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The map label for this gene is panC

Identifier: 103488480

GI number: 103488480

Start: 3146034

End: 3146873

Strand: Direct

Name: panC

Synonym: Sala_3003

Alternate gene names: 103488480

Gene position: 3146034-3146873 (Clockwise)

Preceding gene: 103488473

Following gene: 103488481

Centisome position: 94.05

GC content: 68.1

Gene sequence:

>840_bases
GTGCAAATCATCCGTGACATCGCGATGCTCCACCGTGCCGTCACGGCACTGAAACAGGGCGGCAAGAGCATCGCGCTCGT
CCCCACGATGGGAGCGCTGCACGCCGGCCATCTCTCGCTCGTCCGGATGGCAAAGCGCGTCGCCGACCATGTCGTCGTCT
CGATCTTCGTCAACCCGACGCAATTCGGGCCGAACGAGGATTTTGCCGCCTATCCGCGCGACGAGGCGCGCGACGCCGCG
CTGCTCGTCGAGGAAGGGACGAGCCTGCTCTGGGCGCCCGACGTCGGCACCATGTATCCCGGCGGGCACAGCACGCATGT
CGAGGTTGCCGAACTCGGCGCCGATTATTGCGGCGCCGCGCGTCCCGGCCATTTCGACGGCGTTGCGACGGTCGTGGCCA
AATTGTTCAATCAGGTGCGTCCCGACATCGCGATCTTCGGTGAAAAGGACTGGCAACAGCTCGCGATCATCCGTCGCATG
GCGCGCGACCTCGATTTCGGCATCGACATATTGGGCGCGCCGATCGCGCGCGAGGCCGACGGGCTCGCGCTGTCGTCGCG
CAACGCCTATCTGTCGGCCGAGCAGCGCACGGCGGCGGCGGCCTTTCCCGGCGCGCTGAAGACGGCCGCAAAGGCGATCG
CGGACGGCGCCGACGTCGCCGAGACGCTCGCCAGGGCCGAGGCGGCGATCGTCGGGGGCGGGTTCGACAGCGTCGACTAT
GTCGCGCTCGCCGATGCCGACAGCCTCGAACGGCTCGCTGTCTTTCGCGCCCCGGCGCGGCTGCTCGCCGCGGCAAGAAT
CGGCAGGACGCGGCTGATCGACAATTTGCCGGTGGGCTGA

Upstream 100 bases:

>100_bases
CGGAGTTCGTCATGGGGCGTTGCGATTTTCCTGTTGGCGCGGCATGGGCGACCGACGCGCGAAATGATATCATCGCGCCA
ATATCGGAGGGCGCCCGGCC

Downstream 100 bases:

>100_bases
ACAGGGCAAGAAACAGCGGATTTCCAGGCGCTCGGCGCACTATCCACAAAAAATCGGGTCATCGTTAACGCTTTGTTGAC
CATAAACCGCAAGTTTGGCC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MQIIRDIAMLHRAVTALKQGGKSIALVPTMGALHAGHLSLVRMAKRVADHVVVSIFVNPTQFGPNEDFAAYPRDEARDAA
LLVEEGTSLLWAPDVGTMYPGGHSTHVEVAELGADYCGAARPGHFDGVATVVAKLFNQVRPDIAIFGEKDWQQLAIIRRM
ARDLDFGIDILGAPIAREADGLALSSRNAYLSAEQRTAAAAFPGALKTAAKAIADGADVAETLARAEAAIVGGGFDSVDY
VALADADSLERLAVFRAPARLLAAARIGRTRLIDNLPVG

Sequences:

>Translated_279_residues
MQIIRDIAMLHRAVTALKQGGKSIALVPTMGALHAGHLSLVRMAKRVADHVVVSIFVNPTQFGPNEDFAAYPRDEARDAA
LLVEEGTSLLWAPDVGTMYPGGHSTHVEVAELGADYCGAARPGHFDGVATVVAKLFNQVRPDIAIFGEKDWQQLAIIRRM
ARDLDFGIDILGAPIAREADGLALSSRNAYLSAEQRTAAAAFPGALKTAAKAIADGADVAETLARAEAAIVGGGFDSVDY
VALADADSLERLAVFRAPARLLAAARIGRTRLIDNLPVG
>Mature_279_residues
MQIIRDIAMLHRAVTALKQGGKSIALVPTMGALHAGHLSLVRMAKRVADHVVVSIFVNPTQFGPNEDFAAYPRDEARDAA
LLVEEGTSLLWAPDVGTMYPGGHSTHVEVAELGADYCGAARPGHFDGVATVVAKLFNQVRPDIAIFGEKDWQQLAIIRRM
ARDLDFGIDILGAPIAREADGLALSSRNAYLSAEQRTAAAAFPGALKTAAKAIADGADVAETLARAEAAIVGGGFDSVDY
VALADADSLERLAVFRAPARLLAAARIGRTRLIDNLPVG

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=278, Percent_Identity=48.2014388489209, Blast_Score=237, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6322046, Length=248, Percent_Identity=39.5161290322581, Blast_Score=167, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_SPHAL (Q1GNR4)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_618041.1
- ProteinModelPortal:   Q1GNR4
- SMR:   Q1GNR4
- GeneID:   4082947
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_3003
- NMPDR:   fig|317655.9.peg.2859
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- BioCyc:   SALA317655:SALA_3003-MONOMER
- BRENDA:   6.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 29471; Mature: 29471

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIIRDIAMLHRAVTALKQGGKSIALVPTMGALHAGHLSLVRMAKRVADHVVVSIFVNPT
CHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEEEECCC
QFGPNEDFAAYPRDEARDAALLVEEGTSLLWAPDVGTMYPGGHSTHVEVAELGADYCGAA
CCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCEEHHHHHCHHHCCCC
RPGHFDGVATVVAKLFNQVRPDIAIFGEKDWQQLAIIRRMARDLDFGIDILGAPIAREAD
CCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
GLALSSRNAYLSAEQRTAAAAFPGALKTAAKAIADGADVAETLARAEAAIVGGGFDSVDY
CCEEECCCCEECHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCCCCE
VALADADSLERLAVFRAPARLLAAARIGRTRLIDNLPVG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQIIRDIAMLHRAVTALKQGGKSIALVPTMGALHAGHLSLVRMAKRVADHVVVSIFVNPT
CHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHEEEEEEECCC
QFGPNEDFAAYPRDEARDAALLVEEGTSLLWAPDVGTMYPGGHSTHVEVAELGADYCGAA
CCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCCEEHHHHHCHHHCCCC
RPGHFDGVATVVAKLFNQVRPDIAIFGEKDWQQLAIIRRMARDLDFGIDILGAPIAREAD
CCCCCHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCC
GLALSSRNAYLSAEQRTAAAAFPGALKTAAKAIADGADVAETLARAEAAIVGGGFDSVDY
CCEEECCCCEECHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHEECCCCCCCCE
VALADADSLERLAVFRAPARLLAAARIGRTRLIDNLPVG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA