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The map label for this gene is aroE

Identifier: 103488317

GI number: 103488317

Start: 2992714

End: 2993538

Strand: Reverse

Name: aroE

Synonym: Sala_2840

Alternate gene names: 103488317

Gene position: 2993538-2992714 (Counterclockwise)

Preceding gene: 103488318

Following gene: 103488316

Centisome position: 89.49

GC content: 68.24

Gene sequence:

>825_bases
ATGAGCCACCCCTATGCCTCCCCCTTCGCCGAGGTGATCGGAGATCCGATCGCCCAGTCGAAATCGCCGCTGATCCACGG
GTTCTGGCTCGACGCGTTGGGTATGGAGGGCGATTACCGCCGCGCGCATGTAAAGGCCGACGCGCTTGCCGCCTATATCG
CCGAGCGACGGGCCGACCCCGGCTGGCGCGGGTGCAACGTCACCATGCCGCACAAGGCGGCAGTCATGGACCTCGTCGAT
GATCCGGGCGATATTCGCGGCACGATCGGCGCGATGAACACGATCGTTCGCCAGCCCGATGGATCGCTGATCGGCACCAA
TACCGATGCTGCGGGTTTCTATTCGCCGCTCGCGGAGCTGGATCTTGAGGGCGCGCCGATCGCTGTCGTCGGTGCCGGCG
GCGCCGCGCGCGCGGTGTTGTTCGCGCTGGCGCGGGCGAAGGTCGGCAAGGTGGCGATCCTCAATCGCAGTCCGCTGAAG
GCCATGGGACTGCTCGCCACCTTTGGCCTCAAGGGCGATGTCGTCGCGCTCGATGCCGCACTGCCGCCGGTGCGACTGCT
GGTCAATGCAAGCAGTCTCGGCATGGCGGGCCAGCCGCCGCTCGACCTCGACCTGTCGCCGCTGCCGGACGATGCGATCG
TCTATGACCTGGTCTATTCGCCGCTCCGGACCGGGCTCCTCAAGGCCGCCGAGGCGCGCGGGCTCGACACGGTCGACGGG
CTCGACATGCTGATCGGGCAGGCGGCGCTGGCCTTCGAACTCTTCTTCGGCGCGCCGCCGCCCGAGGGGCGCGACGACGA
ACTGCGCGCGCTGCTGGTGGCATGA

Upstream 100 bases:

>100_bases
TGCAATTGTTCGACCGGGTCGAGGGCGACCCCTGGACCATCATCGGCATGCCGATGCTGCCTTTGCTGACATGGCTGCGC
GCGACCGGACTGGCGCCGCA

Downstream 100 bases:

>100_bases
GCCATTTCAAGCGCCCGCTCCTGCCGCTTCGCCGTCCCTTCCTGCTCGGCCTCACCGGCTCGATCGGCATGGGCAAATCG
ACCGCGGCGGCGATGTTCGA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSHPYASPFAEVIGDPIAQSKSPLIHGFWLDALGMEGDYRRAHVKADALAAYIAERRADPGWRGCNVTMPHKAAVMDLVD
DPGDIRGTIGAMNTIVRQPDGSLIGTNTDAAGFYSPLAELDLEGAPIAVVGAGGAARAVLFALARAKVGKVAILNRSPLK
AMGLLATFGLKGDVVALDAALPPVRLLVNASSLGMAGQPPLDLDLSPLPDDAIVYDLVYSPLRTGLLKAAEARGLDTVDG
LDMLIGQAALAFELFFGAPPPEGRDDELRALLVA

Sequences:

>Translated_274_residues
MSHPYASPFAEVIGDPIAQSKSPLIHGFWLDALGMEGDYRRAHVKADALAAYIAERRADPGWRGCNVTMPHKAAVMDLVD
DPGDIRGTIGAMNTIVRQPDGSLIGTNTDAAGFYSPLAELDLEGAPIAVVGAGGAARAVLFALARAKVGKVAILNRSPLK
AMGLLATFGLKGDVVALDAALPPVRLLVNASSLGMAGQPPLDLDLSPLPDDAIVYDLVYSPLRTGLLKAAEARGLDTVDG
LDMLIGQAALAFELFFGAPPPEGRDDELRALLVA
>Mature_273_residues
SHPYASPFAEVIGDPIAQSKSPLIHGFWLDALGMEGDYRRAHVKADALAAYIAERRADPGWRGCNVTMPHKAAVMDLVDD
PGDIRGTIGAMNTIVRQPDGSLIGTNTDAAGFYSPLAELDLEGAPIAVVGAGGAARAVLFALARAKVGKVAILNRSPLKA
MGLLATFGLKGDVVALDAALPPVRLLVNASSLGMAGQPPLDLDLSPLPDDAIVYDLVYSPLRTGLLKAAEARGLDTVDGL
DMLIGQAALAFELFFGAPPPEGRDDELRALLVA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=264, Percent_Identity=34.8484848484849, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787983, Length=263, Percent_Identity=30.7984790874525, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320332, Length=273, Percent_Identity=24.9084249084249, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_SPHAL (Q1GP77)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617878.1
- ProteinModelPortal:   Q1GP77
- SMR:   Q1GP77
- GeneID:   4080633
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2840
- NMPDR:   fig|317655.9.peg.2705
- HOGENOM:   HBG553408
- OMA:   ESVPPEG
- ProtClustDB:   CLSK2777925
- BioCyc:   SALA317655:SALA_2840-MONOMER
- BRENDA:   1.1.1.25
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 28583; Mature: 28452

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: ACT_SITE 72-72

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPYASPFAEVIGDPIAQSKSPLIHGFWLDALGMEGDYRRAHVKADALAAYIAERRADP
CCCCCCCHHHHHHCCHHHCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GWRGCNVTMPHKAAVMDLVDDPGDIRGTIGAMNTIVRQPDGSLIGTNTDAAGFYSPLAEL
CCCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHC
DLEGAPIAVVGAGGAARAVLFALARAKVGKVAILNRSPLKAMGLLATFGLKGDVVALDAA
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECC
LPPVRLLVNASSLGMAGQPPLDLDLSPLPDDAIVYDLVYSPLRTGLLKAAEARGLDTVDG
CCCEEEEEECHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LDMLIGQAALAFELFFGAPPPEGRDDELRALLVA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECC
>Mature Secondary Structure 
SHPYASPFAEVIGDPIAQSKSPLIHGFWLDALGMEGDYRRAHVKADALAAYIAERRADP
CCCCCCHHHHHHCCHHHCCCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GWRGCNVTMPHKAAVMDLVDDPGDIRGTIGAMNTIVRQPDGSLIGTNTDAAGFYSPLAEL
CCCCCCEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHC
DLEGAPIAVVGAGGAARAVLFALARAKVGKVAILNRSPLKAMGLLATFGLKGDVVALDAA
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEECC
LPPVRLLVNASSLGMAGQPPLDLDLSPLPDDAIVYDLVYSPLRTGLLKAAEARGLDTVDG
CCCEEEEEECHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LDMLIGQAALAFELFFGAPPPEGRDDELRALLVA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA