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The map label for this gene is pyrG

Identifier: 103486658

GI number: 103486658

Start: 1204407

End: 1206038

Strand: Reverse

Name: pyrG

Synonym: Sala_1170

Alternate gene names: 103486658

Gene position: 1206038-1204407 (Counterclockwise)

Preceding gene: 103486659

Following gene: 103486657

Centisome position: 36.05

GC content: 62.81

Gene sequence:

>1632_bases
ATGGCGCGGTTCATTTTCATTACCGGCGGCGTGGTCTCCTCGCTTGGCAAGGGTTTGATGGCGGCCAGCCTCGCTGCCCT
CCTGCAAGCGCGTGGCTATCGTGTCCGCATCCGAAAGTTCGATCCCTATCTGAACGTCGATCCGGGCACGATGTCGCCCT
ATCAGCACGGCGAAGTCTATGTGACCGATGACGGAGCGGAAACCGACCTCGACCTGGGCCATTATGAACGCTTCACCGGC
GTTGCGGCGCGGCAGAGCGACAATGTGACCTCGGGCCGTATCTATCAGGGCATCATCGCCAAGGAACGCCGCGGCGACTA
TCTCGGCGCGACGGTACAGGTTGTCCCGCACGTCACCGACGCGATCAAGGATTTCGCCCGCGCCGAAACCGACGACCTCG
ATTTCGTGCTGTGCGAGATCGGCGGCACCGTCGGCGATATCGAATCGCTGCCCTTTATCGAGGCGATCCGCCAGTTGAAG
AATGAGGTCGGCCGCGACAACGCCATCTCGGTCCACGTCACGCTGGTGCCCTATATCGCCGCCGCGGGCGAGTTGAAGAC
AAAGCCGACGCAGCACAGCGTGCGCGAACTCGCCTCGCTCGGCGTCCAGCCCGACATTCTGCTCTGCCGATGCGAAAAGC
CGCTTCCCGACAGCGAACGCGCCAAGATCGCGCTGTTCTGCAATGTCCGCAAGGAAGCGGTGATTCCCGCGCTCGACGCC
GACAGCATCTATTCGGTACCGGTCCAGTATCATGGCGAGGGTCTGGACAGCGAAGTGCTGCGCGCATTCGGAATCCTCGA
CGCGCCCGCGCCCGACCTGACGGCCTGGTATGACATCATGGACCGCAAGCAGCATCCCGAGGGCGAGGTCACGATCGGCG
TCGTCGGCAAATATGTCTCGCTGCCCGATGCCTATAAATCCCTGAACGAGGCGCTGGTCCATGGCGGCATGGCGCACCGG
GTCAAGGTCAATATCCGCTGGCTCGACGCCGAAATGTTCGAGCGCGACGAAGACCTGGTCGCCAATCTCGAACCGCTGCA
CGGCATCCTCGTCCCCGGCGGCTTCGGCGAGCGCGGGTCGGAGGGCAAGATTGCGAGCGTGCGTTTCGCGCGCGAGCGGA
ATGTGCCCTTTTTCGGCATCTGCCTGGGGATGCAGATGGCGTGCATCGAGGCGGCGCGCAATACGAGCGGCATTGCGAAT
GCGTCGAGTACCGAATTCGGTCCGACCGACGAACCCGTCGTCGGCCTGATCACCGAATGGATGAGCGCCGAAGGGCTTCA
GAAACGCGGTGCGAACACCGATCTTGGCGGCACGATGCGCCTCGGCGCCTATGACGCGAAACTTTCGCCGAACAGCCATG
TCGCCAGCGTCTATGGCACGAACGAGATCAGCGAGCGTCACCGCCACCGCTATGAGGTCAACGGGGCCTATCGCGAGCGG
CTCGAAAAGGGCGGGCTCGTCTTTTCAGGCATGTCGCCCGACGGCATGCTACCGGAAATCGTTGAGCGGCCGGACCATCC
GTGGTTTATCGGGGTGCAATTCCACCCGGAACTCAAATCCAAGCCCTTCGACCCGCATCCCCTGTTTGCAGGATTCATCG
AGGCGGCGGTGAAGCAGAGCCGGCTGGTCTGA

Upstream 100 bases:

>100_bases
TCCCGCCTCCGTATCAGCCCGCGCTCACGGAAATAATTTCCGCAGTTCGCGATTCGACGGCTTGCGCCGTCCCCCTCCCT
TTGAGTAAGTCTTTCCTCCC

Downstream 100 bases:

>100_bases
CCGAAAGGGATTGGGGCGATGGATCACGCAAGACTTGCCGAACTGCAGAGCCCCGACAGCATCTTTTCCGGCCTTTCGGT
CGAGGATTGGGCCGAAATCA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MARFIFITGGVVSSLGKGLMAASLAALLQARGYRVRIRKFDPYLNVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFTG
VAARQSDNVTSGRIYQGIIAKERRGDYLGATVQVVPHVTDAIKDFARAETDDLDFVLCEIGGTVGDIESLPFIEAIRQLK
NEVGRDNAISVHVTLVPYIAAAGELKTKPTQHSVRELASLGVQPDILLCRCEKPLPDSERAKIALFCNVRKEAVIPALDA
DSIYSVPVQYHGEGLDSEVLRAFGILDAPAPDLTAWYDIMDRKQHPEGEVTIGVVGKYVSLPDAYKSLNEALVHGGMAHR
VKVNIRWLDAEMFERDEDLVANLEPLHGILVPGGFGERGSEGKIASVRFARERNVPFFGICLGMQMACIEAARNTSGIAN
ASSTEFGPTDEPVVGLITEWMSAEGLQKRGANTDLGGTMRLGAYDAKLSPNSHVASVYGTNEISERHRHRYEVNGAYRER
LEKGGLVFSGMSPDGMLPEIVERPDHPWFIGVQFHPELKSKPFDPHPLFAGFIEAAVKQSRLV

Sequences:

>Translated_543_residues
MARFIFITGGVVSSLGKGLMAASLAALLQARGYRVRIRKFDPYLNVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFTG
VAARQSDNVTSGRIYQGIIAKERRGDYLGATVQVVPHVTDAIKDFARAETDDLDFVLCEIGGTVGDIESLPFIEAIRQLK
NEVGRDNAISVHVTLVPYIAAAGELKTKPTQHSVRELASLGVQPDILLCRCEKPLPDSERAKIALFCNVRKEAVIPALDA
DSIYSVPVQYHGEGLDSEVLRAFGILDAPAPDLTAWYDIMDRKQHPEGEVTIGVVGKYVSLPDAYKSLNEALVHGGMAHR
VKVNIRWLDAEMFERDEDLVANLEPLHGILVPGGFGERGSEGKIASVRFARERNVPFFGICLGMQMACIEAARNTSGIAN
ASSTEFGPTDEPVVGLITEWMSAEGLQKRGANTDLGGTMRLGAYDAKLSPNSHVASVYGTNEISERHRHRYEVNGAYRER
LEKGGLVFSGMSPDGMLPEIVERPDHPWFIGVQFHPELKSKPFDPHPLFAGFIEAAVKQSRLV
>Mature_542_residues
ARFIFITGGVVSSLGKGLMAASLAALLQARGYRVRIRKFDPYLNVDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFTGV
AARQSDNVTSGRIYQGIIAKERRGDYLGATVQVVPHVTDAIKDFARAETDDLDFVLCEIGGTVGDIESLPFIEAIRQLKN
EVGRDNAISVHVTLVPYIAAAGELKTKPTQHSVRELASLGVQPDILLCRCEKPLPDSERAKIALFCNVRKEAVIPALDAD
SIYSVPVQYHGEGLDSEVLRAFGILDAPAPDLTAWYDIMDRKQHPEGEVTIGVVGKYVSLPDAYKSLNEALVHGGMAHRV
KVNIRWLDAEMFERDEDLVANLEPLHGILVPGGFGERGSEGKIASVRFARERNVPFFGICLGMQMACIEAARNTSGIANA
SSTEFGPTDEPVVGLITEWMSAEGLQKRGANTDLGGTMRLGAYDAKLSPNSHVASVYGTNEISERHRHRYEVNGAYRERL
EKGGLVFSGMSPDGMLPEIVERPDHPWFIGVQFHPELKSKPFDPHPLFAGFIEAAVKQSRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=44.8833034111311, Blast_Score=473, Evalue=1e-133,
Organism=Homo sapiens, GI28559085, Length=559, Percent_Identity=42.7549194991055, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI28559083, Length=559, Percent_Identity=42.7549194991055, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI221316689, Length=559, Percent_Identity=42.7549194991055, Blast_Score=450, Evalue=1e-126,
Organism=Escherichia coli, GI1789142, Length=535, Percent_Identity=57.5700934579439, Blast_Score=606, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=36.6174055829228, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322563, Length=570, Percent_Identity=41.7543859649123, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319432, Length=566, Percent_Identity=41.1660777385159, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.9068100358423, Blast_Score=437, Evalue=1e-122,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=43.1411530815109, Blast_Score=373, Evalue=1e-103,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_SPHAL (Q1GTY6)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616219.1
- ProteinModelPortal:   Q1GTY6
- SMR:   Q1GTY6
- GeneID:   4080876
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1170
- NMPDR:   fig|317655.9.peg.1104
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   SALA317655:SALA_1170-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59457; Mature: 59326

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 515-515 ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARFIFITGGVVSSLGKGLMAASLAALLQARGYRVRIRKFDPYLNVDPGTMSPYQHGEVY
CCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGVAARQSDNVTSGRIYQGIIAKERRGDYLGATVQVVPHVTD
EECCCCCCCCCCCHHHHHHCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHH
AIKDFARAETDDLDFVLCEIGGTVGDIESLPFIEAIRQLKNEVGRDNAISVHVTLVPYIA
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHH
AAGELKTKPTQHSVRELASLGVQPDILLCRCEKPLPDSERAKIALFCNVRKEAVIPALDA
HCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCHHHCCCCCCC
DSIYSVPVQYHGEGLDSEVLRAFGILDAPAPDLTAWYDIMDRKQHPEGEVTIGVVGKYVS
CCEEECCCEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCC
LPDAYKSLNEALVHGGMAHRVKVNIRWLDAEMFERDEDLVANLEPLHGILVPGGFGERGS
CCHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHCCHHHHHCCCCCCEEEECCCCCCCCC
EGKIASVRFARERNVPFFGICLGMQMACIEAARNTSGIANASSTEFGPTDEPVVGLITEW
CCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
MSAEGLQKRGANTDLGGTMRLGAYDAKLSPNSHVASVYGTNEISERHRHRYEVNGAYRER
HHHHHHHHCCCCCCCCCEEEECEEECCCCCCCCEEEEECCHHHHHHHHHEEECCHHHHHH
LEKGGLVFSGMSPDGMLPEIVERPDHPWFIGVQFHPELKSKPFDPHPLFAGFIEAAVKQS
HHHCCEEEECCCCCCCCHHHHHCCCCCEEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHH
RLV
CCC
>Mature Secondary Structure 
ARFIFITGGVVSSLGKGLMAASLAALLQARGYRVRIRKFDPYLNVDPGTMSPYQHGEVY
CEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTGVAARQSDNVTSGRIYQGIIAKERRGDYLGATVQVVPHVTD
EECCCCCCCCCCCHHHHHHCHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEHHHHHH
AIKDFARAETDDLDFVLCEIGGTVGDIESLPFIEAIRQLKNEVGRDNAISVHVTLVPYIA
HHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEHHH
AAGELKTKPTQHSVRELASLGVQPDILLCRCEKPLPDSERAKIALFCNVRKEAVIPALDA
HCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECCHHHCCCCCCC
DSIYSVPVQYHGEGLDSEVLRAFGILDAPAPDLTAWYDIMDRKQHPEGEVTIGVVGKYVS
CCEEECCCEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCC
LPDAYKSLNEALVHGGMAHRVKVNIRWLDAEMFERDEDLVANLEPLHGILVPGGFGERGS
CCHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHCCHHHHHCCCCCCEEEECCCCCCCCC
EGKIASVRFARERNVPFFGICLGMQMACIEAARNTSGIANASSTEFGPTDEPVVGLITEW
CCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHH
MSAEGLQKRGANTDLGGTMRLGAYDAKLSPNSHVASVYGTNEISERHRHRYEVNGAYRER
HHHHHHHHCCCCCCCCCEEEECEEECCCCCCCCEEEEECCHHHHHHHHHEEECCHHHHHH
LEKGGLVFSGMSPDGMLPEIVERPDHPWFIGVQFHPELKSKPFDPHPLFAGFIEAAVKQS
HHHCCEEEECCCCCCCCHHHHHCCCCCEEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHH
RLV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA