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The map label for this gene is phhA [H]

Identifier: 103486878

GI number: 103486878

Start: 1447370

End: 1448242

Strand: Reverse

Name: phhA [H]

Synonym: Sala_1392

Alternate gene names: 103486878

Gene position: 1448242-1447370 (Counterclockwise)

Preceding gene: 103486881

Following gene: 103486877

Centisome position: 43.29

GC content: 66.21

Gene sequence:

>873_bases
TTGGCCGCGACGCATATCTTCGACGCACCGCCCGAAGGCGTCGCGGCCGACTGGACGATGCCGCAGGAGTGGCAGGCCTT
CACGCCCGAACAGCATCGCACGTGGCGGACCTTGTTCGACCGGCAGTCGGCGGCGATGGGGGGCTATGCCTGCCGCGCCT
TCCTCGACGGGCTGGGCCTGCTTCGTCGGCTCAGACCCGGTGTTCCCGATTTTGCCGAGCTCAACGCTCTGCTGAAACCG
GCATCGGGATGGGAGGTTGTCGCGGTTCCCGGCTGGATCCCCAACGCCCCCTTTTTCGAGCATCTGGCGAACCGGCGCTT
TCCCGCCGCCAATTTTGTGCGTCCGCCCGAACAGATCGCCTACAGCGAAGAGCCCGACATGTTTCACGACATTTTCGGGC
ATGTGCCGATGCTGGCCAATCCCGCCTTCGGCGACTTTCTGGTCGCCTATGGCGAGGCGGGACTGCGCGCCGAAAGCTTG
GGCGCGTCGGATTATCTCGGGCGGCTCTGGCTCTATACGGTCGAGTTCGGGCTGGTGGTGGAGGAGGGCGAATTGCGCGC
CTTCGGCGGCGGCCTGCTCTCCAGCCTCGCCGAAACGGCCTTTGCGCTGACCGCTCCCGAACCGCGGCGCATCTGGCTCG
ACGTCGAGCGCGCGATGCGGACGCGCTATCATTTCGACGCCTTTCAGCAGACCTATTTCGTCGTCGAGGGGTTCGATCAA
TTGCTGCGCGCGACCGAGGAGGCCGATTTCGCGAGCCTCTATCGCAAGATCGCGAACGAGCCGGCGCTCGCGCCGGGTGA
TGCGTGGCGCGGCGATGTCGCCTATGAAGGACGCCTGCCGGTCCGTCCGGCGAGCGGAGAGGCGGCGACATGA

Upstream 100 bases:

>100_bases
AAGGACATTTGACCCGAAACGGAGGATCATCGTCCGATAATCCGAACAATGTTTGCCTGGGTTCGCGCTACTCTTTCGAA
AGACAATCCGGGAGAGAGGC

Downstream 100 bases:

>100_bases
TCAGGCAGACGCGCGATGGCGACACCGAGGTTTTCGAAACCGAGATCGACGGCGAAACGATCCAGTGGGACAACGGGCTG
ACCTATGCGCGCCACATCCA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MAATHIFDAPPEGVAADWTMPQEWQAFTPEQHRTWRTLFDRQSAAMGGYACRAFLDGLGLLRRLRPGVPDFAELNALLKP
ASGWEVVAVPGWIPNAPFFEHLANRRFPAANFVRPPEQIAYSEEPDMFHDIFGHVPMLANPAFGDFLVAYGEAGLRAESL
GASDYLGRLWLYTVEFGLVVEEGELRAFGGGLLSSLAETAFALTAPEPRRIWLDVERAMRTRYHFDAFQQTYFVVEGFDQ
LLRATEEADFASLYRKIANEPALAPGDAWRGDVAYEGRLPVRPASGEAAT

Sequences:

>Translated_290_residues
MAATHIFDAPPEGVAADWTMPQEWQAFTPEQHRTWRTLFDRQSAAMGGYACRAFLDGLGLLRRLRPGVPDFAELNALLKP
ASGWEVVAVPGWIPNAPFFEHLANRRFPAANFVRPPEQIAYSEEPDMFHDIFGHVPMLANPAFGDFLVAYGEAGLRAESL
GASDYLGRLWLYTVEFGLVVEEGELRAFGGGLLSSLAETAFALTAPEPRRIWLDVERAMRTRYHFDAFQQTYFVVEGFDQ
LLRATEEADFASLYRKIANEPALAPGDAWRGDVAYEGRLPVRPASGEAAT
>Mature_289_residues
AATHIFDAPPEGVAADWTMPQEWQAFTPEQHRTWRTLFDRQSAAMGGYACRAFLDGLGLLRRLRPGVPDFAELNALLKPA
SGWEVVAVPGWIPNAPFFEHLANRRFPAANFVRPPEQIAYSEEPDMFHDIFGHVPMLANPAFGDFLVAYGEAGLRAESLG
ASDYLGRLWLYTVEFGLVVEEGELRAFGGGLLSSLAETAFALTAPEPRRIWLDVERAMRTRYHFDAFQQTYFVVEGFDQL
LRATEEADFASLYRKIANEPALAPGDAWRGDVAYEGRLPVRPASGEAAT

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI4759248, Length=217, Percent_Identity=34.5622119815668, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI31795563, Length=222, Percent_Identity=34.6846846846847, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI88900503, Length=220, Percent_Identity=34.0909090909091, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI88900501, Length=220, Percent_Identity=34.0909090909091, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI88900505, Length=220, Percent_Identity=34.0909090909091, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4557819, Length=221, Percent_Identity=28.9592760180996, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17531391, Length=221, Percent_Identity=31.6742081447964, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=225, Percent_Identity=29.7777777777778, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI115533973, Length=235, Percent_Identity=28.936170212766, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI115532103, Length=235, Percent_Identity=28.936170212766, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71980731, Length=142, Percent_Identity=27.4647887323944, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=32.1428571428571, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=32.1428571428571, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24654994, Length=223, Percent_Identity=30.9417040358744, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136776, Length=215, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136774, Length=215, Percent_Identity=30.2325581395349, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 32270; Mature: 32138

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATHIFDAPPEGVAADWTMPQEWQAFTPEQHRTWRTLFDRQSAAMGGYACRAFLDGLGL
CCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRLRPGVPDFAELNALLKPASGWEVVAVPGWIPNAPFFEHLANRRFPAANFVRPPEQIA
HHHHCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCHHHHC
YSEEPDMFHDIFGHVPMLANPAFGDFLVAYGEAGLRAESLGASDYLGRLWLYTVEFGLVV
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHEEEEEEEEE
EEGELRAFGGGLLSSLAETAFALTAPEPRRIWLDVERAMRTRYHFDAFQQTYFVVEGFDQ
ECCCCEEHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRATEEADFASLYRKIANEPALAPGDAWRGDVAYEGRLPVRPASGEAAT
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
AATHIFDAPPEGVAADWTMPQEWQAFTPEQHRTWRTLFDRQSAAMGGYACRAFLDGLGL
CCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRLRPGVPDFAELNALLKPASGWEVVAVPGWIPNAPFFEHLANRRFPAANFVRPPEQIA
HHHHCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCHHHHC
YSEEPDMFHDIFGHVPMLANPAFGDFLVAYGEAGLRAESLGASDYLGRLWLYTVEFGLVV
CCCCCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCHHHHHHHHHEEEEEEEEE
EEGELRAFGGGLLSSLAETAFALTAPEPRRIWLDVERAMRTRYHFDAFQQTYFVVEGFDQ
ECCCCEEHHHHHHHHHHHHHEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
LLRATEEADFASLYRKIANEPALAPGDAWRGDVAYEGRLPVRPASGEAAT
HHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]