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The map label for this gene is folK [H]

Identifier: 103487037

GI number: 103487037

Start: 1619140

End: 1619661

Strand: Direct

Name: folK [H]

Synonym: Sala_1552

Alternate gene names: 103487037

Gene position: 1619140-1619661 (Clockwise)

Preceding gene: 103487035

Following gene: 103487038

Centisome position: 48.4

GC content: 72.03

Gene sequence:

>522_bases
ATGAGCGATGCAAGGCCGCTGCCCCTCTATGCGATCGGCCTCGGGTCGAATCGCCGCCACGCGCGCCATGGCGACCCTCG
CGCCGTGCTGCTCGCCGCGCTCGCCGCGCTCGAAAGCGATGACATAGAGGCTGTCGACGCCAGCCCGATCATCGCCAGCG
ATCCCATCGGCCCCTCGCGCCGCCGCTATGCCAATGCCGTCGCGCTCGTCGCGTCGGACCTGAGCCCCCCCGAAATGCTC
GAACGGTTGCAGGCGATCGAGGCGCGTTTCGGCCGTCGCACCGGTCAACGCTGGGGCTCGCGCACACTCGACCTCGACAT
ATTGCTCTGGTCGGGCGGCGCCTGGTCCGACGCCGGGCTGACCATCCCCCACCCTGCGCTCGCGCACCGCGCGTTCGTGC
TCGGCCCGCTCCGCGCGATCGTGCCCCAATGGCGCCACCCGCTCCACGCGCGCAGCATCCGCCAGCTCGCCGCGCGGCTC
GTCCGTCCAAAGCCGGTTGACCGCCGCGCCGCAGCGCACTAG

Upstream 100 bases:

>100_bases
CGCAGCGCAACCAGTCGCGGGCAGCGCGAACAGTCGCGCGGCGGCTCGGTTCCGGGCAACGGGCTATCAATTTCCATACG
GCTGCAGTAGGCGCGGAGAT

Downstream 100 bases:

>100_bases
GGCGACGGCTCACTTCGCGCGCCGCTATATTCGGGCGCCGATGGGCCCTTAGCTCAGTCGGTAGAGCAACTGACTTTTAA
TCAGTAGGTCGCTGGTTCGA

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MSDARPLPLYAIGLGSNRRHARHGDPRAVLLAALAALESDDIEAVDASPIIASDPIGPSRRRYANAVALVASDLSPPEML
ERLQAIEARFGRRTGQRWGSRTLDLDILLWSGGAWSDAGLTIPHPALAHRAFVLGPLRAIVPQWRHPLHARSIRQLAARL
VRPKPVDRRAAAH

Sequences:

>Translated_173_residues
MSDARPLPLYAIGLGSNRRHARHGDPRAVLLAALAALESDDIEAVDASPIIASDPIGPSRRRYANAVALVASDLSPPEML
ERLQAIEARFGRRTGQRWGSRTLDLDILLWSGGAWSDAGLTIPHPALAHRAFVLGPLRAIVPQWRHPLHARSIRQLAARL
VRPKPVDRRAAAH
>Mature_172_residues
SDARPLPLYAIGLGSNRRHARHGDPRAVLLAALAALESDDIEAVDASPIIASDPIGPSRRRYANAVALVASDLSPPEMLE
RLQAIEARFGRRTGQRWGSRTLDLDILLWSGGAWSDAGLTIPHPALAHRAFVLGPLRAIVPQWRHPLHARSIRQLAARLV
RPKPVDRRAAAH

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=156, Percent_Identity=34.6153846153846, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18887; Mature: 18756

Theoretical pI: Translated: 11.84; Mature: 11.84

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDARPLPLYAIGLGSNRRHARHGDPRAVLLAALAALESDDIEAVDASPIIASDPIGPSR
CCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHH
RRYANAVALVASDLSPPEMLERLQAIEARFGRRTGQRWGSRTLDLDILLWSGGAWSDAGL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
TIPHPALAHRAFVLGPLRAIVPQWRHPLHARSIRQLAARLVRPKPVDRRAAAH
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDARPLPLYAIGLGSNRRHARHGDPRAVLLAALAALESDDIEAVDASPIIASDPIGPSR
CCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCHH
RRYANAVALVASDLSPPEMLERLQAIEARFGRRTGQRWGSRTLDLDILLWSGGAWSDAGL
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCC
TIPHPALAHRAFVLGPLRAIVPQWRHPLHARSIRQLAARLVRPKPVDRRAAAH
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]