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The map label for this gene is purL [H]

Identifier: 103487678

GI number: 103487678

Start: 2308085

End: 2310328

Strand: Direct

Name: purL [H]

Synonym: Sala_2197

Alternate gene names: 103487678

Gene position: 2308085-2310328 (Clockwise)

Preceding gene: 103487677

Following gene: 103487679

Centisome position: 69.0

GC content: 65.95

Gene sequence:

>2244_bases
ATGACTCAGCCAGCGCCCGCCATCACCCCCGAAATCGTCGCCGAGCACGGCCTTGCTCCGCAAGAATATGAGCGCGTCCT
CGCCGCGCTCGGGCGCGAGCCGAACCTGGTCGAACTGGGTATCTTCTCGGTCATGTGGTCGGAGCATTGCAGCTATAAAA
GCTCGCGCATCCATCTGAAGAAGCTGCCGACCGAGGCGCCGTGGGTGATCTGCGGCCCCGGCGAGAATGCCGGGGTGATC
GACATCGGCGAAGGACCGGACGGCAAGAAGCTCGCCGCGATCTTCAAGATGGAGAGTCACAACCACCCAAGCTACATCGA
ACCCTATCAGGGGGCGGCCACGGGAGTCGGCGGGATCCTGCGCGACGTCTTCACCATGGGCGCGCGCCCGGTCGCGAACC
TCAACGCGCTGCGCTTCGGGCGGCCCGACCATCCGAAGATGCGGCACCTGATCGCGGGGGTCGTCCACGGCATCGGCGGC
TATGGCAATTGCGTCGGCGTGCCGACCGTCGGCGGCGAGGTCAATTTCCATGCCGCCTATGACGGCAATATCCTCGTCAA
CGCGATGACCGTCGGCGTCGCCGAACAGGACAGGATCTTCTATTCGGCCGCATCGGGCGTCGGCAATCCGATCGTCTATG
TCGGCTCGAAAACCGGCCGCGACGGCATCCACGGCGCGACGATGGCGAGTGCCGATTTCGGCGAGGATGCGGAGGAAAAG
CGCCCGACGGTGCAGGTCGGCGACCCCTTTACCGAAAAGCTGCTGATCGAGGCGTGCCTCGAACTGATGGCGTCGGACGC
GATCGTCGCGATCCAGGACATGGGCGCCGCGGGCCTGACCAGTTCGTCGGTCGAAATGGCGTCGAAGGGCGGCGTCGGCA
TCCACCTCAGGATGGACGATGTGCCGCAGCGTGAAACCGGCATGACGGCCTATGAAATGATGCTGTCGGAAAGCCAGGAA
CGCATGTTGATGGTGCTGAAGCCCGGCAAGGAAGAGTTTGCGAAGGCGATCTTCCACAAATGGGAACTCGACTTCGCGGT
CATCGGCACCGTCACCGACACCGGCCGCATGGTGCTCGAACATCATGGGCAAATCGTCTGCGACATTCCGCTCGCCCCGC
TCGCCGACGATGCGCCCCTTTACGACCGTCCGCATGTGCCCACGCCGAAGCAGCCCGAACTGTCCGACGTCCCGGAGACC
AAGGATGTCGCGGCCGACCTCAAGGCCTTGATGGGCACCCCCGATATCGCCAGCCGCCGCTGGATCTGGGAGCAATATGA
CAGCCAGGTCGGCGCCGACACGGTGCAGACCGGCGGCGACGCCGCGCTGGTCCGCATCCACGGCACCAACCGCGCGCTCG
CGATGAGCACCGACTGCACCCCGCGCTATTGCTACGCCGATCCGGTCGAGGGCGGCAAGCAGGCGGTCGCCGAAACGTGG
CGCAACATCAGCGCGGTCGGCGCGACGCCGCTCGCGATCACCAACTGCCTCAATTTCGCCAACCCGCAGCGCCCCGAAAT
CATGGGCCAGATCGTCGGCTGCCTCGACGGCATGGCACAGGCGTGCCGCGCGCTCGACTATCCGATCGTGTCGGGCAACG
TCAGCCTCTACAACGAGTCCAAGGCGACGGGTGGCGGCAGCGCGATCCTGCCGACCCCCGCGATCGGCGGCGTCGGCGTG
ATCGAGGATCTGGGCAAAGCGGTCGGCATCGGCTTCAAGCGCACCGGCGACATCGTCCTCGCGGTCGGCGAACGCATGGG
CCACCTCGGCCAGTCGATCTGGCTGCGCGAAATCCACGGCCGCGAAGAAGGCCCGCCGCCGCCCGTCGACCTCAAGGCCG
AGAAGCGCACCGGCGATTTCATCCGCCAAAGCATCAACGCCGGCTGGATCACCGCGTGCCACGACGTCTCCGACGGCGGC
GTCGCCGTGGCGCTCGCCGAAATGGCCTTGAAGTCGAACATCGGCGTGCTGGTGAGCGAGGAACAGCCGTTCGGGGTGGC
GGAGAGCTTCTTCGGCGAGGATCAGGGGCTGTATCTCGTCACCGTCTGCGACACCTGCCTTGCCGACTTCCTCGACGCCG
CGAATCGCGCCGACGTGCCCGTCGATCCGCTCGGGCGCACGATCAAGGATCGCATCGTGTTCGAGCTGCCCGACAGCGAT
CATCAGGTGACGCTCGCCGAACTGCGCGAAGCGCATGAAGGCTTCTTCCCCAAGCTGATGGGCGCCGACGCGGCGCTGGC
GTAA

Upstream 100 bases:

>100_bases
GCTCGCTTCGCGCTGATCGCGTCTCCGACGGCAGGCCCCTGTCGCCCAAAAGGCGATATGGGGTCTGTTCGTTTCGCCCG
CGCGCCGCTAAAGGCGCGCC

Downstream 100 bases:

>100_bases
CAACCCCACCTCGTCATTCCGGCGAAGGCCGGAATCTCGCCGGTGCGGCATAACGCGACGATGAGATCCCGGCCTCCGCC
GGGATGACGATATAAGGAGG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTQPAPAITPEIVAEHGLAPQEYERVLAALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPTEAPWVICGPGENAGVI
DIGEGPDGKKLAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANLNALRFGRPDHPKMRHLIAGVVHGIGG
YGNCVGVPTVGGEVNFHAAYDGNILVNAMTVGVAEQDRIFYSAASGVGNPIVYVGSKTGRDGIHGATMASADFGEDAEEK
RPTVQVGDPFTEKLLIEACLELMASDAIVAIQDMGAAGLTSSSVEMASKGGVGIHLRMDDVPQRETGMTAYEMMLSESQE
RMLMVLKPGKEEFAKAIFHKWELDFAVIGTVTDTGRMVLEHHGQIVCDIPLAPLADDAPLYDRPHVPTPKQPELSDVPET
KDVAADLKALMGTPDIASRRWIWEQYDSQVGADTVQTGGDAALVRIHGTNRALAMSTDCTPRYCYADPVEGGKQAVAETW
RNISAVGATPLAITNCLNFANPQRPEIMGQIVGCLDGMAQACRALDYPIVSGNVSLYNESKATGGGSAILPTPAIGGVGV
IEDLGKAVGIGFKRTGDIVLAVGERMGHLGQSIWLREIHGREEGPPPPVDLKAEKRTGDFIRQSINAGWITACHDVSDGG
VAVALAEMALKSNIGVLVSEEQPFGVAESFFGEDQGLYLVTVCDTCLADFLDAANRADVPVDPLGRTIKDRIVFELPDSD
HQVTLAELREAHEGFFPKLMGADAALA

Sequences:

>Translated_747_residues
MTQPAPAITPEIVAEHGLAPQEYERVLAALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPTEAPWVICGPGENAGVI
DIGEGPDGKKLAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANLNALRFGRPDHPKMRHLIAGVVHGIGG
YGNCVGVPTVGGEVNFHAAYDGNILVNAMTVGVAEQDRIFYSAASGVGNPIVYVGSKTGRDGIHGATMASADFGEDAEEK
RPTVQVGDPFTEKLLIEACLELMASDAIVAIQDMGAAGLTSSSVEMASKGGVGIHLRMDDVPQRETGMTAYEMMLSESQE
RMLMVLKPGKEEFAKAIFHKWELDFAVIGTVTDTGRMVLEHHGQIVCDIPLAPLADDAPLYDRPHVPTPKQPELSDVPET
KDVAADLKALMGTPDIASRRWIWEQYDSQVGADTVQTGGDAALVRIHGTNRALAMSTDCTPRYCYADPVEGGKQAVAETW
RNISAVGATPLAITNCLNFANPQRPEIMGQIVGCLDGMAQACRALDYPIVSGNVSLYNESKATGGGSAILPTPAIGGVGV
IEDLGKAVGIGFKRTGDIVLAVGERMGHLGQSIWLREIHGREEGPPPPVDLKAEKRTGDFIRQSINAGWITACHDVSDGG
VAVALAEMALKSNIGVLVSEEQPFGVAESFFGEDQGLYLVTVCDTCLADFLDAANRADVPVDPLGRTIKDRIVFELPDSD
HQVTLAELREAHEGFFPKLMGADAALA
>Mature_746_residues
TQPAPAITPEIVAEHGLAPQEYERVLAALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPTEAPWVICGPGENAGVID
IGEGPDGKKLAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANLNALRFGRPDHPKMRHLIAGVVHGIGGY
GNCVGVPTVGGEVNFHAAYDGNILVNAMTVGVAEQDRIFYSAASGVGNPIVYVGSKTGRDGIHGATMASADFGEDAEEKR
PTVQVGDPFTEKLLIEACLELMASDAIVAIQDMGAAGLTSSSVEMASKGGVGIHLRMDDVPQRETGMTAYEMMLSESQER
MLMVLKPGKEEFAKAIFHKWELDFAVIGTVTDTGRMVLEHHGQIVCDIPLAPLADDAPLYDRPHVPTPKQPELSDVPETK
DVAADLKALMGTPDIASRRWIWEQYDSQVGADTVQTGGDAALVRIHGTNRALAMSTDCTPRYCYADPVEGGKQAVAETWR
NISAVGATPLAITNCLNFANPQRPEIMGQIVGCLDGMAQACRALDYPIVSGNVSLYNESKATGGGSAILPTPAIGGVGVI
EDLGKAVGIGFKRTGDIVLAVGERMGHLGQSIWLREIHGREEGPPPPVDLKAEKRTGDFIRQSINAGWITACHDVSDGGV
AVALAEMALKSNIGVLVSEEQPFGVAESFFGEDQGLYLVTVCDTCLADFLDAANRADVPVDPLGRTIKDRIVFELPDSDH
QVTLAELREAHEGFFPKLMGADAALA

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=721, Percent_Identity=24.2718446601942, Blast_Score=112, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17553022, Length=672, Percent_Identity=22.0238095238095, Blast_Score=85, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=735, Percent_Identity=22.5850340136054, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24582111, Length=730, Percent_Identity=25.0684931506849, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24582109, Length=730, Percent_Identity=25.0684931506849, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137292, Length=730, Percent_Identity=25.0684931506849, Blast_Score=108, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 79640; Mature: 79508

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPAPAITPEIVAEHGLAPQEYERVLAALGREPNLVELGIFSVMWSEHCSYKSSRIHLK
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEE
KLPTEAPWVICGPGENAGVIDIGEGPDGKKLAAIFKMESHNHPSYIEPYQGAATGVGGIL
ECCCCCCEEEECCCCCCCEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHH
RDVFTMGARPVANLNALRFGRPDHPKMRHLIAGVVHGIGGYGNCVGVPTVGGEVNFHAAY
HHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEE
DGNILVNAMTVGVAEQDRIFYSAASGVGNPIVYVGSKTGRDGIHGATMASADFGEDAEEK
CCCEEEEEEEECCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCHHHC
RPTVQVGDPFTEKLLIEACLELMASDAIVAIQDMGAAGLTSSSVEMASKGGVGIHLRMDD
CCEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCEEEEEECC
VPQRETGMTAYEMMLSESQERMLMVLKPGKEEFAKAIFHKWELDFAVIGTVTDTGRMVLE
CCCCHHCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHH
HHGQIVCDIPLAPLADDAPLYDRPHVPTPKQPELSDVPETKDVAADLKALMGTPDIASRR
HCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
WIWEQYDSQVGADTVQTGGDAALVRIHGTNRALAMSTDCTPRYCYADPVEGGKQAVAETW
HHHHHHHHHCCCCHHCCCCCEEEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHH
RNISAVGATPLAITNCLNFANPQRPEIMGQIVGCLDGMAQACRALDYPIVSGNVSLYNES
HCCHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECC
KATGGGSAILPTPAIGGVGVIEDLGKAVGIGFKRTGDIVLAVGERMGHLGQSIWLREIHG
CCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCC
REEGPPPPVDLKAEKRTGDFIRQSINAGWITACHDVSDGGVAVALAEMALKSNIGVLVSE
CCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEC
EQPFGVAESFFGEDQGLYLVTVCDTCLADFLDAANRADVPVDPLGRTIKDRIVFELPDSD
CCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEECCCCC
HQVTLAELREAHEGFFPKLMGADAALA
CEEEHHHHHHHHCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TQPAPAITPEIVAEHGLAPQEYERVLAALGREPNLVELGIFSVMWSEHCSYKSSRIHLK
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEE
KLPTEAPWVICGPGENAGVIDIGEGPDGKKLAAIFKMESHNHPSYIEPYQGAATGVGGIL
ECCCCCCEEEECCCCCCCEEECCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHH
RDVFTMGARPVANLNALRFGRPDHPKMRHLIAGVVHGIGGYGNCVGVPTVGGEVNFHAAY
HHHHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEEEE
DGNILVNAMTVGVAEQDRIFYSAASGVGNPIVYVGSKTGRDGIHGATMASADFGEDAEEK
CCCEEEEEEEECCCCCCCEEEEECCCCCCCEEEECCCCCCCCCCCCEECCCCCCCCHHHC
RPTVQVGDPFTEKLLIEACLELMASDAIVAIQDMGAAGLTSSSVEMASKGGVGIHLRMDD
CCEEEECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCEEEEEECC
VPQRETGMTAYEMMLSESQERMLMVLKPGKEEFAKAIFHKWELDFAVIGTVTDTGRMVLE
CCCCHHCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHH
HHGQIVCDIPLAPLADDAPLYDRPHVPTPKQPELSDVPETKDVAADLKALMGTPDIASRR
HCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
WIWEQYDSQVGADTVQTGGDAALVRIHGTNRALAMSTDCTPRYCYADPVEGGKQAVAETW
HHHHHHHHHCCCCHHCCCCCEEEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHH
RNISAVGATPLAITNCLNFANPQRPEIMGQIVGCLDGMAQACRALDYPIVSGNVSLYNES
HCCHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEECC
KATGGGSAILPTPAIGGVGVIEDLGKAVGIGFKRTGDIVLAVGERMGHLGQSIWLREIHG
CCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCC
REEGPPPPVDLKAEKRTGDFIRQSINAGWITACHDVSDGGVAVALAEMALKSNIGVLVSE
CCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEC
EQPFGVAESFFGEDQGLYLVTVCDTCLADFLDAANRADVPVDPLGRTIKDRIVFELPDSD
CCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCEEEECCCCC
HQVTLAELREAHEGFFPKLMGADAALA
CEEEHHHHHHHHCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA