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The map label for this gene is tme [H]

Identifier: 103488269

GI number: 103488269

Start: 2956269

End: 2958533

Strand: Direct

Name: tme [H]

Synonym: Sala_2792

Alternate gene names: 103488269

Gene position: 2956269-2958533 (Clockwise)

Preceding gene: 103488267

Following gene: 103488271

Centisome position: 88.37

GC content: 65.21

Gene sequence:

>2265_bases
ATGGACGGCGGTAGCAAGGTGCAGTTTTCCGACCGCGAGGCCCTGCTTTACCACGAACATGGCCGACCGGGGAAAATCGA
GATCGTCGCGTCGAAGCCGATGGCGACGCAGCGCGATCTGAGCCTTGCCTATTCGCCCGGCGTCGCGGTGCCGGTGAAAG
CGATCGCCGAAGATCCCGCCAGGGCCTATGACTATACGATCAAGGGCAATCTGGTCGCCGTCATCTCGAACGGGACCGCG
ATCCTGGGGCTCGGCAACCTCGGCGCGCTCGCGTCGAAACCGGTGATGGAAGGCAAGGCGGTGCTGTTCAAGCGCTTTGC
CGACGTCGATTCGATCGATCTCGAGGTCGATACCGAAGACCCGCAGCGTTTCATCGAGGCGGTCGAACTGCTCGCGCCGA
GCTTTGGCGGCATCAACCTGGAAGACATTGCCGCGCCCAATTGTTTCATCATCGAGGCCGCGCTGAAAGAGCGGATGAAC
ATTCCGGTGTTCCATGACGACCAGCATGGCACCGCGATCATCACCGCCGCGGGGCTGATCAACGCCTGTTACCTGACCGG
GCGCGACCTCGCGACGGTCAAGGTCGTCGTCAACGGCGCAGGGGCGGCGGCGATCGCGTGCACCTCGCTCATCAAATCGA
TGGGCGTACGCCACGAAAATGTCATCATGTGCGACCGCAAGGGCACGATCTATCAGGGCCGTACCGAGGGCATGGACCAG
TGGAAGTCCGCCCACGCCGTCCCGACCGAGGCGCGCGACCTGACCGAAGCGCTGGTCGGCGCCGACGTGTTCCTTGGCCT
CTCCGCCGCGGGCGCGCTGAAGCCCGAGATGGTCAAGGACATGGCGCCGGCGCCGATCATCTTTGCGATGGCGAACCCCG
ATCCCGAAATCTCGCCGCCAGATGCCCGTGCAGCAAGACCTGACGCGATCATCGCGACGGGGCGCTCGGACTATCCGAAC
CAGGTCAATAATGTGCTGTGCTTCCCCTTCATCTTCCGCGGCGCGCTCGACGTCCACGCGACCGCGATCAACGAGGAGAT
GAAGATCGCCGCGGCCTATGCAATCGCCGACCTCGCGCGCCAGCAGGTGCCCGAAGAGGTCGCCGCGGCCTATGGCGGGC
GCGCGTCGAGCTTTGGCCCCGAATATATCATCCCCTCGCCCTTCGACCCGCGGTTGATGGAAATCGTTCCCGCCGCGGTC
GCCAAGGCGGCGATGGCGACGGGCGTCGCGCAGAAACCGATCGCCGATCTCGACGCCTATCGCACGTCCTTGCGCGCGCG
GCTCAACCCGACGACCTCGGTGCTCACCCTCGCTTATGAAGCCGCGCGGACCAACCCGAAGCGCGTCGTCTTTGCCGAGG
GCGAAGAAGAAACCGTGCTGCGCGCCGCGATCCAGTTCCGCGACGGCGGTTACGGCACACCGGTGCTCGTCGGGCGCGAA
GGGCTGCACGACAAGCTGCGCGCGATGGGCGTCGCCGACGCCGAAAGCTTCGAGGTCCACAACAGCGTCAATTCGCCGCA
TGTCCCCGCGATGGTCGACATGCTCTACGAGCGGCTCCAGCGCCGCGGATATCTGCGCCGCGATGTCGAACGGATGGTCA
ACCGCGACCGCAACATCTTTGGCTCGCTGCTGCTCAAAATGGGGCTGGGCGATGCGATGATCACCGGCACGACGCGCACC
TATTCGCAGACGATGCGCGAAATCCGCCGCGTGATCGACCATGCCGAGGGCAAGACGCCGTTCGGCATCCATGTCCTCGT
CGACCAGCATCACACCATCTTCATGGCCGACACGACGGTCAACGAGCGTCCATCGGCCGAAATGCTCGCCGACATCGCCG
AACGCACCGCGCAGGTCGCGCGGCGGATGGGGCACGAACCGCGCGTCGCTTTCCTGTCCTATTCGACCTTCGGCAACCCC
GAGGGGAGCTGGCTGGAGAATATCCGCGAGGCGGTCGCGATCCTCGACCGGCGCCAGCCCGCCTTCGAATATGAAGGCGA
AATGGCGCCCGACGTCGCGCTGAATGCCAAGGTGATGAAAAACTATCCCTTCTGCCGCCTGTCGGGGCCCGCCAATGTGC
TGGTGATGCCGGGGCTGCAATCGGCGAACCTGTCGGCGAAGCTGCTGCGCGAACTCGGCGGCGGCGCGGTGATCGGCCCG
ATGCTGGTCGGTATGGAACATCCCGTGCAGGTCGCGACGATGGCGTCGACCGCATCGGACCTGGTAACGCTGGCCGTGCT
CGCCGCGGGCGGGATCGCGCAATAG

Upstream 100 bases:

>100_bases
TTCGCCACCCACACCCAACATTGGCGGTTACATTTTCGCGAGGTCGCGTTAGGGGAAAGGCTCGGGCGCGCATCTTGTGG
ATCATATGAGAGGATTGAAT

Downstream 100 bases:

>100_bases
CATAAGGGCGCGTCGCCCCCGCGAAGGCGGGGACCGTTATCGGGGTAGCGCAAGGCCGCCAGCGGCCCCCGCCTTCGCGG
GGGCGACGGCTCTAATCCGT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 754; Mature: 754

Protein sequence:

>754_residues
MDGGSKVQFSDREALLYHEHGRPGKIEIVASKPMATQRDLSLAYSPGVAVPVKAIAEDPARAYDYTIKGNLVAVISNGTA
ILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVDTEDPQRFIEAVELLAPSFGGINLEDIAAPNCFIIEAALKERMN
IPVFHDDQHGTAIITAAGLINACYLTGRDLATVKVVVNGAGAAAIACTSLIKSMGVRHENVIMCDRKGTIYQGRTEGMDQ
WKSAHAVPTEARDLTEALVGADVFLGLSAAGALKPEMVKDMAPAPIIFAMANPDPEISPPDARAARPDAIIATGRSDYPN
QVNNVLCFPFIFRGALDVHATAINEEMKIAAAYAIADLARQQVPEEVAAAYGGRASSFGPEYIIPSPFDPRLMEIVPAAV
AKAAMATGVAQKPIADLDAYRTSLRARLNPTTSVLTLAYEAARTNPKRVVFAEGEEETVLRAAIQFRDGGYGTPVLVGRE
GLHDKLRAMGVADAESFEVHNSVNSPHVPAMVDMLYERLQRRGYLRRDVERMVNRDRNIFGSLLLKMGLGDAMITGTTRT
YSQTMREIRRVIDHAEGKTPFGIHVLVDQHHTIFMADTTVNERPSAEMLADIAERTAQVARRMGHEPRVAFLSYSTFGNP
EGSWLENIREAVAILDRRQPAFEYEGEMAPDVALNAKVMKNYPFCRLSGPANVLVMPGLQSANLSAKLLRELGGGAVIGP
MLVGMEHPVQVATMASTASDLVTLAVLAAGGIAQ

Sequences:

>Translated_754_residues
MDGGSKVQFSDREALLYHEHGRPGKIEIVASKPMATQRDLSLAYSPGVAVPVKAIAEDPARAYDYTIKGNLVAVISNGTA
ILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVDTEDPQRFIEAVELLAPSFGGINLEDIAAPNCFIIEAALKERMN
IPVFHDDQHGTAIITAAGLINACYLTGRDLATVKVVVNGAGAAAIACTSLIKSMGVRHENVIMCDRKGTIYQGRTEGMDQ
WKSAHAVPTEARDLTEALVGADVFLGLSAAGALKPEMVKDMAPAPIIFAMANPDPEISPPDARAARPDAIIATGRSDYPN
QVNNVLCFPFIFRGALDVHATAINEEMKIAAAYAIADLARQQVPEEVAAAYGGRASSFGPEYIIPSPFDPRLMEIVPAAV
AKAAMATGVAQKPIADLDAYRTSLRARLNPTTSVLTLAYEAARTNPKRVVFAEGEEETVLRAAIQFRDGGYGTPVLVGRE
GLHDKLRAMGVADAESFEVHNSVNSPHVPAMVDMLYERLQRRGYLRRDVERMVNRDRNIFGSLLLKMGLGDAMITGTTRT
YSQTMREIRRVIDHAEGKTPFGIHVLVDQHHTIFMADTTVNERPSAEMLADIAERTAQVARRMGHEPRVAFLSYSTFGNP
EGSWLENIREAVAILDRRQPAFEYEGEMAPDVALNAKVMKNYPFCRLSGPANVLVMPGLQSANLSAKLLRELGGGAVIGP
MLVGMEHPVQVATMASTASDLVTLAVLAAGGIAQ
>Mature_754_residues
MDGGSKVQFSDREALLYHEHGRPGKIEIVASKPMATQRDLSLAYSPGVAVPVKAIAEDPARAYDYTIKGNLVAVISNGTA
ILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVDTEDPQRFIEAVELLAPSFGGINLEDIAAPNCFIIEAALKERMN
IPVFHDDQHGTAIITAAGLINACYLTGRDLATVKVVVNGAGAAAIACTSLIKSMGVRHENVIMCDRKGTIYQGRTEGMDQ
WKSAHAVPTEARDLTEALVGADVFLGLSAAGALKPEMVKDMAPAPIIFAMANPDPEISPPDARAARPDAIIATGRSDYPN
QVNNVLCFPFIFRGALDVHATAINEEMKIAAAYAIADLARQQVPEEVAAAYGGRASSFGPEYIIPSPFDPRLMEIVPAAV
AKAAMATGVAQKPIADLDAYRTSLRARLNPTTSVLTLAYEAARTNPKRVVFAEGEEETVLRAAIQFRDGGYGTPVLVGRE
GLHDKLRAMGVADAESFEVHNSVNSPHVPAMVDMLYERLQRRGYLRRDVERMVNRDRNIFGSLLLKMGLGDAMITGTTRT
YSQTMREIRRVIDHAEGKTPFGIHVLVDQHHTIFMADTTVNERPSAEMLADIAERTAQVARRMGHEPRVAFLSYSTFGNP
EGSWLENIREAVAILDRRQPAFEYEGEMAPDVALNAKVMKNYPFCRLSGPANVLVMPGLQSANLSAKLLRELGGGAVIGP
MLVGMEHPVQVATMASTASDLVTLAVLAAGGIAQ

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=353, Percent_Identity=29.4617563739377, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI62420882, Length=349, Percent_Identity=27.2206303724928, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI62420880, Length=349, Percent_Identity=27.2206303724928, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI239049447, Length=349, Percent_Identity=27.2206303724928, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1788806, Length=744, Percent_Identity=48.7903225806452, Blast_Score=692, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=339, Percent_Identity=30.9734513274336, Blast_Score=119, Evalue=1e-27,
Organism=Escherichia coli, GI1788800, Length=318, Percent_Identity=28.6163522012579, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322823, Length=269, Percent_Identity=30.1115241635688, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646388, Length=348, Percent_Identity=29.5977011494253, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646386, Length=348, Percent_Identity=29.5977011494253, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281362674, Length=348, Percent_Identity=28.735632183908, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281362672, Length=348, Percent_Identity=28.735632183908, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356279, Length=348, Percent_Identity=28.735632183908, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI78707242, Length=345, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78707238, Length=345, Percent_Identity=26.0869565217391, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI78707240, Length=342, Percent_Identity=26.0233918128655, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81133; Mature: 81133

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGGSKVQFSDREALLYHEHGRPGKIEIVASKPMATQRDLSLAYSPGVAVPVKAIAEDPA
CCCCCEEEECCCCEEEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHCCCH
RAYDYTIKGNLVAVISNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVDTED
HHEEEEECCCEEEEEECCEEEEEECCCCCHHCCCCCCHHHHHHHHHCCCCCEEEEECCCC
PQRFIEAVELLAPSFGGINLEDIAAPNCFIIEAALKERMNIPVFHDDQHGTAIITAAGLI
HHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEHHHHHHCCCCEEECCCCCCEEEEHHHHH
NACYLTGRDLATVKVVVNGAGAAAIACTSLIKSMGVRHENVIMCDRKGTIYQGRTEGMDQ
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCHHH
WKSAHAVPTEARDLTEALVGADVFLGLSAAGALKPEMVKDMAPAPIIFAMANPDPEISPP
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCC
DARAARPDAIIATGRSDYPNQVNNVLCFPFIFRGALDVHATAINEEMKIAAAYAIADLAR
CCCCCCCCEEEECCCCCCCHHHCCEEEEHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
QQVPEEVAAAYGGRASSFGPEYIIPSPFDPRLMEIVPAAVAKAAMATGVAQKPIADLDAY
HHCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RTSLRARLNPTTSVLTLAYEAARTNPKRVVFAEGEEETVLRAAIQFRDGGYGTPVLVGRE
HHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCC
GLHDKLRAMGVADAESFEVHNSVNSPHVPAMVDMLYERLQRRGYLRRDVERMVNRDRNIF
CHHHHHHHHCCCCCCCEEHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
GSLLLKMGLGDAMITGTTRTYSQTMREIRRVIDHAEGKTPFGIHVLVDQHHTIFMADTTV
HHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCC
NERPSAEMLADIAERTAQVARRMGHEPRVAFLSYSTFGNPEGSWLENIREAVAILDRRQP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
AFEYEGEMAPDVALNAKVMKNYPFCRLSGPANVLVMPGLQSANLSAKLLRELGGGAVIGP
CCCCCCCCCCCCEECHHHHCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCEEEHH
MLVGMEHPVQVATMASTASDLVTLAVLAAGGIAQ
HHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDGGSKVQFSDREALLYHEHGRPGKIEIVASKPMATQRDLSLAYSPGVAVPVKAIAEDPA
CCCCCEEEECCCCEEEEECCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCHHHHHCCCH
RAYDYTIKGNLVAVISNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLEVDTED
HHEEEEECCCEEEEEECCEEEEEECCCCCHHCCCCCCHHHHHHHHHCCCCCEEEEECCCC
PQRFIEAVELLAPSFGGINLEDIAAPNCFIIEAALKERMNIPVFHDDQHGTAIITAAGLI
HHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEHHHHHHCCCCEEECCCCCCEEEEHHHHH
NACYLTGRDLATVKVVVNGAGAAAIACTSLIKSMGVRHENVIMCDRKGTIYQGRTEGMDQ
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCCCCHHH
WKSAHAVPTEARDLTEALVGADVFLGLSAAGALKPEMVKDMAPAPIIFAMANPDPEISPP
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCCC
DARAARPDAIIATGRSDYPNQVNNVLCFPFIFRGALDVHATAINEEMKIAAAYAIADLAR
CCCCCCCCEEEECCCCCCCHHHCCEEEEHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHH
QQVPEEVAAAYGGRASSFGPEYIIPSPFDPRLMEIVPAAVAKAAMATGVAQKPIADLDAY
HHCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RTSLRARLNPTTSVLTLAYEAARTNPKRVVFAEGEEETVLRAAIQFRDGGYGTPVLVGRE
HHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCEEECCC
GLHDKLRAMGVADAESFEVHNSVNSPHVPAMVDMLYERLQRRGYLRRDVERMVNRDRNIF
CHHHHHHHHCCCCCCCEEHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHH
GSLLLKMGLGDAMITGTTRTYSQTMREIRRVIDHAEGKTPFGIHVLVDQHHTIFMADTTV
HHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCC
NERPSAEMLADIAERTAQVARRMGHEPRVAFLSYSTFGNPEGSWLENIREAVAILDRRQP
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCC
AFEYEGEMAPDVALNAKVMKNYPFCRLSGPANVLVMPGLQSANLSAKLLRELGGGAVIGP
CCCCCCCCCCCCEECHHHHCCCCEEEECCCCCEEEECCCCCCCHHHHHHHHHCCCEEEHH
MLVGMEHPVQVATMASTASDLVTLAVLAAGGIAQ
HHHCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]