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The map label for this gene is acsA [H]

Identifier: 107022980

GI number: 107022980

Start: 1580141

End: 1582063

Strand: Reverse

Name: acsA [H]

Synonym: Bcen_1428

Alternate gene names: 107022980

Gene position: 1582063-1580141 (Counterclockwise)

Preceding gene: 107022981

Following gene: 107022974

Centisome position: 48.02

GC content: 69.16

Gene sequence:

>1923_bases
ATGAGCACCACTGACATACTTTGGCAACCACCGTCCGACTGGCGGACCAGCACGCTGCTAGGTGAACTCTGCGCGTGCCT
GGGCGCATCGTCGTTCGAAGAACTGATCGGGATTTCGCTGCGTGAGCCGCAACGCTACTGGGCCGCGGTGATGACGCACC
TGCAATTCCAGTGGCGAACGCCGCCGCAGCGGCATGTCGACCTGGCGGGCGGCCCCGCGTTTCCGCGATGGTTTCCCGGC
GGTCGACTGAACTGGGTCGATCATGTGCTTGCGCACGCGGACGGTCCACGCGCGATGCAGGCGGCAGTCATCACGGAAAC
GGAGGACGGACGCGTCAGCACGACCAGCTATGCCGCGCTGGCTCGGGAAGTACGGCGCCTGGCTTCGCGGCTCGCCACGC
TTGGCGTCGGTGCAGGCGATCGGGTCGGCATCATGATGACGATGGGGGCGCAGGCCGCGGCCAGCCTGATTGCCGTATCG
GCGCTCGGTGCGATCGCCGTGCCGCTGTTCACCGGCTTCGGGGCGGACGCCGTCGCCGCGCGACTGACGCTGGCCGACGC
GCGTGTGTTGCTGGCGAGCGGCGGCTACCTGCGCCGCGGACGCACCATCGACCTGAAACCCGTGTTCGACGCCGTGCAAG
AACAGATGCCGGGTTTGCGCATCGTCGTCCACGGCGACGAGCCGGCGCGTTCCGCCGCCCTCGACGACCCGGCTTCCGCG
CACGCGGCGGCGCCCCGCGCGTTTCCCGCGCAGGACCCGGACCAGCCGTTCATGATCGTTTTCACGTCCGGCACGACGGG
GGAGCCGAAGGGCACGGTGCACACGCATGCCGGGTTCCCGTTGAAGATCCTGCACGATTGTGCGTACCACTTCGAGTTGC
GCCCCGGCGATCGCTGCCTGTGGCCGAGCGACATGGGCTGGATCGTCGGCCCGCTCACGACGGTCGGCGCGCTCGTCCGC
GGCGCGACCCTGGTGTGCTACGACGGCGCGCCCGACCATCCGGGCGCCGGACGTCTGGCCGAAATCATCGACCGCCACCA
GGTCACGCATTTCGGCGCATCGCCCACGCTGATCCGCAGCCTGGCGGCGTCGCCGGATGCCGTCGACGGCGCGGTGCTGG
AGAGCCTGCGTGTGCTGATGGTGGCCGGCGAGGTGATCGACCCGGATCACTTCGCGTGGTTCTTCCATGCATTCGGCCGG
GCGCGGTTGCCGGTGATCAACTACAGCGGCGGCACGGAGGCGTCGGGCGCGCTGTTGGGCAATGTTCCCGTGCGCCCGAT
CCGTGCCTGCGCTTTCAACGCCGTATCGCCGGGCGTCGACGCGTTTGCCGCCGACGAGAAAGGGCAGCGCGTGCGTGGCG
TTCCCGGTGAACTGGTGATCGCCGCGCCTTTCGTCGGGATGACGTCGGGATTCTGGAACGCGGCCGACCGCTACGAGGAA
ACGTACTGGCGCCAGCGGCCGGGCCTGTGGACGCATGGCGACCTGTTGCTCGAAGACGATGACGGACAATTCTTCATCCT
CGGCCGCGCGGACGACACGCTGAAGATTGCCGGCAAGCGGCTGGGGCCGGCCGAGGTCGAGTCGGTCGTGCTCGGGTCGC
CGCTCGTGCGCGACGTGGCGGCCGTCTCGCTGCCCGATCCGGTGAAAGGGGAGCGGCTGGTGGTTTGCGTCAGTACCCAC
GGCGAACCGCCGAGCGTGCTGGTGAAGTCGCTGGCCGATCGGATCGAGGCGGCGCTGGGAAAACCGTTCCGTCCCGGCGT
CGTGCATGTCGTGCCCGATCTGCCGCGCACGCGCAACGGGAAGGTCATGCGCCGCGTGGTGCGAAACGTGTTGCGGGGCT
TGCCGCCGGGCGACGTGAGCGCCCTCGAGAATCCGGCGGCGCTTGCAGCGTTGCAGGCGCTGGCCGATCAGGGCACGGCA
TGA

Upstream 100 bases:

>100_bases
AGGCTGGCCATGATCCGCAACCCTGATCTGTCGCCCTGCCTGCTTGGGGCGATCCGGCAGGGCGACATCGTGCGACTCAC
GATTCGGACGGAGCACTTCG

Downstream 100 bases:

>100_bases
CGGATCGACATCGGAACGGGCGGGGCGCGGTGTGGTGTCATCCCCCCGTCACCGGCGGAAAGAATGCGACCTCGCTGTCC
TCCCGCACGACGAATTCCCC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSTTDILWQPPSDWRTSTLLGELCACLGASSFEELIGISLREPQRYWAAVMTHLQFQWRTPPQRHVDLAGGPAFPRWFPG
GRLNWVDHVLAHADGPRAMQAAVITETEDGRVSTTSYAALAREVRRLASRLATLGVGAGDRVGIMMTMGAQAAASLIAVS
ALGAIAVPLFTGFGADAVAARLTLADARVLLASGGYLRRGRTIDLKPVFDAVQEQMPGLRIVVHGDEPARSAALDDPASA
HAAAPRAFPAQDPDQPFMIVFTSGTTGEPKGTVHTHAGFPLKILHDCAYHFELRPGDRCLWPSDMGWIVGPLTTVGALVR
GATLVCYDGAPDHPGAGRLAEIIDRHQVTHFGASPTLIRSLAASPDAVDGAVLESLRVLMVAGEVIDPDHFAWFFHAFGR
ARLPVINYSGGTEASGALLGNVPVRPIRACAFNAVSPGVDAFAADEKGQRVRGVPGELVIAAPFVGMTSGFWNAADRYEE
TYWRQRPGLWTHGDLLLEDDDGQFFILGRADDTLKIAGKRLGPAEVESVVLGSPLVRDVAAVSLPDPVKGERLVVCVSTH
GEPPSVLVKSLADRIEAALGKPFRPGVVHVVPDLPRTRNGKVMRRVVRNVLRGLPPGDVSALENPAALAALQALADQGTA

Sequences:

>Translated_640_residues
MSTTDILWQPPSDWRTSTLLGELCACLGASSFEELIGISLREPQRYWAAVMTHLQFQWRTPPQRHVDLAGGPAFPRWFPG
GRLNWVDHVLAHADGPRAMQAAVITETEDGRVSTTSYAALAREVRRLASRLATLGVGAGDRVGIMMTMGAQAAASLIAVS
ALGAIAVPLFTGFGADAVAARLTLADARVLLASGGYLRRGRTIDLKPVFDAVQEQMPGLRIVVHGDEPARSAALDDPASA
HAAAPRAFPAQDPDQPFMIVFTSGTTGEPKGTVHTHAGFPLKILHDCAYHFELRPGDRCLWPSDMGWIVGPLTTVGALVR
GATLVCYDGAPDHPGAGRLAEIIDRHQVTHFGASPTLIRSLAASPDAVDGAVLESLRVLMVAGEVIDPDHFAWFFHAFGR
ARLPVINYSGGTEASGALLGNVPVRPIRACAFNAVSPGVDAFAADEKGQRVRGVPGELVIAAPFVGMTSGFWNAADRYEE
TYWRQRPGLWTHGDLLLEDDDGQFFILGRADDTLKIAGKRLGPAEVESVVLGSPLVRDVAAVSLPDPVKGERLVVCVSTH
GEPPSVLVKSLADRIEAALGKPFRPGVVHVVPDLPRTRNGKVMRRVVRNVLRGLPPGDVSALENPAALAALQALADQGTA
>Mature_639_residues
STTDILWQPPSDWRTSTLLGELCACLGASSFEELIGISLREPQRYWAAVMTHLQFQWRTPPQRHVDLAGGPAFPRWFPGG
RLNWVDHVLAHADGPRAMQAAVITETEDGRVSTTSYAALAREVRRLASRLATLGVGAGDRVGIMMTMGAQAAASLIAVSA
LGAIAVPLFTGFGADAVAARLTLADARVLLASGGYLRRGRTIDLKPVFDAVQEQMPGLRIVVHGDEPARSAALDDPASAH
AAAPRAFPAQDPDQPFMIVFTSGTTGEPKGTVHTHAGFPLKILHDCAYHFELRPGDRCLWPSDMGWIVGPLTTVGALVRG
ATLVCYDGAPDHPGAGRLAEIIDRHQVTHFGASPTLIRSLAASPDAVDGAVLESLRVLMVAGEVIDPDHFAWFFHAFGRA
RLPVINYSGGTEASGALLGNVPVRPIRACAFNAVSPGVDAFAADEKGQRVRGVPGELVIAAPFVGMTSGFWNAADRYEET
YWRQRPGLWTHGDLLLEDDDGQFFILGRADDTLKIAGKRLGPAEVESVVLGSPLVRDVAAVSLPDPVKGERLVVCVSTHG
EPPSVLVKSLADRIEAALGKPFRPGVVHVVPDLPRTRNGKVMRRVVRNVLRGLPPGDVSALENPAALAALQALADQGTA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=676, Percent_Identity=28.8461538461538, Blast_Score=266, Evalue=5e-71,
Organism=Homo sapiens, GI253970489, Length=689, Percent_Identity=28.7373004354136, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI28416953, Length=629, Percent_Identity=30.6836248012719, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI13375727, Length=640, Percent_Identity=27.1875, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI31982927, Length=654, Percent_Identity=25.8409785932722, Blast_Score=204, Evalue=3e-52,
Organism=Homo sapiens, GI42544132, Length=512, Percent_Identity=25.5859375, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI38505220, Length=504, Percent_Identity=24.6031746031746, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI157311624, Length=545, Percent_Identity=24.4036697247706, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI157311622, Length=545, Percent_Identity=24.4036697247706, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI115511026, Length=568, Percent_Identity=24.2957746478873, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI122937307, Length=503, Percent_Identity=23.8568588469185, Blast_Score=115, Evalue=2e-25,
Organism=Homo sapiens, GI58082049, Length=544, Percent_Identity=24.0808823529412, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI156151445, Length=536, Percent_Identity=24.6268656716418, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI42544134, Length=350, Percent_Identity=23.1428571428571, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=31.5541601255887, Blast_Score=293, Evalue=2e-80,
Organism=Escherichia coli, GI1786529, Length=641, Percent_Identity=31.6692667706708, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI221142682, Length=533, Percent_Identity=23.0769230769231, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI145693145, Length=529, Percent_Identity=24.952741020794, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788107, Length=542, Percent_Identity=24.7232472324723, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789201, Length=469, Percent_Identity=24.5202558635394, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786810, Length=508, Percent_Identity=23.0314960629921, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71982997, Length=644, Percent_Identity=27.1739130434783, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71983001, Length=644, Percent_Identity=27.1739130434783, Blast_Score=227, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17569507, Length=584, Percent_Identity=24.3150684931507, Blast_Score=159, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71985884, Length=555, Percent_Identity=21.8018018018018, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=529, Percent_Identity=22.117202268431, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319264, Length=640, Percent_Identity=29.53125, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6323182, Length=654, Percent_Identity=30.2752293577982, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24667955, Length=650, Percent_Identity=31.0769230769231, Blast_Score=275, Evalue=9e-74,
Organism=Drosophila melanogaster, GI62472339, Length=552, Percent_Identity=32.0652173913043, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24667959, Length=522, Percent_Identity=31.4176245210728, Blast_Score=234, Evalue=2e-61,
Organism=Drosophila melanogaster, GI21355225, Length=609, Percent_Identity=27.2577996715928, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI21355181, Length=532, Percent_Identity=24.4360902255639, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI18859661, Length=490, Percent_Identity=24.8979591836735, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI20130357, Length=538, Percent_Identity=23.7918215613383, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356947, Length=370, Percent_Identity=26.2162162162162, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR019758 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 68170; Mature: 68038

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTDILWQPPSDWRTSTLLGELCACLGASSFEELIGISLREPQRYWAAVMTHLQFQWRT
CCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHEEEECC
PPQRHVDLAGGPAFPRWFPGGRLNWVDHVLAHADGPRAMQAAVITETEDGRVSTTSYAAL
CCHHCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHEEEEEEEECCCCCEEHHHHHHH
AREVRRLASRLATLGVGAGDRVGIMMTMGAQAAASLIAVSALGAIAVPLFTGFGADAVAA
HHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RLTLADARVLLASGGYLRRGRTIDLKPVFDAVQEQMPGLRIVVHGDEPARSAALDDPASA
HHHHHHCEEEEECCCEEECCCEEECHHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCCHH
HAAAPRAFPAQDPDQPFMIVFTSGTTGEPKGTVHTHAGFPLKILHDCAYHFELRPGDRCL
HCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHEEEECCCCCEE
WPSDMGWIVGPLTTVGALVRGATLVCYDGAPDHPGAGRLAEIIDRHQVTHFGASPTLIRS
CCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAASPDAVDGAVLESLRVLMVAGEVIDPDHFAWFFHAFGRARLPVINYSGGTEASGALLG
HHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEC
NVPVRPIRACAFNAVSPGVDAFAADEKGQRVRGVPGELVIAAPFVGMTSGFWNAADRYEE
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCEEEEECCHHHCCCCCHHHHHHHH
TYWRQRPGLWTHGDLLLEDDDGQFFILGRADDTLKIAGKRLGPAEVESVVLGSPLVRDVA
HHHHHCCCCCCCCCEEEECCCCCEEEEECCCCCEEECCCCCCHHHHHHHHCCCHHHHHHH
AVSLPDPVKGERLVVCVSTHGEPPSVLVKSLADRIEAALGKPFRPGVVHVVPDLPRTRNG
HHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
KVMRRVVRNVLRGLPPGDVSALENPAALAALQALADQGTA
HHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STTDILWQPPSDWRTSTLLGELCACLGASSFEELIGISLREPQRYWAAVMTHLQFQWRT
CCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHEEEECC
PPQRHVDLAGGPAFPRWFPGGRLNWVDHVLAHADGPRAMQAAVITETEDGRVSTTSYAAL
CCHHCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHEEEEEEEECCCCCEEHHHHHHH
AREVRRLASRLATLGVGAGDRVGIMMTMGAQAAASLIAVSALGAIAVPLFTGFGADAVAA
HHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RLTLADARVLLASGGYLRRGRTIDLKPVFDAVQEQMPGLRIVVHGDEPARSAALDDPASA
HHHHHHCEEEEECCCEEECCCEEECHHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCCHH
HAAAPRAFPAQDPDQPFMIVFTSGTTGEPKGTVHTHAGFPLKILHDCAYHFELRPGDRCL
HCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHEEEECCCCCEE
WPSDMGWIVGPLTTVGALVRGATLVCYDGAPDHPGAGRLAEIIDRHQVTHFGASPTLIRS
CCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHH
LAASPDAVDGAVLESLRVLMVAGEVIDPDHFAWFFHAFGRARLPVINYSGGTEASGALLG
HHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEC
NVPVRPIRACAFNAVSPGVDAFAADEKGQRVRGVPGELVIAAPFVGMTSGFWNAADRYEE
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCEEEEECCHHHCCCCCHHHHHHHH
TYWRQRPGLWTHGDLLLEDDDGQFFILGRADDTLKIAGKRLGPAEVESVVLGSPLVRDVA
HHHHHCCCCCCCCCEEEECCCCCEEEEECCCCCEEECCCCCCHHHHHHHHCCCHHHHHHH
AVSLPDPVKGERLVVCVSTHGEPPSVLVKSLADRIEAALGKPFRPGVVHVVPDLPRTRNG
HHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCC
KVMRRVVRNVLRGLPPGDVSALENPAALAALQALADQGTA
HHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]