYKEKLDKV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LDFLALENQPTSVRASEIKDYLKLLNYLLKG
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA