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The map label for this gene is thlA [H]

Identifier: 108563100

GI number: 108563100

Start: 707722

End: 708897

Strand: Direct

Name: thlA [H]

Synonym: HPAG1_0675

Alternate gene names: 108563100

Gene position: 707722-708897 (Clockwise)

Preceding gene: 108563099

Following gene: 108563101

Centisome position: 44.33

GC content: 46.0

Gene sequence:

>1176_bases
ATGAATGAAGTGGTTATAGTGGCGGCAAAACGGAGCGCTGTGGGGAGTTTTCTAGGCTCTTTAAAGAATGTGGGTGCTAG
AGAAATGGGTGTTTGCGTGCTTAAAGACGCTTTGAATGCGAGTTCTCTTAAGCCTAGCGATGTGGATTCCGTCATTTTGG
GCAATGTTTTAGGCGCTGGTTTGGGTCAAAATATCGCTAGGCAGATCCAACTAGACGCCGGCATCCCGAATGACAAAAAC
GCTTTTAGCGTCAATATGGTTTGTGGATCGTCTATGAAAGCCATTCAATTAGCACATGACAGCATCATGCTTGGGCATGG
TGAGGTGGTGGTGTGCGGTGGCGTGGAGAACATGAGCATGGCACCTTATTTGTCGTTTGACATGCGAGATGGGAAAAGAA
TGGGGAATGCGAACATGATAGACTCCATGATCCATGACGGATTGTGGGATGCTTTCAATGATTACCACATGGGGATCACC
GCTGATAATGTCGCTCAAGCATACCACATAAGCCGAGAAGAGCAAGATAATTTCGCGCTCCAATCGCAACTCAAAGCAAG
AGCCGCCATTAATGCAGGGAAATTCCAAGAAGAAATCACGCCCATTGAAATAGCGAATAAAAAAGGCGTGGTGGTTTTTA
AAGAAGACGAATACCCTAGAGACACGACGCTAGAATCCCTTGCAAAGCTCAAACCCGCTTTCAAAAAAGACGGATCGGTA
ACGGCGGGAAATTCATCAGGGATCAATGATGGCGCGAGTATTATCATTTTATGCAGCGCTCAAAAAGCGCAAAAATTGGG
GTTAAAAACCATGGCAACTATCAAGGGGTTTGGTTTGGGTGGTTGCAGTCCGGATATAATGGGGATATGCCCTAGCATCG
CTATTAAAAACAACCTTAAAAATGTCAAAATGAATCTCAATGACATCAATCTTTTTGAACTCAATGAAGCCTTTGCCGCG
CAAAGCCTAGCCGTGTTAAAAGAGCTTGAGTTAAACCCTAATATCGTGAATGTGAATGGAGGTGCGATAGCGATTGGCCA
CCCTATTGGCGCGAGCGGCGCTAGGATCTTAGTGACTTTATTGCATGAAATGAAAAGGAGCGGGCATGGCGTGGGTTGCG
CGTCATTGTGTGTGGGCGGCGGGCAAGGTCTTTCTGTGGTAGTTGAACAAAAATAA

Upstream 100 bases:

>100_bases
CCTCAATCTAAAACAAAACCTAAAACAAAATCCAACCTGTTAGGGCGTCAATCACCTAAAAGTGATACTATGATGAGTAA
ATCAACTTAAAGGCAAAGAC

Downstream 100 bases:

>100_bases
GGAGAATGAGATGAACAAGGTTATAACCGATTTAGACAAAGCATTGAGCGGGTTAAAAGACGGGGACACTATTTTAGTGG
GCGGTTTTGGGCTGTGCGGG

Product: acetyl coenzyme A acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MNEVVIVAAKRSAVGSFLGSLKNVGAREMGVCVLKDALNASSLKPSDVDSVILGNVLGAGLGQNIARQIQLDAGIPNDKN
AFSVNMVCGSSMKAIQLAHDSIMLGHGEVVVCGGVENMSMAPYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGIT
ADNVAQAYHISREEQDNFALQSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRDTTLESLAKLKPAFKKDGSV
TAGNSSGINDGASIIILCSAQKAQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLKNVKMNLNDINLFELNEAFAA
QSLAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTLLHEMKRSGHGVGCASLCVGGGQGLSVVVEQK

Sequences:

>Translated_391_residues
MNEVVIVAAKRSAVGSFLGSLKNVGAREMGVCVLKDALNASSLKPSDVDSVILGNVLGAGLGQNIARQIQLDAGIPNDKN
AFSVNMVCGSSMKAIQLAHDSIMLGHGEVVVCGGVENMSMAPYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGIT
ADNVAQAYHISREEQDNFALQSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRDTTLESLAKLKPAFKKDGSV
TAGNSSGINDGASIIILCSAQKAQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLKNVKMNLNDINLFELNEAFAA
QSLAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTLLHEMKRSGHGVGCASLCVGGGQGLSVVVEQK
>Mature_391_residues
MNEVVIVAAKRSAVGSFLGSLKNVGAREMGVCVLKDALNASSLKPSDVDSVILGNVLGAGLGQNIARQIQLDAGIPNDKN
AFSVNMVCGSSMKAIQLAHDSIMLGHGEVVVCGGVENMSMAPYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGIT
ADNVAQAYHISREEQDNFALQSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRDTTLESLAKLKPAFKKDGSV
TAGNSSGINDGASIIILCSAQKAQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLKNVKMNLNDINLFELNEAFAA
QSLAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTLLHEMKRSGHGVGCASLCVGGGQGLSVVVEQK

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=47.5826972010178, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=44.6428571428571, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=40.9669211195929, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=38.4810126582278, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.8962264150943, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=27.7634961439589, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=49.616368286445, Blast_Score=388, Evalue=1e-109,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=49.7448979591837, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI1787663, Length=409, Percent_Identity=38.3863080684597, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=40.3990024937656, Blast_Score=238, Evalue=3e-64,
Organism=Escherichia coli, GI1788683, Length=414, Percent_Identity=29.2270531400966, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=43.298969072165, Blast_Score=320, Evalue=6e-88,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=38.1074168797954, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI25147385, Length=385, Percent_Identity=36.3636363636364, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=30.2798982188295, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=29.1079812206573, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6325229, Length=393, Percent_Identity=42.4936386768448, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=36.0406091370558, Blast_Score=205, Evalue=9e-54,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=47.8260869565217, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=41.2820512820513, Blast_Score=308, Evalue=4e-84,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=43.1876606683805, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=31.5294117647059, Blast_Score=171, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41165; Mature: 41165

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVVIVAAKRSAVGSFLGSLKNVGAREMGVCVLKDALNASSLKPSDVDSVILGNVLGAG
CCCEEEEEECHHHHHHHHHHHHHCCCHHHHHEEEHHHCCCCCCCCCCCHHHHHHHHHHCC
LGQNIARQIQLDAGIPNDKNAFSVNMVCGSSMKAIQLAHDSIMLGHGEVVVCGGVENMSM
CCHHHHHEEEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEECCCCEEEECCCCCCCC
APYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGITADNVAQAYHISREEQDNFAL
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHH
QSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRDTTLESLAKLKPAFKKDGSV
HHHHHHHHHHCCCHHHHHCCCEEEECCCCEEEEECCCCCCCHHHHHHHHHCHHHHCCCCE
TAGNSSGINDGASIIILCSAQKAQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLK
ECCCCCCCCCCCEEEEEECCHHHHHCCCHHHHHHCCCCCCCCCCHHHHCCCCHHHHCCCC
NVKMNLNDINLFELNEAFAAQSLAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTL
EEEEECCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHHHH
LHEMKRSGHGVGCASLCVGGGQGLSVVVEQK
HHHHHHCCCCCCHHHHEECCCCCEEEEEECC
>Mature Secondary Structure
MNEVVIVAAKRSAVGSFLGSLKNVGAREMGVCVLKDALNASSLKPSDVDSVILGNVLGAG
CCCEEEEEECHHHHHHHHHHHHHCCCHHHHHEEEHHHCCCCCCCCCCCHHHHHHHHHHCC
LGQNIARQIQLDAGIPNDKNAFSVNMVCGSSMKAIQLAHDSIMLGHGEVVVCGGVENMSM
CCHHHHHEEEEECCCCCCCCEEEEEEEECCCCCEEEEECCEEEECCCCEEEECCCCCCCC
APYLSFDMRDGKRMGNANMIDSMIHDGLWDAFNDYHMGITADNVAQAYHISREEQDNFAL
CCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHH
QSQLKARAAINAGKFQEEITPIEIANKKGVVVFKEDEYPRDTTLESLAKLKPAFKKDGSV
HHHHHHHHHHCCCHHHHHCCCEEEECCCCEEEEECCCCCCCHHHHHHHHHCHHHHCCCCE
TAGNSSGINDGASIIILCSAQKAQKLGLKTMATIKGFGLGGCSPDIMGICPSIAIKNNLK
ECCCCCCCCCCCEEEEEECCHHHHHCCCHHHHHHCCCCCCCCCCHHHHCCCCHHHHCCCC
NVKMNLNDINLFELNEAFAAQSLAVLKELELNPNIVNVNGGAIAIGHPIGASGARILVTL
EEEEECCEEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCCCHHHHHHHH
LHEMKRSGHGVGCASLCVGGGQGLSVVVEQK
HHHHHHCCCCCCHHHHEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]