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The map label for this gene is ilvD

Identifier: 103486677

GI number: 103486677

Start: 1229244

End: 1231103

Strand: Direct

Name: ilvD

Synonym: Sala_1189

Alternate gene names: 103486677

Gene position: 1229244-1231103 (Clockwise)

Preceding gene: 103486676

Following gene: 103486678

Centisome position: 36.75

GC content: 65.86

Gene sequence:

>1860_bases
ATGCCTTCTTATCGTTCGCGCACCACAACCCATGGCCGCAACATGGCCGGTGCCCGCGGCCTGTGGCGTGCGACGGGGAT
GAAGGACAGCGACTTCGGCAAGCCCATCATCGCGGTGGTCAACAGCTTCACCCAGTTTGTGCCGGGCCATGTTCACCTGA
AAGACCTGGGCCAGATGGTCGCGCGCGAGATCGAGGCAGCCGGAGGCGTTGCCAAGGAGTTCAACACGATCGCGGTCGAT
GACGGCATCGCGATGGGACACGACGGGATGCTCTATTCGCTGCCCAGCCGCGACCTGATCGCCGACAGTGTCGAGTATAT
GGTCAATGCGCATTGCGCCGATGCGATGGTGTGCATTTCCAACTGCGACAAGATCACGCCGGGGATGTTGATGGCGGCGC
TGCGCATCAACATCCCCGTGGTGTTCGTGTCGGGCGGGCCGATGGAGGCGGGCAAGGTCGTGCTGAAGGGCAAGGAGGTC
GCGCTCGACCTGGTCGACGCGATGGTCGCCGCCGCCGACGAAAAATACAGCGACGAAGAAGTGCTGGCAATCGAACAGGC
GGCGTGCCCGACATGCGGATCATGTTCGGGCATGTTCACCGCCAATTCGATGAACTGCCTGACCGAAGCGTTGGGGCTGT
CGCTGCCGGGCAATGGCTCGACGCTGGCGACCCACGCCGACCGCAAGGAGCTGTTCCTGCGCGCCGGGCGGATCGTCGTC
GAAATGTGTCGCCGTCATTATGAGGAAGGCGACGACAGCGTCCTGCCGCGCAATATCGCGACGTTCGAGGCGTTTGAAAA
TGCGATGAGCCTCGACATCGCGATGGGCGGATCGACCAACACCGTGCTCCACCTGCTCGCCGCCGCGCATGAAGCGGGCG
TCGATTTCACGATGGAAGACATCGACCGGCTGTCGCGTCGCGTGCCGTGCCTGTCAAAGGTCGCGCCGGCCAAGAGCGAC
GTGCATATGGAGGATGTCCACCGCGCGGGCGGGATCATGGCGATCCTCGGCGAACTCGACCGCGCGGGGCTGCTCCACGC
GCATCTGCCGACGGTGCATAGCGCCACGCTGGGCGATGCGCTCAACAAATGGGACATTGCGCGCACGAACGACCCGGAGG
TGCAGAAGTTCTTCATGGCCGCCCCCGGCGGCGTGCCGACGCAGACGGCGTTCAGCCAGGCCCGGCGCTGGGACAGCCTT
GACCTCGACCGGATAAGCGGTGTGATCCGTTCGGCGGACCATGCGTTCAGCAAGGACGGCGGGCTGGCGGTGCTGAGCGG
CAATGTCGCGCCCGACGGCTGCATCGTGAAGACCGCGGGGGTCGATGAAAGCATCCTCAAGTTCAGCGGGCCGGCGAAGG
TGTTCGAGAGCCAGGACGCCGCGGTTGCGGGCATATTGACCGGGCAGGTCGAGGCGGGCGACGTCGTCGTCATCCGCTAC
GAAGGGCCGAAGGGCGGGCCGGGGATGCAGGAAATGCTCTATCCGACCAGCTATCTGAAATCGAAAGGGCTGGGCGCCGC
CTGTGCGCTCGTCACCGATGGGCGCTTTTCGGGCGGCACGTCGGGCCTGTCGATCGGCCATGTCTCGCCCGAGGCGGCCG
AAGGCGGGACGATCGGGCTGGTCGAGAATGGCGACCTCATCAACATCGACATTCCGTCGCGGACGATCACGCTCGCGGTG
GCCGACAGCGTGCTCGCCGAACGCCGCGCCGCGATGGAGGCGAAGGGTGACGCCGCCTGGCAGCCCGCCAAGCCGCGCCC
GCGCAAGGTTTCGGTGGCGCTTCAGGCCTATGCCGCGATGACGACGAGCGCCGCGCGCGGCGCGGTGCGCGACCTGTCGC
AGCTGAAGGGCAAGGGATGA

Upstream 100 bases:

>100_bases
CGCGAATGTGCAGGAAAGTGACATTGAACATCGGGGAATAGGCGTGTAGAGGCGCATCTTGCCTCTAGTTTTTGAAACAA
AATTATCAGGATTGAGTGAA

Downstream 100 bases:

>100_bases
TTCGCAAACGCGGCGCGGTCCCGGTTGTGCTGATGTTTCTCGGCGCTTGCGGCGGCGCGCCCGGCGACGAAGCGGCGGAT
GCGGGCAAGGCGCGGATCGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPSYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRINIPVVFVSGGPMEAGKVVLKGKEV
ALDLVDAMVAAADEKYSDEEVLAIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKELFLRAGRIVV
EMCRRHYEEGDDSVLPRNIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVDFTMEDIDRLSRRVPCLSKVAPAKSD
VHMEDVHRAGGIMAILGELDRAGLLHAHLPTVHSATLGDALNKWDIARTNDPEVQKFFMAAPGGVPTQTAFSQARRWDSL
DLDRISGVIRSADHAFSKDGGLAVLSGNVAPDGCIVKTAGVDESILKFSGPAKVFESQDAAVAGILTGQVEAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVENGDLINIDIPSRTITLAV
ADSVLAERRAAMEAKGDAAWQPAKPRPRKVSVALQAYAAMTTSAARGAVRDLSQLKGKG

Sequences:

>Translated_619_residues
MPSYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRINIPVVFVSGGPMEAGKVVLKGKEV
ALDLVDAMVAAADEKYSDEEVLAIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKELFLRAGRIVV
EMCRRHYEEGDDSVLPRNIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVDFTMEDIDRLSRRVPCLSKVAPAKSD
VHMEDVHRAGGIMAILGELDRAGLLHAHLPTVHSATLGDALNKWDIARTNDPEVQKFFMAAPGGVPTQTAFSQARRWDSL
DLDRISGVIRSADHAFSKDGGLAVLSGNVAPDGCIVKTAGVDESILKFSGPAKVFESQDAAVAGILTGQVEAGDVVVIRY
EGPKGGPGMQEMLYPTSYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVENGDLINIDIPSRTITLAV
ADSVLAERRAAMEAKGDAAWQPAKPRPRKVSVALQAYAAMTTSAARGAVRDLSQLKGKG
>Mature_618_residues
PSYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAALRINIPVVFVSGGPMEAGKVVLKGKEVA
LDLVDAMVAAADEKYSDEEVLAIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKELFLRAGRIVVE
MCRRHYEEGDDSVLPRNIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVDFTMEDIDRLSRRVPCLSKVAPAKSDV
HMEDVHRAGGIMAILGELDRAGLLHAHLPTVHSATLGDALNKWDIARTNDPEVQKFFMAAPGGVPTQTAFSQARRWDSLD
LDRISGVIRSADHAFSKDGGLAVLSGNVAPDGCIVKTAGVDESILKFSGPAKVFESQDAAVAGILTGQVEAGDVVVIRYE
GPKGGPGMQEMLYPTSYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAAEGGTIGLVENGDLINIDIPSRTITLAVA
DSVLAERRAAMEAKGDAAWQPAKPRPRKVSVALQAYAAMTTSAARGAVRDLSQLKGKG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=73.7439222042139, Blast_Score=937, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=538, Percent_Identity=30.8550185873606, Blast_Score=192, Evalue=7e-50,
Organism=Escherichia coli, GI2367371, Length=550, Percent_Identity=30, Blast_Score=190, Evalue=3e-49,
Organism=Escherichia coli, GI1786464, Length=553, Percent_Identity=30.379746835443, Blast_Score=185, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=613, Percent_Identity=36.8678629690049, Blast_Score=357, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SPHAL (Q1GTW7)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616238.1
- GeneID:   4080837
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1189
- NMPDR:   fig|317655.9.peg.1123
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   SALA317655:SALA_1189-MONOMER
- BRENDA:   4.2.1.9
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65134; Mature: 65003

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRINIPVVFVSGGPMEAGKVVLKGKEVALDLVDAMVAAADEKYSDEE
CCCCCCHHHHHHHHEECCEEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
VLAIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKELFLRAGRIVV
EEEEHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
EMCRRHYEEGDDSVLPRNIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVDFTMED
HHHHHHHCCCCCCCCCCCHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHH
IDRLSRRVPCLSKVAPAKSDVHMEDVHRAGGIMAILGELDRAGLLHAHLPTVHSATLGDA
HHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHH
LNKWDIARTNDPEVQKFFMAAPGGVPTQTAFSQARRWDSLDLDRISGVIRSADHAFSKDG
HCCCCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
GLAVLSGNVAPDGCIVKTAGVDESILKFSGPAKVFESQDAAVAGILTGQVEAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VENGDLINIDIPSRTITLAVADSVLAERRAAMEAKGDAAWQPAKPRPRKVSVALQAYAAM
EECCCEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHH
TTSAARGAVRDLSQLKGKG
HHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSYRSRTTTHGRNMAGARGLWRATGMKDSDFGKPIIAVVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRINIPVVFVSGGPMEAGKVVLKGKEVALDLVDAMVAAADEKYSDEE
CCCCCCHHHHHHHHEECCEEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
VLAIEQAACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSTLATHADRKELFLRAGRIVV
EEEEHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHH
EMCRRHYEEGDDSVLPRNIATFEAFENAMSLDIAMGGSTNTVLHLLAAAHEAGVDFTMED
HHHHHHHCCCCCCCCCCCHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHH
IDRLSRRVPCLSKVAPAKSDVHMEDVHRAGGIMAILGELDRAGLLHAHLPTVHSATLGDA
HHHHHHHCCHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHH
LNKWDIARTNDPEVQKFFMAAPGGVPTQTAFSQARRWDSLDLDRISGVIRSADHAFSKDG
HCCCCCCCCCCHHHHHHEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
GLAVLSGNVAPDGCIVKTAGVDESILKFSGPAKVFESQDAAVAGILTGQVEAGDVVVIRY
CEEEEECCCCCCCEEEEECCCCHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCCEEEEEE
EGPKGGPGMQEMLYPTSYLKSKGLGAACALVTDGRFSGGTSGLSIGHVSPEAAEGGTIGL
CCCCCCCCHHHHHCCHHHHHCCCCCEEEEEEECCCCCCCCCCEEECCCCCCCCCCCEEEE
VENGDLINIDIPSRTITLAVADSVLAERRAAMEAKGDAAWQPAKPRPRKVSVALQAYAAM
EECCCEEEEECCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHH
TTSAARGAVRDLSQLKGKG
HHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA