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The map label for this gene is kynA [H]

Identifier: 103486877

GI number: 103486877

Start: 1446468

End: 1447373

Strand: Reverse

Name: kynA [H]

Synonym: Sala_1391

Alternate gene names: 103486877

Gene position: 1447373-1446468 (Counterclockwise)

Preceding gene: 103486878

Following gene: 103486876

Centisome position: 43.27

GC content: 62.91

Gene sequence:

>906_bases
ATGATCAGGCAGACGCGCGATGGCGACACCGAGGTTTTCGAAACCGAGATCGACGGCGAAACGATCCAGTGGGACAACGG
GCTGACCTATGCGCGCCACATCCAGACCGCGCAGTTGCTTTCGGCGCAGGTGCCCGTGTCGGACAAGCCCGATGAGATGC
TGTTCATCATCATGCACCAGACGATGGAGCTGTGGCTCAAGCTGGTGCTGCACGAGGCGCGCCTCGTCCATGACGCGATC
AAGGACGATCGGCTCGAAATCGCGGGCAAGGGGCTTGACCGCATCGCGACGATCCAGCGCCACATGATCCACAGCTGGGA
AGTGCTCGCGACGCTGACCCCGCATGATTTCCTGACCTTTCGCGGGTTCCTCCGCCGCGCGTCGGGGTTCCAGTCGCAGC
AGTATCGCGAACTCGAATATCTGCTCGGCAACAAGCGCGGCGACATGATGATCGTCCACAAGGACGACGCGGAAGCCACG
GCACGGTTGCGCGCGGTGTTTGAGGCGCCGTCGCTCTATGACGAGCTGCTGCGGCTGCTCGCGCGGCGCGGCTTCGCCAT
ACCGGCGGGGCATCTGGAGCGCGACTGGACGCAGCCCTATGCGACGTCGGAAGCGGTCGAGCAGGCGTGGCTCGCGATCT
ATACCGACCCCGAACGGCATTGGGATCTCTACACGCTCGCTGAAAAGGTCACGGCGCTTGAGTATTATTTCCAGGAATGG
CGCTTCAAGCACATGAAGACCGTCGCGCGCGTGATCGGGCACAAGCCGGGGACGGGCGGCTCGTCGGGGGTCAATTATCT
CGTCAAGGCGCTCGATCTCAGCTTCTTTCCCGAACTCTGGTCGATGCGGACCGAAATGGTCGCGCCGCGCGAGGGTGGCG
ACTATGCGGCAGGGGAACGCAAATGA

Upstream 100 bases:

>100_bases
TCGCGAACGAGCCGGCGCTCGCGCCGGGTGATGCGTGGCGCGGCGATGTCGCCTATGAAGGACGCCTGCCGGTCCGTCCG
GCGAGCGGAGAGGCGGCGAC

Downstream 100 bases:

>100_bases
GCCGGATTTGGGACATTTCCCAGCCGCTGCACGCCGCGGTGCCGGTGTGGCCCGGCGAGCCCGCCTTCTCGCTCCACAGC
CATGCGGTGATCGGCGAGGG

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MIRQTRDGDTEVFETEIDGETIQWDNGLTYARHIQTAQLLSAQVPVSDKPDEMLFIIMHQTMELWLKLVLHEARLVHDAI
KDDRLEIAGKGLDRIATIQRHMIHSWEVLATLTPHDFLTFRGFLRRASGFQSQQYRELEYLLGNKRGDMMIVHKDDAEAT
ARLRAVFEAPSLYDELLRLLARRGFAIPAGHLERDWTQPYATSEAVEQAWLAIYTDPERHWDLYTLAEKVTALEYYFQEW
RFKHMKTVARVIGHKPGTGGSSGVNYLVKALDLSFFPELWSMRTEMVAPREGGDYAAGERK

Sequences:

>Translated_301_residues
MIRQTRDGDTEVFETEIDGETIQWDNGLTYARHIQTAQLLSAQVPVSDKPDEMLFIIMHQTMELWLKLVLHEARLVHDAI
KDDRLEIAGKGLDRIATIQRHMIHSWEVLATLTPHDFLTFRGFLRRASGFQSQQYRELEYLLGNKRGDMMIVHKDDAEAT
ARLRAVFEAPSLYDELLRLLARRGFAIPAGHLERDWTQPYATSEAVEQAWLAIYTDPERHWDLYTLAEKVTALEYYFQEW
RFKHMKTVARVIGHKPGTGGSSGVNYLVKALDLSFFPELWSMRTEMVAPREGGDYAAGERK
>Mature_301_residues
MIRQTRDGDTEVFETEIDGETIQWDNGLTYARHIQTAQLLSAQVPVSDKPDEMLFIIMHQTMELWLKLVLHEARLVHDAI
KDDRLEIAGKGLDRIATIQRHMIHSWEVLATLTPHDFLTFRGFLRRASGFQSQQYRELEYLLGNKRGDMMIVHKDDAEAT
ARLRAVFEAPSLYDELLRLLARRGFAIPAGHLERDWTQPYATSEAVEQAWLAIYTDPERHWDLYTLAEKVTALEYYFQEW
RFKHMKTVARVIGHKPGTGGSSGVNYLVKALDLSFFPELWSMRTEMVAPREGGDYAAGERK

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=340, Percent_Identity=26.1764705882353, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32564651, Length=128, Percent_Identity=38.28125, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=128, Percent_Identity=38.28125, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17530891, Length=345, Percent_Identity=28.1159420289855, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 34795; Mature: 34795

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQTRDGDTEVFETEIDGETIQWDNGLTYARHIQTAQLLSAQVPVSDKPDEMLFIIMHQ
CCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHH
TMELWLKLVLHEARLVHDAIKDDRLEIAGKGLDRIATIQRHMIHSWEVLATLTPHDFLTF
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHEEECCCHHHHHH
RGFLRRASGFQSQQYRELEYLLGNKRGDMMIVHKDDAEATARLRAVFEAPSLYDELLRLL
HHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHH
ARRGFAIPAGHLERDWTQPYATSEAVEQAWLAIYTDPERHWDLYTLAEKVTALEYYFQEW
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
RFKHMKTVARVIGHKPGTGGSSGVNYLVKALDLSFFPELWSMRTEMVAPREGGDYAAGER
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
K
C
>Mature Secondary Structure
MIRQTRDGDTEVFETEIDGETIQWDNGLTYARHIQTAQLLSAQVPVSDKPDEMLFIIMHQ
CCCCCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHH
TMELWLKLVLHEARLVHDAIKDDRLEIAGKGLDRIATIQRHMIHSWEVLATLTPHDFLTF
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHEEECCCHHHHHH
RGFLRRASGFQSQQYRELEYLLGNKRGDMMIVHKDDAEATARLRAVFEAPSLYDELLRLL
HHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHH
ARRGFAIPAGHLERDWTQPYATSEAVEQAWLAIYTDPERHWDLYTLAEKVTALEYYFQEW
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
RFKHMKTVARVIGHKPGTGGSSGVNYLVKALDLSFFPELWSMRTEMVAPREGGDYAAGER
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA