Click here to switch to the map view.

The map label for this gene is epsD [H]

Identifier: 103487076

GI number: 103487076

Start: 1667037

End: 1668332

Strand: Direct

Name: epsD [H]

Synonym: Sala_1591

Alternate gene names: 103487076

Gene position: 1667037-1668332 (Clockwise)

Preceding gene: 103487075

Following gene: 103487077

Centisome position: 49.83

GC content: 66.2

Gene sequence:

>1296_bases
GTGCCCATCGATAGCGACCAGAATGTTACCGTCCTCGGTCTGGGCTATATCGGCCTGCCCACCGCGGCGTTGATCGCGCG
GTCGGGCAGCAAGGTCACGGGCGTCGATGTCAGCAAGCATGTCGTCGAGACGGTGAACAGCGGCAAGGTGCATATCGAGG
AGGTCGATCTCGACGGCCTTGTCCAGGGCGTCGTTTCACGCGGCTCGCTGGTCGCCTCGACAAAGGTCGCCCCCGCCGAC
GTGTTCGTGATTGCGGTCCCGACCCCGCACGACGACGAGCATCGCCCCGACATCAGCCATGTGCTCTCGGCCGCACGCGC
CATCGCGCCGCAACTCGTACCCGGCAATCTCGTCATCCTCGAATCGACCTCGCCCGTCGGCACGACCGAAAAGGTCGCGG
CGCTGCTCGCCGAGCTGCGCCCCGACCTCAAGGTTCCGGGCGCCTGCACCGGCGCCGCCGACATCTTCGTCGCCTATTGC
CCCGAGCGCGTGCTGCCGGGGCGCATCCTCGTCGAGCTGGTCGACAATGACCGCTGCATCGGCGGGATCACCCCGCGCTG
CGCGCGCCGTGCGATGACCTTTTATCGCCAGTTCGTTCGCGGTGCCTGCGTCACCACCTCGGCGCGCGCCGCCGAAATGG
TGAAGCTGGTCGAGAACAGCTACCGCGACGTCAACATCGCCTTTGCCAACGAGCTGTCGATGATGGCCGAACATCTCGGC
GTCGATATATGGGAGGTGATCCGCCTCGCCAACCGCCACCCGCGCGTCAATATCCTGCAACCCGGCCCCGGCGTCGGCGG
TCATTGCATCGCGGTCGATCCCTGGTTCCTCGTCCATGGCGCGCCCGGCCACAGCCGCCTGATCCGCACCGCGCGCGAGG
TCAATCTCGCCAAGACAGCGCATGTCATCGGCGCCGCCGAAATGCTGGTGTCGCAGCATCCGGAAGCGCGCGTCGCCTGC
CTCGGCCTCGCCTTCAAGCCCAATATCGACGATTTTCGCGAAAGCCCCGCGGTCGAAGTCGCCGCCGCGCTCGCGCGCCG
TTTCGGCCAGCAGATCCGCATCGTCGAACCCTATGCGCGCGGACTGCCCATGGACTTCGCGGGCACGGGCGCCGAACTGA
TCGATCTCGACAGCGCCCTGGCGAGCTGCGACCTGCTCATCGTCCTGGTCGACCACGATCTGTTCAAGTCGATCCCGCTC
GAGGAACGCGGCGACAAGATTGTCTATGACACGCGCGGGCTGTGGCCCGATCAGCCAAGTGTCGGCAATACAAACCGTTT
CACTCGCGCAGCCTGA

Upstream 100 bases:

>100_bases
AGCCTTTTGGACGATGAAGGCGCCTATAACGCCATGGCGCGCGCGCATAATCCCTTCGGGGACGGCCGCGCCGCGGAACG
AATAGCGGAGATTGTTGCGC

Downstream 100 bases:

>100_bases
CCGTTCTTGCTTGACGTCTCATGGCAGGCCCAACATGGTGGCGCGATGTTGTCTCGCCTCGAAACGATCATCGTGGAAAA
GCCCTGGGGGCGGACTGACA

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPIDSDQNVTVLGLGYIGLPTAALIARSGSKVTGVDVSKHVVETVNSGKVHIEEVDLDGLVQGVVSRGSLVASTKVAPAD
VFVIAVPTPHDDEHRPDISHVLSAARAIAPQLVPGNLVILESTSPVGTTEKVAALLAELRPDLKVPGACTGAADIFVAYC
PERVLPGRILVELVDNDRCIGGITPRCARRAMTFYRQFVRGACVTTSARAAEMVKLVENSYRDVNIAFANELSMMAEHLG
VDIWEVIRLANRHPRVNILQPGPGVGGHCIAVDPWFLVHGAPGHSRLIRTAREVNLAKTAHVIGAAEMLVSQHPEARVAC
LGLAFKPNIDDFRESPAVEVAAALARRFGQQIRIVEPYARGLPMDFAGTGAELIDLDSALASCDLLIVLVDHDLFKSIPL
EERGDKIVYDTRGLWPDQPSVGNTNRFTRAA

Sequences:

>Translated_431_residues
MPIDSDQNVTVLGLGYIGLPTAALIARSGSKVTGVDVSKHVVETVNSGKVHIEEVDLDGLVQGVVSRGSLVASTKVAPAD
VFVIAVPTPHDDEHRPDISHVLSAARAIAPQLVPGNLVILESTSPVGTTEKVAALLAELRPDLKVPGACTGAADIFVAYC
PERVLPGRILVELVDNDRCIGGITPRCARRAMTFYRQFVRGACVTTSARAAEMVKLVENSYRDVNIAFANELSMMAEHLG
VDIWEVIRLANRHPRVNILQPGPGVGGHCIAVDPWFLVHGAPGHSRLIRTAREVNLAKTAHVIGAAEMLVSQHPEARVAC
LGLAFKPNIDDFRESPAVEVAAALARRFGQQIRIVEPYARGLPMDFAGTGAELIDLDSALASCDLLIVLVDHDLFKSIPL
EERGDKIVYDTRGLWPDQPSVGNTNRFTRAA
>Mature_430_residues
PIDSDQNVTVLGLGYIGLPTAALIARSGSKVTGVDVSKHVVETVNSGKVHIEEVDLDGLVQGVVSRGSLVASTKVAPADV
FVIAVPTPHDDEHRPDISHVLSAARAIAPQLVPGNLVILESTSPVGTTEKVAALLAELRPDLKVPGACTGAADIFVAYCP
ERVLPGRILVELVDNDRCIGGITPRCARRAMTFYRQFVRGACVTTSARAAEMVKLVENSYRDVNIAFANELSMMAEHLGV
DIWEVIRLANRHPRVNILQPGPGVGGHCIAVDPWFLVHGAPGHSRLIRTAREVNLAKTAHVIGAAEMLVSQHPEARVACL
GLAFKPNIDDFRESPAVEVAAALARRFGQQIRIVEPYARGLPMDFAGTGAELIDLDSALASCDLLIVLVDHDLFKSIPLE
ERGDKIVYDTRGLWPDQPSVGNTNRFTRAA

Specific function: Probably involved in the synthesis of sugar components of EPS I, by converting NDP-N-acetyl-D-galactosamine into NDP-N- acetyl-D-galactosaminuronic acid [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=440, Percent_Identity=23.8636363636364, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI48994968, Length=416, Percent_Identity=54.3269230769231, Blast_Score=450, Evalue=1e-128,
Organism=Escherichia coli, GI1788340, Length=358, Percent_Identity=24.5810055865922, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17560350, Length=357, Percent_Identity=28.8515406162465, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI17136908, Length=375, Percent_Identity=27.7333333333333, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46236; Mature: 46105

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIDSDQNVTVLGLGYIGLPTAALIARSGSKVTGVDVSKHVVETVNSGKVHIEEVDLDGL
CCCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCEEEEEEECHHHH
VQGVVSRGSLVASTKVAPADVFVIAVPTPHDDEHRPDISHVLSAARAIAPQLVPGNLVIL
HHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEE
ESTSPVGTTEKVAALLAELRPDLKVPGACTGAADIFVAYCPERVLPGRILVELVDNDRCI
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEECCCCCCCCCEEEEEECCCCEE
GGITPRCARRAMTFYRQFVRGACVTTSARAAEMVKLVENSYRDVNIAFANELSMMAEHLG
CCCCHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHC
VDIWEVIRLANRHPRVNILQPGPGVGGHCIAVDPWFLVHGAPGHSRLIRTAREVNLAKTA
CCHHHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHH
HVIGAAEMLVSQHPEARVACLGLAFKPNIDDFRESPAVEVAAALARRFGQQIRIVEPYAR
HHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEECHHHC
GLPMDFAGTGAELIDLDSALASCDLLIVLVDHDLFKSIPLEERGDKIVYDTRGLWPDQPS
CCCCCCCCCCCHHEEHHHHHHCCCEEEEEECCHHHHCCCCCCCCCEEEEECCCCCCCCCC
VGNTNRFTRAA
CCCCCCCCCCC
>Mature Secondary Structure 
PIDSDQNVTVLGLGYIGLPTAALIARSGSKVTGVDVSKHVVETVNSGKVHIEEVDLDGL
CCCCCCCEEEEEECCHHHHHHHHHHCCCCEEECCCHHHHHHHHHCCCEEEEEEECHHHH
VQGVVSRGSLVASTKVAPADVFVIAVPTPHDDEHRPDISHVLSAARAIAPQLVPGNLVIL
HHHHHHCCCEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEE
ESTSPVGTTEKVAALLAELRPDLKVPGACTGAADIFVAYCPERVLPGRILVELVDNDRCI
ECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHEECCCCCCCCCEEEEEECCCCEE
GGITPRCARRAMTFYRQFVRGACVTTSARAAEMVKLVENSYRDVNIAFANELSMMAEHLG
CCCCHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHC
VDIWEVIRLANRHPRVNILQPGPGVGGHCIAVDPWFLVHGAPGHSRLIRTAREVNLAKTA
CCHHHHHHHHCCCCCEEEECCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHH
HVIGAAEMLVSQHPEARVACLGLAFKPNIDDFRESPAVEVAAALARRFGQQIRIVEPYAR
HHHHHHHHHHHCCCCCEEEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCEEEECHHHC
GLPMDFAGTGAELIDLDSALASCDLLIVLVDHDLFKSIPLEERGDKIVYDTRGLWPDQPS
CCCCCCCCCCCHHEEHHHHHHCCCEEEEEECCHHHHCCCCCCCCCEEEEECCCCCCCCCC
VGNTNRFTRAA
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]