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The map label for this gene is sppA [H]

Identifier: 103487702

GI number: 103487702

Start: 2331783

End: 2333768

Strand: Direct

Name: sppA [H]

Synonym: Sala_2221

Alternate gene names: 103487702

Gene position: 2331783-2333768 (Clockwise)

Preceding gene: 103487701

Following gene: 103487705

Centisome position: 69.71

GC content: 67.77

Gene sequence:

>1986_bases
ATGACCGACAGCACCGCGACCACGCCCAACGATCCCGCCGGCCCCTGGGCCATTCCCGTCCGTCGGCCGCTACCGGGCGA
GGACAAGCCGCGCAGCACCACGAGCTTTCCGCGCAAGGTCTGGAAACTGCTCGTCGCGATCAAGGATGCGCTGGCGCTGA
TCTTCCTGCTGCTTTTCTTCGTGGCGCTGTTCGGGCTGCTCGCGGGGCGCCCCAATGCGGGCCTGCCGGTCAGCGAGGGT
GCGCTGCTGATCGAGCTTGACGGCATCGTCACCGAACAGCCGACCGAAACCGATCCCTTCGCGGCGCTGTCGGGCGGCCC
GCAACTCAAGGAAATCCGCACGCGCGATGTCGTCCACGCGCTCGAAACCGCGGCTTCGGACAAGCGCATCACCTCGGTCG
TGCTCGACCTCGACCGCTTCCTCGGCGGCGGGCAGGTGTCGCTCGCCGAAATCGGCGGCGCCATCGACAAGGTGCGCGCA
AAGAAAAAGCCGGTGCTGGCCTTTGCCACCGCCTATACCACGGACAGCTATCAGATCGCCGCACATGCGAGCGAAATCTG
GGCCGACAGTATCGGCGGCGTCGCGATTGCGGGACCGGGCGGGTCGCGCCTCTATTACAAAGGGTTGATGGACCGGCTGG
GCATCACCGCGAACATCTATCGCGTCGGCACCTTCAAAAGCGCGGTCGAGCCATATCTCCGCAGCGACCAGTCGCCCGAA
GCGAAGGAAGCCAACCTCGCCTATGCCAGCGTCCTGTGGGACAATTGGCTGGCGGATGTGAAGAAAGCGCGCCCGGCGGC
CAAGCTCGACGCCTATATCGCCGATACCGTCGGCGCGGTGCGCGCGGCGGGCAATGACCTGTCGAAGGCTTCGCTCGACG
CAGGGCTGGTCGACAGGCTCGGCAGCCGCATGGCGTTCAGCCGCCGCGTCGCCGAAATCAGCGGCGCGACCGACGAGGGC
AAGCCGTGGGAGTTCAACGCCATCCCGCTCGAAAACTGGGTCGCCGCCAATCCGCCCGCAGAAAAGGGCAGCGCGATCGC
GGTTGTCCCCGTCGTCGGCGACATCGTCGATGGCGAGGCGCCGACGGGGCTTGCCGGCGGCACGACGATCGCCGAGCACA
TCCTCGACGCCGCCACCGACAGCAGCGTCAAGGCGATCGTCCTGCGCGTCGATTCGCCCGGCGGATCCGTGCTGGCGTCG
GAGGAGATCCGCCAGGCGCTGCTCGCGGCCAAGGCCAGGAAGCTGCCCGTCGTCGTGTCGATGGCGAATGTCGCCGCGTC
GGGCGGTTATTGGATTTCGACCCCGGCAGACCGCATCTTTGCCGAACCCGAAACGATCACCGGGTCGATCGGCGTGTTCG
GCATCCTGCCGAGCTTCGATCGGGCGCTGGCCAAGATCGGCGTCAACGCCGACGGCATCGCCACGACGCCGCTGTCGGGG
CAGCCCGACATCTTCGGCGGCGTGAACGAGGAGTTCAACGCGCTGGCGCAGGCGAGCGTCGAGGACGTCTATACGCGCTT
CACCGGGCTGGTCGCCAAGAGCCGCAAGCAGCCGCTCGACAAGATCCTGCCGATCGCCGAAGGGCGCGTCTGGGCGGGCG
GCACCGCGCGCCAGCTTGGCCTCGTCGACCAGTTCGGCGGCCTCCCCGAAGCGCTCGCCGCCGCGGCGAAACTCGCCAAG
GTCGAGGGCGATTTCCACGCCAGATATTTCGAGGAAGAGCCGAGCGAATTGTCCAGGCTGCTCGCCAACTGGTCGGGCGC
CGGAGAAGAGGAAACCGCGGCGCTCCCGCGCGGCTGGTTCGGCATCGCGGCGATGAACCGCCAGCTCACCGAGCGACGGC
TGGTGCAGGATCTGGCGCTGCTCACGCGGGTGGGGTCGGTCCAGGCGGCCTGCCTCGACTGCCGCGCCTATCTGCCTGCC
ATCCCGCGGCCGGGCAAGCGCGAGGCGCAGGGCTTTCTTGCGACGCTGGCGATGTTGTTGAAATAA

Upstream 100 bases:

>100_bases
GGATGACAGATTGAGGGAATACCGACCGCCCATGCGCTCCCATCGCCCGCCCGTCGAAGCGTGCATTGCCAACGACCGGG
CGCATCCCTAGATTTGACCG

Downstream 100 bases:

>100_bases
TCCCCCCGCTTGCGGGAGGGGTTAGGGGAGGGCCTGTTCAGGCAGCTCTCCCCGAGCGACATGTCCTCCCCCGACCCCTC
CCATAAATGGGAGGCGAGAT

Product: signal peptide peptidase SppA, 67K type

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MTDSTATTPNDPAGPWAIPVRRPLPGEDKPRSTTSFPRKVWKLLVAIKDALALIFLLLFFVALFGLLAGRPNAGLPVSEG
ALLIELDGIVTEQPTETDPFAALSGGPQLKEIRTRDVVHALETAASDKRITSVVLDLDRFLGGGQVSLAEIGGAIDKVRA
KKKPVLAFATAYTTDSYQIAAHASEIWADSIGGVAIAGPGGSRLYYKGLMDRLGITANIYRVGTFKSAVEPYLRSDQSPE
AKEANLAYASVLWDNWLADVKKARPAAKLDAYIADTVGAVRAAGNDLSKASLDAGLVDRLGSRMAFSRRVAEISGATDEG
KPWEFNAIPLENWVAANPPAEKGSAIAVVPVVGDIVDGEAPTGLAGGTTIAEHILDAATDSSVKAIVLRVDSPGGSVLAS
EEIRQALLAAKARKLPVVVSMANVAASGGYWISTPADRIFAEPETITGSIGVFGILPSFDRALAKIGVNADGIATTPLSG
QPDIFGGVNEEFNALAQASVEDVYTRFTGLVAKSRKQPLDKILPIAEGRVWAGGTARQLGLVDQFGGLPEALAAAAKLAK
VEGDFHARYFEEEPSELSRLLANWSGAGEEETAALPRGWFGIAAMNRQLTERRLVQDLALLTRVGSVQAACLDCRAYLPA
IPRPGKREAQGFLATLAMLLK

Sequences:

>Translated_661_residues
MTDSTATTPNDPAGPWAIPVRRPLPGEDKPRSTTSFPRKVWKLLVAIKDALALIFLLLFFVALFGLLAGRPNAGLPVSEG
ALLIELDGIVTEQPTETDPFAALSGGPQLKEIRTRDVVHALETAASDKRITSVVLDLDRFLGGGQVSLAEIGGAIDKVRA
KKKPVLAFATAYTTDSYQIAAHASEIWADSIGGVAIAGPGGSRLYYKGLMDRLGITANIYRVGTFKSAVEPYLRSDQSPE
AKEANLAYASVLWDNWLADVKKARPAAKLDAYIADTVGAVRAAGNDLSKASLDAGLVDRLGSRMAFSRRVAEISGATDEG
KPWEFNAIPLENWVAANPPAEKGSAIAVVPVVGDIVDGEAPTGLAGGTTIAEHILDAATDSSVKAIVLRVDSPGGSVLAS
EEIRQALLAAKARKLPVVVSMANVAASGGYWISTPADRIFAEPETITGSIGVFGILPSFDRALAKIGVNADGIATTPLSG
QPDIFGGVNEEFNALAQASVEDVYTRFTGLVAKSRKQPLDKILPIAEGRVWAGGTARQLGLVDQFGGLPEALAAAAKLAK
VEGDFHARYFEEEPSELSRLLANWSGAGEEETAALPRGWFGIAAMNRQLTERRLVQDLALLTRVGSVQAACLDCRAYLPA
IPRPGKREAQGFLATLAMLLK
>Mature_660_residues
TDSTATTPNDPAGPWAIPVRRPLPGEDKPRSTTSFPRKVWKLLVAIKDALALIFLLLFFVALFGLLAGRPNAGLPVSEGA
LLIELDGIVTEQPTETDPFAALSGGPQLKEIRTRDVVHALETAASDKRITSVVLDLDRFLGGGQVSLAEIGGAIDKVRAK
KKPVLAFATAYTTDSYQIAAHASEIWADSIGGVAIAGPGGSRLYYKGLMDRLGITANIYRVGTFKSAVEPYLRSDQSPEA
KEANLAYASVLWDNWLADVKKARPAAKLDAYIADTVGAVRAAGNDLSKASLDAGLVDRLGSRMAFSRRVAEISGATDEGK
PWEFNAIPLENWVAANPPAEKGSAIAVVPVVGDIVDGEAPTGLAGGTTIAEHILDAATDSSVKAIVLRVDSPGGSVLASE
EIRQALLAAKARKLPVVVSMANVAASGGYWISTPADRIFAEPETITGSIGVFGILPSFDRALAKIGVNADGIATTPLSGQ
PDIFGGVNEEFNALAQASVEDVYTRFTGLVAKSRKQPLDKILPIAEGRVWAGGTARQLGLVDQFGGLPEALAAAAKLAKV
EGDFHARYFEEEPSELSRLLANWSGAGEEETAALPRGWFGIAAMNRQLTERRLVQDLALLTRVGSVQAACLDCRAYLPAI
PRPGKREAQGFLATLAMLLK

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=568, Percent_Identity=39.0845070422535, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1787527, Length=217, Percent_Identity=28.110599078341, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 69789; Mature: 69658

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTATTPNDPAGPWAIPVRRPLPGEDKPRSTTSFPRKVWKLLVAIKDALALIFLLLFF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VALFGLLAGRPNAGLPVSEGALLIELDGIVTEQPTETDPFAALSGGPQLKEIRTRDVVHA
HHHHHHHCCCCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LETAASDKRITSVVLDLDRFLGGGQVSLAEIGGAIDKVRAKKKPVLAFATAYTTDSYQIA
HHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHCCHHHHHHHCCCCEEEEEEEECCCCEEEE
AHASEIWADSIGGVAIAGPGGSRLYYKGLMDRLGITANIYRVGTFKSAVEPYLRSDQSPE
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCC
AKEANLAYASVLWDNWLADVKKARPAAKLDAYIADTVGAVRAAGNDLSKASLDAGLVDRL
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GSRMAFSRRVAEISGATDEGKPWEFNAIPLENWVAANPPAEKGSAIAVVPVVGDIVDGEA
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECHHCCCCC
PTGLAGGTTIAEHILDAATDSSVKAIVLRVDSPGGSVLASEEIRQALLAAKARKLPVVVS
CCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCEEEE
MANVAASGGYWISTPADRIFAEPETITGSIGVFGILPSFDRALAKIGVNADGIATTPLSG
EHHHHCCCCEEEECCHHHHCCCCCCCCCCCHHEECCCHHHHHHHHHCCCCCCEEECCCCC
QPDIFGGVNEEFNALAQASVEDVYTRFTGLVAKSRKQPLDKILPIAEGRVWAGGTARQLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCCCHHHHC
LVDQFGGLPEALAAAAKLAKVEGDFHARYFEEEPSELSRLLANWSGAGEEETAALPRGWF
CHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCCHH
GIAAMNRQLTERRLVQDLALLTRVGSVQAACLDCRAYLPAIPRPGKREAQGFLATLAMLL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
K
C
>Mature Secondary Structure 
TDSTATTPNDPAGPWAIPVRRPLPGEDKPRSTTSFPRKVWKLLVAIKDALALIFLLLFF
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VALFGLLAGRPNAGLPVSEGALLIELDGIVTEQPTETDPFAALSGGPQLKEIRTRDVVHA
HHHHHHHCCCCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LETAASDKRITSVVLDLDRFLGGGQVSLAEIGGAIDKVRAKKKPVLAFATAYTTDSYQIA
HHHHCCCHHHHHHHHHHHHHCCCCCEEHHHHCCHHHHHHHCCCCEEEEEEEECCCCEEEE
AHASEIWADSIGGVAIAGPGGSRLYYKGLMDRLGITANIYRVGTFKSAVEPYLRSDQSPE
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHCCCCCC
AKEANLAYASVLWDNWLADVKKARPAAKLDAYIADTVGAVRAAGNDLSKASLDAGLVDRL
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GSRMAFSRRVAEISGATDEGKPWEFNAIPLENWVAANPPAEKGSAIAVVPVVGDIVDGEA
HHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEEEECHHCCCCC
PTGLAGGTTIAEHILDAATDSSVKAIVLRVDSPGGSVLASEEIRQALLAAKARKLPVVVS
CCCCCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCEEEE
MANVAASGGYWISTPADRIFAEPETITGSIGVFGILPSFDRALAKIGVNADGIATTPLSG
EHHHHCCCCEEEECCHHHHCCCCCCCCCCCHHEECCCHHHHHHHHHCCCCCCEEECCCCC
QPDIFGGVNEEFNALAQASVEDVYTRFTGLVAKSRKQPLDKILPIAEGRVWAGGTARQLG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCCCHHHHC
LVDQFGGLPEALAAAAKLAKVEGDFHARYFEEEPSELSRLLANWSGAGEEETAALPRGWF
CHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHCCCCHH
GIAAMNRQLTERRLVQDLALLTRVGSVQAACLDCRAYLPAIPRPGKREAQGFLATLAMLL
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3522590; 9097039; 9278503; 7973728 [H]