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The map label for this gene is capI [H]

Identifier: 103487038

GI number: 103487038

Start: 1619856

End: 1620863

Strand: Direct

Name: capI [H]

Synonym: Sala_1553

Alternate gene names: 103487038

Gene position: 1619856-1620863 (Clockwise)

Preceding gene: 103487037

Following gene: 103487044

Centisome position: 48.42

GC content: 62.6

Gene sequence:

>1008_bases
TTGTCGACGCTGATTACGGGCGCTGCCGGATTCATCGGGATGCAGGTCGCGGCGGCTTTGCTTCGCCGCGGTGAGGCGGT
TGTCGGGATCGACAATTTCACGCCCTATTATTCGGTCGAACTCAAGCGCGCGCGCGTCGCGCGGCTCGACGCCGGTTTTG
GTGGCCTGTTCACCTTCATCGACGGCGATTTTGGTGACGCTGCGGCGCTCGCCGGTGCGCTGGCGGGCCAAAGGATCGAC
CGGATCGTCCATCTTGGTGCCCAGCCCGGCGTGCGCTATTCGCTCGAAAATCCGGCGGCATATGTCCATTCCAACATCGC
GGGGCACGTCAACATCCTCGAACTTGCGCGACATCGTGCGGTTTCGCATCTTGTCTATGCCTCCTCCTCGTCGGTCTACG
GCATGCGCGCCGACACGCCCTTTCGCGTCGCCGACCGCGCCGATACGCCGATTTCGCTCTACGCGGCGACCAAGCGTGCC
GACGAATTGCTGAGCGAAACCTATGCGCATCTGTTCCGCATTCCCCTGACCGGCCTTCGCTTCTTCACCGTCTATGGCCC
GTGGGGTCGCCCCGACATGGCGGTGTGGAAATTTACCGAGGCGGTGCTGCAAGGTCGACCGATAGACGTCTATAATCACG
GCGATATGCGCCGCGATTTCACCTTTGTCGACGATATTGTGAACGGCGTCGTCCTCGCGCTCGACCACCCGCCCGCCGAC
GATCATCGCGAGAAGCCGGGCGGCTTCACGACCCCGCACCGGCTATACAATATCGGCAACAACCGGTCGGAAAGGCTGAC
CGACATGATTGCCATCATCGAACAGGCGTGCGGGCGCAAGGCCGAGCTCAACCTGCTGCCGATGCAGGCGGGCGACGTGT
ACCAGACCGCAGCCGATATCGACGACATCCAGCGCGACCTCGGCTTTGCGCCGACGACGCCGATTTCGGTCGGTATCCCC
GCCTTTGTCGACTGGTATCGAACCGACTGGCTGTCGCGAAAGGCATAG

Upstream 100 bases:

>100_bases
GTTCGAACCCAGCAGGGCTCACCACATTTAAACCACTATGATTCCATAAGCTGCTCCCGCACGAACCGTCGCATGGATGC
GGTTCAATGGAGGACATTCA

Downstream 100 bases:

>100_bases
GCTTCTGGCCCTGATGTTCACCAGCGCAGGAAGCGTGGCAGAATCAGCCGCCCGGCGACCGCCGAGACGACGACGGCCAA
ACCGTGCCACAGCGCGATGT

Product: NAD-dependent epimerase/dehydratase

Products: UDP-L-iduronate

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSTLITGAAGFIGMQVAAALLRRGEAVVGIDNFTPYYSVELKRARVARLDAGFGGLFTFIDGDFGDAAALAGALAGQRID
RIVHLGAQPGVRYSLENPAAYVHSNIAGHVNILELARHRAVSHLVYASSSSVYGMRADTPFRVADRADTPISLYAATKRA
DELLSETYAHLFRIPLTGLRFFTVYGPWGRPDMAVWKFTEAVLQGRPIDVYNHGDMRRDFTFVDDIVNGVVLALDHPPAD
DHREKPGGFTTPHRLYNIGNNRSERLTDMIAIIEQACGRKAELNLLPMQAGDVYQTAADIDDIQRDLGFAPTTPISVGIP
AFVDWYRTDWLSRKA

Sequences:

>Translated_335_residues
MSTLITGAAGFIGMQVAAALLRRGEAVVGIDNFTPYYSVELKRARVARLDAGFGGLFTFIDGDFGDAAALAGALAGQRID
RIVHLGAQPGVRYSLENPAAYVHSNIAGHVNILELARHRAVSHLVYASSSSVYGMRADTPFRVADRADTPISLYAATKRA
DELLSETYAHLFRIPLTGLRFFTVYGPWGRPDMAVWKFTEAVLQGRPIDVYNHGDMRRDFTFVDDIVNGVVLALDHPPAD
DHREKPGGFTTPHRLYNIGNNRSERLTDMIAIIEQACGRKAELNLLPMQAGDVYQTAADIDDIQRDLGFAPTTPISVGIP
AFVDWYRTDWLSRKA
>Mature_334_residues
STLITGAAGFIGMQVAAALLRRGEAVVGIDNFTPYYSVELKRARVARLDAGFGGLFTFIDGDFGDAAALAGALAGQRIDR
IVHLGAQPGVRYSLENPAAYVHSNIAGHVNILELARHRAVSHLVYASSSSVYGMRADTPFRVADRADTPISLYAATKRAD
ELLSETYAHLFRIPLTGLRFFTVYGPWGRPDMAVWKFTEAVLQGRPIDVYNHGDMRRDFTFVDDIVNGVVLALDHPPADD
HREKPGGFTTPHRLYNIGNNRSERLTDMIAIIEQACGRKAELNLLPMQAGDVYQTAADIDDIQRDLGFAPTTPISVGIPA
FVDWYRTDWLSRKA

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=351, Percent_Identity=23.9316239316239, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI42516563, Length=335, Percent_Identity=26.2686567164179, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI56237023, Length=325, Percent_Identity=25.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI56118217, Length=325, Percent_Identity=25.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI189083684, Length=325, Percent_Identity=25.8461538461538, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788353, Length=360, Percent_Identity=24.7222222222222, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786974, Length=328, Percent_Identity=24.390243902439, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI48994969, Length=349, Percent_Identity=25.5014326647564, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71982038, Length=344, Percent_Identity=26.453488372093, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=342, Percent_Identity=26.6081871345029, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17539532, Length=337, Percent_Identity=26.1127596439169, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17568069, Length=342, Percent_Identity=24.2690058479532, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115532424, Length=274, Percent_Identity=22.2627737226277, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=339, Percent_Identity=26.2536873156342, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19923002, Length=321, Percent_Identity=27.4143302180685, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356223, Length=340, Percent_Identity=25.2941176470588, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.12

Molecular weight: Translated: 36823; Mature: 36692

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLITGAAGFIGMQVAAALLRRGEAVVGIDNFTPYYSVELKRARVARLDAGFGGLFTFI
CCCEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHHHHCCCCCCEEEEE
DGDFGDAAALAGALAGQRIDRIVHLGAQPGVRYSLENPAAYVHSNIAGHVNILELARHRA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHH
VSHLVYASSSSVYGMRADTPFRVADRADTPISLYAATKRADELLSETYAHLFRIPLTGLR
HHHHEEECCCCEEEEECCCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEE
FFTVYGPWGRPDMAVWKFTEAVLQGRPIDVYNHGDMRRDFTFVDDIVNGVVLALDHPPAD
EEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCC
DHREKPGGFTTPHRLYNIGNNRSERLTDMIAIIEQACGRKAELNLLPMQAGDVYQTAADI
CCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
DDIQRDLGFAPTTPISVGIPAFVDWYRTDWLSRKA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STLITGAAGFIGMQVAAALLRRGEAVVGIDNFTPYYSVELKRARVARLDAGFGGLFTFI
CCEECCHHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEHHHHHHHHCCCCCCEEEEE
DGDFGDAAALAGALAGQRIDRIVHLGAQPGVRYSLENPAAYVHSNIAGHVNILELARHRA
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHCCCCCCHHHHHHHHHHH
VSHLVYASSSSVYGMRADTPFRVADRADTPISLYAATKRADELLSETYAHLFRIPLTGLR
HHHHEEECCCCEEEEECCCCEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCEE
FFTVYGPWGRPDMAVWKFTEAVLQGRPIDVYNHGDMRRDFTFVDDIVNGVVLALDHPPAD
EEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCEEEEECCCCCC
DHREKPGGFTTPHRLYNIGNNRSERLTDMIAIIEQACGRKAELNLLPMQAGDVYQTAADI
CCCCCCCCCCCCHHHEECCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
DDIQRDLGFAPTTPISVGIPAFVDWYRTDWLSRKA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucuronate

Specific reaction: UDP-glucuronate = UDP-L-iduronate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]