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The map label for this gene is hflC [H]

Identifier: 103487729

GI number: 103487729

Start: 2361286

End: 2362137

Strand: Reverse

Name: hflC [H]

Synonym: Sala_2248

Alternate gene names: 103487729

Gene position: 2362137-2361286 (Counterclockwise)

Preceding gene: 103487730

Following gene: 103487728

Centisome position: 70.61

GC content: 62.91

Gene sequence:

>852_bases
ATGTTCGCGCCGCTTTTCCGCAATCCCGTGCGCCTGCTGGTCGGCATCGTCGCCCTGCTGGTGCTGTTGTCGATGACGGT
GTCGATCGTGCCGGAGGACCGGCAGGCGGTCGTGCTGCGCGTCGGTGAGGTTTATGGCACCAAAAACGCCTATAAGCCGG
GCGAACAATTCGGCCGTTCGGGCGCCGGACTGCTCTTCACCATGCCCTTCGCCGATTCGGTGCAGCTGATCGACAAGCGC
ATCCTGGGCATCAACATGGAGCGCCAGCAGGTGCTCTCGACCGATCAGCAGCGATTGCAGGTCGACGCCTTTGCGCGCTT
CCGCATCACCAATCCGGTGCGTATGTATACCGCGATCCGCACCGAGGAGCGCTTGCAGCAGCAGCTCGCGACGATCCTCG
GTTCGTCGCTGCGCAACGAACTGGGCAAGCGGACCTTTGCCACCTTGCTGTCGGCCGAACGCGGCGCCGTGATGGACAAT
ATCCAGGTGGCCTTGAACCGCGAGGCGCAGAAATATGGCGCCGCGATCATCGACGTCAGGATCAAGCGCGCCGACCTGCC
CGAAGGCGCGACGCTGGAAGCCGCCTACAACCGGATGCGCACCGCGCGGCAGCAGGAAGCGATCTCGATCCGCGCCGAAG
GGCAGAAGGAAGCGCAGATCATCCGCGGCAGCGCCGACGGCGAAGCGGCGCGCATCTATGCCGCCAGCTTTGGCAAGGAT
CCCGAATTTTACGATTTCTACCGCGCGATGCAGAGCTATCGGCAGACCTTCCTCGGCGAGAACAACGAGGGCGGAACGTC
GATCATCCTGTCGCCTGACAATGAATATCTGAAACGGTTCAGCGGCGGATAG

Upstream 100 bases:

>100_bases
AGACGATTGTCGAAGCGCGCGGGGTGACCCCCTATCTGCCGCTCAACGAGGTCCAGAGACGACTGCGCGCGCCCGAAGCC
GTGACAAAGGGAGGCGAATG

Downstream 100 bases:

>100_bases
TCGCGCCCATCGCGCCGATGAACGGAACGTCTCGCGCTTGTTCATGTTCAATCGGCGTTCAGCCGCCCCGCCGCAGAGAC
CGGCGGCCGGGGTTTGAAGT

Product: band 7 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MFAPLFRNPVRLLVGIVALLVLLSMTVSIVPEDRQAVVLRVGEVYGTKNAYKPGEQFGRSGAGLLFTMPFADSVQLIDKR
ILGINMERQQVLSTDQQRLQVDAFARFRITNPVRMYTAIRTEERLQQQLATILGSSLRNELGKRTFATLLSAERGAVMDN
IQVALNREAQKYGAAIIDVRIKRADLPEGATLEAAYNRMRTARQQEAISIRAEGQKEAQIIRGSADGEAARIYAASFGKD
PEFYDFYRAMQSYRQTFLGENNEGGTSIILSPDNEYLKRFSGG

Sequences:

>Translated_283_residues
MFAPLFRNPVRLLVGIVALLVLLSMTVSIVPEDRQAVVLRVGEVYGTKNAYKPGEQFGRSGAGLLFTMPFADSVQLIDKR
ILGINMERQQVLSTDQQRLQVDAFARFRITNPVRMYTAIRTEERLQQQLATILGSSLRNELGKRTFATLLSAERGAVMDN
IQVALNREAQKYGAAIIDVRIKRADLPEGATLEAAYNRMRTARQQEAISIRAEGQKEAQIIRGSADGEAARIYAASFGKD
PEFYDFYRAMQSYRQTFLGENNEGGTSIILSPDNEYLKRFSGG
>Mature_283_residues
MFAPLFRNPVRLLVGIVALLVLLSMTVSIVPEDRQAVVLRVGEVYGTKNAYKPGEQFGRSGAGLLFTMPFADSVQLIDKR
ILGINMERQQVLSTDQQRLQVDAFARFRITNPVRMYTAIRTEERLQQQLATILGSSLRNELGKRTFATLLSAERGAVMDN
IQVALNREAQKYGAAIIDVRIKRADLPEGATLEAAYNRMRTARQQEAISIRAEGQKEAQIIRGSADGEAARIYAASFGKD
PEFYDFYRAMQSYRQTFLGENNEGGTSIILSPDNEYLKRFSGG

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI21686995, Length=175, Percent_Identity=26.8571428571429, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI221316744, Length=175, Percent_Identity=26.8571428571429, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790617, Length=321, Percent_Identity=25.5451713395639, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71987621, Length=164, Percent_Identity=31.0975609756098, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71987612, Length=164, Percent_Identity=31.0975609756098, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25153583, Length=169, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71989955, Length=167, Percent_Identity=29.940119760479, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71989948, Length=167, Percent_Identity=29.940119760479, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569499, Length=269, Percent_Identity=29.7397769516729, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569497, Length=283, Percent_Identity=25.4416961130742, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71989963, Length=137, Percent_Identity=32.8467153284672, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17570459, Length=275, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17570161, Length=217, Percent_Identity=25.8064516129032, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193210507, Length=217, Percent_Identity=25.8064516129032, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32566490, Length=182, Percent_Identity=26.3736263736264, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193209764, Length=204, Percent_Identity=26.4705882352941, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=204, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18860517, Length=271, Percent_Identity=25.4612546125461, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45556022, Length=280, Percent_Identity=26.4285714285714, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24657857, Length=183, Percent_Identity=27.3224043715847, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281365664, Length=183, Percent_Identity=27.3224043715847, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI62484448, Length=183, Percent_Identity=27.3224043715847, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62484274, Length=183, Percent_Identity=27.3224043715847, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 31609; Mature: 31609

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAPLFRNPVRLLVGIVALLVLLSMTVSIVPEDRQAVVLRVGEVYGTKNAYKPGEQFGRS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCCHHHHCCC
GAGLLFTMPFADSVQLIDKRILGINMERQQVLSTDQQRLQVDAFARFRITNPVRMYTAIR
CCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
TEERLQQQLATILGSSLRNELGKRTFATLLSAERGAVMDNIQVALNREAQKYGAAIIDVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHCCEEEEEE
IKRADLPEGATLEAAYNRMRTARQQEAISIRAEGQKEAQIIRGSADGEAARIYAASFGKD
EEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHEEECCCCCCCEEEEEECCCCC
PEFYDFYRAMQSYRQTFLGENNEGGTSIILSPDNEYLKRFSGG
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCC
>Mature Secondary Structure
MFAPLFRNPVRLLVGIVALLVLLSMTVSIVPEDRQAVVLRVGEVYGTKNAYKPGEQFGRS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHCCCCCCCCHHHHCCC
GAGLLFTMPFADSVQLIDKRILGINMERQQVLSTDQQRLQVDAFARFRITNPVRMYTAIR
CCCEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
TEERLQQQLATILGSSLRNELGKRTFATLLSAERGAVMDNIQVALNREAQKYGAAIIDVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHHCCEEEEEE
IKRADLPEGATLEAAYNRMRTARQQEAISIRAEGQKEAQIIRGSADGEAARIYAASFGKD
EEECCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCHHHHEEECCCCCCCEEEEEECCCCC
PEFYDFYRAMQSYRQTFLGENNEGGTSIILSPDNEYLKRFSGG
CHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]