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The map label for this gene is 103487953

Identifier: 103487953

GI number: 103487953

Start: 2613764

End: 2615185

Strand: Reverse

Name: 103487953

Synonym: Sala_2474

Alternate gene names: NA

Gene position: 2615185-2613764 (Counterclockwise)

Preceding gene: 103487954

Following gene: 103487952

Centisome position: 78.18

GC content: 63.43

Gene sequence:

>1422_bases
ATGCAGACAGGGGAAGGGCGAGCGCCATTCGGCGGCGCGGGCGAACGGGACGCCGGCGAGGCAATCTCGATCGCGTTTCT
CGGGGCGGCGGGTACGGTGACCGGCTCGCGATATCTTCTCGGAGATCGCAGCGCGAAGATCATGATCGACTGCGGCCTGT
TTCAGGGTGGTCGTGAGCTTCGTGAACGAAATTGGGAGCCGGCGCTCTCTGACCACCGGGCCATCGACACCATCGTTCTG
ACCCATGCGCATCTCGATCATTCAGGCTATATTCCGCGCTTTGTGAAGGAAGGCTGGAGCGGCCGGATTCTATGCACCGA
CGCCACCGCGGACCTTTGCGGCCTCCTCTTGCCCGACAGCGGCTTTCTCCAGGAGAATGATGCGGCGTTCGCCAATCGCC
ACGGCTATTCGCGCCACAAGCCCGCGCTTCCTCTCTACACGAAGAAGGACGCCGAGGTGGCGCTCGACTATCTCGATCCG
GTCCGCTTCGGGGCATATCGTTCGGTGGCAGGGGGCGCCGAACTTCGCTTCCATCGTGCCGGACATATACTCGGGGCGGC
ATTCGTCGAACTCAAATGGCGTGACCGCACGATCCTCTTCTCGGGAGACCTGGGCCGCTTCAACGATCCGGTCATGCTCG
ATCCCTCGCCTCCCGTGGAAGCGGATTATCTGATCGTCGAATCGACCTATGGCAACCGGAGCCATGAGGCGCTGGATGCC
GTAGCGGCCCTTGGCGATGCCATCGAGCGCTGTGTTCGCCGCGGCGGAACCGTGGTCATTCCGGCCTTCGCCGTCGGCCG
GGCCCAATCCATCCTCTATCATCTATCACGCCTGCGCGCCGCAGGGCGGATCAGCAATGTTCCCGTCTATCTCGATAGCC
CGATGGCAATCGACGCGAGCGGCATCTTCTGCCGCCATGCCGGCGACCACAGGCTGACCGAAGCGGAATGCGATGCCGCT
TGCAAGGTCGCGCGCTATGTTCGCGATGTCGAAGAGTCCAAGGCGCTCACAATGAGTCCGGTGCCCAAGGTCATTATCTC
GGCAAGCGGAATGGCAACAGGTGGCCGCGTTCTCCACCATCTCAAACGTTATGCGCCCGATGGCCGCAACCTCATTCTGT
TCGCCGGCTTCCAGGCGTCCGGCACGCGCGGCGCTGCAATGGTGGCGGGTGCTCCCAGCGTCAAGATCCATGGCGAACAG
GTTCCCGTGCGAGCCGAGGTGCGCAATCTTTCGATGCTGTCCGCGCACGCCGATGCCGACGAGATACTGAAGTGGCTCGG
CCAGTTCGTACGGGCGCCCCGGATGACGTTCATCACCCATGGTGAGCCCGATGCCGCGGCCGCTCTTGCGCGGCGCATCG
GCGACGAGCTCGGCTGGCCGTGCCAGATACCCGGCCTTGGTGATCGAGTGGTGCTCGAATGA

Upstream 100 bases:

>100_bases
CCGGTTTGCTTGGGTCCGTCTTTGCGGTTATTGCGTATTCCCGGCCCGGTCATTTGCGGCGATCTCCTCAGCCCATGGTT
CAACAGGCTGGGTAGAGACG

Downstream 100 bases:

>100_bases
CCCACCCCGTCCCGGATACCGGACCCGCGTCGGAGAATATGGCACCCCATCGCCTCCGGGCTCGGCCCCTCGGCCTGTTC
CTGCCGCAGCAACAACCGGC

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MQTGEGRAPFGGAGERDAGEAISIAFLGAAGTVTGSRYLLGDRSAKIMIDCGLFQGGRELRERNWEPALSDHRAIDTIVL
THAHLDHSGYIPRFVKEGWSGRILCTDATADLCGLLLPDSGFLQENDAAFANRHGYSRHKPALPLYTKKDAEVALDYLDP
VRFGAYRSVAGGAELRFHRAGHILGAAFVELKWRDRTILFSGDLGRFNDPVMLDPSPPVEADYLIVESTYGNRSHEALDA
VAALGDAIERCVRRGGTVVIPAFAVGRAQSILYHLSRLRAAGRISNVPVYLDSPMAIDASGIFCRHAGDHRLTEAECDAA
CKVARYVRDVEESKALTMSPVPKVIISASGMATGGRVLHHLKRYAPDGRNLILFAGFQASGTRGAAMVAGAPSVKIHGEQ
VPVRAEVRNLSMLSAHADADEILKWLGQFVRAPRMTFITHGEPDAAAALARRIGDELGWPCQIPGLGDRVVLE

Sequences:

>Translated_473_residues
MQTGEGRAPFGGAGERDAGEAISIAFLGAAGTVTGSRYLLGDRSAKIMIDCGLFQGGRELRERNWEPALSDHRAIDTIVL
THAHLDHSGYIPRFVKEGWSGRILCTDATADLCGLLLPDSGFLQENDAAFANRHGYSRHKPALPLYTKKDAEVALDYLDP
VRFGAYRSVAGGAELRFHRAGHILGAAFVELKWRDRTILFSGDLGRFNDPVMLDPSPPVEADYLIVESTYGNRSHEALDA
VAALGDAIERCVRRGGTVVIPAFAVGRAQSILYHLSRLRAAGRISNVPVYLDSPMAIDASGIFCRHAGDHRLTEAECDAA
CKVARYVRDVEESKALTMSPVPKVIISASGMATGGRVLHHLKRYAPDGRNLILFAGFQASGTRGAAMVAGAPSVKIHGEQ
VPVRAEVRNLSMLSAHADADEILKWLGQFVRAPRMTFITHGEPDAAAALARRIGDELGWPCQIPGLGDRVVLE
>Mature_473_residues
MQTGEGRAPFGGAGERDAGEAISIAFLGAAGTVTGSRYLLGDRSAKIMIDCGLFQGGRELRERNWEPALSDHRAIDTIVL
THAHLDHSGYIPRFVKEGWSGRILCTDATADLCGLLLPDSGFLQENDAAFANRHGYSRHKPALPLYTKKDAEVALDYLDP
VRFGAYRSVAGGAELRFHRAGHILGAAFVELKWRDRTILFSGDLGRFNDPVMLDPSPPVEADYLIVESTYGNRSHEALDA
VAALGDAIERCVRRGGTVVIPAFAVGRAQSILYHLSRLRAAGRISNVPVYLDSPMAIDASGIFCRHAGDHRLTEAECDAA
CKVARYVRDVEESKALTMSPVPKVIISASGMATGGRVLHHLKRYAPDGRNLILFAGFQASGTRGAAMVAGAPSVKIHGEQ
VPVRAEVRNLSMLSAHADADEILKWLGQFVRAPRMTFITHGEPDAAAALARRIGDELGWPCQIPGLGDRVVLE

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=432, Percent_Identity=27.5462962962963, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI33300633, Length=469, Percent_Identity=26.0127931769723, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32564696, Length=473, Percent_Identity=27.6955602536998, Blast_Score=151, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI32566029, Length=441, Percent_Identity=26.530612244898, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323307, Length=452, Percent_Identity=25.8849557522124, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24648013, Length=458, Percent_Identity=27.0742358078603, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21358523, Length=474, Percent_Identity=27.0042194092827, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 51063; Mature: 51063

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTGEGRAPFGGAGERDAGEAISIAFLGAAGTVTGSRYLLGDRSAKIMIDCGLFQGGREL
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCHHH
RERNWEPALSDHRAIDTIVLTHAHLDHSGYIPRFVKEGWSGRILCTDATADLCGLLLPDS
HHCCCCCCCCCCHHEEEEEEEEEECCCCCCCCHHHHCCCCCEEEEECCCHHHHHEECCCC
GFLQENDAAFANRHGYSRHKPALPLYTKKDAEVALDYLDPVRFGAYRSVAGGAELRFHRA
CCCCCCCCHHHHCCCCCCCCCCCCEEECCCHHHHHHHHCCHHHCCHHHCCCCCEEEEECC
GHILGAAFVELKWRDRTILFSGDLGRFNDPVMLDPSPPVEADYLIVESTYGNRSHEALDA
CCEEEEEEEEEEECCEEEEEECCCCCCCCCEEECCCCCCCCCEEEEEECCCCCHHHHHHH
VAALGDAIERCVRRGGTVVIPAFAVGRAQSILYHLSRLRAAGRISNVPVYLDSPMAIDAS
HHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEECCC
GIFCRHAGDHRLTEAECDAACKVARYVRDVEESKALTMSPVPKVIISASGMATGGRVLHH
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCHHHHHHH
LKRYAPDGRNLILFAGFQASGTRGAAMVAGAPSVKIHGEQVPVRAEVRNLSMLSAHADAD
HHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHCCEEHCCCCCHH
EILKWLGQFVRAPRMTFITHGEPDAAAALARRIGDELGWPCQIPGLGDRVVLE
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCEEEEC
>Mature Secondary Structure
MQTGEGRAPFGGAGERDAGEAISIAFLGAAGTVTGSRYLLGDRSAKIMIDCGLFQGGREL
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCHHH
RERNWEPALSDHRAIDTIVLTHAHLDHSGYIPRFVKEGWSGRILCTDATADLCGLLLPDS
HHCCCCCCCCCCHHEEEEEEEEEECCCCCCCCHHHHCCCCCEEEEECCCHHHHHEECCCC
GFLQENDAAFANRHGYSRHKPALPLYTKKDAEVALDYLDPVRFGAYRSVAGGAELRFHRA
CCCCCCCCHHHHCCCCCCCCCCCCEEECCCHHHHHHHHCCHHHCCHHHCCCCCEEEEECC
GHILGAAFVELKWRDRTILFSGDLGRFNDPVMLDPSPPVEADYLIVESTYGNRSHEALDA
CCEEEEEEEEEEECCEEEEEECCCCCCCCCEEECCCCCCCCCEEEEEECCCCCHHHHHHH
VAALGDAIERCVRRGGTVVIPAFAVGRAQSILYHLSRLRAAGRISNVPVYLDSPMAIDAS
HHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEECCC
GIFCRHAGDHRLTEAECDAACKVARYVRDVEESKALTMSPVPKVIISASGMATGGRVLHH
CEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCHHHHHHH
LKRYAPDGRNLILFAGFQASGTRGAAMVAGAPSVKIHGEQVPVRAEVRNLSMLSAHADAD
HHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHCCEEHCCCCCHH
EILKWLGQFVRAPRMTFITHGEPDAAAALARRIGDELGWPCQIPGLGDRVVLE
HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA