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The map label for this gene is tpx [H]

Identifier: 108563427

GI number: 108563427

Start: 1057818

End: 1058318

Strand: Reverse

Name: tpx [H]

Synonym: HPAG1_1002

Alternate gene names: 108563427

Gene position: 1058318-1057818 (Counterclockwise)

Preceding gene: 108563430

Following gene: 108563413

Centisome position: 66.3

GC content: 41.72

Gene sequence:

>501_bases
ATGCAAGAAGTTACTTTTAAAGAAGAAACATATCAGTTAGAAGGGAAACCCTTAAAGGTGGGCGATAAAGCCCCTGATGT
GAAATTGGTCAATGGCGATTTGCAAGAAGTCAATTTGTTGAAGCAAGGCGTGCGTTTTCAAGTCGTTAGCTCGCTTCCTA
GTTTAACCGGATCGGTTTGCTTGCTCCAAGCCAAGCGCTTCAATGAGCAAGTCGGCAAACTGCCTTCTGTGAGTTTTAGC
GTTATTTCTATGGACTTGCCTTTTTCTCAAGGGCAAATTTGCGGCGCTGAAGGCATTAAGGACTTAAGAATCTTAAGCGA
TTTTAGGTATAAGGCTTTTGGGGAAAATTACGGCGTGCTGTTGGGCAAAGGCTCTTTGCAAGGCTTACTCGCTCGATCGG
TGTTTGTTCTTGATGATAAGGGAGTGGTTATCTATAAAGAAATCGTTCAAAACATTTTAGAAGAGCCCAATTATGAAGTG
CTTTTAAAAGTGTTGAAATAG

Upstream 100 bases:

>100_bases
AACGACTTTTTAAACAAATTTTTTTCAAATTTTTTGAAAGTTAATCTTAATGGACTATTATTCTAACGCAATATAGCAAT
TCATTAGAAAGGATTTAACC

Downstream 100 bases:

>100_bases
GAAATCCTTAAAAGGAGGGGGCTACAATTTAGTGAATCTCAACGCAAAAAGCCCCACTTATTAAAAAGCGTTGGCAACAA
AGACTAAAAAATAAGAAGTT

Product: adhesin-thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MQEVTFKEETYQLEGKPLKVGDKAPDVKLVNGDLQEVNLLKQGVRFQVVSSLPSLTGSVCLLQAKRFNEQVGKLPSVSFS
VISMDLPFSQGQICGAEGIKDLRILSDFRYKAFGENYGVLLGKGSLQGLLARSVFVLDDKGVVIYKEIVQNILEEPNYEV
LLKVLK

Sequences:

>Translated_166_residues
MQEVTFKEETYQLEGKPLKVGDKAPDVKLVNGDLQEVNLLKQGVRFQVVSSLPSLTGSVCLLQAKRFNEQVGKLPSVSFS
VISMDLPFSQGQICGAEGIKDLRILSDFRYKAFGENYGVLLGKGSLQGLLARSVFVLDDKGVVIYKEIVQNILEEPNYEV
LLKVLK
>Mature_166_residues
MQEVTFKEETYQLEGKPLKVGDKAPDVKLVNGDLQEVNLLKQGVRFQVVSSLPSLTGSVCLLQAKRFNEQVGKLPSVSFS
VISMDLPFSQGQICGAEGIKDLRILSDFRYKAFGENYGVLLGKGSLQGLLARSVFVLDDKGVVIYKEIVQNILEEPNYEV
LLKVLK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=166, Percent_Identity=36.7469879518072, Blast_Score=114, Evalue=3e-27,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18381; Mature: 18381

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEVTFKEETYQLEGKPLKVGDKAPDVKLVNGDLQEVNLLKQGVRFQVVSSLPSLTGSVC
CCCCCCCCCEEEECCCEEECCCCCCCEEEECCCHHHHHHHHHCCHHHHHHHCCCCCHHHH
LLQAKRFNEQVGKLPSVSFSVISMDLPFSQGQICGAEGIKDLRILSDFRYKAFGENYGVL
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCEE
LGKGSLQGLLARSVFVLDDKGVVIYKEIVQNILEEPNYEVLLKVLK
EECCCHHHHHHHEEEEECCCCEEEHHHHHHHHHHCCCHHHHHHHHC
>Mature Secondary Structure
MQEVTFKEETYQLEGKPLKVGDKAPDVKLVNGDLQEVNLLKQGVRFQVVSSLPSLTGSVC
CCCCCCCCCEEEECCCEEECCCCCCCEEEECCCHHHHHHHHHCCHHHHHHHCCCCCHHHH
LLQAKRFNEQVGKLPSVSFSVISMDLPFSQGQICGAEGIKDLRILSDFRYKAFGENYGVL
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCEE
LGKGSLQGLLARSVFVLDDKGVVIYKEIVQNILEEPNYEVLLKVLK
EECCCHHHHHHHEEEEECCCCEEEHHHHHHHHHHCCCHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]