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The map label for this gene is pyrE

Identifier: 103486892

GI number: 103486892

Start: 1461146

End: 1461736

Strand: Direct

Name: pyrE

Synonym: Sala_1406

Alternate gene names: 103486892

Gene position: 1461146-1461736 (Clockwise)

Preceding gene: 103486880

Following gene: 103486893

Centisome position: 43.68

GC content: 67.85

Gene sequence:

>591_bases
ATGACTGACGACCAAATCCTGGCCGAGTTCCGTGCCGCCGACGCCCTGCTGCAGGGGCATTTCCTGCTCTCCTCCGGCCG
CCACAGCGAATATTATCTGCAATGCGCGCGCGTGCTGATGGATACGGAACGCGCCGGGCGCCTCGCCGCCGCGCTCGCCG
CCAAGCTGCCGCGCGAACTCAAGCAGGCGATCGACCTTGTCGTCTCGCCCGCGATGGGCGGCGTCATCATCGGGCACGAA
ATGGGCCGCGCGCTCGGCAAGCCGGCGATTTTCGTCGAACGCCCGACCGGCACCTTCGAACTGCGTCGCGGCTTCACCAT
CGATCCCGGCGCCAAGGTGCTGATGGTCGAGGACGTCGTGACCACCGGCCTGTCCTCACGCGAAGCCATGGAAGCGGTGC
GCGCCGCAGGCGGCGAGGTCGTCGCCGAAGCCGCGCTCGTCGATCGCTCGGCAGGTAGCAACATCGACCTTGGCGTGCCC
TTCTACCCGCTCGTCGCGATCAACTTCCCGACCTATGCCGCCGACGAACTGCCCCCCGAACTCGCGGGCACCGAGGCGAT
CAAGCCCGGCAGCCGGAGTGTGGCAGCTTGA

Upstream 100 bases:

>100_bases
CCTCAAGCATCTCTAACACTATTTTGCGGCGGGCAAACAGGCGCCGCCAAAACCCGGTCGCCCGCCGCGGGCGACGCTAT
GGACAAAAGACCGATCTCCC

Downstream 100 bases:

>100_bases
ACGTCGCGCCCTCTCCGCACCGCCTGCGGCTCGGCGTCAACATCGACCATGTCGCGACGATCCGCAATGCGCGCGGCGGC
GAGCATCCCGACCCGGTGCG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 196; Mature: 195

Protein sequence:

>196_residues
MTDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPRELKQAIDLVVSPAMGGVIIGHE
MGRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVVTTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVP
FYPLVAINFPTYAADELPPELAGTEAIKPGSRSVAA

Sequences:

>Translated_196_residues
MTDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPRELKQAIDLVVSPAMGGVIIGHE
MGRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVVTTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVP
FYPLVAINFPTYAADELPPELAGTEAIKPGSRSVAA
>Mature_195_residues
TDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPRELKQAIDLVVSPAMGGVIIGHEM
GRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVVTTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVPF
YPLVAINFPTYAADELPPELAGTEAIKPGSRSVAA

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_SPHAL (Q1GTA2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616453.1
- ProteinModelPortal:   Q1GTA2
- SMR:   Q1GTA2
- GeneID:   4081762
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1406
- NMPDR:   fig|317655.9.peg.1340
- HOGENOM:   HBG404341
- OMA:   FYLQSAK
- ProtClustDB:   PRK00455
- BioCyc:   SALA317655:SALA_1406-MONOMER
- BRENDA:   2.4.2.10
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 20719; Mature: 20588

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 121-121 BINDING 149-149

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPREL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQAIDLVVSPAMGGVIIGHEMGRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVV
HHHHHHHHCCCCCCEEECHHHHHHHCCCEEEEECCCCCEEECCCCEECCCCEEEEEHHHH
TTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVPFYPLVAINFPTYAADELPPE
HCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHH
LAGTEAIKPGSRSVAA
HCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDDQILAEFRAADALLQGHFLLSSGRHSEYYLQCARVLMDTERAGRLAAALAAKLPREL
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQAIDLVVSPAMGGVIIGHEMGRALGKPAIFVERPTGTFELRRGFTIDPGAKVLMVEDVV
HHHHHHHHCCCCCCEEECHHHHHHHCCCEEEEECCCCCEEECCCCEECCCCEEEEEHHHH
TTGLSSREAMEAVRAAGGEVVAEAALVDRSAGSNIDLGVPFYPLVAINFPTYAADELPPE
HCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHH
LAGTEAIKPGSRSVAA
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA