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The map label for this gene is metC [H]

Identifier: 103488535

GI number: 103488535

Start: 3209390

End: 3210592

Strand: Reverse

Name: metC [H]

Synonym: Sala_3059

Alternate gene names: 103488535

Gene position: 3210592-3209390 (Counterclockwise)

Preceding gene: 103488536

Following gene: 103488534

Centisome position: 95.98

GC content: 69.58

Gene sequence:

>1203_bases
ATGACGACCGACGACGACAGCCTCCGCCCCGCGACGCGGCTCGTTCAGGGCGGGCGGCGGCCCGAATGGACCGGCGATCC
GCGGCTGGGCGGCGGGATCGTCAATCCGCCCGTCTGGCGCGCGTCGACGATCCTGTACGACACTGTCGCCGACCTGAAGG
CGCGCGGTCATGCGACGCACGACAAGCTTTATTACGGCCGCCGCGGGACGCCGACGGTGTGGGCACTCGCCGACGCCCTG
ACGGCGATGGAGCCGGGCGCCGCAGGAACCTTGCTCTATCCCTCCGGGGTCGCCGCCAATTCGGCGGGGCTGCTCGCGCT
GCTGTCGCCGGGCGATCACCTGCTGATGGTCGACAGCGCCTATGAGCCGACGCGCGCCTTCTGCGACGGGATGCTCGCGC
GGCTGGGCGTGACGACGACCTATTATGATCCGCTCGTCGGTGCCGCGATCGCCGAACTGATCCGCCCCGAAACGCGGCTG
ATCTTCCTCGAATCGCCGGGCAGCCTGACCTTCGAGGTGCAGGATGTGCCCGCGATCACCGGCGTCGCGCGGGCACGCGG
CGTGCTGACGATGATCGACAATACGTGGGCGACGCCCTTGCTGTTTCCCGCGCTGGCGCACGGGGTCGATGTCGCGATGA
TGAGCCTCACCAAATATGTCGGCGGGCACAGCGACGCGATGATGGGCTCGCTCACCGCGACGCGCGCCGTGTGGCCGAAG
CTGCGCAGCGCCGCCTATCAACTCGGCCAGGCGGTGTCGCCCGACGATTGCGCGCTCATGCTGCGCGGACTGCGCACGCT
CGACGTACGGATGCAGCGCCATGGCGAAAATGGGCTTGTGGTCGCAAACTGGCTTGCCGCGCGCGGCGAAGTCGGCCGCG
TGCTCCATCCGGCGCTGGCAGGCGATGGCGGCCATGCGATCTGGGCGCGCGATTTTTCGGGCCCCAGCGGGCTGTTCGGC
TTCACGCTGAAGGGCGCCGACGAGGGCGCGCGCACGCGCTTTATCGACGCACTGACGCAATTCGGCATAGGCTTCAGCTG
GGGCGGTTATGAAAGCCTTGTCGTGCCCGCCGACCCGGCGGGCATCCGCACCGCGACACGCTGGACCGACCCCGACCCGC
TCGTCCGCCTGTCGATCGGGCTCGAGGACCCGGCCGACCTGATCGCCGACCTCGAGCGCGGCTTTGCCGCGATGACGGCA
TGA

Upstream 100 bases:

>100_bases
GGATTGTGCCGGTGCTGGCGCTCTGTTCGGCGGCCGGTCTGCTGGTCGGCTTTGTCGTTCCGTCACTGGATTTTACCTGA
CGCTTCGCTACGATTGCCCG

Downstream 100 bases:

>100_bases
ACGAACTCGACGCGCTGTTCGCCCGCATGGGTTTTCCGGCGCTCGCCGAGGCGCAGCTGGTCGAGCTGGGCGTCGCGGGG
GGGCTGGCGGTGTTTGCGCT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTTDDDSLRPATRLVQGGRRPEWTGDPRLGGGIVNPPVWRASTILYDTVADLKARGHATHDKLYYGRRGTPTVWALADAL
TAMEPGAAGTLLYPSGVAANSAGLLALLSPGDHLLMVDSAYEPTRAFCDGMLARLGVTTTYYDPLVGAAIAELIRPETRL
IFLESPGSLTFEVQDVPAITGVARARGVLTMIDNTWATPLLFPALAHGVDVAMMSLTKYVGGHSDAMMGSLTATRAVWPK
LRSAAYQLGQAVSPDDCALMLRGLRTLDVRMQRHGENGLVVANWLAARGEVGRVLHPALAGDGGHAIWARDFSGPSGLFG
FTLKGADEGARTRFIDALTQFGIGFSWGGYESLVVPADPAGIRTATRWTDPDPLVRLSIGLEDPADLIADLERGFAAMTA

Sequences:

>Translated_400_residues
MTTDDDSLRPATRLVQGGRRPEWTGDPRLGGGIVNPPVWRASTILYDTVADLKARGHATHDKLYYGRRGTPTVWALADAL
TAMEPGAAGTLLYPSGVAANSAGLLALLSPGDHLLMVDSAYEPTRAFCDGMLARLGVTTTYYDPLVGAAIAELIRPETRL
IFLESPGSLTFEVQDVPAITGVARARGVLTMIDNTWATPLLFPALAHGVDVAMMSLTKYVGGHSDAMMGSLTATRAVWPK
LRSAAYQLGQAVSPDDCALMLRGLRTLDVRMQRHGENGLVVANWLAARGEVGRVLHPALAGDGGHAIWARDFSGPSGLFG
FTLKGADEGARTRFIDALTQFGIGFSWGGYESLVVPADPAGIRTATRWTDPDPLVRLSIGLEDPADLIADLERGFAAMTA
>Mature_399_residues
TTDDDSLRPATRLVQGGRRPEWTGDPRLGGGIVNPPVWRASTILYDTVADLKARGHATHDKLYYGRRGTPTVWALADALT
AMEPGAAGTLLYPSGVAANSAGLLALLSPGDHLLMVDSAYEPTRAFCDGMLARLGVTTTYYDPLVGAAIAELIRPETRLI
FLESPGSLTFEVQDVPAITGVARARGVLTMIDNTWATPLLFPALAHGVDVAMMSLTKYVGGHSDAMMGSLTATRAVWPKL
RSAAYQLGQAVSPDDCALMLRGLRTLDVRMQRHGENGLVVANWLAARGEVGRVLHPALAGDGGHAIWARDFSGPSGLFGF
TLKGADEGARTRFIDALTQFGIGFSWGGYESLVVPADPAGIRTATRWTDPDPLVRLSIGLEDPADLIADLERGFAAMTA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=380, Percent_Identity=31.5789473684211, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI299473759, Length=380, Percent_Identity=28.9473684210526, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI25453487, Length=379, Percent_Identity=28.7598944591029, Blast_Score=132, Evalue=4e-31,
Organism=Escherichia coli, GI1789383, Length=395, Percent_Identity=46.0759493670886, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1790375, Length=372, Percent_Identity=33.6021505376344, Blast_Score=165, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI71980708, Length=403, Percent_Identity=31.2655086848635, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17538055, Length=383, Percent_Identity=32.8981723237598, Blast_Score=175, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17560056, Length=382, Percent_Identity=33.2460732984293, Blast_Score=174, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=325, Percent_Identity=45.8461538461538, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6319307, Length=349, Percent_Identity=30.6590257879656, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321904, Length=399, Percent_Identity=27.3182957393484, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=393, Percent_Identity=24.9363867684478, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323333, Length=392, Percent_Identity=23.9795918367347, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19922554, Length=396, Percent_Identity=34.8484848484849, Blast_Score=200, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42550; Mature: 42419

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDDDSLRPATRLVQGGRRPEWTGDPRLGGGIVNPPVWRASTILYDTVADLKARGHATH
CCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCH
DKLYYGRRGTPTVWALADALTAMEPGAAGTLLYPSGVAANSAGLLALLSPGDHLLMVDSA
HHEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEECCCCEEEEEECC
YEPTRAFCDGMLARLGVTTTYYDPLVGAAIAELIRPETRLIFLESPGSLTFEVQDVPAIT
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCHHH
GVARARGVLTMIDNTWATPLLFPALAHGVDVAMMSLTKYVGGHSDAMMGSLTATRAVWPK
HHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LRSAAYQLGQAVSPDDCALMLRGLRTLDVRMQRHGENGLVVANWLAARGEVGRVLHPALA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHHHHHHC
GDGGHAIWARDFSGPSGLFGFTLKGADEGARTRFIDALTQFGIGFSWGGYESLVVPADPA
CCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
GIRTATRWTDPDPLVRLSIGLEDPADLIADLERGFAAMTA
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTDDDSLRPATRLVQGGRRPEWTGDPRLGGGIVNPPVWRASTILYDTVADLKARGHATH
CCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCH
DKLYYGRRGTPTVWALADALTAMEPGAAGTLLYPSGVAANSAGLLALLSPGDHLLMVDSA
HHEEECCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCEEEEECCCCEEEEEECC
YEPTRAFCDGMLARLGVTTTYYDPLVGAAIAELIRPETRLIFLESPGSLTFEVQDVPAIT
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCHHH
GVARARGVLTMIDNTWATPLLFPALAHGVDVAMMSLTKYVGGHSDAMMGSLTATRAVWPK
HHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LRSAAYQLGQAVSPDDCALMLRGLRTLDVRMQRHGENGLVVANWLAARGEVGRVLHPALA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHHHHHHC
GDGGHAIWARDFSGPSGLFGFTLKGADEGARTRFIDALTQFGIGFSWGGYESLVVPADPA
CCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
GIRTATRWTDPDPLVRLSIGLEDPADLIADLERGFAAMTA
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]