Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 103487153

GI number: 103487153

Start: 1755865

End: 1757178

Strand: Reverse

Name: hemN [H]

Synonym: Sala_1668

Alternate gene names: 103487153

Gene position: 1757178-1755865 (Counterclockwise)

Preceding gene: 103487154

Following gene: 103487151

Centisome position: 52.53

GC content: 66.06

Gene sequence:

>1314_bases
ATGTGGTCCTATTATCCCGACCTGCTGGCCCGACCGGTCCCGCGCTACACCAGCTACCCGACCGCGATGGAGTTCACCGG
CGAGGTCGGAGCCGATGATCATGCACAGGCGCTCGACCGCGTCACGGCGGCAACGCCGATCTCGCTTTATGTCCACATTC
CTTTTTGCGAACAGATATGCTGGTATTGCGGCTGCAACACCGGCGCGGCCGGACGCAAGCAGCGGCTGGCCGACTATCTG
GCCGCGCTGCGGGCCGAGGTCGCGCTCGTCGCAAAGCGTCTCGGCGGGCGGGGGAGGGTGCAGCGCATCGCCTTTGGCGG
CGGCAGTCCCAACGCGATTGCACCCGTCGAACTGGTGCGTCTGCTCGATCGCATCCTGACCGTTTTCGATTGCCACCGGC
CGGAGATTTCGATCGAACTCGACCCGCGCGGTCTCGACGCCGAATGGGCGCTGGTGCTCGCCGCAGCACGCGTCACGCGC
GTCAGCCTGGGCGTGCAGACCTTCGCGCCACATGTCCAGCAGGCGATCGGACGTATCCAGCCGCTGTCGCATATCGAGCG
TGTCGTCGCGGCGCTCCGCCTGCGCGACATCGATGCGATCAATTTTGACCTGATGTACGGACTGCCGGGGCAGAGGCTGG
AGGATCTGGACGCAACCCTTGACGAAACGATCCGCCTCGCGCCCAGCCGGATTGCGCTGTTCGGCTATGCCCATCTGCCC
GACATGATTCCGCGGCAGCGACAGATAGACGGAGTGATGCTGCCGGATCAGCGGCTGCGTTTCGACCAGGCTGAGTTGGG
TTACCGTCGACTGACCGCGGCGGGCTATCATCCCGTCGGTTTCGACCATTTCGCGCGCGGCGACGATCCGTTGGCGGTCG
CAGCGCGCGAAGGGCGCGTCAGCCGCAATTTTCAGGGATTTACCGAGGATATGGCTCCTGTGCTGCTTGGCTTCGGCGCG
AGTGCGATCAGCCGCTTTCCGGACCTCCTCGTCCAGAATGAGAAGCGCCCCGGTCCCTATCGCGACATGGTGGGCGGCGG
GCGGCTGGCGACAGCGCGCGGCATAGCCGTCACCGACGCGGAGCGGCTGCGCGGCGCGCATATCTGCGACCTTCTGTGCC
GCGGCCGAACCTCTGTCGGTCCGGCGTTGCAAAGCGCGGTACGCGCGGCGATGGCCGATTATGAGCGCTATGGGATCGTC
GAATGGGCCGGGAACGACCTGGTCATCCGCGATGACGGTCTTCCCTATGCGCGCCACGTCGCGGCCCAGTTCGACAGCGC
CAGGGGGCCGATCCGATCCGTCGACGCGCTCTGA

Upstream 100 bases:

>100_bases
GGCGCGGAAAGGGCGCGGCGGGGAGAGGCGGGCGCTGCTGATGCGCGCGCCGTTGATGCCGATCAATGCCATGCCGCGCC
AATGCGATCAGGAGCCGCGC

Downstream 100 bases:

>100_bases
CCGCGCCGGGTTGTGACGCCTCAGTCACCCACCCCGATCATTACGAAGAAAAGTGCGGCCGCAAAGCTTGCCAGCGAAGC
CGCCATGACGGGAGCGGCCG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MWSYYPDLLARPVPRYTSYPTAMEFTGEVGADDHAQALDRVTAATPISLYVHIPFCEQICWYCGCNTGAAGRKQRLADYL
AALRAEVALVAKRLGGRGRVQRIAFGGGSPNAIAPVELVRLLDRILTVFDCHRPEISIELDPRGLDAEWALVLAAARVTR
VSLGVQTFAPHVQQAIGRIQPLSHIERVVAALRLRDIDAINFDLMYGLPGQRLEDLDATLDETIRLAPSRIALFGYAHLP
DMIPRQRQIDGVMLPDQRLRFDQAELGYRRLTAAGYHPVGFDHFARGDDPLAVAAREGRVSRNFQGFTEDMAPVLLGFGA
SAISRFPDLLVQNEKRPGPYRDMVGGGRLATARGIAVTDAERLRGAHICDLLCRGRTSVGPALQSAVRAAMADYERYGIV
EWAGNDLVIRDDGLPYARHVAAQFDSARGPIRSVDAL

Sequences:

>Translated_437_residues
MWSYYPDLLARPVPRYTSYPTAMEFTGEVGADDHAQALDRVTAATPISLYVHIPFCEQICWYCGCNTGAAGRKQRLADYL
AALRAEVALVAKRLGGRGRVQRIAFGGGSPNAIAPVELVRLLDRILTVFDCHRPEISIELDPRGLDAEWALVLAAARVTR
VSLGVQTFAPHVQQAIGRIQPLSHIERVVAALRLRDIDAINFDLMYGLPGQRLEDLDATLDETIRLAPSRIALFGYAHLP
DMIPRQRQIDGVMLPDQRLRFDQAELGYRRLTAAGYHPVGFDHFARGDDPLAVAAREGRVSRNFQGFTEDMAPVLLGFGA
SAISRFPDLLVQNEKRPGPYRDMVGGGRLATARGIAVTDAERLRGAHICDLLCRGRTSVGPALQSAVRAAMADYERYGIV
EWAGNDLVIRDDGLPYARHVAAQFDSARGPIRSVDAL
>Mature_437_residues
MWSYYPDLLARPVPRYTSYPTAMEFTGEVGADDHAQALDRVTAATPISLYVHIPFCEQICWYCGCNTGAAGRKQRLADYL
AALRAEVALVAKRLGGRGRVQRIAFGGGSPNAIAPVELVRLLDRILTVFDCHRPEISIELDPRGLDAEWALVLAAARVTR
VSLGVQTFAPHVQQAIGRIQPLSHIERVVAALRLRDIDAINFDLMYGLPGQRLEDLDATLDETIRLAPSRIALFGYAHLP
DMIPRQRQIDGVMLPDQRLRFDQAELGYRRLTAAGYHPVGFDHFARGDDPLAVAAREGRVSRNFQGFTEDMAPVLLGFGA
SAISRFPDLLVQNEKRPGPYRDMVGGGRLATARGIAVTDAERLRGAHICDLLCRGRTSVGPALQSAVRAAMADYERYGIV
EWAGNDLVIRDDGLPYARHVAAQFDSARGPIRSVDAL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=243, Percent_Identity=27.1604938271605, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI87082341, Length=382, Percent_Identity=38.7434554973822, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1789325, Length=318, Percent_Identity=28.3018867924528, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 48049; Mature: 48049

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSYYPDLLARPVPRYTSYPTAMEFTGEVGADDHAQALDRVTAATPISLYVHIPFCEQIC
CCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHH
WYCGCNTGAAGRKQRLADYLAALRAEVALVAKRLGGRGRVQRIAFGGGSPNAIAPVELVR
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHH
LLDRILTVFDCHRPEISIELDPRGLDAEWALVLAAARVTRVSLGVQTFAPHVQQAIGRIQ
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLSHIERVVAALRLRDIDAINFDLMYGLPGQRLEDLDATLDETIRLAPSRIALFGYAHLP
HHHHHHHHHHHHHHHCCCEECEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHCH
DMIPRQRQIDGVMLPDQRLRFDQAELGYRRLTAAGYHPVGFDHFARGDDPLAVAAREGRV
HHCCCHHCCCCEECCHHHHCCCHHHHCHHHHHHCCCCCCCCHHHCCCCCCEEEEECCCCC
SRNFQGFTEDMAPVLLGFGASAISRFPDLLVQNEKRPGPYRDMVGGGRLATARGIAVTDA
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCEEECCH
ERLRGAHICDLLCRGRTSVGPALQSAVRAAMADYERYGIVEWAGNDLVIRDDGLPYARHV
HHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEEEECCCCCHHHHH
AAQFDSARGPIRSVDAL
HHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MWSYYPDLLARPVPRYTSYPTAMEFTGEVGADDHAQALDRVTAATPISLYVHIPFCEQIC
CCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHH
WYCGCNTGAAGRKQRLADYLAALRAEVALVAKRLGGRGRVQRIAFGGGSPNAIAPVELVR
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHH
LLDRILTVFDCHRPEISIELDPRGLDAEWALVLAAARVTRVSLGVQTFAPHVQQAIGRIQ
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PLSHIERVVAALRLRDIDAINFDLMYGLPGQRLEDLDATLDETIRLAPSRIALFGYAHLP
HHHHHHHHHHHHHHHCCCEECEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECHHCH
DMIPRQRQIDGVMLPDQRLRFDQAELGYRRLTAAGYHPVGFDHFARGDDPLAVAAREGRV
HHCCCHHCCCCEECCHHHHCCCHHHHCHHHHHHCCCCCCCCHHHCCCCCCEEEEECCCCC
SRNFQGFTEDMAPVLLGFGASAISRFPDLLVQNEKRPGPYRDMVGGGRLATARGIAVTDA
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEECCEEECCH
ERLRGAHICDLLCRGRTSVGPALQSAVRAAMADYERYGIVEWAGNDLVIRDDGLPYARHV
HHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEEEECCCCCHHHHH
AAQFDSARGPIRSVDAL
HHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11157943; 12597275 [H]