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The map label for this gene is bioA [H]

Identifier: 108563382

GI number: 108563382

Start: 1003576

End: 1004886

Strand: Reverse

Name: bioA [H]

Synonym: HPAG1_0957

Alternate gene names: 108563382

Gene position: 1004886-1003576 (Counterclockwise)

Preceding gene: 108563386

Following gene: 108563378

Centisome position: 62.95

GC content: 39.21

Gene sequence:

>1311_bases
ATGAATTTTCAAGAAAATTTAGCCGCTTTGGATTTGGAATATCTTTGGCACCCTTGCTCGCAAATGCAAGAGCATCAAAA
TTTCCCCATTATCCCCATTAAAAAGGCTCAAGGGATTTACCTCTATGATTTTAATGATAACGCTTACATGGATTTAATCA
GCTCATGGTGGGTGAATCTTTTTGGGCATAATAACGCCTATATCAGCCAGCAGCTTAAAAATCAAATTGATAATCTAGAG
CATGTCCTTTTGGCTTCTTTTAGCCATAAGCCCATTATTACGCTTTCTCAAAGGCTTTGCCAGCTCACTCATATGGACAA
ATGCTTTTATGCGGATAACGGCTCATCTTGTATTGAAATCGCTTTGAAAATGAGCTATCACGCCCATTTTTTAAAGAATC
AAACGCGCCGCAAAAAGCTTTTTTTATCGCTCTCTAATTCCTATCATGGCGAGACTTTGGGAGCGTTAAGCGTGGGCGAT
GTGAAACTTTATAAAGACACTTACACCCCACTATTACTCAAAAATCTCACCACACCCGTGCCTAAAAACGACAATGAAAT
AGAAAATAGTTTGAACGCTTTAAAGCGTTTGTTAGATAAACATCATGAAGAAATTTGCGCCTTCATTGCAGAGCCTCTTT
TGCAATGCGCAGGGAATATGCATATTTATAGCGCAAAATATTTAAAACAAGCCGTTTTGTTGTGCAAGCAAAAAAACATC
CACATTATTTTTGATGAAATCGCTACCGGGTTTGGGCGCACAGGGAGCATGTTTGCTTATGAGCAATGCGGGATCGAGCC
TGATTTTTTATGCTTGTCTAAAGGGATTAGTGGGGGGTATTTGCCTTTAAGCGCGCTATTAACCCATAATGAAATCTATA
ACCAATTTTACGCTCCCTATGAAGAAAATAAAGCGTTTTTGCATTCGCACAGCTACACAGGAAACGCCCTAGCATGCGCA
TGCGCGAACGCTACGCTGGATATTTTTGAAAAAGAAAATGTTATTGAAAAGAACAAGGCTTTAAGCGAATTTATTTTTAA
TACGCTCCAAAACGCATTAAAACCCCTGATAGAGCAACAAGTGGTGTCTAACTTAAGGCATTTGGGCATGGTCTTTGCCT
TTGAAGTCTTTATTCAAACCAAAGAGCGTTTGAGTTTGGCGGTTTTTAAAAAAGCTCTAAAAAAAGGCCTGTTATTACGC
CCTTTAAACAACACCATTTACCTCATGCCCCCTTATATTATCACGCATGAAGAAGTCAAAAAGGCGGTTGCAAGGCTAGC
GGAAATTCTTGATGAGTTAAAAAAAGGCTGA

Upstream 100 bases:

>100_bases
AAATGTGAAATTCAGGTTTAAACAACCTTATAGTAAAATCAAATAACCCTATTTTAACCAAAGGTTATTAAAATTATCCT
TATTATAGAGAGTTTTTAAC

Downstream 100 bases:

>100_bases
AAGCGTTTTTAAAAATAAAATAGTAAAAAGCTTGAATTGGATCAAGCGATAGCTTTTTTCTGTCTATTTGATTTCAAAAA
TCAAGTTTTTAACTTGATAT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAYEQCGIEPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSEFIFNTLQNALKPLIEQQVVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALKKGLLLR
PLNNTIYLMPPYIITHEEVKKAVARLAEILDELKKG

Sequences:

>Translated_436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAYEQCGIEPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSEFIFNTLQNALKPLIEQQVVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALKKGLLLR
PLNNTIYLMPPYIITHEEVKKAVARLAEILDELKKG
>Mature_436_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNLFGHNNAYISQQLKNQIDNLE
HVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEIALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
HIIFDEIATGFGRTGSMFAYEQCGIEPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPYEENKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKALSEFIFNTLQNALKPLIEQQVVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALKKGLLLR
PLNNTIYLMPPYIITHEEVKKAVARLAEILDELKKG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=402, Percent_Identity=27.6119402985075, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI284507298, Length=311, Percent_Identity=28.6173633440514, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=24.4186046511628, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI24119277, Length=442, Percent_Identity=23.7556561085973, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=23.5981308411215, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI13994255, Length=378, Percent_Identity=25.6613756613757, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI226442709, Length=376, Percent_Identity=23.936170212766, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=35.1288056206089, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789759, Length=399, Percent_Identity=28.3208020050125, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI145693181, Length=406, Percent_Identity=27.0935960591133, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=25.5980861244019, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788044, Length=405, Percent_Identity=26.9135802469136, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1787560, Length=414, Percent_Identity=26.5700483091787, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=413, Percent_Identity=23.9709443099274, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=26.1261261261261, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=310, Percent_Identity=25.8064516129032, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=23.5697940503432, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324386, Length=468, Percent_Identity=32.9059829059829, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6323470, Length=432, Percent_Identity=25.462962962963, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=24.5657568238213, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357415, Length=412, Percent_Identity=25.2427184466019, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=24.8792270531401, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28574759, Length=444, Percent_Identity=25.6756756756757, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161085790, Length=436, Percent_Identity=24.5412844036697, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49776; Mature: 49776

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKNQIDNLEHVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLTTPV
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEECCEEEECCCCCHHHHHHCCCCC
PKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAYEQCGIEPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPY
EEEHHHHHCCCCCCCCEEEHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCH
EENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSEFIFNTLQNALKPLIEQQ
HCCCCEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALKKGLLLRPLNNTIYLMPPYIITHEEVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCEEECHHHHH
KAVARLAEILDELKKG
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNDNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKNQIDNLEHVLLASFSHKPIITLSQRLCQLTHMDKCFYADNGSSCIEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHAHFLKNQTRRKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLTTPV
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCEEECCEEEECCCCCHHHHHHCCCCC
PKNDNEIENSLNALKRLLDKHHEEICAFIAEPLLQCAGNMHIYSAKYLKQAVLLCKQKNI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAYEQCGIEPDFLCLSKGISGGYLPLSALLTHNEIYNQFYAPY
EEEHHHHHCCCCCCCCEEEHHHCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCH
EENKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKALSEFIFNTLQNALKPLIEQQ
HCCCCEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVSNLRHLGMVFAFEVFIQTKERLSLAVFKKALKKGLLLRPLNNTIYLMPPYIITHEEVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCEEECHHHHH
KAVARLAEILDELKKG
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]