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The map label for this gene is gppA [H]

Identifier: 103487238

GI number: 103487238

Start: 1846348

End: 1847847

Strand: Reverse

Name: gppA [H]

Synonym: Sala_1753

Alternate gene names: 103487238

Gene position: 1847847-1846348 (Counterclockwise)

Preceding gene: 103487239

Following gene: 103487236

Centisome position: 55.24

GC content: 71.53

Gene sequence:

>1500_bases
TTGAGACGAAACGGCTTGGCCCTGCTGCGCACCTCGAAACCGGCGGTTCATCGCTCGGCGGTCATCGACATCGGCTCCAA
CTCGGTCCGCCTCGTCGTTTATGAAGGGCCGCCGCGCGCCCCCGCGGTGATTTTCAACGAAAAGGTCGCGGCGGGTCTTG
GGCGTGGACTGGCGATCGACGGCCGCATTGCCGAAGCCGACGCCGAACGCGGGCTCACTGCGCTCCGCCGCTATGCGCTG
CTCGCGCGGCATATGGAGGTAAAGGATCTCGTCTGCGTCGCCACCGCCGCGGTGCGCGACGCCGAAAATGGTCCGGGTTT
CATCGCCGCCGCCGCCGAAGCGGGGCTCAGCATCCGCCTGCTGTCGGGTCAGGAAGAGGCCGAGGCGGCGGGTTACGGCG
TGCTGTCGGCGATCCCCGAAGCGCGTGGCATCGCCGTCGATCTGGGCGGCGGCAGCCTCGAACTCGCCGAGGTTGCGCAT
GGAGAGGTCGGACGTCGCGCCTCCTTTCCGCTCGGCGTGCTGCGGCTGCCCGCGCTCCGGCGCGAGGGGCCGCAGGCGTT
CGAGCGCGCGGTGCGCAAGATGCTGCGCGGCGCGGGCTGGCCGGGCGGCATGGCCGGATTGCCGCTCTATCTTGTCGGCG
GATCGTGGCGCGCGCTGGCGCGCCTCGACCTCGAACTCACCAACGATCCGCTCGCGGTGCTCGATCAGCACAGCTTTCCG
CGCACCGCGCTGCGCCGCCTCGTCCGCGCGACCCGGCGGCTGAGCTTCGAGGAATTGCGCGCGATCCCCGGCATGGCGTC
GAACCGCGCGGCGACGCTGCCCGACGCCGCGGCGCTGCTCGCGGCGCTCGCCAACATCATCGACGTCCCCGAAATGACCG
TCTCTTCGTCGGGGCTGCGCGAAGGGCTGCTCTATCAGGCGCTCGACCCCGCGACGCGCGCGCAGGATCCGCTGATCGTC
GCGGCGGAGTTCGAGGGACGGCGCCTTGCGCGCTTCGCGCCGCACGGGCGCGCGATCACCGAATGGATCGCGCCGCTTTT
TGTCGGGGAAGCGCCGGCCGACAGCCGCGTCCGCCTCGCCGCCAGCCTGCTCAGCGACGTCGCCTGGTCGGCCAATCCCG
ACTTTCGCGCCGAACGCGGGATGGAGATCGGGCTGCACGGCAACTGGCGCGGCATCGACATTCCGGGGCGTATCCTGCTC
GCCCGCGCGCTTCACGCGGGCTTTGGCGGCGCCGACGGCGATTTTCCCGCGATGAGCACGCTGGTCGGCGCCGAGCGGCT
GGCGCGCGCGCGGCAATGGGGGCTGGCGATCCGGCTCGCGCAGCGGCTGACCGGCGGGGTCGAGGCGCCGCTGAAGGCAA
GCCGCATCGCGATCGAGGACGGACGGCTCGTCCTTGGCCTGCAAAGCGGCTGGCACCATCTCGCGGGCGAATCGGTCGAC
CGCCGCCTGCGCTCGCTCGCGCAGGCGCTGGGCGCAAAACCCGAACTGGTGCTGCTTTAG

Upstream 100 bases:

>100_bases
TGCACCATTATTTCATGAACAACCCGTCGCTGTCGGGTCGCGGCACCGCGCTTCACCAGCGTCAGGACGTGCCGACGCTC
GCCTACGACCTTCGCGAAGA

Downstream 100 bases:

>100_bases
TTTAGAGGTCTTCGTCGCCCCCGCCTGCGGAAGCGATGTTTATGTCATCACCGGCTCATGTTTCGGCAGCCACCGCCGCG
TCGATCTCGCTCATCACCAG

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MRRNGLALLRTSKPAVHRSAVIDIGSNSVRLVVYEGPPRAPAVIFNEKVAAGLGRGLAIDGRIAEADAERGLTALRRYAL
LARHMEVKDLVCVATAAVRDAENGPGFIAAAAEAGLSIRLLSGQEEAEAAGYGVLSAIPEARGIAVDLGGGSLELAEVAH
GEVGRRASFPLGVLRLPALRREGPQAFERAVRKMLRGAGWPGGMAGLPLYLVGGSWRALARLDLELTNDPLAVLDQHSFP
RTALRRLVRATRRLSFEELRAIPGMASNRAATLPDAAALLAALANIIDVPEMTVSSSGLREGLLYQALDPATRAQDPLIV
AAEFEGRRLARFAPHGRAITEWIAPLFVGEAPADSRVRLAASLLSDVAWSANPDFRAERGMEIGLHGNWRGIDIPGRILL
ARALHAGFGGADGDFPAMSTLVGAERLARARQWGLAIRLAQRLTGGVEAPLKASRIAIEDGRLVLGLQSGWHHLAGESVD
RRLRSLAQALGAKPELVLL

Sequences:

>Translated_499_residues
MRRNGLALLRTSKPAVHRSAVIDIGSNSVRLVVYEGPPRAPAVIFNEKVAAGLGRGLAIDGRIAEADAERGLTALRRYAL
LARHMEVKDLVCVATAAVRDAENGPGFIAAAAEAGLSIRLLSGQEEAEAAGYGVLSAIPEARGIAVDLGGGSLELAEVAH
GEVGRRASFPLGVLRLPALRREGPQAFERAVRKMLRGAGWPGGMAGLPLYLVGGSWRALARLDLELTNDPLAVLDQHSFP
RTALRRLVRATRRLSFEELRAIPGMASNRAATLPDAAALLAALANIIDVPEMTVSSSGLREGLLYQALDPATRAQDPLIV
AAEFEGRRLARFAPHGRAITEWIAPLFVGEAPADSRVRLAASLLSDVAWSANPDFRAERGMEIGLHGNWRGIDIPGRILL
ARALHAGFGGADGDFPAMSTLVGAERLARARQWGLAIRLAQRLTGGVEAPLKASRIAIEDGRLVLGLQSGWHHLAGESVD
RRLRSLAQALGAKPELVLL
>Mature_499_residues
MRRNGLALLRTSKPAVHRSAVIDIGSNSVRLVVYEGPPRAPAVIFNEKVAAGLGRGLAIDGRIAEADAERGLTALRRYAL
LARHMEVKDLVCVATAAVRDAENGPGFIAAAAEAGLSIRLLSGQEEAEAAGYGVLSAIPEARGIAVDLGGGSLELAEVAH
GEVGRRASFPLGVLRLPALRREGPQAFERAVRKMLRGAGWPGGMAGLPLYLVGGSWRALARLDLELTNDPLAVLDQHSFP
RTALRRLVRATRRLSFEELRAIPGMASNRAATLPDAAALLAALANIIDVPEMTVSSSGLREGLLYQALDPATRAQDPLIV
AAEFEGRRLARFAPHGRAITEWIAPLFVGEAPADSRVRLAASLLSDVAWSANPDFRAERGMEIGLHGNWRGIDIPGRILL
ARALHAGFGGADGDFPAMSTLVGAERLARARQWGLAIRLAQRLTGGVEAPLKASRIAIEDGRLVLGLQSGWHHLAGESVD
RRLRSLAQALGAKPELVLL

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=308, Percent_Identity=28.8961038961039, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788848, Length=319, Percent_Identity=25.705329153605, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 53000; Mature: 53000

Theoretical pI: Translated: 10.63; Mature: 10.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRNGLALLRTSKPAVHRSAVIDIGSNSVRLVVYEGPPRAPAVIFNEKVAAGLGRGLAID
CCCCCEEEEECCCCCHHCEEEEEECCCCEEEEEECCCCCCCEEEECCHHHHHCCCCEEEC
GRIAEADAERGLTALRRYALLARHMEVKDLVCVATAAVRDAENGPGFIAAAAEAGLSIRL
CEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEE
LSGQEEAEAAGYGVLSAIPEARGIAVDLGGGSLELAEVAHGEVGRRASFPLGVLRLPALR
ECCCCHHHHHCCHHHHHCCCCCCEEEECCCCCEEHHHHHCCCCCCCCCCCCHHHHCCHHH
REGPQAFERAVRKMLRGAGWPGGMAGLPLYLVGGSWRALARLDLELTNDPLAVLDQHSFP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEEEEEECCCCHHHHCCCCCC
RTALRRLVRATRRLSFEELRAIPGMASNRAATLPDAAALLAALANIIDVPEMTVSSSGLR
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHH
EGLLYQALDPATRAQDPLIVAAEFEGRRLARFAPHGRAITEWIAPLFVGEAPADSRVRLA
HHHHHHHCCCHHCCCCCEEEEEECCCCEEHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
ASLLSDVAWSANPDFRAERGMEIGLHGNWRGIDIPGRILLARALHAGFGGADGDFPAMST
HHHHHHHHCCCCCCCHHHCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHH
LVGAERLARARQWGLAIRLAQRLTGGVEAPLKASRIAIEDGRLVLGLQSGWHHLAGESVD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEECCCCHHHCCHHHH
RRLRSLAQALGAKPELVLL
HHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure
MRRNGLALLRTSKPAVHRSAVIDIGSNSVRLVVYEGPPRAPAVIFNEKVAAGLGRGLAID
CCCCCEEEEECCCCCHHCEEEEEECCCCEEEEEECCCCCCCEEEECCHHHHHCCCCEEEC
GRIAEADAERGLTALRRYALLARHMEVKDLVCVATAAVRDAENGPGFIAAAAEAGLSIRL
CEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEE
LSGQEEAEAAGYGVLSAIPEARGIAVDLGGGSLELAEVAHGEVGRRASFPLGVLRLPALR
ECCCCHHHHHCCHHHHHCCCCCCEEEECCCCCEEHHHHHCCCCCCCCCCCCHHHHCCHHH
REGPQAFERAVRKMLRGAGWPGGMAGLPLYLVGGSWRALARLDLELTNDPLAVLDQHSFP
CCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEEEEEECCCCHHHHCCCCCC
RTALRRLVRATRRLSFEELRAIPGMASNRAATLPDAAALLAALANIIDVPEMTVSSSGLR
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHH
EGLLYQALDPATRAQDPLIVAAEFEGRRLARFAPHGRAITEWIAPLFVGEAPADSRVRLA
HHHHHHHCCCHHCCCCCEEEEEECCCCEEHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
ASLLSDVAWSANPDFRAERGMEIGLHGNWRGIDIPGRILLARALHAGFGGADGDFPAMST
HHHHHHHHCCCCCCCHHHCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHH
LVGAERLARARQWGLAIRLAQRLTGGVEAPLKASRIAIEDGRLVLGLQSGWHHLAGESVD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEECCCCHHHCCHHHH
RRLRSLAQALGAKPELVLL
HHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA