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The map label for this gene is hemF [H]

Identifier: 103486833

GI number: 103486833

Start: 1406635

End: 1407495

Strand: Direct

Name: hemF [H]

Synonym: Sala_1347

Alternate gene names: 103486833

Gene position: 1406635-1407495 (Clockwise)

Preceding gene: 103486832

Following gene: 103486836

Centisome position: 42.05

GC content: 64.69

Gene sequence:

>861_bases
ATGATCCCGCTCGATCCGCAGCAACAGAAGGCGCGCAACTGGTTCGAATCGCTTCGCGACCGCATCTGCGCCGAGTTCGA
GGCGATCGAGGCCGAAGCGGGCAGCGACGCGCGCTTCACCTATACGTCGTGGGATCGCGAGGCCGAGGGACTTGAACCCG
GCGAAGGCGGCGGTGGTGTGCGCGGAGTGATGACGGGCAAGGTGTTTGAAAAGGTCGGCGTCAACGTCTCGACCGTCGGC
GGCGAGTTCGCGCCCGATTTCGCGTCCTCGATCCATGGCGCGGGCGACGATCCGCGCTTTTTCGCGACGGGGATCAGCCT
CGTCGCGCATATGGCGAACCCGCACGTCCCCGCCGTGCATATGAACACGCGCTTCCTCGTCACGACGAAGCGCTGGTTCG
GCGGTGGCGCCGACCTCAATCCACCGATCCCGTACCAGGAGGACACCGATGCCTTTCACGCGCGACTGCGCGCCGCCTGT
GCCCCCTTCGGTCCCGATGTCTATGAACGCTATGCCAAATGGGCGGACGAGTATTTCTATATTCCGCACCGCGGCGTCCA
CCGCGGCGTCGGCGGTATCTTCTACGACCATCTCGAATGCGGCGACGACGCCGAGTTCGATCGCAATTTCCAGTTGACGC
AGGCGGTGGGCGAGGCGTTCCTCGACATCTTCCCGCGGATCGTGCGACGTCGGATGGATCAGCCCTTCACCGACGCCGAA
CGCGACGCGCAACTCGTCTGGCGCGGCCGATATGCCGAGTTCAATCTCGTCTACGACCGCGGCACGCTCTTCGGCCTCAA
GACCGGCGGCAATATCGACGCCATCCTGATGAGCCTGCCGCCGCTCGCCAAGTGGAGCTGA

Upstream 100 bases:

>100_bases
TCGCGATTCCGATGCAGCCCGGCTTTCGATGCTTGAATGTCGCGGTCGCGGCTGGCATCGCGCTCGCCGAGGCGCTCAGG
CAGACGAAAGGCTTTCCGGC

Downstream 100 bases:

>100_bases
AAAGGGCGCCCCGCAGCCAGTGGAGCGCCCCTTCCTGATCGTCTGCGCCGATCAGGCGAAGATGTCGCCCGATGCGCGCG
GAGCGATAGCGCGATACACG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MIPLDPQQQKARNWFESLRDRICAEFEAIEAEAGSDARFTYTSWDREAEGLEPGEGGGGVRGVMTGKVFEKVGVNVSTVG
GEFAPDFASSIHGAGDDPRFFATGISLVAHMANPHVPAVHMNTRFLVTTKRWFGGGADLNPPIPYQEDTDAFHARLRAAC
APFGPDVYERYAKWADEYFYIPHRGVHRGVGGIFYDHLECGDDAEFDRNFQLTQAVGEAFLDIFPRIVRRRMDQPFTDAE
RDAQLVWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPLAKWS

Sequences:

>Translated_286_residues
MIPLDPQQQKARNWFESLRDRICAEFEAIEAEAGSDARFTYTSWDREAEGLEPGEGGGGVRGVMTGKVFEKVGVNVSTVG
GEFAPDFASSIHGAGDDPRFFATGISLVAHMANPHVPAVHMNTRFLVTTKRWFGGGADLNPPIPYQEDTDAFHARLRAAC
APFGPDVYERYAKWADEYFYIPHRGVHRGVGGIFYDHLECGDDAEFDRNFQLTQAVGEAFLDIFPRIVRRRMDQPFTDAE
RDAQLVWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPLAKWS
>Mature_286_residues
MIPLDPQQQKARNWFESLRDRICAEFEAIEAEAGSDARFTYTSWDREAEGLEPGEGGGGVRGVMTGKVFEKVGVNVSTVG
GEFAPDFASSIHGAGDDPRFFATGISLVAHMANPHVPAVHMNTRFLVTTKRWFGGGADLNPPIPYQEDTDAFHARLRAAC
APFGPDVYERYAKWADEYFYIPHRGVHRGVGGIFYDHLECGDDAEFDRNFQLTQAVGEAFLDIFPRIVRRRMDQPFTDAE
RDAQLVWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPLAKWS

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=270, Percent_Identity=40.7407407407407, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1788777, Length=288, Percent_Identity=44.7916666666667, Blast_Score=235, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6320249, Length=307, Percent_Identity=39.0879478827362, Blast_Score=201, Evalue=9e-53,
Organism=Drosophila melanogaster, GI17864388, Length=293, Percent_Identity=39.9317406143345, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 31960; Mature: 31960

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLDPQQQKARNWFESLRDRICAEFEAIEAEAGSDARFTYTSWDREAEGLEPGEGGGGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
RGVMTGKVFEKVGVNVSTVGGEFAPDFASSIHGAGDDPRFFATGISLVAHMANPHVPAVH
EEEHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
MNTRFLVTTKRWFGGGADLNPPIPYQEDTDAFHARLRAACAPFGPDVYERYAKWADEYFY
ECCEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEE
IPHRGVHRGVGGIFYDHLECGDDAEFDRNFQLTQAVGEAFLDIFPRIVRRRMDQPFTDAE
CCCCCHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RDAQLVWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPLAKWS
CCCEEEEECCCEEEEEEEECCEEEEEECCCCCEEHEECCCCCCCCC
>Mature Secondary Structure
MIPLDPQQQKARNWFESLRDRICAEFEAIEAEAGSDARFTYTSWDREAEGLEPGEGGGGV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
RGVMTGKVFEKVGVNVSTVGGEFAPDFASSIHGAGDDPRFFATGISLVAHMANPHVPAVH
EEEHHHHHHHHHCCEEEECCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
MNTRFLVTTKRWFGGGADLNPPIPYQEDTDAFHARLRAACAPFGPDVYERYAKWADEYFY
ECCEEEEEEHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEE
IPHRGVHRGVGGIFYDHLECGDDAEFDRNFQLTQAVGEAFLDIFPRIVRRRMDQPFTDAE
CCCCCHHHCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RDAQLVWRGRYAEFNLVYDRGTLFGLKTGGNIDAILMSLPPLAKWS
CCCEEEEECCCEEEEEEEECCEEEEEECCCCCEEHEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA