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The map label for this gene is menB [H]

Identifier: 107022981

GI number: 107022981

Start: 1582138

End: 1582941

Strand: Reverse

Name: menB [H]

Synonym: Bcen_1429

Alternate gene names: 107022981

Gene position: 1582941-1582138 (Counterclockwise)

Preceding gene: 107022982

Following gene: 107022980

Centisome position: 48.05

GC content: 66.42

Gene sequence:

>804_bases
ATGAACTATGAGGACATTCTGTATCGCGAAGCGGGCGGCGTGGCGACGATCACGATCAACCGTCCGTCGGTGTACAACGC
GTTCCGCGCCAGGACGGTCGACGAACTGCTGCATGCCTTTCAGCAGGCGGGCTGGAATCGCGAGATCGGCGTGATCGTGC
TGACCGGCGCCGGCGAAAAGGCCTTTTGCACCGGCGGCGACCAGACGAGCCACGGCGATGGCGGCTACGGTGGCCGCGGC
GCGATCGGCTTGCCCGTGGACGAGTTGCAGAGCCTCATTCGCGACGTGCCGAAGCCGGTGATCGCGCGCGTCAACGGCTA
TGCGATCGGCGGCGGCAACGTGCTCGTGACGGTGTGCGACCTGGCGATCGCGAGCGAAGCGGCCCAGCTCGGGCAGGTGG
GGCCCAGGGTGGGGTCGGTGGATCCCGGCTTCGGCACGGCGCTGCTCGCACGTGTCCTCGGCGAAAAACGCGCGCGGGAA
GTGTGGTTCCTGTGCCGGCGCTACACGGCGCGCGAAGCGCTTGCAATGGGGTGGCTCAATGCGGTCGTGCCTGCCGATCA
GCTCGACGGGGAAGTCGCGCGATGGTGCGACGAAATCCTTGCACTGAGCCCCACGGCGCTGGCGATCGCCAAGCGGTCGT
TCAACGCGGATTCCGAGAACATTCGCGCGATCGGTGCGCTGGGATTCGAGGCGCTGTCGCTGTACTACGACACCGACGAA
TCGAAGGAGGGCACGCGTGCTTTCCGCGAAAGGCGCAAGCCCGATTTCCGGCGTGGAAAGGCTGGCCATGATCCGCAACC
CTGA

Upstream 100 bases:

>100_bases
ACGTGGTGATCGTGACGCCGCCGCTCGTCATCTCGCGCACGGAGCTGGACGAGGGACTGGATGCGCTCGACGCGGCGCTG
ACGGTGCTGGAGGCCGCGCG

Downstream 100 bases:

>100_bases
TCTGTCGCCCTGCCTGCTTGGGGCGATCCGGCAGGGCGACATCGTGCGACTCACGATTCGGACGGAGCACTTCGATGAGC
ACCACTGACATACTTTGGCA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNYEDILYREAGGVATITINRPSVYNAFRARTVDELLHAFQQAGWNREIGVIVLTGAGEKAFCTGGDQTSHGDGGYGGRG
AIGLPVDELQSLIRDVPKPVIARVNGYAIGGGNVLVTVCDLAIASEAAQLGQVGPRVGSVDPGFGTALLARVLGEKRARE
VWFLCRRYTAREALAMGWLNAVVPADQLDGEVARWCDEILALSPTALAIAKRSFNADSENIRAIGALGFEALSLYYDTDE
SKEGTRAFRERRKPDFRRGKAGHDPQP

Sequences:

>Translated_267_residues
MNYEDILYREAGGVATITINRPSVYNAFRARTVDELLHAFQQAGWNREIGVIVLTGAGEKAFCTGGDQTSHGDGGYGGRG
AIGLPVDELQSLIRDVPKPVIARVNGYAIGGGNVLVTVCDLAIASEAAQLGQVGPRVGSVDPGFGTALLARVLGEKRARE
VWFLCRRYTAREALAMGWLNAVVPADQLDGEVARWCDEILALSPTALAIAKRSFNADSENIRAIGALGFEALSLYYDTDE
SKEGTRAFRERRKPDFRRGKAGHDPQP
>Mature_267_residues
MNYEDILYREAGGVATITINRPSVYNAFRARTVDELLHAFQQAGWNREIGVIVLTGAGEKAFCTGGDQTSHGDGGYGGRG
AIGLPVDELQSLIRDVPKPVIARVNGYAIGGGNVLVTVCDLAIASEAAQLGQVGPRVGSVDPGFGTALLARVLGEKRARE
VWFLCRRYTAREALAMGWLNAVVPADQLDGEVARWCDEILALSPTALAIAKRSFNADSENIRAIGALGFEALSLYYDTDE
SKEGTRAFRERRKPDFRRGKAGHDPQP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=261, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI31542718, Length=248, Percent_Identity=28.2258064516129, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI45643119, Length=257, Percent_Identity=27.2373540856031, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI260275230, Length=257, Percent_Identity=27.2373540856031, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI260274832, Length=257, Percent_Identity=27.2373540856031, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4502327, Length=262, Percent_Identity=27.4809160305344, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI25453481, Length=214, Percent_Identity=26.6355140186916, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538573, Length=214, Percent_Identity=26.6355140186916, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4757966, Length=214, Percent_Identity=26.6355140186916, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI51538581, Length=214, Percent_Identity=26.6355140186916, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4757968, Length=216, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI49355787, Length=216, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI68989263, Length=191, Percent_Identity=30.8900523560209, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=50.5747126436782, Blast_Score=258, Evalue=2e-70,
Organism=Escherichia coli, GI87082183, Length=264, Percent_Identity=28.7878787878788, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787659, Length=252, Percent_Identity=29.3650793650794, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=28.7878787878788, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=34.9397590361446, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=33.2, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17549921, Length=214, Percent_Identity=28.0373831775701, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=26.8867924528302, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=248, Percent_Identity=21.7741935483871, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=248, Percent_Identity=27.8225806451613, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=260, Percent_Identity=35.3846153846154, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653477, Length=260, Percent_Identity=35.3846153846154, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24653139, Length=259, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI19922422, Length=255, Percent_Identity=25.0980392156863, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357171, Length=183, Percent_Identity=30.6010928961749, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24654903, Length=192, Percent_Identity=24.4791666666667, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 28778; Mature: 28778

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYEDILYREAGGVATITINRPSVYNAFRARTVDELLHAFQQAGWNREIGVIVLTGAGEK
CCHHHHEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCE
AFCTGGDQTSHGDGGYGGRGAIGLPVDELQSLIRDVPKPVIARVNGYAIGGGNVLVTVCD
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCEEECCCCEEEHHHH
LAIASEAAQLGQVGPRVGSVDPGFGTALLARVLGEKRAREVWFLCRRYTAREALAMGWLN
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVPADQLDGEVARWCDEILALSPTALAIAKRSFNADSENIRAIGALGFEALSLYYDTDE
HHCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCC
SKEGTRAFRERRKPDFRRGKAGHDPQP
CCHHHHHHHHHCCCCHHCCCCCCCCCC
>Mature Secondary Structure
MNYEDILYREAGGVATITINRPSVYNAFRARTVDELLHAFQQAGWNREIGVIVLTGAGEK
CCHHHHEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCE
AFCTGGDQTSHGDGGYGGRGAIGLPVDELQSLIRDVPKPVIARVNGYAIGGGNVLVTVCD
EEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCEEECCCCEEEHHHH
LAIASEAAQLGQVGPRVGSVDPGFGTALLARVLGEKRAREVWFLCRRYTAREALAMGWLN
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVVPADQLDGEVARWCDEILALSPTALAIAKRSFNADSENIRAIGALGFEALSLYYDTDE
HHCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEECCCC
SKEGTRAFRERRKPDFRRGKAGHDPQP
CCHHHHHHHHHCCCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629163; 8566759; 9387221; 9384377 [H]